Review
Endocrinology & Metabolism
Emilia Grzeda, Julia Matuszewska, Kamil Ziarniak, Anna Gertig-Kolasa, Izabela Krzysko- Pieczka, Bogda Skowronska, Joanna H. Sliwowska
Summary: The prenatal period is critical for human development, and the foetus is particularly vulnerable to environmental factors. Maternal nutrition plays a significant role in the offspring's health, with imbalanced metabolic status potentially leading to metabolic disorders. Animal studies and human research have shown the influence of maternal diet on offspring development, but the mechanisms linking impaired foetal development and adult diseases are still not fully understood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Gita Thapaliya, Poorbita Kundu, Elena Jansen, Marcus A. Naymik, Richard Lee, Muriel Marisa Katharina Bruchhage, Viren D'Sa, Matthew J. Huentelman, Candace R. Lewis, Hans-Georg Muller, Sean C. L. Deoni, Susan RESONANCE Consortium, Susan Carnell
Summary: This study found that common genetic risk for obesity is associated with differences in early development of brain reward circuitry, suggesting the importance of investigating the dynamic relationships among genotype, brain, behavior, and weight throughout development.
Article
Medicine, General & Internal
Teresa L. Serafim, Teresa Cunha-Oliveira, Claudia M. Deus, Vilma A. Sardao, Ines M. Cardoso, Shanshan Yang, John F. Odhiambo, Adel B. Ghnenis, Ashley M. Smith, Junfei Li, Peter W. Nathanielsz, Stephen P. Ford, Paulo J. Oliveira
Summary: Maternal obesity impacts foetal liver mitochondrial oxidative capacity and total mitochondrial phospholipid content, as well as the regulation of foetal liver redox pathways, revealing metabolic adaptations to a higher foetal lipid environment. In utero programming of foetal hepatic metabolism may persist and compromise mitochondrial bioenergetics in later life, increasing susceptibility to metabolic diseases.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Morteza Gholami
Summary: This study identifies the FTO gene as a major shared gene between breast cancer, type 2 diabetes mellitus, and obesity based on two DNA repair and inflammatory mechanisms. These findings provide a new perspective on the important role of the FTO gene and repair mechanism in the relationship between these diseases.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Neurosciences
M. H. Vickers
Summary: Changes in early life nutrition can have significant effects on the risk of obesity and metabolic disorders in later life, which can be passed on to future generations. This process, known as developmental programming, plays a role in the origins of health and disease. Early nutritional compromise can lead to adverse health outcomes in offspring, with the potential for exacerbation by a poor postnatal nutrition environment. The mechanisms underlying programming are not yet fully understood, but altered neuroendocrine circuits that regulate satiety and energy balance have been identified as a common feature in preclinical models.
Review
Nutrition & Dietetics
Natassia Rodrigo, Sonia Saad, Carol Pollock, Sarah J. Glastras
Summary: Maternal obesity has serious implications for both mother and offspring, with potential transgenerational effects. Research using rodent models plays a crucial role in studying the impacts of maternal obesity and exploring intervention strategies to mitigate these effects. Further understanding of the pathophysiology of obesity and its interaction with reproductive health is essential for public health efforts.
Article
Biochemistry & Molecular Biology
Michael Le Pepke, Thomas Kvalnes, Sarah Lundregan, Winnie Boner, Pat Monaghan, Bernt-Erik Saether, Henrik Jensen, Thor Harald Ringsby
Summary: The study demonstrates that early-life telomere length has low heritability and is strongly affected by environmental conditions, it is a polygenic trait.
Review
Dentistry, Oral Surgery & Medicine
Elizabeth J. Leslie
Summary: This review describes the evidence for a genetic etiology in orofacial clefts (OFCs), statistical genetic approaches employed to identify genetic causes, and how the results have shaped our current understanding of the genetic architectures of syndromic and nonsyndromic OFCs.
Article
Biochemistry & Molecular Biology
Tae Hoon Kim, Nayoung Bae, Taeho Kim, Albert L. Hsu, Mark Hunter, Jung-Ho Shin, Jae-Wook Jeong
Summary: Endometriosis is positively associated with obesity, but negatively associated with low BMI. High-fat diet-induced obesity can increase the development of endometriosis, while obesity with leptin deficiency and leptin receptor deficiency can suppress the development of endometriosis. These findings suggest that leptin and its receptor play a critical role in the development of endometriosis.
