Article
Microbiology
Stephen Raimon Jada, Alfred Dusabimana, Gasim Abd-Elfarag, Samuel Okaro, Nele Brusselaers, Jane Y. Carter, Makoy Yibi Logora, Jacopo Mattia Rovarini, Charles R. Newton, Robert Colebunders
Summary: A two-phase survey conducted in Mundri villages in South Sudan revealed a high prevalence and incidence of epilepsy. Urgent action is needed to prevent onchocerciasis-associated epilepsy by strengthening elimination programs.
Article
Microbiology
Stephen Raimon, Alfred Dusabimana, Gasim Abd-Elfarag, Samuel Okaro, Jane Y. Carter, Charles R. Newton, Makoy Yibi Logora, Robert Colebunders
Summary: A study conducted in Mvolo County, South Sudan, revealed a high prevalence and incidence of epilepsy, with factors such as younger age, male gender, skin itching, blindness, and living near the Naam River identified as risk factors for epilepsy. Additionally, the transmission of parasites remains high in the region, with a low percentage of individuals receiving treatment.
Review
Immunology
Bin Zhan, Maria Elena Bottazzi, Peter J. Hotez, Sara Lustigman
Summary: Human onchocerciasis is a devastating tropical disease caused by infection of Onchocerca volvulus, leading to visual impairment and dermatitis. Mass drug administration has reduced prevalence, but challenges such as drug resistance and adverse events remain, highlighting the need for vaccine development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Parasitology
Adam Hendy, Meryam Krit, Kenneth Pfarr, Christine Laemmer, Jacobus De Witte, Philippe Nwane, Joseph Kamgno, Hugues C. Nana-Djeunga, Michel Boussinesq, Jean-Claude Dujardin, Rory Post, Robert Colebunders, Sarah O'Neill, Peter Enyong, Alfred K. Njamnshi
Summary: The study found high densities of biting black flies sustaining transmission of O. volvulus along the lower Mbam river, despite relatively low infection rates that do not meet the WHO threshold for interruption of transmission.
PARASITES & VECTORS
(2021)
Article
Infectious Diseases
Kenneth Bentum Otabil, Blessing Ankrah, Emmanuel John Bart-Plange, Emmanuel Sam Donkoh, Fiona Amoabil Avarikame, Fredrick Obeng Ofori-Appiah, Theophilus Nti Babae, Prince-Charles Kudzordzi, Vera Achiaa Darko, Joseph Ameyaw, Joseph Gyekye Bamfo, Raji Abdul Sakibu, Daniel Antwi-Berko, Joseph Nelson Siewe Fodjo, Maria-Gloria Basanez, Henk D. F. H. Schallig, Robert Colebunders
Summary: This study investigated the prevalence and clinical characteristics of epilepsy in the Bono Region of Ghana after 27 years of ivermectin mass drug administration (MDA). The prevalence of epilepsy in the Bono region was found to be 1.4%, with generalized seizures being the most common type. The study also revealed a high microfilarial prevalence and low coverage of ivermectin treatment. Therefore, there is a need for the Ghana Onchocerciasis Elimination Programme to enhance its efforts to achieve the elimination of onchocerciasis by 2030.
INFECTIOUS DISEASES OF POVERTY
(2023)
Article
Clinical Neurology
Rodney Ogwang, Albert Ningwa, Pamela Akun, Paul Bangirana, Ronald Anguzu, Rajarshi Mazumder, Noriko Salamon, Oliver Johannes Henning, Charles R. Newton, Catherine Abbo, Amos Deogratius Mwaka, Kevin Marsh, Richard Idro
Summary: Research in northern Uganda shows that epilepsies associated with Onchocerca may have a broader clinical spectrum and brain imaging features, such as focal onset tonic-clonic seizures, cortical and cerebellar atrophy.
FRONTIERS IN NEUROLOGY
(2021)
Article
Microbiology
Arnauld Efon Ekangouo, Hugues C. Nana Djeunga, Guilhem Sempere, Joseph Kamgno, Flobert Njiokou, Paul Moundipa Fewou, Anne Geiger
Summary: This study explores the potential of blackfly bacteriome as a novel approach for controlling onchocerciasis by investigating its composition and variability in the presence of Onchocerca volvulus infection. The results suggest a causal relationship between the bacteriome composition and the onset of blackflies' infection by O. volvulus.
