Article
Parasitology
Franklin Ayisi, Naniogue Sedou, Stephanie Kouahou Dieunang, Florent Yaya, Edmond Francois Tchago, Cosmas Ejong Ndellejong, Benjamin Biholong, Daniel Adjei Boakye
Summary: This study aims to provide information on the breeding sites and species distribution of S. damnosum in different regions of Cameroon. The findings suggest that there are differences in breeding sites and species composition across different ecological regions, which is important for understanding the epidemiology of onchocerciasis.
PARASITES & VECTORS
(2022)
Article
Parasitology
J. Frank Walsh, Robert A. Cheke, Stephen Young
Summary: Female Simulium damnosum s.l. were captured in a savannah zone beside the Mono River in Togo and their short-range dispersal behavior was investigated. The number of flies caught and the proportion of parous flies decreased as the distance from the river increased. Statistical analysis showed that nulliparous flies tended to disperse further than parous flies. The study also identified different members of the S. damnosum species complex and found transmission of the disease occurred both at the riverside and 10 km away.
Article
Immunology
Housseini Dolo, Yaya Coulibaly, Moussa Sow, Massitan Dembele, Salif S. Doumbia, Siaka Y. Coulibaly, Moussa B. Sangare, Ilo Dicko, Abdallah A. Diallo, Lamine Soumaoro, Michel E. Coulibaly, Dansine Diarra, Robert Colebunders, Thomas B. Nutman, Martin Walker, Maria-Gloria Basanez
Summary: The seroprevalence of Ov16 and Wb123 among children in Bakoye and Faleme is consistent with achieving the goals of onchocerciasis elimination and LF elimination as a public health problem after 24-25 years of treatment. Testing and follow-up are suggested for the few Ov16-seropositive children.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Parasitology
Adam Hendy, Meryam Krit, Kenneth Pfarr, Christine Laemmer, Jacobus De Witte, Philippe Nwane, Joseph Kamgno, Hugues C. Nana-Djeunga, Michel Boussinesq, Jean-Claude Dujardin, Rory Post, Robert Colebunders, Sarah O'Neill, Peter Enyong, Alfred K. Njamnshi
Summary: The study found high densities of biting black flies sustaining transmission of O. volvulus along the lower Mbam river, despite relatively low infection rates that do not meet the WHO threshold for interruption of transmission.
PARASITES & VECTORS
(2021)
Article
Microbiology
Stephen Raimon, Tom L. Lakwo, Wilson John Sebit, Joseph Nelson Siewe Fodjo, Peter Alinda, Jane Y. Carter, Rory J. Post, Robert Colebunders
Summary: The study implemented slash and clear intervention at Maridi dam in South Sudan to reduce O. volvulus transmission by reducing Simulium damnosum s.l. biting rates. The method proved effective in reducing black fly biting rates caused by Simulium sirbanum, potentially accelerating onchocerciasis elimination when combined with high CDTI coverage.
Article
Public, Environmental & Occupational Health
Nicole Hassoun, Leon Cosler
Summary: Neglected tropical diseases (NTDs) have a significant impact on lifespan and livelihood, but receive little research and development. Using existing data on treatment effectiveness, our models estimate that in 2015, NTD treatments averted 2,778,131.78 disability-adjusted life years (DALYs). Treatments targeting soil-transmitted helminths accounted for the majority of DALYs averted, followed by schistosomiasis, lymphatic filariasis, and onchocerciasis.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Article
Chemistry, Medicinal
Paul McGillan, Neil G. Berry, Gemma L. Nixon, Suet C. Leung, Peter J. H. Webborn, Mark C. Wenlock, Stefan Kavanagh, Andrew Cassidy, Rachel H. Clare, Darren A. Cook, Kelly L. Johnston, Louise Ford, Stephen A. Ward, Mark J. Taylor, W. David Hong, Paul M. O'Neill
Summary: Anti-Wolbachia therapy using pyrazolopyrimidine compounds shows promising results in combating filarial diseases by improving metabolic stability and solubility. Phenotypic screening reveals analogues with potent activity against Wolbachia, with lead compound 15f demonstrating strong potential for in vivo studies. Further optimization and development of this compound series for filariasis treatment is highly anticipated.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Parasitology
Blaise Armand Defo Talom, Peter Enyong, Robert A. Cheke, Rousseau Djouaka, Frances M. Hawkes
Summary: The Host Decoy Trap (HDT) showed high capture rate for adult Simulium blackflies, similar to Human Landing Catches (HLC) and significantly better than the Esperanza Window Trap (EWT). In addition to its efficiency, the HDT was also able to collect infected flies, making it a valuable tool for blackfly collection in elimination settings where large numbers of flies are needed for parasite screening.
