Article
Environmental Sciences
Wenlan Yu, Xiaoyue Chang, Jianzhao Liao, Jinwen Quan, Siying Liu, Ting He, Gaolong Zhong, Jilei Huang, Zhonghua Liu, Zhaoxin Tang
Summary: Long-term ingestion of tribasic copper chloride may result in cognitive dysfunction and disrupt mitochondrial metabolism by inhibiting mitophagy.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Multidisciplinary
Bei-ni Wang, Cheng-biao Wu, Zi-miao Chen, Pei-pei Zheng, Ya-qian Liu, Jun Xiong, Jing-yu Xu, Pei-feng Li, Abdullah Al Mamun, Li-bing Ye, Zhi-long Zheng, Yan-qing Wu, Jian Xiao, Jian Wang
Summary: DL-3-n-Butylphthalide (DL-NBP), extracted from Chinese celery seeds, shows neuroprotective effects by improving cognitive decline associated with diabetes, including enhancing learning and memory function, reducing morphological changes, increasing neuronal survival, and restoring synaptic protein levels and dendritic density in the hippocampus. Additionally, DL-NBP decreases oxidative stress through Nrf2/HO-1 signaling and boosts brain-derived neurotrophic factor (BDNF) expression via PI3K/Akt/CREB signaling, suggesting its potential as a pharmacologic treatment for DACD.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Endocrinology & Metabolism
Huanxin Ding, Chuxuan Liu, Shuo Zhang, Bingjun Li, Qian Xu, Bowen Shi, Songhan Li, Shuohui Dong, Xiaomin Ma, Yun Zhang, Mingwei Zhong, Guangyong Zhang
Summary: The study found that sleeve gastrectomy can improve cognitive function in diabetic rats, which may be related to the activation of the PI3K signaling pathway, and has important clinical implications.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Naieli Schiefelbein Souto, Micheli Dassi, Ana Claudia Monteiro Braga, Erica Vanessa Furlan Rosa, Michele Rechia Fighera, Luiz Fernando Freire Royes, Mauro Schneider Oliveira, Marcel Henrique Marcondes Sari, Ana Flavia Furian
Summary: Several studies have demonstrated the toxicity of both aspartame (ASP) and aflatoxin B-1 (AFB(1)) separately, but little is known about their concomitant exposure and hazardous consequences. In this study, male rats were exposed to AFB(1), ASP, or both substances for 14 days. The results showed that the combination of ASP and AFB(1) had greater behavioral impairments and oxidative status imbalance compared to the groups treated with only ASP or AFB(1). These findings suggest that the co-exposure to ASP and AFB(1) disrupts brain homeostasis.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Endocrinology & Metabolism
Karis Little, Aditi Singh, Angel Del Marco, Maria Llorian-Salvador, Maria Vargas-Soria, Mireia Turch-Anguera, Montse Sole, Noelle Bakker, Sarah Scullion, Joan X. Comella, Ingeborg Klaassen, Rafael Simo, Monica Garcia-Alloza, Vijay K. Tiwari, Alan W. Stitt
Summary: Type 2 diabetes affects the cellular and molecular architecture of the cerebral cortex, leading to dysfunctions in the neurovascular unit and cognitive decline. This study identifies gene expression changes and cell population alterations in the cerebral cortex of diabetic mice and individuals with type 2 diabetes, providing insights into the pathogenesis of cognitive decline in diabetes.
Article
Nutrition & Dietetics
Maribel Huerta-Cervantes, Donovan J. Pena-Montes, Miguel Angel Lopez-Vazquez, Rocio Montoya-Perez, Christian Cortes-Rojo, Maria Esther Olvera-Cortes, Alfredo Saavedra-Molina
Summary: Gestational diabetes negatively impacts neurodevelopment in second-generation offspring, leading to alterations in metabolism, anxiety-like behavior, and spatial working memory. Male offspring show higher levels of anxiety-like behavior while female offspring exhibit lower levels, with deficiencies in short-term memory observed in adult females. Oxidative stress biomarkers in the cerebral cortex are altered in female offspring, along with metabolic disturbances in lipid and insulin levels in both male and female offspring.
Article
Pharmacology & Pharmacy
Azubuike P. Ebokaiwe, Odobi R. Ushang, Iyiagwor P. Chimezie, Nvene Chiamaka
Summary: This study investigated the protective effects of zinc (Zn) on the brain damage caused by cadmium (Cd) exposure in rats. The results showed that Zn reversed the increased activities of indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) induced by Cd exposure, as well as the disruption in antioxidant systems and the elevation in malondialdehyde (MDA) levels. In addition, Zn prevented the altered behavioral indices and brain histological changes caused by Cd exposure.