Article
Parasitology
Vera Wewer, Helga Peisker, Katharina Gutbrod, Mazen Al-Bahra, Dirk Menche, Ngongeh Glory Amambo, Fanny F. Fombad, Abdel Jelil Njouendou, Kenneth Pfarr, Samuel Wanji, Achim Hoerauf, Peter Doermann
Summary: The study screened urine samples from individuals in Cameroon infected with O. volvulus, Loa loa, Mansonella perstans, or a combination. Elevated levels of NATOG and cinnamoylglycine were found in O. volvulus-infected individuals, suggesting a potential for using a combination of urine metabolites for onchocerciasis assessment at a population level.
PARASITES & VECTORS
(2021)
Article
Microbiology
Melissa Krizia Vieri, An Hotterbeekx, Michel Mandro, Joseph Nelson Siewe Fodjo, Alfred Dusabimana, Francoise Nyisi, Deby Mukendi, Joe Gwatsvaira, Samir Kumar-Singh, Robert Colebunders
Summary: Despite the association between O. volvulus and OAE, elevated serotonin levels are not able to explain the pathogenesis of OAE. Other hypotheses will need to be investigated to identify the causal mechanism of OAE.
Article
Parasitology
Joseph Nelson Siewe Fodjo, Leonard Ngarka, Wepnyu Yembe Njamnshi, Peter Ayuk Enyong, Anne-Cecile Zoung-Kanyi Bissek, Alfred Kongnyu Njamnshi
Summary: This study investigated the onchocerciasis situation in the Ntui Health District in Cameroon, revealing high biting rates but low black fly infection rates, with a higher prevalence in epilepsy patients. It also found evidence of ongoing O. volvulus infection endemicity in these communities.
PARASITES & VECTORS
(2022)
Article
Biochemistry & Molecular Biology
Samuel K. Kwofie, Emmanuel Broni, Faruk U. Yunus, John Nsoh, Dela Adoboe, Whelton A. Miller, Michael D. Wilson
Summary: Onchocerciasis is a major public health problem in tropical areas, with antibiotic resistance becoming an increasing global threat. This study identified six potential novel antiwolbachial agents from natural products, which could serve as filaricides for onchocerciasis.
Review
Immunology
David Abraham, John Graham-Brown, Darrick Carter, Sean A. Gray, Jessica A. Hess, Benjamin L. Makepeace, Sara Lustigman
Summary: The development of a prophylactic vaccine for onchocerciasis is crucial for achieving the goal of eliminating the disease by 2030. Various animal models have shown promising results in inducing protective immunity, laying the foundation for future clinical trials to evaluate the vaccine's effectiveness in humans.
EXPERT REVIEW OF VACCINES
(2021)
Article
Microbiology
Paul M. Airs, Kathy Vaccaro, Kendra J. Gallo, Nathalie Dinguirard, Zachary W. Heimark, Nicolas J. Wheeler, Jiaye He, Kurt R. Weiss, Nathan E. Schroeder, Jan Huisken, Mostafa Zamanian
Summary: Lymphatic filariasis is a chronic disease affecting over 60 million people, and the current control methods are ineffective against adults. By using spatial transcriptomic approaches, researchers have identified new drug and vaccine targets, as well as potential hidden antigens. This study is of great importance for the development of antiparasitic drugs and vaccines.
Review
Dermatology
T. Ju, A. Vander Does, G. Ingrasci, S. A. Norton, G. Yosipovitch
Summary: Itch is a common symptom in tropical parasitic diseases and studying its characteristics can improve diagnosis and management. This review examines major itch-inducing tropical parasitic diseases, focusing on the link between itch and other symptoms, etiology, clinical staging, and therapeutic options.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Immunology
Nathan M. Ryan, Jessica A. Hess, Fernando Pardo-Manuel de Villena, Benjamin E. Leiby, Ayako Shimada, Lei Yu, Amir Yarmahmoodi, Nikolai Petrovsky, Bin Zhan, Maria Elena Bottazzi, Benjamin L. Makepeace, Sara Lustigman, David Abraham
Summary: This study demonstrated that an Onchocerca volvulus vaccine can induce protective immunity in genetically diverse mice, with each mouse line showing a unique immune response to the vaccine and challenge. The findings suggest that the vaccine is polyfunctional and effective in genetically complex populations.
