Article
Pharmacology & Pharmacy
Burak Tan, Umut Bakkaloglu, Meral Ascioglu, Cem Suer
Summary: This study found that thyroid hormone excessiveness during perinatal period can lead to long-lasting effects on hippocampal function, with differences in behavior and molecular indicators between rats treated with l-thyroxine during maternal period and in young adulthood. These effects may contribute to memory problems observed in adolescents with lactational hyperthyroidism.
PHARMACOLOGICAL REPORTS
(2021)
Article
Medicine, Research & Experimental
Fateme Khodabande, Esmaeil Akbari, Motahareh Rouhi Ardeshiri
Summary: The orexin 1 receptors in the dorsal raphe nucleus play a significant role in the consolidation of spatial reference memory in rats, while the orexin 2 receptors do not have an effect.
Article
Neurosciences
Yeseul Lee, Zuner A. Bortolotto, Clarrisa A. Bradley, Thomas M. Sanderson, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge
Summary: Inhibition of GSK-3 improves learning speed in behavioral tasks and enhances the accuracy of long-term spatial memory.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Soniya Assudani Patel, Karyn M. Frick, Paul A. Newhouse, Robert S. Astur
Summary: The study examined the role of estradiol in hippocampal-dependent spatial memory in women. Results showed that the high estradiol group demonstrated superior spatial reference memory, while the low estradiol group exhibited the poorest probe trial performance. There were no group differences in performance on the virtual memory tasks.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Keyvan Mehri, Zohreh Zavvari Oskuye, Ehsan Nassireslami, Esmail Karami, Mohammad Reza Parvizi
Summary: This study investigated the effects of Botulinum toxin on spatial memory and biochemical and histological parameters in the hippocampus of male rats. Results showed that Botox significantly impaired memory performance and led to a decrease in acetylcholine levels, increase in acetylcholinesterase activity, and morphological damage in the hippocampus. Administration of Rivastigmine partially alleviated these effects and could serve as a protective approach.
Article
Behavioral Sciences
Niklas Lonnemann, Martin Korte, Shirin Hosseini
Summary: Alzheimer's disease is a neurodegenerative disease with no successful treatment. In addition to its features, neuroinflammatory processes, genetic factors, and lifestyle also play important roles. Training in a water maze has shown positive effects on memory formation in AD mice.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Cell Biology
Carlos Wert-Carvajal, Melissa Reneaux, Tatjana Tchumatchenko, Claudia Clopath
Summary: Dopamine and serotonin are important neuromodulators that affect synaptic plasticity. In the hippocampus, they play different roles in encoding uncertainty and reward. This study compares different rules to describe their action and finds that their interaction improves learning performance.
Article
Neurosciences
David A. Cinalli, Sarah J. Cohen, Mariah Calubag, Goksu Oz, Lylybell Zhou, Robert W. Stackman
Summary: This study used the DREADDs method to investigate the effects of CA1 pyramidal neurons in the hippocampus on the retrieval of long-term memory for nonspatial and spatial information in mice. The results showed that the inhibition of CA1 neuronal activity significantly impaired the memory retrieval in mice. These findings support the use of mice as a model system to study the neurobiological mechanisms of human episodic memory.
Article
Geriatrics & Gerontology
Marta Balietti, Arianna Pugliese, Fiorenzo Conti
Summary: It has been demonstrated that cognitive stimulation in late life can prevent cognitive decline in still cognitively preserved animals and improve cognitive compromised animals. Future research should focus on individually tailored stimulation protocols to enhance their effectiveness.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Neurosciences
Arne D. Ekstrom, Paul F. Hill
Summary: This passage discusses the close relationship between spatial navigation and memory at the cognitive and neural levels. It introduces models that suggest a central role for the medial temporal lobes, including the hippocampus, in both navigation and memory. However, these models have limitations in explaining functional and neuroanatomical differences. The idea of navigation as a dynamically acquired skill and memory as an internally driven process is explored, as well as network models that focus more on connections rather than specific brain regions.
