Article
Radiology, Nuclear Medicine & Medical Imaging
Vineeta Ojha, Kartik P. Ganga, Tulika Seth, Ambuj Roy, Nitish Naik, Priya Jagia, Gurpreet S. Gulati, Sanjeev Kumar, Sanjiv Sharma
Summary: This study assessed the importance of detecting MIO through CMR-T2* and found that GRS correlated with T2*, while GLS and GCS did not. FT-strain may be an effective way to identify early contractile dysfunction in TM patients.
EUROPEAN RADIOLOGY
(2021)
Article
Hematology
Antonella Meloni, Luigi Barbuto, Laura Pistoia, Vincenzo Positano, Stefania Renne, Giuseppe Peritore, Priscilla Fina, Anna Spasiano, Massimo Allo, Giuseppe Messina, Tommaso Casini, Antonella Massa, Luigia Romano, Alessia Pepe, Filippo Cademartiri
Summary: Renal iron accumulation is not common in sickle/beta-thalassemia patients, with a significantly lower frequency compared to homozygous SCD patients. Kidney T2* values are similar between sickle/beta-thalassemia and TM patients, but significantly lower in regularly transfused homozygous SCD patients. Age, gender, splenectomy, and transfusion or chelation therapy are not associated with global renal T2* values, but there is a significant inverse correlation with serum lactate dehydrogenase and indirect bilirubin.
ANNALS OF HEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hanan Kamel M. Saad, Alawiyah Awang Abd Rahman, Azly Sumanty Ab Ghani, Wan Rohani Wan Taib, Imilia Ismail, Muhammad Farid Johan, Abdullah Saleh Al-Wajeeh, Hamid Ali Nagi Al-Jamal
Summary: Iron homeostasis is regulated by hepcidin, which is influenced by factors such as iron stores, hypoxia, inflammation, and erythropoiesis. Beta-thalassemia patients exhibit iron deficiency, iron overload, and ineffective erythropoiesis. Recent research has identified new diagnostic markers and therapeutic targets for beta-thalassemia.
Article
Medicine, General & Internal
Anna Spasiano, Antonella Meloni, Silvia Costantini, Emilio Quaia, Filippo Cademartiri, Patrizia Cinque, Alessia Pepe, Paolo Ricchi
Summary: The study indicates that a serum ferritin level <500 ng/mL is achievable and safe for certain TDT patients. This target is associated with the absence of significant cardiac iron overload, significantly lower hepatic IO, and triglycerides, both of which are well-demonstrated markers for cardiac and liver complications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Alessia Pepe, Laura Pistoia, Maria Rita Gamberini, Liana Cuccia, Roberto Lisi, Valerio Cecinati, Aurelio Maggio, Francesco Sorrentino, Aldo Filosa, Rosamaria Rosso, Giuseppe Messina, Massimiliano Missere, Riccardo Righi, Stefania Renne, Antonino Vallone, Stefano Dalmiani, Vincenzo Positano, Massimo Midiri, Antonella Meloni
Summary: The tailored chelation therapy guided by MRI in the MIOT network has shown significant improvement in the prognosis of TM patients. Continuous monitoring of cardiac iron levels and personalized treatment can reduce cardiac burden, improve cardiac function, and reduce complications and death from heart failure related to myocardial iron overload.