Article
Immunology
Jeremy T. Campillo, Naomi P. Awaca-Uvon, Francois Missamou, Jean-Paul Tambwe, Godefroy Kuyangisa-Simuna, Gary J. Weil, Frederic Louya, Michel Boussinesq, Sebastien D. S. Pion, Cedric B. Chesnais
Summary: Two community trials in the Republic of Congo and the Democratic Republic of the Congo showed the efficacy of semiannual mass drug administration with albendazole alone on lymphatic filariasis, with a high interindividual heterogeneity in infection clearance. Analysis of trial data revealed a clear dose-response relationship between individual adherence to albendazole and clearance of circulating filarial antigenemia and microfilaremia.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
David J. Blok, Joseph Kamgno, Sebastien D. Pion, Hugues C. Nana-Djeunga, Yannick Niamsi-Emalio, Cedric B. Chesnais, Charles D. Mackenzie, Amy D. Klion, Daniel A. Fletcher, Thomas B. Nutman, Sake J. de Vlas, Michel Boussinesq, Wilma A. Stolk
Summary: The study shows that in L loa co-endemic areas, using a test-and-not-treat (TaNT) strategy can eliminate onchocerciasis, and the required treatment duration is only slightly longer than in areas with conventional Mass Drug Administration (MDA), provided that participation is good.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Jeremy T. Campillo, Emmanuel B. Chabot, Naomi-Pitchouna Awaca-Uvon, Jean-Paul Tambwe, Godefroy Kuyangisa-Simuna, Michel Boussinesq, Cedric B. Chesnais, Sebastien D. Pion
Summary: This study examined the relationship between Wuchereria bancrofti and hookworm infections with pregnancy outcomes in 82 women living in rural Democratic Republic of the Congo. The study found high infection rates of filarial antigenemia and hookworm, and a lower frequency of neonatal death history in women with a history of anthelmintic treatment. The association between anthelmintic treatment and reduced risk of neonatal death warrants further investigation in larger groups of women.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Immunology
Yannick Niamsi-Emalio, Hugues C. Nana-Djeunga, Cedric B. Chesnais, Sebastien D. S. Pion, Jules B. Tchatchueng-Mbougua, Michel Boussinesq, Maria-Gloria Basanez, Joseph Kamgno
Summary: This study found a significant relationship between L. loa microfilarial density (Loa MFD) and the probability of testing positive by skin snip technique (SST). The probability of testing SST positive exceeded 27% when Loa MFD was above 4080 mf/mL, indicating a considerable impact of L. loa density on SST results.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pharmacology & Pharmacy
Jeremy T. Campillo, Celine Eiden, Michel Boussinesq, Sebastien D. S. Pion, Jean-Luc Faillie, Cedric B. Chesnais
Summary: Levamisole was initially used for treating intestinal worms and has immunomodulatory properties, but is misused as a cocaine adulterant. This study found that levamisole is more frequently associated with psychiatric disorders, hepatobiliary disorders, vasculitis, encephalopathy, neuropathy, and other adverse drug reactions compared to other drugs.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Parasitology
Jeremy T. Campillo, Naomi P. Awaca-Uvon, Jean-Paul Tambwe, Godefroy Kuyangisa-Simuna, Johnny Vlaminck, Gary J. Weil, Michel Boussinesq, Cedric B. Chesnais, Sebastien D. S. Pion
Summary: The impact of semiannual mass drug administration with albendazole on lymphatic filariasis and soil-transmitted helminth infections was assessed in trials conducted in the Republic of Congo and the Democratic Republic of Congo. Compliance with ALB treatment was found to be crucial in achieving sustained clearance of STH infections, with a dose-related effect observed for hookworm, Ascaris lumbricoides, and Trichuris trichiura infections. Compliance with MDA was shown to be more effective in individuals with light baseline infection intensities.
