Review
Endocrinology & Metabolism
Bashir Ahmad Laway, Mohammad Salem Baba
Summary: Sheehan syndrome caused by postpartum hemorrhage leads to pituitary hormone deficiency, resulting in various abnormalities including lipid and glucose abnormalities, increased body fat, insulin resistance, coagulation abnormalities, increased leptin concentration, low-grade inflammation, and endothelial dysfunction. Replacement with growth hormone in addition to standard hormone replacement improves the cardiometabolic profile of patients with Sheehan syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Federico Oldoni, Kevin Bass, Julia Kozlitina, Hannah Hudson, Lisa M. Shihanian, Viktoria Gusarova, Jonathan C. Cohen, Helen H. Hobbs
Summary: Plasma A8 levels vary significantly across different racial/ethnic groups and are associated with BMI, fasting glucose, insulin, and TG levels. However, genetic variants in the A8 locus do not appear to have a causal relationship with the metabolic phenotypes associated with A8 levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Xiaohua Jiang, Ruijun Liu, Ting Liao, Ye He, Caihua Li, Peipei Guo, Ping Zhou, Yunxia Cao, Zhaolian Wei
Summary: This study developed a nomogram model based on clinical data to predict the odds of live birth for women with polycystic ovary syndrome undergoing frozen-thawed embryo transfer. The model showed good calibration and discriminative capabilities, making it a valuable tool for pre-transfer management.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ilaria Barchetta, Laura Bertoccini, Federica Sentinelli, Diego Bailetti, Giacomo Marini, Flavia Agata Cimini, Valentina Ceccarelli, Joachim Struck, Janin Schulte, Sandro Loche, Efisio Cossu, Olle Melander, Maria G. Cavallo, Marco G. Baroni
Summary: Elevated plasma pro-NT levels in children are associated with obesity and predict weight gain and metabolic impairment in the future.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Sport Sciences
Won-Mok Son, Jung-Jun Park
Summary: This study examined the effects of resistance band exercise training in obese postmenopausal women with MetS. The results showed significant improvements in blood glucose, insulin, blood lipid profile, blood pressure, body fat percentage, waist circumference, lean body mass, and high-density lipoprotein cholesterol after exercise intervention. Resistance band exercise training may be an effective therapeutic intervention to combat MetS components and reduce the risk for cardiovascular disease in this population.
JOURNAL OF SPORTS SCIENCE AND MEDICINE
(2021)
Article
Health Care Sciences & Services
Anastasiia S. Boiko, Irina A. Mednova, Elena G. Kornetova, Anastasiia A. Goncharova, Arkadiy Semke, Nikolay A. Bokhan, Svetlana A. Ivanova
Summary: Metabolic syndrome (MetS) is a common complication of schizophrenia that is exacerbated by long-term use of antipsychotics. The study found that levels of leptin were significantly increased in MetS patients, while ghrelin levels were significantly decreased. There were fewer significant correlations between ghrelin and other hormones in MetS patients compared to those without MetS.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Dong-Keon Lee, Taesam Kim, Junyoung Byeon, Minsik Park, Suji Kim, Joohwan Kim, Seunghwan Choi, Gihwan Lee, Chanin Park, Keun Woo Lee, Yong Jung Kwon, Jeong-Hyung Lee, Young-Guen Kwon, Young-Myeong Kim
Summary: The REDD1-NF-kappa B axis plays a crucial role in metabolic inflammation and dysregulation, with Redd1 deficiency inhibiting diet-induced obesity, inflammation, insulin resistance, and hepatic steatosis.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Shangang Zhao, Qian Lin, Wei Xiong, Li Li, Leon Straub, Dinghong Zhang, Rizaldy Zapata, Qingzhang Zhu, Xue-Nan Sun, Zhuzhen Zhang, Jan-Bernd Funcke, Chao Li, Shiuhwei Chen, Yi Zhu, Nisi Jiang, Guannan Li, Ziying Xu, Steven C. Wyler, May-Yun Wang, Juli Bai, Xianlin Han, Christine M. Kusminski, Ningyan Zhang, Zhiqiang An, Joel K. Elmquist, Olivia Osborn, Chen Liu, Philipp E. Scherer
Summary: Antipsychotic drugs can cause weight gain and diabetes, and hyperleptinemia plays a key role. Suppression of leptin rise can reduce the adverse effects of these drugs.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Editorial Material
Endocrinology & Metabolism
Nils B. Kroemer
Summary: As most studies have mainly focused on the effects of insulin in the brain on men, there is limited understanding of metabolic changes during the menstrual cycle in women. Hummel et al. found that insulin sensitivity is reduced during the luteal phase through intranasal insulin administration and functional MRI.
Article
Endocrinology & Metabolism
Zhenwei Wang, Wei Li, Jingjie Li, Naifeng Liu
Summary: Insulin resistance (IR) is associated with cardiovascular disease (CVD), but its association with subclinical myocardial injury (SC-MI) remains unclear. This study aimed to assess the association between IR and SC-MI. The results showed a nonlinear relationship between IR and SC-MI in the general population without CVD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Tao Hong, Jiao-Yang Li, Ya-Di Wang, Xiao-Yan Qi, Zhe-Zhen Liao, Poonam Bhadel, Li Ran, Jing Yang, Bin Yan, Jiang-Hua Liu, Xin-Hua Xiao
Summary: The study found that serum asprosin levels were higher in subjects with MetS and showed an increasing trend with the number of metabolic components. Asprosin was positively correlated with BMI, waist circumference, triglycerides, glucose, insulin, and inflammatory markers, and negatively correlated with HDL cholesterol.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Jose E. Galgani, Rodrigo Fernandez-Verdejo
Summary: Glucose, fatty acids, and amino acids are oxidized to produce ATP for energy, and the complex adaptive systems in the body adjust fuel oxidation rates based on fuel availability. Metabolic flexibility refers to the ability of cells, tissues, or organisms to adapt fuel oxidation to fuel availability, which can be impaired in conditions like insulin resistance, diabetes, and obesity. Mitochondrial dysfunction in these conditions has been linked to metabolic inflexibility and overall metabolic health.