EUROPEAN HEART JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Antonella Meloni, Laura Pistoia, Vincenzo Positano, Antonio De Luca, Nicola Martini, Anna Spasiano, Ilaria Fotzi, Pier Paolo Bitti, Domenico Visceglie, Gianna Alberini, Gianfranco Sinagra, Alessia Pepe, Filippo Cademartiri
Summary: This study evaluated the association between myocardial extracellular volume (ECV) and demographics, cardiovascular magnetic resonance (CMR) findings, and cardiac involvement in patients with thalassemia major. The results showed that increased ECV was associated with myocardial iron overload and heart failure, potentially indicating diffuse interstitial fibrosis.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, Research & Experimental
Antonella Meloni, Luigi Barbuto, Vincenzo Positano, Laura Pistoia, Anna Spasiano, Tommaso Casini, Francesco Massei, Crocetta Argento, Piera Giovangrossi, Angelica Barone, Luigia Romano, Filippo Cademartiri
Summary: We evaluated the pattern and clinical correlates of renal T2* measurements in adult β-thalassemia major (β-TM) patients. A total of 11.1% of β-TM patients showed renal iron overload, which was associated with liver iron concentration (LIC) values and pancreas T2* values. Renal iron overload was more common in patients with cardiac iron overload. MRI LIC and lactate dehydrogenase (LDH) were strong predictors of global kidney T2* values. An MRI LIC > 4.83 mg/g dw predicted the presence of renal iron overload.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Medicine, General & Internal
Farrukh Shah, Krystal Huey, Sohan Deshpande, Monica Turner, Madhura Chitnis, Emma Schiller, Aylin Yucel, Luciana Moro Bueno, Esther Natalie Oliva
Summary: This article examines the association between serum ferritin levels and clinical outcomes and patient-reported outcomes in patients with beta-thalassemia through a systematic literature review and data analysis. The results suggest that higher serum ferritin levels are associated with worsened outcomes, particularly an increased risk of endocrine dysfunction.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Carla Casu, Alison Liu, Gianluca De Rosa, Audrey Low, Aae Suzuki, Sayantani Sinha, Yelena Z. Ginzburg, Charles Abrams, Mariam Aghajan, Shuling Guo, Stefano Rivella
Summary: Polycythemia Vera (PV) is a chronic myeloproliferative neoplasm caused by a driver mutation in the JAK2 gene, leading to overproduction of mature erythrocytes and high hematocrit levels. Therapeutic phlebotomy is the standard treatment, but using antisense oligonucleotides against Tmprss6 mRNA to increase hepcidin could provide a less invasive alternative for PV patients.
Review
Biochemistry & Molecular Biology
Coralia Cotoraci, Alina Ciceu, Alciona Sasu, Anca Hermenean
Summary: Anemia is a common health issue affecting people of all ages, with treatment options including blood transfusion and oral iron supplements, which may have side effects and poor absorption. Biologically active compounds and plant extracts show therapeutic potential as alternative treatments for various types of anemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ying Liu, Carine Fillebeen, Anik Forest, Amy Botta, Thibault V. Varin, Andre Marette, Yan Burelle, Christine Des Rosiers, Kostas Pantopoulos, Gary Sweeney
Summary: This study using the Th3/+ mouse model found that altered lipid metabolism and gut microbiota may be related to the development of cardiomyopathy in thalassemia. These findings are important for understanding the early biomarkers and therapeutic targets for the development of cardiomyopathy in thalassemia.
Article
Clinical Neurology
Christoph Berliner, Zhiyue J. Wang, Sylvia T. Singer, Regine Grosse, Rosalie McDonough, Eric Padua, Qing Yuan, Marcela Weyhmiller, Ellen James, Elliott Vichinsky, Gerhard Adam, Jin Yamamura, Peter Bannas, Roland Fischer, Bjoern P. Schoennagel
Summary: This study investigated the accuracy of different MRI-based pituitary volumetric approaches in patients with transfusion-dependent anemia, and found that 3D or precise 2D volumetry is needed for accurate assessment of anterior pituitary size. Additionally, anterior pituitary volume Z-scores and R2 values can help identify patients at risk of pituitary dysfunction.
CLINICAL NEURORADIOLOGY
(2022)
Article
Medicine, General & Internal
Reem Aldwaik, Tamara Abu Mohor, Israa Idyabi, Salam Warasna, Shatha Abdeen, Bashar Karmi, Rania Abu Seir
Summary: Management of beta-thalassemia in the West Bank presents challenges due to the lack of available therapies, leading to recurrent transfusions. Characteristics of patients include anemia, iron overload, and abnormal liver function tests. Iron chelation medication choice is associated with serum ferritin levels, highlighting the need for personalized assessment and follow-up protocols.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Antonella Meloni, Laura Pistoia, Maria Rita Gamberini, Paolo Ricchi, Valerio Cecinati, Francesco Sorrentino, Liana Cuccia, Massimo Allo, Riccardo Righi, Priscilla Fina, Ada Riva, Stefania Renne, Giuseppe Peritore, Stefano Dalmiani, Vincenzo Positano, Emilio Quaia, Filippo Cademartiri, Alessia Pepe
Summary: The study revealed a significant association between pancreatic iron overload and disturbances in glucose metabolism and heart disease in patients with thalassemia intermedia. Pancreatic iron overload was more common in regularly transfused patients and was linked to splenectomy and hepatitis C virus infection. A normal pancreas T2* value demonstrated a 100% negative predictive value for cardiac iron overload.