Editorial Material
Public, Environmental & Occupational Health
Fasil Tekola-Ayele
Summary: Research has shown a positive relationship between measures of adiposity and epigenetic clocks in non-Hispanic White women, highlighting the need for further study on the complex relationship between obesity and epigenetic aging. The early-life period is considered a unique opportunity to explore links between developmental processes and aging in later life.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Immunology
T. Norris, J. M. Blodgett, N. T. Rogers, M. Hamer, S. M. Pinto Pereira
Summary: The study found that early-adult obesity is associated with an increased risk of poor physical functioning in mid-life, with approximately 23% of this effect mediated by its impact on C-reactive protein.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Genetics & Heredity
Carla Aoun, Aline Hajj, Fabienne Hajj, Tatiana Papazian, Lydia Rabbaa Khabbaz
Summary: The study found that FTO rs9939609 was significantly associated with WHR, and MC4R was associated with all phenotypic traits linked to obesity (BMI, WC and WHR). However, the MTHFR polymorphism did not show significant correlation with anthropometric parameters. Adherence to the Mediterranean Diet and high levels of physical activity do not seem to protect against overweight and obesity in genetically predisposed individuals.
Review
Medicine, General & Internal
Maria Puche-Juarez, Juan M. Toledano, Julio J. Ochoa, Javier Diaz-Castro, Jorge Moreno-Fernandez
Summary: Background: Obesity and being overweight have become severe global health issues. Maternal dietary habits and other factors during pregnancy can have a significant impact on the prevention of obesity in children. A review of recent human studies aims to determine modifiable factors that influence adiposity and prevent specific disorders later in life. Conclusion: A healthy diet and lifestyle starting from pregnancy and throughout childhood, particularly in the first two years, can prevent the emergence of noncommunicable diseases and metabolic syndrome-related pathologies.
Article
Materials Science, Multidisciplinary
Lingling Chen, Zhiyuan Wang, Aftab Ahmad Khan, Majid Khan, Muhammad Faisal Javed, Abdulaziz Alaskar, Sayed M. Eldin
Summary: In this study, predictive models for the split tensile strength (STS) and elastic modulus (E) of waste foundry sand concrete (WFSC) were generated using gene expression programming (GEP) and multi-expression programming (MEP). The reliability and accuracy of the models were evaluated using various statistical indicators. The results showed that both GEP and MEP accurately predicted the E, but GEP performed better in predicting STS. The models showed excellent performance and generalization potential. The findings of this study can promote the use of waste foundry sand in sustainable concrete construction.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Review
Pharmacology & Pharmacy
Zunera Chauhdary, Kanwal Rehman, Muhammad Sajid Hamid Akash
Summary: Obesity has become a global pandemic mainly due to lifestyle changes and environmental factors, such as lack of physical activity and consumption of high-energy diets. Research has shown the significant role of FTO in human obesity, affecting energy expenditure and food intake, and is correlated with body mass index and body composition.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Fatemeh Hassani-Nezhad-Gashti, Tuire Salonurmi, Heidi Hautajarvi, Aana Rysa, Jukka Hakkola, Janne Hukkanen
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2020)
Article
Nutrition & Dietetics
Mousa Khalafi, Hamid Mohebbi, Michael E. Symonds, Pouran Karimi, Amir Akbari, Elma Tabari, Mehrsa Faridnia, Kamilia Moghaddami
Article
Pharmacology & Pharmacy
Tuire Salonurmi, Heba Nabil, Justiina Ronkainen, Tuulia Hyotylainen, Heidi Hautajarvi, Markku J. Savolainen, Ari Tolonen, Matej Oresic, Paivi Kansakoski, Jaana Rysa, Jukka Hakkola, Janne Hukkanen
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Medicine, General & Internal
Young-Gyun Seo, Tuire Salonurmi, Terhi Jokelainen, Pasi Karppinen, Anna-Maria Teeriniemi, Junhee Han, Kyung Hee Park, Harri Oinas-Kukkonen, Markku J. Savolainen
ANNALS OF MEDICINE
(2020)
Editorial Material
Physiology
Michael E. Symonds
EXPERIMENTAL PHYSIOLOGY
(2020)
Review
Sport Sciences
Mousa Khalafi, Michael E. Symonds
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2020)
Article
Cell Biology
Hilda Anaid Lugo Leija, Ksenija Velickovic, Ian Bloor, Harold Sacks, Michael E. Symonds, Virginie Sottile
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Endocrinology & Metabolism
James M. Law, David E. Morris, Lindsay Robinson, Tabitha Randell, Louise Denvir, Michael E. Symonds, Helen Budge
Summary: Type 1 diabetes affects the activity of brown adipose tissue, as shown by lower supraclavicular temperatures in children with diabetes compared to controls. Insulin delivery method may significantly impact the response of BAT to stimulation. Further research is needed to fully understand the glucose-insulin-BAT relationship.