PARASITES & VECTORS
(2021)
Article
Public, Environmental & Occupational Health
Sebastien D. S. Pion, Cedric B. Chesnais, Gary J. Weil, Frederic Louya, Michel Boussinesq, Francois Missamou
Summary: The semi-annual community treatment with albendazole has significantly reduced the rates of lymphatic filariasis and soil transmitted helminth infections in the village of Seke Pembe, Republic of the Congo.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Immunology
Jeremy T. Campillo, Paul Bikita, Marlhand Hemilembolo, Frederic Louya, Francois Missamou, Sebastien D. S. Pion, Michel Boussinesq, CedricB Chesnais
Summary: In a trial conducted in the Republic of the Congo, researchers assessed the safety and efficacy of levamisole for individuals with high microfilarial densities of Loa loa. The results showed that a single dose of 2.5mg/kg levamisole temporarily reduced the microfilarial densities, indicating its potential as a pretreatment to prevent adverse events after ivermectin treatment. However, further testing with higher doses or longer regimens is needed.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Parasitology
Andre Domche, Hugues C. Nana-Djeunga, Linda Djune Yemeli, Cedric Lenou Nanga, Michel Boussinesq, Flobert Njiokou, Sebastien Pion, Joseph Kamgno
Summary: Despite a high density of black flies in persisting onchocerciasis foci in Cameroon, no vector control has been carried out to complement Community-Directed Treatment with Ivermectin (CDTI). This study revealed that residents have a certain level of understanding of onchocerciasis, black fly nuisance, and ecological knowledge, but lack knowledge on transmission modes and vector ecology. Implementing community-based vector control is necessary to support CDTI and reduce black fly nuisance.
PARASITES & VECTORS
(2021)
Article
Public, Environmental & Occupational Health
Hugues C. Nana-Djeunga, Capucine M. Sicard, Aude E. Mogoung-Wafo, Cedric B. Chesnais, Hugo Deleglise, Rufine Touka-Nounkeu, Andre Domche, Allison Golden, Amy D. Klion, Thomas B. Nutman, Michel Boussinesq, Joseph Kamgno, Sebastien D. Pion
Summary: The stability of SD Bioline (R) IgG4 rapid diagnostic test results over 1 month was evaluated. The study found high consistency in results read at different time points, but 3.6% of the tests showed inconsistent results between 30 minutes and 24 hours. This change can affect the estimation of disease antibody prevalence.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Review
Infectious Diseases
Joseph A. Ngatse, Gilbert Ndziessi, Francois Missamou, Rodrigue Kinouani, Marlhand Hemilembolo, Sebastien D. Pion, Kirsten A. Bork, Ange A. Abena, Michel Boussinesq, Cedric B. Chesnais
Summary: This article investigates the prevalence of neglected tropical diseases (PC-NTDs) in the Republic of the Congo, revealing that PC-NTDs other than trachoma are still endemic in specific areas of the country. To eliminate these diseases, further studies and investment in scientific research are required.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Entomology
Andre Domche, Philippe B. Nwane, Hugues C. Nana Djeunga, Guy R. Njitchouang, Sebastien D. Pion, Michel Boussinesq, Flobert Njiokou, Joseph Kamgno
Summary: This study investigated the entomological indicators of onchocerciasis transmission and the impact of climatic variables on vector population dynamics. Despite more than two decades of mass drug administration, transmission of onchocerciasis is still ongoing in the study area. Control measures should be implemented during the long dry season to interrupt transmission.
JOURNAL OF MEDICAL ENTOMOLOGY
(2022)
Review
Infectious Diseases
Charles Whittaker, Cedric B. Chesnais, Sebastien D. S. Pion, Joseph Kamgno, Martin Walker, Maria-Gloria Basanez, Michel Boussinesq
Summary: This study investigates the factors associated with the inter-individual pharmacokinetic variation of albendazole sulfoxide, the active metabolite of albendazole. The findings suggest that factors such as age, parasitic infection, and receipt of a fatty meal prior to treatment are systematically associated with the variation in albendazole sulfoxide pharmacokinetics.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Parasitology
Jeremy T. Campillo, Frederic Louya, Paul Bikita, Francois Missamou, Sebastien D. S. Pion, Michel Boussinesq, Cedric B. Chesnais
Summary: This study mathematically characterized the periodicity of L. loa microfilaremia and found that body temperature plays a role in its variation.
