Article
Biochemistry & Molecular Biology
Xiaoyu Ma, Chen Chen, Yaxin Lu, Ling Fang, Baohua Cao, Xueqiang Hu, Wei Qiu, Yaqing Shu
Summary: This study found that serum levels of GSDMD are elevated in patients with anti-NMDAR encephalitis and are associated with disease prognosis. After treatment, GSDMD levels decreased and clinical symptoms improved in patients, indicating a potential role of GSDMD in monitoring and predicting disease progression of anti-NMDAR encephalitis.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Immunology
Fanshi Zhang, Mei Liu, Jinmei Tuo, Li Zhang, Jun Zhang, Changyin Yu, Zucai Xu
Summary: This article reviews how neuroinflammation mediates the development of levodopa-induced dyskinesia (LID) through the regulation of NMDA receptors. It also evaluates the potential of common anti-inflammatory drugs and NMDA receptor antagonists to mitigate the development of LID by regulating central neuroinflammation, providing a new theoretical basis for finding new therapeutic targets for LID.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiao-Ting Huang, Jun-Xiao Yang, Zun Wang, Chen-Yu Zhang, Zi-Qiang Luo, Wei Liu, Si-Yuan Tang
Summary: The study highlights the role of the glutamate/NMDAR axis in obesity-related metabolic syndrome, with evidence showing that targeting NMDAR can be a promising therapeutic strategy. In obese mice, increased glutamate levels and blockade of NMDAR by Memantine improved insulin sensitivity and reduced hepatic steatosis, while NMDA treatment induced obesity and metabolic disorders. In vitro studies demonstrated that NMDAR activation promoted lipid accumulation and impaired fatty acid oxidation through PPARa signaling, suggesting a potential mechanism for NMDAR-mediated metabolic syndrome in obesity.
Article
Multidisciplinary Sciences
Tuo Ji, Zhi Huang, Yajun Lian, Chengze Wang, Qiaoman Zhang
Summary: This study investigated the role of free triiodothyronine (FT3) in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. The findings suggest that low FT3 levels upon admission may be associated with more severe disease progression and poorer outcomes in these patients. Monitoring FT3 levels could potentially aid in clinical prediction and decision-making in the treatment of anti-NMDAR encephalitis.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Yingzhe Shao, Juan Du, Yajun Song, Yanfei Li, Lijun Jing, Zhe Gong, Ranran Duan, Yaobing Yao, Yanjie Jia, Shujie Jiao
Summary: This study aimed to explore the difference in coagulation function between healthy individuals and patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis and its relationship with disease severity. The results showed that serum D-dimer and neutrophil levels were independent predictors of disease severity in patients with first-attack anti-NMDAR encephalitis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Stefan Macher, Tobias Zrzavy, Romana Hoeftberger, Patrick Altmann, Ekatarina Pataraia, Fritz Zimprich, Thomas Berger, Paulus Rommer
Summary: CSF-NfL levels in anti-NMDARE patients do not predict short-term outcomes, but are associated with ICU stay and extreme delta brushes. High CSF-NfL levels are associated with long-term outcomes, suggesting early aggressive immunotherapy to prevent neuroaxonal damage.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Oskar Stevens-Jones, Hana Mojzisova, Martin Elisak, Radu Constantinescu, Jitka Hanzalova, Markus Axelsson, David Krysl
Summary: This study aimed to discover clinically relevant biomarkers in NMDAR and LGI1 encephalitis using a proteomic approach. The results showed that SIRT2 may serve as a biomarker for NMDAR encephalitis and be associated with ovarian teratoma.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Immunology
Yuchen Li, Keyu Yang, Fang Zhang, Jing Wang, Huijun Shen, Miaomiao Liu, Junhong Guo, Jie Wang
Summary: This study identified potential CSF biomarkers for the occurrence, development, and prognosis of anti-NMDAR encephalitis using high-throughput proteomic analysis. The identified biomarkers are associated with immune/inflammatory responses and altered levels of autophagy. These biomarkers show promise in evaluating the severity and prognosis of anti-NMDAR encephalitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physiology
Yi-Shiou Tseng, Chun-Hou Liao, Wen-Bin Wu, Ming-Chieh Ma
Summary: The study demonstrates that NMDAR blockade alleviates D-serine-induced renal injury, possibly through the involvement of NOX4-mediated oxidative stress. These findings have important implications for preventing acute renal injury caused by D-serine.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Review