Article
Multidisciplinary Sciences
Lars Nyberg, Fredrik Magnussen, Anders Lundquist, William Baare, David Bartres-Faz, Lars Bertram, C. J. Boraxbekk, Andreas M. Brandmaier, Christian A. Drevon, Klaus Ebmeier, Paolo Ghisletta, Richard N. Henson, Carme Junque, Rogier Kievit, Maike Kleemeyer, Ethan Knights, Simone Kuhn, Ulman Lindenberger, Brenda W. J. H. Penninx, Sara Pudas, Oystein Sorensen, Lidia Vaque-Alcazar, Kristine B. Walhovd, Anders M. Fjell
Summary: Despite the modest association between education and cortical volume, higher education does not influence the rates of brain aging. The findings challenge the assumption that education slows down brain aging.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Kumari Vandana Singh, Chandra Prakash, Jay Prakash Nirala, Ranjan Kumar Nanda, Paulraj Rajamani
Summary: Mobile phones are commonly used devices for digital media and communication, but their radiofrequency electromagnetic radiation (RF-EMR) can have adverse effects on the brains of young adolescents. This study found that exposure to RF-EMR led to lipid peroxidation, DNA damage, and reduced neurogenesis and neuronal degeneration in the brain of rats.
Article
Medicine, Research & Experimental
Tao Wang, Yusheng Zhang, Weiwu Chen, Jin Tao, Qiao Xue, Wei Ge, Wanchen Dou, Chao Ma
Summary: This study utilized a high throughput quantitative proteomic approach to evaluate proteomic changes in the hippocampus and motor cortex in a rat model of cerebral palsy (CP) induced by lipopolysaccharide (LPS) combined with hypoxia/ischemia (H/I). The research revealed that neuroinflammatory responses in the brain induced by the CP model could be reversed by the topical application of Baimai ointment. Furthermore, the application of Baimai ointment not only alleviated motor deficits in CP model rats, but also restored the proteomes in the brain cortex.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yang Zhou, Monica K. Chawla, Jose L. Rios-Monterrosa, Lingzhi Wang, Marc A. Zempare, Victor J. Hruby, Carol A. Barnes, Minying Cai
Summary: The study found significant correlations between the expression of MCR subtypes in the frontal cortex/hypothalamus and hippocampus regions and the performance of spatial learning and memory in aged rats, supporting the hypothesis that aging has a direct impact on MCR expression and function.
Article
Pharmacology & Pharmacy
Hongli Li, Yejun Tan, Xin Cheng, Zheyu Zhang, Jianhua Huang, Shan Hui, Lemei Zhu, Yuqing Liu, Di Zhao, Zhao Liu, Weijun Peng
Summary: This study investigated the neuroprotective mechanisms of Bushen Tiansui Formula (BSTSF) against Alzheimer's disease (AD) by analyzing metabolite profiles in the hippocampus and cortex of AD rats. The results showed that BSTSF significantly improved memory deficits and typical histopathological changes in AD rats. Metabolomics analysis revealed that BSTSF treatment ameliorated metabolic disorders in the hippocampus and cerebral cortex, suggesting its neuroprotective effects against AD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Maud M. van Dinther, Astrid E. Hooghiemstra, Esther Bron, Adriaan E. Versteeg, Anna Leeuwis, Tugba E. Kalay, Justine Moonen, Sanne H. Kuipers, Walter Backes, Jacobus F. A. Jansen, Mathias J. P. van Osch, Geert-Jan Biessels, Julie J. Staals, Robert van Oostenbrugge, Heart-Brain Connection consortium
Summary: Impaired cerebral blood flow (CBF) at baseline is associated with faster cognitive decline in VCI and normal aging. Our results suggest that low CBF precedes and contributes to the development of vascular cognitive impairment. CBF determined by ASL might be used as a biomarker to monitor disease progression or treatment responses in VCI.
ALZHEIMERS & DEMENTIA
(2023)
Article
Agriculture, Dairy & Animal Science
Wei-Yu Yeh, Yi-Ling Lin, Wen-Yuan Yang, Chung-Hsi Chou, Yi-Hsieng Samuel Wu, Yi-Chen Chen
Summary: This study highlights the potential benefits of chicken-liver hydrolysate (CLH) in improving glucose homeostasis and cognitive decline in diabetic mice. CLH supplementation lowered blood glucose levels, enhanced antioxidant capacities, improved memory and cognitive behavior, and reduced neuron damage and deposition caused by diabetes. These findings suggest that CLH could have therapeutic potential for insulin resistance and cognitive decline in hyperglycemia.
