Review
Chemistry, Analytical
Guihai Gan, Tengfei Ma, Guoying Zhang, Kewu He, Jinming Hu
Summary: Researchers have visualized and monitored nitric oxide and carbon monoxide to understand their roles in maintaining biological homeostasis. Luminescence-based probes have emerged as a powerful technique for non-invasive, highly selective, and real-time detection and imaging of these gaseous signaling molecules.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Alicja Nowaczyk, Magdalena Kowalska, Jacek Nowaczyk, Grzegorz Grzesk
Summary: In the 100th anniversary of the confirmation of neurotransmission, the discovery of over 100 neurotransmitters belonging to various chemical groups highlights the significance of this field. Nitric oxide and carbon monoxide, known as gasotransmitters, have emerged as key players in the study of endogenous gaseous transmitters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Lei Gao, Jian Cheng, Zhiqiang Shen, Guoying Zhang, Shiyong Liu, Jinming Hu
Summary: The covalent grafting of nitric oxide (NO) and carbon monoxide (CO) releasing moiety demonstrated superior antimicrobial effects on Gram-positive bacteria. Furthermore, this treatment showed better therapeutic capacity than vancomycin in a murine skin wound model.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Preecha Kittikhunnatham, Gabrielle A. Leith, Abhijai Mathur, Jennifer K. Naglic, Corey R. Martin, Kyoung Chul Park, Katherine McCullough, H. D. A. Chathumal Jayaweera, Ryan E. Corkill, Jochen Lauterbach, Stavros G. Karakalos, Mark D. Smith, Sophya Garashchuk, Donna A. Chen, Natalia B. Shustova
Summary: This study investigated the efficient delivery of reactive and toxic gaseous reagents in organic reactions using metal-organic frameworks (MOFs). It was found that MOFs can serve as both gas cargo vehicles and catalysts, leading to high product yields. Moreover, the MOFs can be recycled without sacrificing product yield and crystallinity, indicating the potential of developing multifunctional MOF-based reagent-catalyst cargo vessels as an attractive alternative to toxic pure gases or gas generators.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Energy & Fuels
Xiwei Ke, Ling Jiang, Yiran Li, Hairui Yang, JunFu Lyu, Man Zhang
Summary: This study focuses on the reduction of NO over chars and quantifies the impact of CO on char-NO reactivity under different conditions. CO can promote NO reduction at low temperatures, but leads to a decrease in NO conversion rate at high temperatures.
Review
Biochemistry & Molecular Biology
Subir Kumar Juin, Rosemary Ouseph, Dibson Dibe Gondim, Venkatakrishna Rao Jala, Utpal Sen
Summary: Diabetic nephropathy (DN) is still the main cause of morbidity and mortality in diabetes patients. Gasotransmitters, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), play a vital role in the development and progression of DN. Aberrant levels of gasotransmitters have been observed in patients with diabetes, and gasotransmitter donors show potential in ameliorating diabetic renal dysfunction. This review provides an overview of the physiological relevance of gasotransmitters and their interaction with other factors in the severity modulation of DN, highlighting the possible therapeutic interventions.
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Biochemistry & Molecular Biology
Amira Moustafa
Summary: Gasotransmitters are gaseous molecules synthesized within the body that play roles in various physiological and pathological processes at the cellular level. Long-term exposure to restraint stress has been shown to negatively impact male reproductive functions in rats, with changes in hormone levels and alterations in the expression of gasotransmitter producing enzymes in the hypothalamus and testes.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Wout Verbeure, Harry van Goor, Hideki Mori, Andre P. van Beek, Jan Tack, Peter R. van Dijk
Summary: Gasotransmitters such as NO, CO, and H2S play significant roles in various physiological processes at low concentrations, which are regulated by gut peptides like gastrin and cholecystokinin, though the relationship between them is poorly understood.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Inorganic & Nuclear
Luiz Gonzaga de Franca Lopes, Florencio S. Gouveia Junior, Alda Karine Medeiros Holanda, Idalina Maria Moreira de Carvalho, Elisane Longhinotti, Tercio F. Paulo, Dieric S. Abreu, Paul Bernhardt, Marie-Alda Gilles-Gonzalez, Izaura Cirino Nogueira Diogenes, Eduardo Henrique Silva Sousa
Summary: This article discusses the roles of diatomic molecules O-2, NO, and CO in biology, as well as the sensing proteins developed by nature to perceive and respond to changes in their levels. It focuses on heme-based proteins and their advanced structural and electronic adjustments for sensing, along with their possible role in redox sensing. Finally, the potential therapeutic interventions on these gas sensors and the design of small diatomic molecules for medical treatments are highlighted.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Pharmacology & Pharmacy
Rosalba Siracusa, Vanessa A. Voltarelli, Angela Trovato Salinaro, Sergio Modafferi, Salvatore Cuzzocrea, Edward J. Calabrese, Rosanna Di Paola, Leo E. Otterbein, Vittorio Calabrese
Summary: Oxygen, carbon dioxide, nitric oxide, hydrogen sulfide, and carbon monoxide are gases that play critical physiological roles in the brain. The functional interaction between these gases is complex and intriguing. Considering toxicology concepts becomes imperative when developing therapies involving these gases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Polymer Science
Yuanmeng Fang, Jian Cheng, Zhiqiang Shen, Tao You, Shenggang Ding, Jinming Hu
Summary: Although nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S) have long been considered as gas pollutants, they are actually endogenous gaseous signaling molecules (GSMs) with important signaling functions and medical applications. Stimuli-responsive nanocarriers have been developed to achieve controlled delivery of GSMs and reduce side effects, with ultrasound being an attractive modality for tracking drug carriers, triggering drug release, and improving drug deposition. This minireview summarizes recent advancements in designing ultrasound-responsive nanocarriers for controlled delivery of GSMs and their biomedical applications. This emerging research direction enables targeted delivery of GSMs to deep tissues, and the combination with ultrasound imaging techniques offers potential for new theranostic platforms.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Xiaoduo Tang, Jingyan Ren, Xin Wei, Tao Wang, Haiqiu Li, Yihan Sun, Yang Liu, Mingli Chi, Shoujun Zhu, Laijin Lu, Junhu Zhang, Bai Yang
Summary: The authors have developed a hydrogel patch that releases carbon monoxide and nitric oxide gases on demand, which can provide timely blood supply for skin flap transplantation during surgery, reducing the incidence of flap necrosis and long-term functional loss.