Neurosciences
Shuang Chen, Da Xu, Liu Fan, Zhi Fang, Xiufeng Wang, Man Li
Summary: This article reviews the regulation of NMDAR and its possible mechanisms in epilepsy, discussing the role of NMDAR in onset, development, and treatment, and providing more evidence for future studies.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Zhu Sha, Shi Jing, Gao Feng, Hongjun Hao, Xianzeng Liu
Summary: A case of neurosyphilis with positive anti-NMDAR antibody was reported in a 54-year-old man with acute memory deficits. The patient was initially diagnosed with acute ischemic stroke (AIS) and treated with rt-PA, but episodic memory and orientation disorder persisted. Positive results for syphilis and elevated leukocyte count and protein level in cerebrospinal fluid (CSF) were found. The patient was ultimately diagnosed with neurosyphilis with positive anti-NMDAR antibody and showed improvement with treatment.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Yan Zhang, Lili Cui, Weibi Chen, Huijin Huang, Gang Liu, Yingying Su, Johannes Boltze
Summary: This study aims to explore the clinical characteristics and outcome of SD in anti-NMDAR encephalitis. The results show that SD is rare in adult patients but is associated with severity and worse short-term outcomes. Early recognition of SD and timely treatment is crucial for shortening the recovery time.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yara A. Samra, Dina Kira, Pragya Rajpurohit, Riyaz Mohamed, Leah A. Owen, Akbar Shakoor, Ivana K. Kim, Margaret M. DeAngelis, Nader Sheibani, Mohamed Al-Shabrawey, Amany Tawfik
Summary: The study suggests that the activation of NMDAR in the retina pigment epithelium may be a mechanism for AMD induced by HHcy. Inhibition of NMDAR could be a promising therapeutic target for AMD, as knocking down RPE NMDAR improved retinal structure and CNV in mice with AMD-like features induced by HHcy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ran Zhou, Fei Jiang, Haobing Cai, Qiuming Zeng, Huan Yang
Summary: The presence of anti-N-Methyl-D-Aspartate receptor antibody in patients with multiple sclerosis can lead to complex, diverse, and atypical clinical symptoms. Hence, neurologists need to pay high attention and increased alertness to such cases for accurate diagnosis and treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Amany Tawfik, Riyaz Mohamed, Dina Kira, Suhib Alhusban, Mohamed Al-Shabrawey
Summary: Elevated levels of homocysteine (Hcy) known as hyperhomocysteinemia (HHcy) are associated with diabetic retinopathy (DR) and age-related macular degeneration (AMD). This study suggests that HHcy alters blood-retinal barrier (BRB) by activating N-methyl-D-aspartate receptor (NMDAR). Inhibition or elimination of NMDAR can potentially improve retinal hyperpermeability and morphology under HHcy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Physiology
Kai Gu, Duoduo Qian, Huiyuan Qin, Chang Cui, W. C. Hewith A. Fernando, Daowu Wang, Juejin Wang, Kejiang Cao, Minglong Chen
Summary: The W410R mutation in the KCNH2 gene decreases the activity of hERG channels, leading to elongated repolarization of cardiomyocytes and potentially inducing the pathogenesis of LQT2. E-4031 can partially rescue the decreased activity of hERG(W410R) channels.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chao Ye, Ying Tong, Nan Wu, Guo-wei Wan, Fen Zheng, Jing-yu Chen, Jian-zhen Lei, Hong Zhou, Ai-dong Chen, Jue-jin Wang, Qi Chen, Yue-hua Li, Yu-ming Kang, Guo-qing Zhu
Summary: The study demonstrated that miR-135a-5p promotes vascular smooth muscle cell (VSMC) proliferation in spontaneously hypertensive rats (SHRs), while FNDC5 inhibits it. Silencing miR-135a-5p or upregulating FNDC5 could attenuate VSMC proliferation and vascular remodeling in SHRs. These findings suggest that manipulating miR-135a-5p or FNDC5 levels may be a therapeutic strategy for reducing vascular remodeling and hypertension.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Bing Zhou, Lu-Lu Wu, Fen Zheng, Nan Wu, Ai-Dong Chen, Hong Zhou, Jing-Yu Chen, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
Summary: miR-31-5p plays a crucial role in oxidative stress and VSMC migration by inhibiting FNDC5 expression, leading to increased oxidative stress and cell migration in SHR. The imbalance of miR-31-5p and FNDC5 exacerbates oxidative stress and cell migration in vascular smooth muscle cells.