Article
Parasitology
Robert A. Cheke, Rory J. Post, Daniel A. Boakye
Summary: Simulium damnosum s.l., the most important vector of onchocerciasis in Africa, is a complex of sibling species described on the basis of differences in their larval polytene chromosomes. The distribution of cytospecies in Togo and Benin has changed due to vector control and environmental changes. The elimination of the Djodji form of S. sanctipauli in south-western Togo seems to have had no long-term effects on the distribution of the other cytospecies.
Article
Public, Environmental & Occupational Health
Kathryn L. Zoerhoff, Pamela S. Mbabazi, Katherine Gass, John Kraemer, Brian B. Fuller, Lynsey Blair, Roland Bougma, Aboulaye Meite, Nebiyu Negussu, Bizuayehu Gashaw, Scott D. Nash, Nana-Kwadwo Biritwum, Jean Frantz Lemoine, Helena Ullyartha Pangaribuan, Eksi Wijayanti, Karsor Kollie, Clara Fabienne Rasoamanamihaja, Lazarus Juziwelo, Square Mkwanda, Pradip Rimal, Issa Gnandou, Bocar Diop, Ameyo Monique Dorkenoo, Rachel Bronzan, Edridah Muheki Tukahebwa, Fatima Kabole, Violetta Yevstigneyeva, Donal Bisanzio, Lauren Courtney, Joseph Koroma, Egide Endayishimye, Richard Reithinger, Margaret C. Baker, Fiona M. Fleming
Summary: Delivering preventive chemotherapy through mass drug administration (MDA) is an important approach in controlling or eliminating neglected tropical diseases (NTDs). Reported treatment coverage is often used to estimate coverage, but it may be inaccurate due to errors in data compilation. This study shows that for most MDAs, the routinely reported data is accurate enough to make programmatic decisions.
Article
Public, Environmental & Occupational Health
Obiora A. Eneanya, Lincoln Gankpala, Charles W. Goss, Fatorma K. Bolay, Gary J. Weil, Peter U. Fischer
Summary: A study in Liberia compared the impact of annual and semiannual mass drug administration (MDA) on helminthic infections. The results showed that both annual and semiannual MDA were equally effective in reducing LF and soil-transmitted helminth infection parameters over a 3-year period.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Parasitology
Relindis Ekanya, Elisabeth Dibando Obie, Louise Hamill, Sophie Thorogood, Raphael Awah Abong, Abdel Jelil Njouendou, Andrew Amuam, Bertrand Lontum Ndzeshang, Desmond Akumtoh Nkimbeng, Jerome Fru Cho, Mathias Eyong Esum, Peter Enyong, Joseph D. Turner, Mark J. Taylor, Samuel Wanji
Summary: The study in the Meme River Basin in Cameroon found active transmission of onchocerciasis, susceptibility of Simulium larvae to temephos, and identified nine cytospecies. Non-target aquatic fauna were also observed.
PARASITES & VECTORS
(2022)
Review
Immunology
Alexandra Ehrens, Achim Hoerauf, Marc P. Huebner
Summary: This review summarizes the importance of eosinophil effector functions in controlling filarial infections and their impact on filarial pathology. Eosinophils play a crucial role in the immune response against filariae by modulating the function of other leukocytes and directly attacking the parasites. They are both beneficial in controlling the infection and can contribute to disease pathology in certain conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Parasitology
Melanie Abongwa, Moses Samje, Godfred A. Ayimele, Smith B. Babiaka, Christina Bulman, Judy Sakanari, Nick J. Koszewski, Saurabh Verma, Jesse Goff, Fidelis Cho-Ngwa, Richard J. Martin, Alan P. Robertson
Summary: In this study, extracts from Daniellia oliveri and Psorospermum febrifugum were found to be effective against parasitic roundworms such as Onchocerca ochengi and Brugia pahangi, supporting their traditional use in the treatment of onchocerciasis and LF. Further purification of these extracts could lead to the discovery and development of lead compounds for filarial drug.