PEDIATRIC DIABETES
(2021)
Article
Biochemistry & Molecular Biology
Timo Paavola, Ulrich Bergmann, Sanna Kuusisto, Sakari Kakko, Markku J. Savolainen, Tuire Salonurmi
Summary: The study analyzed the lipidome of HDL2 and HDL3 subfractions in families with low HDL-C predisposing to premature CHD, and found altered levels of certain lipid species in MetS compared to non-affected subjects. Certain lipid ratios related consistently to CHD and MetS, suggesting a potential role in the pathogenesis of these conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Peter Aldiss, Jo E. Lewis, Irene Lupini, Ian Bloor, Ramyar Chavoshinejad, David J. Boocock, Amanda K. Miles, Francis J. P. Ebling, Helen Budge, Michael E. Symonds
Summary: This study demonstrates that chronic suppression of adaptive thermogenesis leads to weight gain and increased fat mass in rodents. Living in a cool environment (20 degrees C) and treatment with a β3-adrenoreceptor agonist (YM-178) had minimal effects on metabolic health in obese rats raised at thermoneutrality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Noora Oikarinen, Terhi Jokelainen, Laura Heikkilae, Marjukka Nurkkala, Janne Hukkanen, Tuire Salonurmi, Markku J. Savolainen, Anna-Maria Teeriniemi
Summary: Success in long-term weight management relies on psychological and behavioral factors. This study investigates the association between eating self-efficacy (ESE) and various eating behaviors and difficulties in weight management. Participants with low ESE showed lower cognitive restraint (CR) and higher levels of uncontrolled eating (UE), emotional eating (EE), and binge eating (BE) compared to those with high ESE. The risk of low ESE was increased by high levels of UE, EE, and BE in men, and by low CR, high UE, and high EE in women. These findings highlight the importance of considering eating behavior tendencies when counseling individuals with overweight and obesity.
SCIENTIFIC REPORTS
(2023)
Review
Multidisciplinary Sciences
Mousa Khalafi, Michael E. Symonds, Mohammad Hossein Sakhaei, Faeghe Ghasemi
Summary: The meta-analysis showed that exercise training reduces sICAM-1 but does not significantly affect sVCAM-1 in adults. Both aerobic and resistance training are effective in decreasing sICAM-1 in adults with metabolic disorders and cardiovascular diseases.
Article
Information Science & Library Science
Noora Hirvonen, Heidi Enwald, Anne-Kathrin Mayer, Raija Korpelainen, Riitta Pyky, Tuire Salonurmi, Markku J. Savolainen, Cathrine Nengomasha, Ruth Abankwah, Wilhelm Uutoni, Raimo Niemela, Maija-Leena Huotari
HEALTH INFORMATION AND LIBRARIES JOURNAL
(2020)
Article
Endocrinology & Metabolism
Saeid Doaei, Naser Kalantari, Pantea Izadi, Tuire Salonurmi, Alireza Mosavi Jarrahi, Shahram Rafieifar, Ghasem Azizi Tabesh, Ghazaleh Rahimzadeh, Maryam Gholamalizadeh, Mark O. Goodarzi
Article
Medicine, General & Internal
Saeid Doaei, Naser Kalantari, Nastaran Keshavarz Mohammadi, Pantea Izadi, Maryam Gholamalizadeh, Hassan Eini-Zinab, Tuire Salonurmi, Alireza Mosavi Jarrahi, Shahram Rafieifar, Reza Janipoor, Mahnaz Sadeghypor, Ghasem Azizi Tabesh, Mark O. Goodarzi
ARCHIVES OF MEDICAL SCIENCE
(2019)
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.