Article
Biochemistry & Molecular Biology
Vandana Veenit, Xiaoqun Zhang, Wojciech Paslawski, Ioannis Mantas, Per Svenningsson
Summary: This study reveals the important role of GPR37L1 gene in emotional behaviors and physiological mechanisms in mice, particularly in aversive learning processes. Lack of GPR37L1 also leads to increased body weight and alterations in related biochemical markers, with age- and sex-specific effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Meng-Shiun Wu, Ting-Wei Liao, Chun-Yuan Wu, Tzu-Han Hsieh, Ping-Chung Kuo, Yue-Chiun Li, Kuan-Chung Cheng, Hsueh-Cheng Chiang
Summary: Animals acquire surrounding information for appropriate behavior through social learning and self-learning. However, the regulatory mechanism of social learning, especially in transmitting aversive conditioning information, is still unknown. This study revealed species-dependent differences in how observer flies process aversive conditioning information acquired from demonstrator flies during social learning. Solitary flies, on the other hand, cannot learn this information through social learning, suggesting it is not an innate behavior.
Article
Neurosciences
Daniela Calvigioni, Janos Fuzik, Pierre Le Merre, Marina Slashcheva, Felix Jung, Cantin Ortiz, Antonio Lentini, Veronika Csillag, Marta Graziano, Ifigeneia Nikolakopoulou, Moritz Weglage, Iakovos Lazaridis, Hoseok Kim, Irene Lenzi, Hyunsoo Park, Bjorn Reinius, Marie Carlen, Konstantinos Meletis
Summary: The authors use patch-sequencing to study the diversity of hypothalamic neurons projecting to the habenula. They identify an estrogen receptor-expressing neuron type that signals aversion and stress in female mice. The glutamatergic LHA-LHb neurons have unique electrophysiological properties, molecular profiles, and projection patterns, with Esr1(+) neurons inducing aversion and Npy(+) neurons controlling rearing behavior.
NATURE NEUROSCIENCE
(2023)
Review
Neurosciences
Daniela Vazquez, Kevin N. Schneider, Matthew R. Roesch
Summary: The article examines how neural processes affect monitoring of outcomes and behaviors in social contexts, focusing on the roles of the dorsal striatum and anterior cingulate cortex in appetitive and aversive events.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Shaul Yahil, David F. Wozniak, Zihan Yan, Steven Mennerick, Maria S. Remedi
Summary: ATP-sensitive potassium gain-of-function mutations can lead to neonatal diabetes and various neurological deficits, with neuronal KATP-GOF potentially playing a role in cognitive dysfunction. Further research is needed to develop novel drugs to address these neurological features caused by neuronal KATP-GOF mutations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Psychology, Biological
Minakshi Doobay, Shelly K. Cross-Mellor, Deanne T. O. Wah, Martin Kavaliers, Klaus-Peter Ossenkopp
Summary: This study investigated escape behaviors in rats experiencing the conditioned aversive effects of lithium chloride (LiCl) in a distinct context, finding that the LiCl-treated rats exhibited significantly increased rearing behavior, indicative of conditioned aversion.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Cody A. Freas, Antoine Wystrach, Sebastian Schwarz, Marcia L. Spetch
Summary: Ants establish foraging routes through learning views of the visual panorama. They rapidly learn and perceive aversive views, which trigger changes in behavior. A logarithmic relationship between captivity duration and hesitations suggests how aversive view learning could be executed within the mushroom bodies circuitry.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Marcella M. Cline, Barbara Juarez, Avery Hunker, Ernesto G. Regiarto, Bryan Hariadi, Marta E. Soden, Larry S. Zweifel
Summary: The axonal guidance cue netrin-1 plays a critical role in neural circuit development by promoting growth cone motility, axonal branching, and synaptogenesis. This study found that Ntn1 function is important for maintaining excitatory connectivity in both GABAergic and dopaminergic neurons in the adult midbrain. The balance in this connectivity between these two cell types is crucial for the proper functioning of the mesolimbic system.
Article
Pharmacology & Pharmacy
Gustavo Lopez-Cordoba, Guadalupe Martinez-Lorenzana, Jair Lozano-Cuenca, Miguel Condes-Lara, Abimael Gonzalez-Hernandez
Summary: Spinal alpha(2)-adrenoceptors induce analgesia by inhibiting primary afferent fibers. The alpha(2A) subtype is involved in acute or tonic nociception, while the alpha(2C) subtype has an opposing effect under tonic nociceptive input.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Isabel Forner-Piquer, Adele Faucherre, Julia Byram, Marine Blaquiere, Frederic de Bock, Laurence Gamet-Payrastre, Sandrine Ellero-Simatos, Etienne Audinat, Chris Jopling, Nicola Marchi
Summary: In zebrafish larvae, exposure to high concentrations of glyphosate leads to behavioral and neurophysiological defects, while cellular and transcript signatures can be detected in response to low doses.
