Article
Psychiatry
Jane E. Persons, Paul Lodder, William H. Coryell, John Nurnberger, Jess G. Fiedorowicz
Summary: This study found that manic and anxiety symptoms did not significantly contribute to suicidal ideation and behavior in individuals with bipolar disorder during a depressive state, with the main risk factor being severe depressive symptoms. The limitations of small sample size and measurement tools may have influenced these findings, suggesting future studies would benefit from larger samples and more rigorous assessments.
PSYCHIATRY RESEARCH
(2022)
Review
Clinical Neurology
Guido Cereda, Paolo Enrico, Valentina Ciappolino, Giuseppe Delvecchio, Paolo Brambilla
Summary: Most studies found no significant differences in vitamin D levels between bipolar disorder patients and other psychiatric disorders, with the average values in the bipolar population being sub-threshold for deficiency. Although an association between vitamin D levels and clinical symptoms was observed, it is not a specific marker for bipolar disorder but a common characteristic shared with other psychiatric disorders. Additionally, vitamin D supplementation was linked to a reduction in depressive and manic symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Ole Kohler-Forsberg, Louisa G. Sylvia, Vicki Fung, Lindsay Overhage, Michael Thase, Joseph R. Calabrese, Thilo Deckersbach, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Michael J. Ostacher, Dan V. Iosifescu, Andrew A. Nierenberg
Summary: In this study, adjunctive antidepressant treatment was not associated with lower depressive symptoms or higher mania symptoms in outpatients with bipolar disorder. There were no differences in treatment effects on mania scales, and potential biases due to nonrandomized design complicated causal interpretations, with no evidence suggesting better treatment effects of adjunctive antidepressants.
DEPRESSION AND ANXIETY
(2021)
Article
Psychiatry
Catarina Rodrigues Cordeiro, Beatriz Romao Corte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This systematic review aimed to identify triggers of acute mood episodes in bipolar disorder (BD). The review found that pharmacotherapy, particularly the use of antidepressants, was the trigger with the strongest evidence for manic/hypomanic relapse. Other identified triggers for mania included brain stimulation, energy drinks, acetyl-lcarnitine, St. John's wort, seasonal changes, hormonal changes, and viral infections. However, there is a lack of evidence regarding triggers for depressive relapses in BD, highlighting the need for further research in this area.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Rebecca E. Easter, Kelly A. Ryan, Ryne Estabrook, David F. Marshall, Melvin G. McInnis, Scott A. Langenecker
Summary: This study found that cognitive performance is largely unrelated to depressive and manic symptoms in patients with bipolar disorder. The results suggest that cognitive dysfunction is stable in BD and is not dependent on mood state. Future research could investigate how treatment affects the relationship between cognition and mood.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Psychiatry
Marta Migo, Kendra Simpson, Amy Peters, Kristen K. Ellard, Tina Chou, Andrew A. Nierenberg, Darin D. Dougherty, Thilo Deckersbach
Summary: By dimensionally analyzing symptom severity in patients with bipolar disorder, more accurate differences in neural responses to emotional stimuli can be captured. There is a correlation between symptom severity and brain activation, with depression severity associated with increased activation in various brain regions and mania severity associated with both increased and decreased activation.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Norio Sugawara, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Reiji Yoshimura, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Koichiro Watanabe, Kazutaka Shimoda, Norio Yasui-Furukori
Summary: This study investigated the long-term clinical outcomes of patients with bipolar disorder (BD) and identified several predictors of these outcomes. The findings can assist clinicians in predicting the course of the illness based on demographic and clinical characteristics.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
James A. Karantonis, Susan L. Rossell, Michael Berk, Tamsyn E. Van Rheenen
Summary: The study found a significant increase in subjective cognitive dysfunction in patients with bipolar disorder during the COVID-19 pandemic, but no substantial differences were observed in mood symptoms, fear of COVID-19, lifestyle factors, and social rhythms between patients and healthy controls, indicating a degree of resilience in bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Lisa T. Eyler, Farren B. S. Briggs, Annemiek Dols, Soham Rej, Osvaldo P. Almeida, Alexandra J. M. Beunders, Hilary P. Blumberg, Brent P. Forester, Regan E. Patrick, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Eduard Vieta, Benoit H. Mulsant, Sigfried Schouws, Nadine P. G. Paans, Sergio Strejilevich, Ashley Sutherland, Shangying Tsai, Martha Sajatovic
Summary: This study analyzed the symptom mixity in older-age bipolar disorder (OABD) and its association with everyday function. The results showed that mixed features are predominant in OABD and are associated with worse everyday function. Among those with mixed symptoms, the severity of depression is the main driver of poorer functioning.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Review
Psychiatry
Anna Grunze, Sergey Mosolov, Heinz Grunze, Christoph Born