PARASITES & VECTORS
(2021)
Article
Parasitology
Vera Wewer, Helga Peisker, Katharina Gutbrod, Mazen Al-Bahra, Dirk Menche, Ngongeh Glory Amambo, Fanny F. Fombad, Abdel Jelil Njouendou, Kenneth Pfarr, Samuel Wanji, Achim Hoerauf, Peter Doermann
Summary: The study screened urine samples from individuals in Cameroon infected with O. volvulus, Loa loa, Mansonella perstans, or a combination. Elevated levels of NATOG and cinnamoylglycine were found in O. volvulus-infected individuals, suggesting a potential for using a combination of urine metabolites for onchocerciasis assessment at a population level.
PARASITES & VECTORS
(2021)
Article
Entomology
David Lopez-Pena, Robert A. Cheke, Eduardo Moises Garcia-Roger, Ricardo Jimenez-Peydro
Summary: Data on pre-imaginal stages of blackflies in southern England during the summer and early autumn of 2020 were analysed in relation to environmental factors, showing that differences in blackfly species assemblages can be explained by river depth, temperature, conductivity, and elevation. Of the 14 taxa recorded from 29 locations, seven are of medical and/or veterinary importance.
Article
Entomology
Francine Sado Yousseu, Huguette Simo Tchetgna, Basile Kamgang, Doumani Djonabaye, Philip J. McCall, Roland Ndip Ndip, Charles S. Wondji
Summary: This study aimed to investigate the impact of ticks on livestock and humans in Cameroon. The results showed a high tick infestation rate in cattle, while it was low in small ruminants. The study also revealed a wide diversity of tick species, including some known vectors of important tick-borne diseases.
MEDICAL AND VETERINARY ENTOMOLOGY
(2022)
Article
Entomology
Charles Halerimana, Samuel Kyamanywa, Samuel Olaboro, Pamela Paparu, Stanley T. Nkalubo, John Colvin, Robert A. Cheke, Darren J. Kriticos, Michael H. Otim
Summary: Bean leaf beetles are a major pest of common beans in Africa, causing significant reductions in grain yields. This study investigates the effects of planting timing and insecticide application on bean leaf beetle abundance and crop yield. The results suggest that early planting combined with insecticide application can effectively control bean leaf beetles and improve grain yields.
Article
Engineering, Multidisciplinary
Lin Chen, Jin Yang, Yuanshun Tan, Zijian Liu, Robert A. Cheke
Summary: This paper utilizes impulsive differential equations to describe the combinations of a dendritic cell vaccine and intermittent androgen therapy for treating prostate cancer, and investigates the solutions, threshold conditions, and stationary distribution of the system.
APPLIED MATHEMATICAL MODELLING
(2023)
Article
Parasitology
Wendegoudi Mathias Ouedraogo, Kobie Hyacinthe Toe, Aboubacar Sombie, Mafalda Viana, Clarisse Bougouma, Antoine Sanon, David Weetman, Philip J. McCall, Hirotaka Kanuka, Athanase Badolo
Summary: This study investigates the characteristics and productivity of Aedes container breeding sites in Burkina Faso, shedding light on factors associated with larvae abundance and adult body size. The results suggest that targeting the most productive breeding sites could contribute to dengue vector control strategies.
PARASITES & VECTORS
(2022)
Article
Parasitology
J. Frank Walsh, Robert A. Cheke, Stephen Young
Summary: Female Simulium damnosum s.l. were captured in a savannah zone beside the Mono River in Togo and their short-range dispersal behavior was investigated. The number of flies caught and the proportion of parous flies decreased as the distance from the river increased. Statistical analysis showed that nulliparous flies tended to disperse further than parous flies. The study also identified different members of the S. damnosum species complex and found transmission of the disease occurred both at the riverside and 10 km away.