Review
Chemistry, Multidisciplinary
Chao Ye, Fen Zheng, Nan Wu, Guo-qing Zhu, Xiu-zhen Li
Summary: Vascular remodeling plays a crucial role in the development of various vascular diseases and is closely associated with the release of extracellular vesicles (EVs). EVs impact vascular remodeling by affecting oxidative stress, inflammation, calcification, and lipid plaque formation. Therefore, EVs have the potential to be used as biomarkers for diagnosis and prognosis, as well as therapeutic targets for vascular remodeling and cardiovascular diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Yuan Xue, Sihan Hu, Chichi Chen, Jiachen He, Jie Sun, Yesheng Jin, Yuanshu Zhang, Guoqing Zhu, Qin Shi, Yongjun Rui
Summary: Irisin plays a regulatory role in bone homeostasis and promotes MSC-derived osteogenesis. Lack of Irisin leads to bone loss and enhanced bone resorption, while the presence of Irisin can promote osteogenesis by activating signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Miaomiao Song, Wei Hou, Atta Ul Mustafa, Pengpeng Li, Jianzhen Lei, Yingying Zhou, Li Ji, Yu Sun, Hongmei Zhou, Yinyan Xu, Juejin Wang
Summary: This study found that Rbfox1 regulates vascular constriction by modulating the alternative splicing of Ca(V)1.2 channel exons 9* and 33. The protein level of Rbfox1 is significantly decreased in hypertensive rats, suggesting its involvement in the pathogenesis of cardiovascular diseases. This research reveals the underlying mechanisms for the regulation of Ca(V)1.2 channels and provides a potential therapeutic target for hypertension.
Article
Biochemistry & Molecular Biology
Lu-Lu Wu, Yue Zhang, Xiu-Zhen Li, Xin-Li Du, Ying Gao, Jing-Xiao Wang, Xiao-Li Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Xiao Tan
Summary: Selective renal afferent denervation attenuated sympathetic activity, oxidative stress, vascular remodeling, and hypertension in spontaneously hypertensive rats (SHR).
Review
Behavioral Sciences
Xiaoyu Ma, Juejin Wang
Summary: Formononetin (FMN) is a phytoestrogen with pharmacological effects of antioxidation, antihypertension, antitumor, and anti-infection. It has significant potential in neuroprotection and can be used for the treatment of various neurological diseases.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Article
Oncology
Bing Zhou, Nan Wu, Yuan Yan, Lu-Lu Wu, Guo-Qing Zhu, Xiao-Qing Xiong
Summary: This study demonstrates that the upregulation of miR-31-5p and the downregulation of FNDC5 contribute to Ang II-induced VSMC proliferation and migration.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Li Wang, Jing-Xiao Wang, Jun-Liu Chen, Wen-Yuan Hao, Wen-Zhou Xu, Zhi-Qin Xu, Yu-Tong Jiang, Pei-Qi Luo, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Xiu-Zhen Li
Summary: This study discovered that high expression of asprosin in the PVN increased sympathetic outflow and blood pressure via the cAMP-PKA signaling-mediated NADPH oxidase activation and subsequent superoxide production. These findings highlight the important role of asprosin in regulating sympathetic and cardiovascular function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biology
Juejin Wang, Zhaoyang Chen, Hongchang Guo, Rui Wang, Ruijuan Sun
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Jing-Xiao Wang, Xiao-Li Wang, Zhi-Qin Xu, Yue Zhang, Dong Xue, Rong Zhu, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Xiao Tan
Summary: This study found that chemerin-9 in the PVN increases sympathetic activity and blood pressure through CMKLR1-dependent calcium influx, glutamate receptor-mediated NADPH oxidase activation, and subsequent superoxide production.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jin-Hua Bo, Jing-Xiao Wang, Xiao-Li Wang, Yang Jiao, Ming Jiang, Jun-Liu Chen, Wen-Yuan Hao, Qi Chen, Yue-Hua Li, Zheng-Liang Ma, Guo-Qing Zhu
Summary: Research shows that the use of dexmedetomidine can attenuate sympathetic activity and inflammation in sepsis. The drug reduces NADPH oxidase-dependent superoxide production by inhibiting the adenylate cyclase-cAMP-PKA signaling pathway and activating GABA(A) receptors, thus alleviating sympathetic overactivity.
Article
Medicine, Research & Experimental
Fen Zheng, Chao Ye, Rui Ge, Yu Wang, Xiao-Lei Tian, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Bing Zhou
Summary: This study demonstrates the important roles of EVs-mediated miR21-3p transfer in promoting VSMC proliferation and migration in SHR and identifies SORBS2 as a target of miR-21-3p in this process.
Article
Medicine, Research & Experimental
Chao Ye, Fen Zheng, Tao Xu, Nan Wu, Ying Tong, Xiao-Qing Xiong, Ye-Bo Zhou, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Guo-Qing Zhu, Ying Han
Summary: This study reveals that NE promotes the release of small EVs and ACE transfer from AFs, leading to VSMCs proliferation in hypertension. Intervention of AFs-derived EVs release may be a potential therapeutic approach for vascular remodeling in hypertension related to excessive sympathetic activation.
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.