Review
Nutrition & Dietetics
Lucia Melguizo-Rodriguez, Victor J. Costela-Ruiz, Enrique Garcia-Recio, Elvira De Luna-Bertos, Concepcion Ruiz, Rebeca Illescas-Montes
Summary: The prevalence of hypovitaminosis D has been increasing in developed countries due to lifestyle changes and unhealthy habits. Scientific evidence shows an inverse relationship between vitamin D deficiency and metabolic syndrome (MetS), with supplementation helping improve outcomes in individuals with MetS. Maintaining optimal vitamin D concentrations is proposed as a preventive strategy against MetS.
Review
Endocrinology & Metabolism
Milica M. Borovcanin, Katarina Vesic, Milena Jovanovic, Natasa R. Mijailovic
Summary: Recent studies have suggested that patients with schizophrenia have specific immunometabolic profiles, with elevated levels of Gal-3 potentially linked to antipsychotic treatment and impacting the onset of inflammation, development of obesity, and cognitive changes. Animal studies have shown that downregulation of Gal-3 can be beneficial for insulin regulation of obesity and cognitive preservation. Strategies involving plasma exchange, particularly in the context of Gal-3 elimination, are discussed in this review.
WORLD JOURNAL OF DIABETES
(2021)
Article
Biochemistry & Molecular Biology
Eirini Dikaiakou, Fani Athanasouli, Anatoli Fotiadou, Maria Kafetzi, Stefanos Fakiolas, Stefanos Michalacos, Elpis Athina Vlachopapadopoulou
Summary: This study aimed to assess the prevalence of the hypertriglyceridemic waist (HTGW) phenotype in children with overweight or obesity and its association with insulin resistance and dyslipidemia. The study found that 19.3% of the sample had the HTGW phenotype, which was associated with elevated triglyceride levels, increased insulin resistance, and higher cardiometabolic risk.
Review
Cardiac & Cardiovascular Systems
Sho-ichi Yamagishi, Kei Fukami, Takanori Matsui
CARDIOVASCULAR DIABETOLOGY
(2015)
Review
Urology & Nephrology
Yuichi Makino, Yukihiro Fujita, Masakazu Haneda
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2015)
Article
Medicine, General & Internal
Juris J. Meier
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2015)
Review
Endocrinology & Metabolism
Juraj Koska, Michelle Sands, Camelia Burciu, Peter Reaven
DIABETES & VASCULAR DISEASE RESEARCH
(2015)
Article
Endocrinology & Metabolism
S. R. K. Seshasai, R. L. Bennett, J. R. Petrie, M. Bengus, S. Ekman, M. Dixon, M. Herz, J. B. Buse, K. K. Ray
DIABETES OBESITY & METABOLISM
(2015)
Review
Endocrinology & Metabolism
Donna Ryan, Andres Acosta
Article
Chemistry, Multidisciplinary
Meng-wei Chang, Chih-hung Chen, Yi-ching Chen, Ying-chun Wu, Yen-yi Zhen, Steve Leu, Tzu-hsien Tsai, Sheung-fat Ko, Pei-hsun Sung, Chih-chau Yang, Hsin-ju Chiang, Hsueh-wen Chang, Yen-ta Chen, Hon-kan Yip
ACTA PHARMACOLOGICA SINICA
(2015)
Review
Pharmacology & Pharmacy
David J. Grieve, Roslyn S. Cassidy, Brian D. Green
BRITISH JOURNAL OF PHARMACOLOGY
(2009)
Article
Endocrinology & Metabolism
Daniel J. Drucker
Review
Endocrinology & Metabolism
P. Anagnostis, V. G. Athyros, F. Adamidou, A. Panagiotou, M. Kita, A. Karagiannis, D. P. Mikhailidis
DIABETES OBESITY & METABOLISM
(2011)
Review
Endocrinology & Metabolism
John R. Ussher, Daniel J. Drucker
Review
Endocrinology & Metabolism
Rania Abu-Hamdah, Atoosa Rabiee, Graydon S. Meneilly, Richard P. Shannon, Dana K. Andersen, Dariush Elahi
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2009)
Review
Pharmacology & Pharmacy
Abd A. Tahrani, Milan K. Piya, Amy Kennedy, Anthony H. Barnett
PHARMACOLOGY & THERAPEUTICS
(2010)
Review
Pharmacology & Pharmacy
Gian Paolo Fadini, Angelo Avogaro
VASCULAR PHARMACOLOGY
(2011)
Review
Cardiac & Cardiovascular Systems
Ayako Takahashi, Madoka Ihara, Satoru Yamazaki, Hiroshi Asanuma, MaSarlori Asakura, Masafumi Kitakaze
INTERNATIONAL HEART JOURNAL
(2015)