PARASITES & VECTORS
(2022)
Article
Parasitology
Maxime P. M. Doret, Hugues C. Nana-Djeunga, Narcisse Nzune-Toche, Sebastien D. S. Pion, Cedric B. Chesnais, Michel Boussinesq, Joseph Kamgno, Emmanuelle Varlet-Marie, Sabrina Locatelli
Summary: This study aimed to demonstrate non-invasive molecular diagnosis of human filariasis by targeting DNA fragments in stool samples. However, no filarial gene fragments were detected in the stools of the patients, indicating the need for further research to explore potential reasons for this.
Article
Parasitology
Gabriela Martinez Moura Tavares, Hannar Angelica de Melo Alverga, Estela Moraes Felix, Giovana de Oliveira Dichman, Gabriel Monteiro Pinheiro, Yara Juliano, Priscila Paruci, Dennis Minoru Fujita, Lucas Melo Neves, Marina Tiemi Shio, Luiz Henrique da Silva Nali
Summary: This study investigated the frequency of N. gonorrhoeae infection in women in a poor area of São Paulo and found that most of the strains detected showed resistance to one or more antimicrobials.
Article
Parasitology
Qian Yao, Ying-Ying Fan, Shuang Huang, Gui-Rong Hu, Jun-Ke Song, Xin Yang, Guang-Hui Zhao
Summary: This study found that the expression of miR-4521 was upregulated during C. parvum infection, and this upregulation was related to the TLR/NF-kappa B signal pathway. Additionally, miR-4521 promoted the propagation of C. parvum in HCT-8 cells by regulating BCL2-mediated cell apoptosis through targeting foxm1.
Article
Parasitology
Cho Naing, Maxine A. Whittaker, Wong Siew Tung, Htar Aung, Joon Wah Mak
Summary: This study aimed to estimate the prevalence of zoonotic brugian filariasis in animals and compare it with the prevalence in humans in the same area. The findings suggest that cats, dogs, and leaf-eating monkeys may serve as potential reservoirs for human brugian filariasis.
Review
Parasitology
Raissa Nogueira de Brito, Susan Tanner, Julie Velasquez Runk, Juliana Hoyos
Summary: This study conducted a scoping review to identify major research themes and knowledge gaps in the social science literature on leishmaniases or Chagas disease. The findings showed that research in this field mainly focuses on the sociocultural, economic, historical, and political dimensions of the diseases. Future research should pay more attention to how social institutions and economic factors shape disease education, control measures, healthcare access, and quality of life of affected individuals.
Article
Parasitology
Minghao Zheng, Mengyao Zhang, Hao Li, Shipo Wu, Yuee Zhao, Jinlong Zhang, Yunyue Zhou, Mohamed Boie Jalloh, Kun Zhang, Lina Chen, Zhiqiang Mi, Yong Cui, Lihua Hou
Summary: Rapid and convenient detection of Plasmodium falciparum, the deadliest malaria parasite in Africa, is crucial for malaria eradication efforts in medical resource-limited settings. A CRISPR-based diagnostic method that can detect P. falciparum without nucleic acid extraction was developed and showed high sensitivity and consistency with qPCR test. It can also detect artemisinin-resistant strains and other laboratory-cultured strains. This method has great potential for clinical testing and large-scale community screening in Africa and other regions.
Article
Parasitology
Fabian Correa-Morales, Cassandra Gonzalez-Acosta, David Ibarra-Ojeda, Miguel Moreno-Garcia
Summary: Since 2002, West Nile Virus (WNV) has been reported in 18 states in Mexico. This paper discusses the proposed hypotheses for the absence of WNV outbreaks in Latin America and provides a context-specific explanation for Mexico.