Article
Physics, Multidisciplinary
Daipeng Chen, Xiaodan Sun, Robert A. Cheke
Summary: In this study, we updated the procedure of performing the extended convergent cross-mapping (CCM) to infer the causality between periodic variables. We confirmed the applicability of the refined method on real data in Shaanxi province, China, and found that air quality, temperature, and humidity affect daily influenza-like illness cases, with a time delay of 11 days for increased air quality index (AQI).
Article
Parasitology
Aboubacar Sombie, Wendegoudi Mathias Ouedraogo, Manabu Ote, Erisha Saiki, Tatsuya Sakurai, Felix Yameogo, Antoine Sanon, Philip J. McCall, Hirotaka Kanuka, David Weetman, Athanase Badolo
Summary: Since 2000, Burkina Faso has seen regular dengue cases and outbreaks, highlighting the increasing importance of dengue as a health concern in the country. Resistance to pyrethroid insecticides in Aedes aegypti mosquitoes has been linked to specific kdr mutations. This study confirms high resistance to pyrethroids in the Ae. aegypti populations and proposes a new PCR-based diagnostic method for detecting kdr mutations.
PARASITES & VECTORS
(2023)
Review
Virology
Luca Facchinelli, Athanase Badolo, Philip J. McCall
Summary: Ae. aegypti is a common mosquito vector of arboviruses in urbanized areas of the tropics and subtropics, but control of this species is difficult and costly. The literature on adult Ae. aegypti biology and behavior near human homes is lacking in important details, making it unreliable for developing control interventions. Basic information sources are poor and outdated, while commonly accepted facts lack evidence. Topics such as sugar feeding, resting preferences, and blood feeding require further research to identify vulnerabilities for control efforts in different contexts.
Article
Ecology
Rachel Dobson, Andy J. J. Challinor, Robert A. A. Cheke, Stewart Jennings, Stephen G. G. Willis, Martin Dallimer
Summary: Species distribution models (SDM) are widely used to understand species distribution and abundance changes. However, existing SDM tools lack the ability to model species distributions driven by dynamic environmental conditions. dynamicSDM provides novel tools that consider the temporal dimension, allowing for more accurate and detailed modeling. It is flexible, compatible with other SDM tools, and has low computing power and storage needs.
METHODS IN ECOLOGY AND EVOLUTION
(2023)
Article
Infectious Diseases
Yan Liu, Xia Wang, Sanyi Tang, Robert A. Cheke
Summary: This study built a mathematical model based on meteorological and mosquito vector monitoring data in Guangdong Province, China, to explore the effects of temperature and rainfall on the population dynamics of Aedes albopictus. The study found that temperature and rainfall had different effects on the developmental stages of mosquitoes in different periods and locations. It also identified rainfall as being more important than temperature distribution and evenness for mosquito population development, with peak summer rainfall being the best indicator.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Biology
Yasser M. Qureshi, Vitaly Voloshin, Luca Facchinelli, Philip J. McCall, Olga Chervova, Cathy E. Towers, James A. Covington, David P. Towers
Summary: This paper presents a method for identifying key behavioral differences between male, female, and in copula mosquito pairs by analyzing their flight tracks. The approach uses machine learning to classify track segments as either male or non-male and combines the segment classifications to classify the overall track. This methodology provides valuable insights into the behavior of mosquitoes and other insects.
Article
Computer Science, Interdisciplinary Applications
Jin Yang, Zhuo Chen, Yuanshun Tan, Zijian Liu, Robert A. Cheke
Summary: This paper proposes and analyzes an age-structured infectious disease dynamical model that considers two diseases simultaneously with limited medical resources. The asymptotic smoothness and persistence of the solution semi-flow are investigated. Conditions for the existence of a global attractor are derived, indicating that the disease persists when 910 > 1. Using a Lyapunov function, it is shown that the infection-free equilibrium is globally asymptotically stable if 910 < 1 and the infection equilibrium is globally asymptotically stable if 910 > 1. The presence of limited medical resources suggests the significance of equitable distribution for treating low-risk and high-risk diseases, and maintaining a moderate level of resource sharing coefficient helps eliminate the disease.
MATHEMATICS AND COMPUTERS IN SIMULATION
(2023)
Article
Mathematics, Applied
Sha He, Sanyi Tang, Qimin Zhang, Libin Rong, Robert A. Cheke
Summary: Respiratory diseases are influenced by seasonal changes and air pollution control, making the dynamics complex. In this study, deterministic and stochastic models were developed to investigate the effects of factors such as random noise and air pollution control on respiratory diseases. The models were fitted with Air Quality Index data for Xi'an city, and the optimal solutions were analyzed theoretically to provide theoretical support for more reasonable air pollution control strategies.