Review
Veterinary Sciences
Muhammad Zulfadhli Othman, Zurina Hassan, Ahmad Tarmizi Che Has
Summary: The Morris water maze has been a popular tool for assessing spatial learning and memory for about 40 years, with advantages such as effectiveness, reliability, and adaptability. Despite some experimental and analysis loopholes, improvements and adaptations have ensured its relevance as a tool for understanding spatial learning and memory mechanisms.
EXPERIMENTAL ANIMALS
(2021)
Review
Psychology, Biological
Alba Gutierrez-Menendez, Marta Mendez, Jorge L. Arias
Summary: Spatial memory encodes, stores, evaluates, and recovers spatial information, and is mainly supported by the hippocampus and its interaction with other structures. Sex differences in spatial tasks have been found in adults, but few studies have examined sex differences in early postnatal development. This study analyzed the performance and metabolic brain activity of juvenile male and female rats in a spatial reference memory task, revealing faster consolidation in females.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Leila Karimi-Zandi, Maryam Zahmatkesh, Gholamreza Hassanzadeh, Soheila Hosseinzadeh
Summary: This study found an increase in fractalkine-positive microvesicles in the early stages of Alzheimer's disease, suggesting their potential as a biomarker for early diagnosis.
Article
Neurosciences
Lisa Wintzell, Samuel Klemetz, Stefan Lange, Eric Hanse, Caroline Wass, Joakim Strandberg
Summary: The endogenous peptide antisecretory factor (AF) enhances long-term potentiation (LTP) and spatial learning and memory by disinhibiting GABAergic transmission in the rat hippocampus.
Article
Behavioral Sciences
Amanda Dyer, Maxine De Butte
Summary: This study aimed to examine the effects of chronic low-dose vanadium administration on the behavior of young male rats. The findings suggest that vanadium does not significantly affect exploration, locomotion, or anxiety-like behavior in rats, but does affect novel object recognition performance. Additionally, vanadium administration led to lower latency times in the Morris Water maze task.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Oncology
Fereshteh Asgharzadeh, Niloufar Naghibzadeh, Milad Hashemzehi, Asma Mostafapour, Seyed Mahdi Hassanian, Amir Avan, Majid Khazaei
Summary: This study investigates the anti-metastatic effects of valsartan, an angiotensin II receptor type 1 (AT1R) antagonist, in a lung metastasis model of colorectal carcinoma (CRC). The results show that valsartan, especially in combination with 5-fluorouracil (5-FU), significantly reduces lung metastatic nodules and metastatic area. Additionally, it decreases inflammatory and angiogenic markers, while increasing oxidative stress markers. This suggests that valsartan, when used in combination with standard chemotherapeutic agents, can have a synergistic effect in treating CRC lung metastasis.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Medicine, Research & Experimental
Atena Soleimani, Parisa Dadjoo, Amir Avan, Saman Soleimanpour, Majid Rajabian, Gordon Ferns, Mikhail Ryzhikov, Majid Khazaei, Seyed Mahdi Hassanian
Summary: CD133, a CSC marker, is highly expressed in gastric cancer and is associated with malignant behaviors, chemoresistance, and poor prognosis. It also plays an important role in tumor progression and metastasis.
Article
Pharmacology & Pharmacy
Fereshteh Asgharzadeh, Asma Mostafapour, Safieh Ebrahimi, Forouzan Amerizadeh, Reihaneh Sabbaghzadeh, Maryam Fakhraei, Alieh Farshbaf, Gordon A. Ferns, Elisa Giovannetti, Amir Avan, Majid Khazaei, Seyed Mahdi Hassanian
Summary: This study found that targeting the RAS pathway using valsartan can interfere with cell proliferation, induce apoptosis, reduce migration, and synergistically interact with 5-FU in the treatment of colorectal cancer.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Review
Oncology
Sadaf Ghanaatgar-Kasbi, Farzaneh Pouya, Negar Khoshghamat, Ghazaleh Ghorbannezhad, Majid Khazaei, Malihe Hasanzadeh, Gordon A. Ferns, Amir Avan
Summary: The dysregulation of the TGF-beta signaling pathway has been observed in the development of gynecological cancers, providing potential therapeutic targets and prognostic biomarkers. This article provides an overview of the biological role and clinical impact of TGF-beta inhibitors as single agents or combination therapies in gynecological cancers, specifically focusing on clinical trials. Inhibition of TGF-beta shows promise for the treatment of gynecological cancers, and several inhibitors are currently being tested in clinical trials.