Article
Parasitology
Umberto Molini, Lauren M. Coetzee, Vernon Christians, Maria Y. Hemberger, Bernard Chiwome, Maria Amukwaya, Siegfried Khaiseb, Giovanni Cattoli, William G. Dundon, Giovanni Franzo
Summary: Porcine circovirus 3 (PCV-3) has been reported globally since its first identification in 2015. Limited data on PCV-3 in Africa led to a study in Namibia, which found a high prevalence of PCV-3 in backyard piggeries, but not in commercial farms with higher biosecurity measures. The source of viral introduction and factors such as semen importation, feeding backyard pigs with human food waste, pig exchanges, and wildlife movements may be involved in the dispersal of PCV-3 within Namibia. Further studies are needed to understand the epidemiology and impact of PCV-3 on pig productivity and wildlife health.
Article
Parasitology
Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Panitnan Punyathi, Sawang Kesdangsakonwut, Tanit Kasantikul, Somporn Techangamsuwan
Summary: This study provides insights into the pathology of natural SARS-CoV-2 infection in dogs, revealing severe damage to the lungs and involvement of multiple organs. The findings suggest the potential utility of dogs as a model for studying SARS-CoV-2 infection in humans, highlighting the need for further investigation.
Article
Parasitology
Julian Avila-Jimenez, Juan David Gutierrez, Mariano Altamiranda-Saavedra
Summary: Leishmaniasis is a parasitic disease transmitted to humans by sandfly vectors and vertebrate hosts. This study used ecological niche modeling to investigate the potential distribution of host and vector species associated with cutaneous leishmaniasis transmission, revealing different distribution patterns under varying climatic conditions.
Article
Parasitology
Luis A. Gomez-Puerta, Juan Olazabal, Santiago Paredes, Juan Lopez, Miguel Anampa, Angelica Mondragon, Ana Vargas-Calla, Hugo Castillo
Summary: This study reports the first detection of Candidatus M. haemolamae infection in vicunas from the Pampa Galeras National Reserve in Peru, using molecular diagnosis. Tick-infested vicunas had a higher likelihood of being infected with Candidatus M. haemolamae compared to tick-free vicunas. Gender and age were not associated with infection.
Article
Parasitology
Berlin Londono-Renteria, Zakaria Seidu, Helena Lamptey, Michael F. Ofori, Lars Hviid, Mary Lopez-Perez
Summary: Heterozygous carriers of HbAS and HbAC have a reduced risk of severe malaria, but not immunity against Plasmodium falciparum infection. Antibody levels against gSG6-P1 peptide in Anopheles mosquito saliva can serve as a serological biomarker for exposure to Plasmodium infection. This study highlights the importance of studying the role of hemoglobinopathies in malaria transmission for improving control interventions.
Article
Parasitology
Imane Belbacha, Meryem El Azzouzi, Rajae Bensghir, Kamal Filali Marhoum, Khadija Hajjout, El Mir Elharti, Khalid Sadki, Hicham Oumzil
Summary: This study investigates the association of three SNPs in the APOBEC3G gene with disease outcomes in Moroccan HIV-1 infected patients. The rs2294367 CG genotype is strongly associated with protection against HIV-1 infection, particularly in older individuals.
Article
Parasitology
Tan Luong, Do Kien Tran, Anh Hung Pham, Thi Thu-Ha Hoang, Van Khang Pham, Quang Thai Pham, Thi Mai Hung Tran, Minh Hoa Luong, Thanh Long Pham, Jason K. Blackburn
Summary: This study examined the epidemiology of anthrax in Lai Chau province, Vietnam, using historical data. Spatial clusters of human and livestock anthrax were identified, and the characteristics of the disease were described. The study found that there were distinct differences between the high-risk areas for human and livestock anthrax, and most human cases occurred during specific seasons. Additionally, the decrease in livestock anthrax vaccine coverage was associated with an increase in disease incidence.
Article
Parasitology
Jin-tao Chen, Jian-bo Zhan, Ming-chao Zhu, Kai-ji Li, Man-qing Liu, Bin Hu, Kun Cai, Hai-rong Xiong, Shu-liang Chen, Wei-long Tan, Liang-jun Chen, Wei Hou
Summary: This study investigated the prevalence and variation of orthohantavirus in rodents and humans in Hubei province, China. It identified the diversity of orthohantaviruses circulating in the region, with the HV004-like subtype being the main genotype in rodents and patients. This highlights the importance of continued attention and research on orthohantaviruses, especially newly identified strains.