NATURE COMMUNICATIONS
(2023)
Review
Cardiac & Cardiovascular Systems
Yoon Kyung Choi, Young-Myeong Kim
Summary: The interaction between CO and NO plays a crucial role in maintaining vascular homeostasis and regeneration by improving endothelial function and promoting cell-cell communication, thus sustaining the health of cardiovascular and neurovascular systems.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Ronald F. Coburn
Summary: The major toxic effects of acute carbon monoxide poisoning are caused by increased reactive oxygen species and reactive nitrogen species, resulting in oxidative stress. This study aims to describe the deregulation of NO and H2S signaling pathways during CO poisoning and their interaction with CO signaling pathways, which contribute to cell injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Tahira Wangnoo, Gerald Stanley Zavorsky, Ashli Owen-Smith
JOURNAL OF NEUROTRAUMA
(2020)
Meeting Abstract
Critical Care Medicine
Gerald Zavorsky, Samuel Gasparyan, Rebecca Brooks
Correction
Multidisciplinary Sciences
Seteena L. Ueberschlag, James R. Seay, Alexandra H. Roberts, Pamela C. DeSpirito, Jeremy M. Stith, Rodney J. Folz, Kathleen A. Carter, Edward P. Weiss, Gerald S. Zavorsky
Article
Physiology
Alessandra Magini, Mauro Contini, Emanuele Spadafora, Anna Apostolo, Elisabetta Salvioni, Simone Barbieri, Susanna Sciomer, Daniele Andreini, Fabrizio Veglia, Gerald S. Zavorsky, Piergiuseppe Agostoni
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2020)
Letter
Sport Sciences
Gerald S. Zavorsky
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Physiology
Alessandra Magini, Gerald S. Zavorsky, Anna Apostolo, Mauro Contini, Simone Barbieri, Piergiuseppe Agostoni
Summary: In heart failure patients, the week-to-week variability in DMCO was lowest when using the single-step NO-CO technique, while Vcap estimation was unreliable. The DMCO derived from double diffusion most closely matched that from the RF method.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Article
Respiratory System
Gerald Stanley Zavorsky, Ahmad Saleh Almamary, Mobarak Khalid Alqahtani, Shi Huh Samuel Shan, Douglas Shawn Gardenhire
Summary: This study aimed to demonstrate the need for race-specific reference equations for DLNO, as there are small but significant racial differences in DLNO and DLCO in healthy black adults.
BMC PULMONARY MEDICINE
(2021)
Article
Medical Laboratory Technology
Gerald S. Zavorsky, Xander M. R. van Wijk, Samuel Gasparyan, Nicholas S. Stollenwerk, Rebecca A. Brooks
Summary: The study found that sodium, ionized calcium, and chloride in whole blood remain stable at room temperature, but after 67 minutes of storage in slushed ice, there is a 5% probability that potassium concentration will increase by at least 0.3 mmol/L.
JOURNAL OF APPLIED LABORATORY MEDICINE
(2022)
Article
Respiratory System
Gerald Stanley Zavorsky, Jiguo Cao
Summary: In this study, the researchers compared generalized additive models and segmented regression models to determine the reference equations for pulmonary diffusing capacity for carbon monoxide and nitric oxide. The results showed that segmented linear regression can be used as an alternative to GAMLSS, especially when the predictive accuracy is similar between the two models. Additionally, the equipment used for measurement also had an impact on the results.
BMJ OPEN RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Arturo Cortes-Telles, Esperanza Figueroa-Hurtado, Diana Lizbeth Ortiz-Farias, Gerald Stanley Zavorsky
Summary: This study examined lung function in Hispanic subjects recovering from mild COVID-19. It found that one-third of patients had impaired pulmonary diffusing capacity for carbon monoxide (DLCO) and one-fifth had a restrictive spirometric pattern. Factors such as age, spirometric pattern, and symptoms were associated with impaired DLCO.
BMC PULMONARY MEDICINE
(2022)
Letter
Medical Laboratory Technology
Gerald S. Zavorsky
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Gerald S. Zavorsky, Rebecca A. Brooks
Summary: This study found that sexual activity within 30 minutes to 24 hours before exercise does not appear to affect aerobic fitness, musculoskeletal endurance, or strength/power.
SCIENTIFIC REPORTS
(2022)
Article
Medical Laboratory Technology
Gerald S. Zavorsky, Xander M. R. van Wijk
Summary: The objective of this study was to determine the stability of blood gases under different storage conditions using survival analyses. The results showed that pCO(2) and pH in blood samples remained stable for 60 minutes at room temperature and 3 hours in slushed ice. However, storing samples in slushed ice reduced the stability time for pO(2), especially when the baseline pO(2) was ≥60 mmHg. In conclusion, according to RCPA guidelines, blood gas and CO-oximetry panels can be stored for up to 40 minutes at room temperature.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Meeting Abstract
Critical Care Medicine
G. S. Zavorsky, J. Cao
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Meeting Abstract
Critical Care Medicine
G. S. Zavorsky
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.