APPLIED MATHEMATICS AND COMPUTATION
(2023)
Article
Multidisciplinary Sciences
Luca Facchinelli, Bashir Alsharif, Jeff D. Jones, Agnes Matope, Rosangela M. R. Barbosa, Constancia F. J. Ayres, Philip J. McCall
Summary: This study found that Aedes aegypti mosquitoes prefer to rest at the base of walls, especially at higher temperatures, highlighting the importance of this resting behavior for mosquito control. The researchers discovered that treating the lowest 20 cm of indoor walls with insecticide significantly reduced the mosquito population.
Article
Parasitology
Gabriela Martinez Moura Tavares, Hannar Angelica de Melo Alverga, Estela Moraes Felix, Giovana de Oliveira Dichman, Gabriel Monteiro Pinheiro, Yara Juliano, Priscila Paruci, Dennis Minoru Fujita, Lucas Melo Neves, Marina Tiemi Shio, Luiz Henrique da Silva Nali
Summary: This study investigated the frequency of N. gonorrhoeae infection in women in a poor area of São Paulo and found that most of the strains detected showed resistance to one or more antimicrobials.
Article
Parasitology
Qian Yao, Ying-Ying Fan, Shuang Huang, Gui-Rong Hu, Jun-Ke Song, Xin Yang, Guang-Hui Zhao
Summary: This study found that the expression of miR-4521 was upregulated during C. parvum infection, and this upregulation was related to the TLR/NF-kappa B signal pathway. Additionally, miR-4521 promoted the propagation of C. parvum in HCT-8 cells by regulating BCL2-mediated cell apoptosis through targeting foxm1.
Article
Parasitology
Cho Naing, Maxine A. Whittaker, Wong Siew Tung, Htar Aung, Joon Wah Mak
Summary: This study aimed to estimate the prevalence of zoonotic brugian filariasis in animals and compare it with the prevalence in humans in the same area. The findings suggest that cats, dogs, and leaf-eating monkeys may serve as potential reservoirs for human brugian filariasis.
Review
Parasitology
Raissa Nogueira de Brito, Susan Tanner, Julie Velasquez Runk, Juliana Hoyos
Summary: This study conducted a scoping review to identify major research themes and knowledge gaps in the social science literature on leishmaniases or Chagas disease. The findings showed that research in this field mainly focuses on the sociocultural, economic, historical, and political dimensions of the diseases. Future research should pay more attention to how social institutions and economic factors shape disease education, control measures, healthcare access, and quality of life of affected individuals.
Article
Parasitology
Minghao Zheng, Mengyao Zhang, Hao Li, Shipo Wu, Yuee Zhao, Jinlong Zhang, Yunyue Zhou, Mohamed Boie Jalloh, Kun Zhang, Lina Chen, Zhiqiang Mi, Yong Cui, Lihua Hou
Summary: Rapid and convenient detection of Plasmodium falciparum, the deadliest malaria parasite in Africa, is crucial for malaria eradication efforts in medical resource-limited settings. A CRISPR-based diagnostic method that can detect P. falciparum without nucleic acid extraction was developed and showed high sensitivity and consistency with qPCR test. It can also detect artemisinin-resistant strains and other laboratory-cultured strains. This method has great potential for clinical testing and large-scale community screening in Africa and other regions.
Article
Parasitology
Fabian Correa-Morales, Cassandra Gonzalez-Acosta, David Ibarra-Ojeda, Miguel Moreno-Garcia
Summary: Since 2002, West Nile Virus (WNV) has been reported in 18 states in Mexico. This paper discusses the proposed hypotheses for the absence of WNV outbreaks in Latin America and provides a context-specific explanation for Mexico.