CURRENT CANCER DRUG TARGETS
(2023)
Review
Pharmacology & Pharmacy
Nima Zafari, Mahla Velayati, Shima Mehrabadi, Sedigheh Damavandi, Majid Khazaei, Seyed Mahdi Hassanian, Gordon A. Ferns, Amir Avan
Summary: The increasing burden of colorectal cancer and its rising prevalence in young adults highlight the importance of understanding its mechanisms, risk factors, and treatment options. Obesity is positively associated with colorectal cancer, and gut microbiota dysbiosis plays a pivotal role in its carcinogenesis. Sequencing studies have shown altered composition and ecology of intestinal microorganisms in both colorectal cancer and obese patients, identifying certain bacteria as key players. This review aims to provide an overview of how gut microbiota influences the development and progression of colorectal cancer, and discusses the potential links between gut microbiota and obesity. Evidence supporting targeted interventions on the microbiota for reducing cancer risk and enhancing therapy efficacy is also presented.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Genetics & Heredity
Reihaneh Alsadat Mahmoudian, Maharati Amirhosein, Parvaneh Mahmoudian, Fatemeh Fardi Golyan, Leila Mokhlessi, Mina Maftooh, Majid Khazaei, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Gordon Ferns, Soodabeh Shahidsales, Amir Avan
Summary: Gastric cancer is a leading cause of mortality globally and presents challenges in diagnosis, prognosis, and therapy. Cancer-testis antigens (CTAs) have been identified as potential biomarkers and targets for cancer immunotherapy. Numerous studies have reported the dysregulation of CTAs in gastric cancer, and clinical trials have been conducted to evaluate their immunotherapeutic potential.
Article
Biotechnology & Applied Microbiology
Mahdieh Darroudi, Seyedeh Elnaz Nazari, Maryam Karimzadeh, Fereshteh Asgharzadeh, Nima Khalili-Tanha, Seyyedeh Zahra Asghari, Sara Ranjbari, Fatemeh Babaei, Majid Rezayi, Majid Khazaei
Summary: Cervical cancer, as a leading cause of cancer-related death in women, requires novel therapeutic approaches for improved effectiveness. Mxene-based nanocarriers, such as Ti3C2-Fe3O4@SiO2-FA, show promise in targeted drug delivery for cervical cancer treatment. The nanocarrier, when magnetically controlled, exhibits significant tumor growth suppression and synergistic therapeutic efficacy with pharmaceuticals.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Mahdieh Darroudi, Seyedeh Elnaz Nazari, Maryam Karimzadeh, Fereshteh Asgharzadeh, Seyyedeh Zahra Asghari, Nima Khalili-Tanha, Majid Rezayi, Majid Khazaei
Summary: The study introduces an innovative nanocarrier by combining functionalized magnetic nanocomposite nano-chitosan and cisplatin. Magnetic nanoparticles modified with biocompatible copolymers can be used for delivering hydrophobic drugs such as cisplatin. The study aims to determine the antitumor effects of cisplatin-encapsulated Fe3O4@SiO2@N-Chit-FA in cervical cancer cells and increase the stability of the carrier by coating an additional layer of nanochitosan.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Biology
Nima Zafari, Parsa Bathaei, Mahla Velayati, Fatemeh Khojasteh-Leylakoohi, Majid Khazaei, Hamid Fiuji, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Gordon A. Ferns, Elham Nazari, Amir Avan
Summary: The burden and increasing trend of colorectal cancer in young adults highlight the importance of understanding its mechanisms, identifying new markers, and improving treatments. Precision medicine is a global trend, and the discovery of biomarkers and therapeutic targets is a step towards this trend. Multi-omics data and integrated analysis are being explored for personalized colorectal cancer management, but data integration and analysis present challenges. This review summarizes the application of statistical and machine learning techniques to analyze multi-omics data and their contribution to the discovery of diagnostic and prognostic biomarkers and therapeutic targets, as well as discusses the future clinical management of colorectal cancer.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Education & Educational Research
Roghayeh Gandomkar, Tahereh Changiz, Athar Omid, Mahasti Alizadeh, Majid Khazaei, Abtin Heidarzadah, Pouria Rouzrokh, Mitra Amini, Hamid Honarpisheh, Reza Laripour, Farshid Abedi, Babak Sabet, Azim Mirzazadeh
Summary: This study developed and validated national standards for Undergraduate Medical Education (UME) in Iran using the World Federation for Medical Education (WFME) framework. The standards were developed through consultative workshops and feedback from UME stakeholders, resulting in nine areas, 24 sub-areas, 82 basic standards, 40 quality development standards, and 84 annotations.