Summary: This narrative review examines the epidemiology, consequences, and treatment options of tobacco use disorder (TUD) and nicotine dependence (ND) in individuals with bipolar disorder (BD). The study found that smoking rates are 2-3 times higher in individuals with BD compared to community samples. Smoking has a detrimental impact on both mental and physical health as well as mortality in individuals with BD. Treatment options include pharmacological interventions and psychosocial interventions.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Xiuhua Song, Yufang Feng, Lei Yi, Baoliang Zhong, Yi Li
Summary: The objective of this case-control study is to determine whether the blood thyroid hormone levels in bipolar disorder patients are associated with different types of first onset. The study found that thyroid dysfunction may be involved in the disease progression of bipolar disorder and correlated with the clinical symptoms in patients with depression or mania as the first episode.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Ioanna Mylona, Georgios D. Floros
Summary: Recent clinical studies suggest that blocking shorter-wavelength blue light may benefit the treatment of bipolar disorder. This critical review aims to evaluate the quality of evidence supporting these claims and explore the underlying neurobiology, while introducing a common set of research criteria for the field.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Madison K. Titone, Namni Goel, Tommy H. Ng, Laura E. MacMullen, Lauren B. Alloy
Summary: This study examined the relationships between impulsivity, sleep and circadian rhythm disturbance, and symptoms in individuals at high-risk for or with recent-onset bipolar spectrum disorders. The findings revealed that less total sleep time predicted increased next-day mood symptoms, and the relationship between impulsivity and mood symptoms was moderated by sleep time and circadian rhythm alterations.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Madison K. Titone, Namni Goel, Tommy H. Ng, Laura E. MacMullen, Lauren B. Alloy
Summary: Impulsivity, sleep disturbance, and circadian rhythm alterations are closely associated with bipolar spectrum disorders. Less total sleep time predicts increased mood symptoms, and individuals with less sleep and later circadian rhythms are more likely to exhibit a positive relationship between impulsivity and mood symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Mark Shevlin, Sarah Butter, Orla McBride, Jamie Murphy, Jilly Gibson-Miller, Todd K. Hartman, Liat Levita, Liam Mason, Anton P. Martinez, Ryan McKay, Thomas V. A. Stocks, Kate Bennett, Philip Hyland, Richard P. Bentall
Summary: This study conducted a longitudinal survey of UK adults and found that there is heterogeneity in the mental health response to the COVID-19 pandemic within the population. The prevalence of anxiety-depression remained stable, while COVID-19-related posttraumatic stress disorder (PTSD) reduced over time. Three trajectories of mental health were identified: stable, improving, and deteriorating, and psychological factors played a significant role in differentiating these trajectories.
PSYCHOLOGICAL MEDICINE
(2023)
Letter
Psychology, Clinical
Mark Shevlin, Sarah Butter, Orla McBride, Jamie Murphy, Jilly Gibson-Miller, Todd K. Hartman, Liat Levita, Liam Mason, Anton P. Martinez, Ryan McKay, Thomas V. A. Stocks, Kate M. Bennett, Philip Hyland, Frederique Vallieres, Richard P. Bentall
PSYCHOLOGICAL MEDICINE
(2023)
Letter
Psychology, Clinical
Philip Hyland, Frederique Vallieres, Orla McBride, Jamie Murphy, Mark Shevlin, Richard P. Bentall, Sarah Butter, Todd K. Hartman, Thanos Karatzias, Malcolm MacLachlan, Rebecca Maguire, Joanna McHugh Power, Eric Spikol, Michael Daly
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Matthew V. Elliott, Serajh A. S. Esmail, Kevin S. Weiner, Sheri L. Johnson
Summary: This study aimed to investigate the neuroanatomical correlates of emotion-related impulsivity (ERI). The findings showed that lower cortical gyrification in the lateral orbitofrontal cortex (OFC) was associated with higher ERI severity. These findings have important implications for predicting psychiatric disorders and related problems.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Orla McBride, Sarah Butter, Anton P. Martinez, Mark Shevlin, Jamie Murphy, Todd K. Hartman, Ryan McKay, Philip Hyland, Kate M. Bennett, Thomas V. A. Stocks, Jilly Gibson-Miller, Liat Levita, Liam Mason, Richard P. Bentall
Summary: This paper describes the protocol and results of Wave 6 of the C19PRC Study, which monitors the psychological and socio-economic impact of the pandemic. The survey assessed COVID-19 related experiences, mental health disorders, psychological characteristics, and social and political attitudes. The results showed lower participation rates among young adults, those born outside the UK, and adults living in cities. The study data provides valuable support for interdisciplinary research on COVID-19.
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
(2023)
Review
Psychology, Clinical
Kristine Brance, Vasileios Chatzimpyros, Richard P. Bentall
Summary: Evidence suggests that social identities play a crucial role in promoting resilience and protecting well-being. This is particularly important for ethnic minorities and migrant populations who face adversity such as discrimination and integration challenges, which negatively impact mental health.
CLINICAL PSYCHOLOGY REVIEW
(2023)
Article
Psychology, Experimental
Devon B. Sandel-Fernandez, Jennifer G. Pearlstein, Benjamin A. Swerdlow, Sheri L. Johnson
Summary: This study found that traits of urgency and distress intolerance are associated with high arousal negative affect and disengagement from emotion. These findings have implications for clinical interventions that focus on emotion regulation, especially during high arousal states.
