期刊
ACTA PHARMACOLOGICA SINICA
卷 39, 期 11, 页码 1797-1803出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41401-018-0083-x
关键词
HOTAIR; LncRNA; lung cancer; single nucleotide polymorphisms
资金
- National Natural Science Foundation of China [81773207, 81372306]
- Tianjin key project of the Natural Science Foundation [16JCZDJC34200]
- Special support program for High Tech Leader and Team of Tianjin [TJTZJHGCCCXCYTD-2-6]
- Tianjin Natural Science Foundation [13JCYBJC22600, 16PTSYJC00160]
- China Scholarship Council [201706940009]
The abnormal expression of the long noncoding RNA (lncRNA) HOX transcript intergenic antisense RNA (HOTAIR) plays an important role in the development of various cancers; however, single nucleotide polymorphisms (SNPs) in HOTAIR and their association with primary lung cancer susceptibility have not yet been reported. Here, we performed a case-control study including 262 primary lung cancer patients and 451 cancer-free control individuals to investigate the association between four haplotype-tagging SNPs (rs920778, rs12826786, rs4759314, and rs1899663) in the HOTAIR lncRNA and the risk of developing primary lung cancer. We found a significant association between the SNPs rs920778 and rs1899663 in the HOTAIR and primary lung cancer susceptibility (P < 0.05). Moreover, homozygous C/T (C/T + TT) for rs920778 (C > T) sites was significantly associated with gender, smoking history, and pathological type. In addition, linkage disequilibrium and haplotype analysis of HOTAIR gene polymorphisms for susceptibility to lung cancer revealed a high degree of linkage disequilibrium between the rs920778 and rs1899663 loci (D' = 0.86, r2 = 0.52). The population of rs920778, rs1899663, and rs4759314 had a significantly increased risk of lung cancer (P< 0.001). In summary, the present study provides persuasive evidence that SNP rs920778 is closely correlated with susceptibility to primary lung cancer. Future studies are warranted to validate and expand these findings, and to further dissect the importance of these SNPs in the development of primary lung cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据