BMC MEDICAL EDUCATION
(2023)
Article
Genetics & Heredity
Niloofar Ghobadi, Ghazaleh Khalili-Tanha, Mehrane Mehramiz, Mina Maftooh, Nastaran Bani, Soodabeh ShahidSales, Majid Khazaei, Saeideh Ahmadi-Simab, Raheleh Rahbarian, Hassan Ramshini, Gordon A. Ferns, Masoumeh Gharib, Amir Avan
Summary: This study explored the association between the 1236C > T; rs1128503 genetic variant of the ABCB1/ MDR1 gene and the development and prognosis of esophageal squamous cell carcinoma (ESCC). The results showed that ESCC patients had a higher frequency of the C allele, and individuals with the TT genotype had a higher risk of ESCC. However, this genetic variant was not associated with progression-free survival and overall survival in ESCC patients.
Article
Integrative & Complementary Medicine
Mohammad-Mostafa Askarnia-Faal, Sayyed-Hadi Sayyed-Hosseinian, Seyedeh Elnaz Nazari, Fereshteh Asgharzadeh, Ehsan Vahedi, Moein Eskandari, Haniyeh Ghasemi, Amir Avan, Maryam Alaei, Hamideh Naimi, Maryam Daghiani, Atena Soleimani, Abbas Alalikhan, Reza Mohammadzadeh, Gordon Ferns, Mikhail Ryzhikov, Majid Khazaei, Seyed Mahdi Hassanian
Summary: This study explores the therapeutic potential of curcumin in attenuating post-operative adhesion band formation in animal models. Results showed that curcumin significantly decreased the severity, length, density, and tolerance of peritendinous adhesions as well as the incidence and severity of abdominal fibrotic bands post-surgery. Curcumin may decrease inflammation by regulating the recruitment of inflammatory cells and oxidant/antioxidant balance, and reduce fibrosis by decreasing quantity, quality, and grading of fibers, and collagen deposition.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Chemistry, Medicinal
Sepideh Ebrahimi, Zohreh Mostafavi-Pour, Majid Khazaei, Seyedeh Elnaz Nazari, Shirin Taraz Jamshidi, Mohammad Soukhtanloo
Summary: This study aimed to evaluate the inhibitory role of auraptene in colorectal cancer metastasis, and the results showed that auraptene can inhibit the proliferation and migration of CT26 cells and reduce the metastasis rate by modulating the expression of MMP-2, MMP-9, E-cadherin, VEGF-A, and VEGFR1 genes. It also induced significant necrosis in tumor cells.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Saeedeh Askarian, Masoumeh Gholami, Ghazaleh Khalili-Tanha, Negin Chaeichi Tehrani, Mona Joudi, Majid Khazaei, Gordon A. Ferns, Seyed Mahdi Hassanian, Amir Avan, Marjan Joodi
Summary: Cleft lip and cleft palate are common congenital malformations, with both genetic and environmental factors playing a role in their development.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2023)
Article
Chemistry, Medicinal
Elham Naderi, Abolfazl Khajavi Rad, Somayeh Nazari, Majid Khazaei, Samira Shahraki, Sara Hosseinian
Summary: The study demonstrates that the aqueous-alcoholic extract of Nigella sativa and thymoquinone can protect the kidney from rhabdomyolysis-induced injury by reducing levels of urea, creatinine, and creatine phosphokinase, as well as improving histological abnormalities in the kidney.
AVICENNA JOURNAL OF PHYTOMEDICINE
(2022)