Article
Biochemistry & Molecular Biology
Ewelina Koziol, Krzysztof Jozwiak, Barbara Budzynska, Peter A. M. de Witte, Danielle Copmans, Krystyna Skalicka-Wozniak
Summary: The study screened 18 different coumarin derivatives for behavioral and physiological antiseizure activity, confirming seven compounds with antiseizure activity; further substantiated in zebrafish the ability of these active compounds to reduce PTZ-induced antiepileptiform activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Harry Stewardson, Thomas D. Sambrook
Summary: This passage discusses reward prediction errors in reinforcement learning and the role of midbrain dopamine neurons, as well as the association between FRN and reward prediction errors, and explores the response of FRN to unconditioned stimuli. The study conducted with electric shocks found that FRN was elicited earlier and more transiently than usual, suggesting the involvement of processes beyond the midbrain dopamine system.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Jessica N. Goedhoop, Bastijn J. G. van den Boom, Rhiannon Robke, Felice Veen, Lizz Fellinger, Wouter van Elzelingen, Tara Arbab, Ingo Willuhn
Summary: This study systematically investigates the role of dopamine in processing aversive stimuli and finds that NAC dopamine primarily tracks the prediction and duration of aversive events, rather than aversive prediction errors.
Article
Biochemistry & Molecular Biology
Chien-Po Liao, Yueh-Chen Chiang, Wai Hou Tam, Yen-Ju Chen, Shih-Hua Chou, Chun-Liang Pan
Summary: Physiological stress induces aversive memory formation through neural circuits and neuromodulatory mechanisms.
Article
Neurosciences
Kainan S. Wang, Mauricio R. Delgado
Summary: The ability to perceive and exercise control significantly influences mental and physical wellbeing. Controllability can protect against the negative impact of uncontrollable aversive stimuli and potentially reverse passive behavior. Experimental findings showed that exposure to controllability increased avoidance behavior among participants, and this effect was associated with increased activation in the ventromedial prefrontal cortex, suggesting its role in encoding the value of control.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cell Biology
Suman Rimal, Jiun Sang, Seeta Poudel, Dhananjay Thakur, Craig Montell, Youngseok Lee
Article
Biology
Young-Cheon Kim, Daeun Choi, Ahra Cha, Yeong-Geun Lee, Nam-In Baek, Suman Rimal, Jiun Sang, Youngseok Lee, Sanghyeob Lee
COMMUNICATIONS BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Bhanu Shrestha, Youngseok Lee
Summary: DEET is a widely used insect repellent that suppresses feeding behavior and affects larval development in fruit flies.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Neurosciences
Seeta Poudel, Hao Guo, Dean P. Smith
Summary: Drosophila odorant receptors consist of a common receptor subunit and tuning receptor subunits that confer odorant specificity to olfactory neuron responses. The phosphorylation state of the common receptor subunit is crucial for olfactory neuron responses, with PKC98E identified as the primary kinase responsible for this phosphorylation. Deletion of PKC98E from olfactory neurons affects peak odorant responses, indicating its importance in regulating olfactory neuron function.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Sonali Puri, Youngseok Lee
Summary: Taste sensation and regulation are highly conserved between insects and mammals. The regulation of internal sodium concentrations is crucial for physiological processes in animals. Both mammals and flies respond differently to low and high salt concentrations based on their internal nutrient state.
Article
Biochemistry & Molecular Biology
Binod Aryal, Youngseok Lee
Summary: The study used fruit flies to dissect the molecular sensors required for histamine taste perception, finding that histamine activates bitter-sensing neurons and identifying GR22e and IR76b as essential receptors for histamine sensing.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Review
Oncology
Sheryl Rodriguez, Kristy Skeet, Tugba Mehmetoglu-Gurbuz, Madeline Goldfarb, Shri Karri, Jackelyn Rocha, Mark Shahinian, Abdallah Yazadi, Seeta Poudel, Ramadevi Subramani
Summary: Hepatocellular carcinoma (HCC) is a prevalent and deadly form of liver cancer, ranking as the sixth most common cancer globally and the second in terms of cancer-related mortality. Despite challenges with current therapies, phytochemicals show promise as alternative or integrative treatments for HCC. Research into the potential of plant-derived molecules continues to provide hope for improved outcomes in HCC treatment.
Meeting Abstract
Oncology
Ramadevi Subramani, Adriana Estrada, Sheryl Rodriguez, Seeta Poudel, Jesse Foskey, Cynthia Jimenez, Kenneth Smith, Mark Shahinian, Abdallah Yazadi, Tugba Mehmetoglu-Gurbuz, Jackelyn Rocha, Rajkumar Lakshmanaswamy
Review
Biochemistry & Molecular Biology
Ramadevi Subramani, Seeta Poudel, Kenneth D. Smith, Adriana Estrada, Rajkumar Lakshmanaswamy
Summary: This article introduces breast cancer as the most commonly diagnosed cancer in women. Metabolomics can provide insights into metabolic changes during cancer development and identify biomarkers for early detection, diagnosis, and treatment of cancers.
Article
Biochemistry & Molecular Biology
Jiun Sang, Subash Dhakal, Youngseok Lee
Summary: Cucurbitacin B (cuc-B) is a bitter-tasting compound that can lower glucose levels and potentially be used to treat chronic metabolic diseases. Additionally, both cuc-B and metformin treatments improved sleep quality and memory consolidation in fruit flies.
MOLECULES AND CELLS
(2021)
Article
Biochemistry & Molecular Biology
Young Gi Hong, Bongsu Kang, Seongsoo Lee, Youngseok Lee, Bong-Gun Ju, Sangyun Jeong
MOLECULES AND CELLS
(2020)
Review
Biochemistry & Molecular Biology
Subash Dhakal, Youngseok Lee
MOLECULES AND CELLS
(2019)
Review
Biochemistry & Molecular Biology
Binod Aryal, Youngseok Lee
Article
Biochemistry & Molecular Biology
Suman Rimal, Jiun Sang, Subash Dhakal, Youngseok Lee
MOLECULES AND CELLS
(2020)