JOURNAL OF CLINICAL MEDICINE
(2021)
Editorial Material
Medicine, General & Internal
Maddalena Casale, Marina Itala Baldini, Patrizia Del Monte, Antonia Gigante, Anna Grandone, Raffaella Origa, Maurizio Poggi, Franco Gadda, Rosalba Lai, Monia Marchetti, Gian Luca Forni
Summary: This study provides important recommendations for the treatment of endocrine complications in haemoglobinopathies based on scientific evidence and clinical experience.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Atoosa Adibi, Ali Shahbazi
IRANIAN JOURNAL OF RADIOLOGY
(2014)
Article
Endocrinology & Metabolism
Alaleh Gheissari, Mahin Hashemipour, Pooya Khosravi, Atoosa Adibi
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
(2012)
Article
Biology
Omer M. Kassid, Samih A. Odhaib, Mahmood Thamer Altemimi
Summary: Flutamide is an effective non-steroidal anti-androgen drug for the treatment of prostatic carcinoma, but it can potentially cause severe hepatotoxicity. We present a case of acute liver failure induced by flutamide therapy, resulting in the death of the patient. Careful monitoring of liver function during flutamide therapy is crucial to prevent serious hepatotoxicity.
JOURNAL OF BIOLOGICAL RESEARCH-BOLLETTINO DELLA SOCIETA ITALIANA DI BIOLOGIA SPERIMENTALE
(2022)
Article
Urology & Nephrology
Atoosa Adibi, Mojgan Mortazavi, Azin Shayganfar, Sima Kamal, Roya Azad, Marzieh Aalinezhad
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2016)
Article
Medicine, General & Internal
Marzeie Sharifzadeh, Atoosa Adibi, Kimia Kazemi, Silva Hovsepian
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2015)
Article
Medicine, General & Internal
Atoosa Adibi, Maryam Khadem, Farahnaz Mardanian, Silva Hovsepian
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2015)
Article
Medicine, General & Internal
Ali Toghiani, Atoosa Adibi, Arash Taghavi
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2015)
Article
Medicine, General & Internal
Atoosa Adibi, Maryam Golshahi, Mehri Sirus, Kimia Kazemi
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2015)
Article
Medicine, General & Internal
Zahra Allameh, Safoura Rouholamin, Atusa Adibi, Mehrnaz Mehdipour, Maryam Adeli
INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
(2013)
Article
Medicine, General & Internal
Atoosa Adibi, Afshin Rezazade, Silva Hovsepian, Razie Koohi, Mohsen Hosseini
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2012)
Article
Medicine, General & Internal
Atoosa Adibi, Parvaneh Niroomand, Mostafa Ghanei
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2012)
Article
Medicine, General & Internal
Atoosa Adibi, Mahshid Haghighi, Mahin Hashemipour, Ammar Hassanzadeh Keshteli, Masoud Amini
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2012)
Article
Pediatrics
Shohreh Ghatreh-Samani, Roya Kelishadi, Atoosa Adibi, Hengameh Noori, Mina Moeini
IRANIAN JOURNAL OF PEDIATRICS
(2011)
Article
Medicine, General & Internal
Mojtaba Rostami, Abbas-Ali Javadi, Farzin Khorvash, Kamyar Mostafavizadeh, Atoosa Adibi, Anahita Babak, Behrooz Ataei, Mohsen Meidani, Alireza Emami Naeini, Hasan Salehi, Majid Avijgan, Mohammad Reza Yazdani, Farshid Rezaei
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2011)
Article
Endocrinology & Metabolism
Elham Faghih Imani, Ashraf Aminorroaya, Fahimeh Soheilipour, Atoosa Adibi, Mehri Sirous, Ehsan Roohi, Mohsen Mostafavi, Masoud Amini
ENDOKRYNOLOGIA POLSKA
(2010)