Article
Clinical Neurology
Orestis Zavlis, Andreas Matheou, Richard Bentall
Summary: This study used network psychometrics and machine learning methods to explore the relationship between depression and mania in bipolar disorder. The results revealed that emotionality and hyperactivity were the most central aspects of depression and mania respectively, and sleep disturbances, anhedonia, suicidal ideation, and impulsivity were crucial symptoms bridging the two poles. The machine learning algorithm confirmed the clinical utility of these symptoms in predicting episodes of mania and depression.
Review
Psychology, Clinical
Matthew V. Elliott, Sheri L. Johnson, Jennifer G. Pearlstein, Daniela E. Munoz Lopez, Hanna Keren
Summary: Emotion-related impulsivity, which refers to regrettable behavior during high emotional states, is a strong predictor of various psychological disorders. However, the cognitive correlates of emotion-related impulsivity are not well understood. This systematic review and meta-regression examined the relationship between emotion-related impulsivity and risky decision-making. The findings suggest that risky decision-making is a cognitive domain that is associated with emotion-related impulsivity.
CLINICAL PSYCHOLOGY REVIEW
(2023)
Article
Psychology, Social
Jennifer G. Pearlstein, Sheri L. Johnson, Kiara R. Timpano, Caitlin A. Stamatis, Morgan Robison, Charles S. Carver
Summary: The study suggests that emotion-related impulsivity may play a role in explaining shared variance in transdiagnostic symptoms of psychopathology. This impulsivity is related to both internalizing and externalizing symptoms.
JOURNAL OF PERSONALITY
(2023)
Article
Psychology, Social
Sheri L. Johnson, Julia M. Levitan, Lana C. Marks, Benjamin A. Swerdlow, Brahamdeep Kaur, Kiara R. Timpano
Summary: Emotion-triggered impulsivity is strongly associated with psychopathologies. We conducted a study to investigate the correlation between one form of emotion-triggered impulsivity, Feelings Trigger Action, and speech disfluencies during high arousal. Our findings showed that participants with higher Feelings Trigger Action scores exhibited slightly more speech repairs when experiencing higher arousal. There was also evidence suggesting that another form of emotion-triggered impulsivity was also related to speech errors during high arousal. These results provide initial evidence that speech disfluencies may be a manifestation of emotion-triggered impulsivity. The limitations and directions for future research are discussed.
JOURNAL OF RESEARCH IN PERSONALITY
(2023)
Article
Multidisciplinary Sciences
Sarah Danson, Fuschia Sirois, Kathryn Fradley, Jonathan Wadsley, Jaydip Ray, Rhian Bishop, Janet Horsman, Colette Mann, Loretta Chantry-Groves, Matthew Young, Richard Bentall
Summary: This study aimed to assess the mental health burden on healthcare workers during the early stages of the COVID-19 pandemic. The findings showed that healthcare workers are more likely to experience somatic symptoms, depression, and anxiety compared to the general population. Additionally, scientific and technical, nursing, and administrative staff were more vulnerable to mental health issues than medical staff.
Article
Psychology, Clinical
Katherine Newman-Taylor, Richard Bentall
Summary: Meta-analyses indicate modest effects of cognitive behavioural therapy for psychosis (CBTp), with some individuals benefitting while others may be harmed. Common factors such as the therapeutic alliance have been neglected in CBTp research, but targeting specific psychological mechanisms may lead to improved outcomes.
PSYCHOLOGY AND PSYCHOTHERAPY-THEORY RESEARCH AND PRACTICE
(2023)
Article
Medicine, General & Internal
Marianne Drabek, Duncan Hodkinson, Suzanne Horvath, Bonnie Millar, Stefan Pszczolkowski Parraguez, Christopher R. Tench, Radu Tanasescu, Sudheer Lankappa, Richard Morriss, David Walsh, Dorothee P. Auer
Summary: This article discusses the common problem of chronic pain and the potential use of non-invasive neuromodulation techniques for pain relief. It presents an optimized treatment protocol using connectivity-guided intermittent theta-burst stimulation (iTBS) and describes a pilot study that will evaluate the feasibility and mechanistic efficacy of this treatment in patients with chronic knee pain.
Article
Psychology, Clinical
Alba Contreras, Sarah Butter, Umberto Granziol, Anna Panzeri, Vanesa Peinado, Almudena Trucharte, Orestis Zavlis, Carmen Valiente, Carmelo Vazquez, Jamie Murphy, Marco Bertamini, Mark Shevlin, Todd K. Hartman, Giovanni Bruno, Giuseppe Mignemi, Andrea Spoto, Giulio Vidotto, Richard P. Bentall
Summary: This study examined the patterns of psychological distress during the COVID-19 pandemic, finding that resilience was the most common mental health response pattern. Higher network connectivity may indicate stable mental health response over time, while fewer clusters may indicate a sustained distress pattern.
JOURNAL OF TRAUMATIC STRESS
(2023)