Article
Parasitology
Umberto Molini, Lauren M. Coetzee, Vernon Christians, Maria Y. Hemberger, Bernard Chiwome, Maria Amukwaya, Siegfried Khaiseb, Giovanni Cattoli, William G. Dundon, Giovanni Franzo
Summary: Porcine circovirus 3 (PCV-3) has been reported globally since its first identification in 2015. Limited data on PCV-3 in Africa led to a study in Namibia, which found a high prevalence of PCV-3 in backyard piggeries, but not in commercial farms with higher biosecurity measures. The source of viral introduction and factors such as semen importation, feeding backyard pigs with human food waste, pig exchanges, and wildlife movements may be involved in the dispersal of PCV-3 within Namibia. Further studies are needed to understand the epidemiology and impact of PCV-3 on pig productivity and wildlife health.
Article
Parasitology
Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Panitnan Punyathi, Sawang Kesdangsakonwut, Tanit Kasantikul, Somporn Techangamsuwan
Summary: This study provides insights into the pathology of natural SARS-CoV-2 infection in dogs, revealing severe damage to the lungs and involvement of multiple organs. The findings suggest the potential utility of dogs as a model for studying SARS-CoV-2 infection in humans, highlighting the need for further investigation.
Article
Parasitology
Julian Avila-Jimenez, Juan David Gutierrez, Mariano Altamiranda-Saavedra
Summary: Leishmaniasis is a parasitic disease transmitted to humans by sandfly vectors and vertebrate hosts. This study used ecological niche modeling to investigate the potential distribution of host and vector species associated with cutaneous leishmaniasis transmission, revealing different distribution patterns under varying climatic conditions.
Article
Parasitology
Luis A. Gomez-Puerta, Juan Olazabal, Santiago Paredes, Juan Lopez, Miguel Anampa, Angelica Mondragon, Ana Vargas-Calla, Hugo Castillo
Summary: This study reports the first detection of Candidatus M. haemolamae infection in vicunas from the Pampa Galeras National Reserve in Peru, using molecular diagnosis. Tick-infested vicunas had a higher likelihood of being infected with Candidatus M. haemolamae compared to tick-free vicunas. Gender and age were not associated with infection.
Article
Parasitology
Berlin Londono-Renteria, Zakaria Seidu, Helena Lamptey, Michael F. Ofori, Lars Hviid, Mary Lopez-Perez
Summary: Heterozygous carriers of HbAS and HbAC have a reduced risk of severe malaria, but not immunity against Plasmodium falciparum infection. Antibody levels against gSG6-P1 peptide in Anopheles mosquito saliva can serve as a serological biomarker for exposure to Plasmodium infection. This study highlights the importance of studying the role of hemoglobinopathies in malaria transmission for improving control interventions.
Article
Parasitology
Imane Belbacha, Meryem El Azzouzi, Rajae Bensghir, Kamal Filali Marhoum, Khadija Hajjout, El Mir Elharti, Khalid Sadki, Hicham Oumzil
Summary: This study investigates the association of three SNPs in the APOBEC3G gene with disease outcomes in Moroccan HIV-1 infected patients. The rs2294367 CG genotype is strongly associated with protection against HIV-1 infection, particularly in older individuals.
Article
Parasitology
Tan Luong, Do Kien Tran, Anh Hung Pham, Thi Thu-Ha Hoang, Van Khang Pham, Quang Thai Pham, Thi Mai Hung Tran, Minh Hoa Luong, Thanh Long Pham, Jason K. Blackburn
Summary: This study examined the epidemiology of anthrax in Lai Chau province, Vietnam, using historical data. Spatial clusters of human and livestock anthrax were identified, and the characteristics of the disease were described. The study found that there were distinct differences between the high-risk areas for human and livestock anthrax, and most human cases occurred during specific seasons. Additionally, the decrease in livestock anthrax vaccine coverage was associated with an increase in disease incidence.
Article
Parasitology
Jin-tao Chen, Jian-bo Zhan, Ming-chao Zhu, Kai-ji Li, Man-qing Liu, Bin Hu, Kun Cai, Hai-rong Xiong, Shu-liang Chen, Wei-long Tan, Liang-jun Chen, Wei Hou
Summary: This study investigated the prevalence and variation of orthohantavirus in rodents and humans in Hubei province, China. It identified the diversity of orthohantaviruses circulating in the region, with the HV004-like subtype being the main genotype in rodents and patients. This highlights the importance of continued attention and research on orthohantaviruses, especially newly identified strains.