Article
Endocrinology & Metabolism
Laura M. McNair, Graeme F. Mason, Golam M. Chowdhury, Lihong Jiang, Xiaoxian Ma, Douglas L. Rothman, Helle S. Waagepetersen, Kevin L. Behar
Summary: Anaplerosis, mediated by pyruvate carboxylase (PC) in astroglia, varies across different brain regions. The rate of PC contributes to oxidative glucose consumption and is positively correlated with glutamate/glutamine cycling.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Nutrition & Dietetics
Zhibin Wang, Wei Zhu, Yi Xing, Jianping Jia, Yi Tang
Summary: This meta-analysis suggests that B vitamin supplementation is associated with slowing of cognitive decline, especially in populations who received early intervention and intervention of long duration; the study also indicates that higher intake of dietary folate, but not B12 or B6, is associated with a reduced risk of incident dementia in non-dementia aged population.
Article
Clinical Neurology
Changming Wang, Zhibin Wang, Beijia Xie, Xinrui Shi, Pengcheng Yang, Lei Liu, Tianshu Qu, Qi Qin, Yi Xing, Wei Zhu, Stefan J. Teipel, Jianping Jia, Guoguang Zhao, Liang Li, Yi Tang
Summary: The study found impairments in binaural processing in Alzheimer's disease and amnestic mild cognitive impairment, with a U-shaped curve change in phase synchrony. The increase in phase synchrony accompanying more severe cognitive stages may reflect neural adaptation for binaural processing, while also being associated with worse memory performance.
ALZHEIMERS & DEMENTIA
(2022)
Article
Biochemistry & Molecular Biology
Haishan Jiao, Jianping Jia
Summary: Ginsenoside Compound K exhibits anti-inflammatory and neuroprotective effects in vitro by inhibiting microglia inflammation possibly through the NF-kappa B pathway via LRP1 activation. Further evaluation of Ginsenoside Compound K as a potential effective modulator for Alzheimer's disease is warranted.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Yang Song, Meina Quan, Tingting Li, Jianping Jia
Summary: This study investigates the changes of homocysteine, vitamin B12, and folate levels in different subtypes of dementia and their associations with cognitive function and MRI markers. The results show that elevated homocysteine levels and lower vitamin B12 levels are associated with various types of dementia. Homocysteine levels are correlated with temporal lobe atrophy in Alzheimer's disease, while vitamin B12 levels are associated with general cognition in vascular dementia. Hyperhomocysteinemia may increase the risk of Alzheimer's disease, vascular dementia, and frontotemporal dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Jingwen Yu, Xiyue Yu, Caihong Li, Muhammad Ayaz, Sulaiman Abdulsalam, Deliang Peng, Rende Qi, Huan Peng, Lingan Kong, Jianping Jia, Wenkun Huang
Summary: Silicon and its compounds have been found to enhance plant resistance against various phytopathogens. The application of silicon has been shown to regulate different defense mechanisms and reduce the severity of nematode infestation. Understanding the role of silicon in plant-nematode interactions is important for effective management of plant-nematode diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Jianping Jia, Yue Zhang, Yuqing Shi, Xuping Yin, Shiyuan Wang, Yan Li, Tan Zhao, Wenying Liu, Aihong Zhou, Longfei Jia
Summary: In this report, a case of a 19-year-old male with gradual memory decline for 2 years and characteristic neuroimaging and biomarker findings for Alzheimer's disease (AD) is presented. Despite the young age of the patient, the clinical presentation and diagnostic tests confirmed a probable diagnosis of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Editorial Material
Medicine, General & Internal
Jianping Jia, Yuye Ning, Meilin Chen, Shuheng Wang, Yan Li, Hao Yang
Article
Medicine, General & Internal
Jianping Jia, Tan Zhao, Zhaojun Liu, Yumei Liang, Fangyu Li, Yan Li, Wenying Liu, Fang Li, Shengliang Shi, Chunkui Zhou, Heyun Yang, Zhengluan Liao, Yang Li, Huiying Zhao, Jintao Zhang, Kunnan Zhang, Minchen Kan, Shanshan Yang, Hao Li, Zhongling Liu, Rong Ma, Jihui Lv, Yue Wang, Xin Yan, Furu Liang, Xiaoling Yuan, Jinbiao Zhang, Serge Gauthier, Jeffrey Cummings
Summary: This study aimed to identify an optimal lifestyle profile for protecting older individuals from memory loss. The findings revealed that a healthy lifestyle is associated with slower memory decline, even in the presence of the APOE epsilon 4 allele. This study offers important information to protect older adults against memory decline.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Qi Qin, Junda Qu, Yunsi Yin, Ying Liang, Yan Wang, Bingxin Xie, Qingqing Liu, Xuan Wang, Xinyi Xia, Meng Wang, Xu Zhang, Jianping Jia, Yi Xing, Chunlin Li, Yi Tang
Summary: An unsupervised machine learning model was developed to predict the risk of progression from subcortical ischemic vascular disease (SIVD) to subcortical vascular cognitive impairment (SVCI). The model achieved high accuracy, sensitivity, and specificity and can be applied to other cohorts and clinical practice.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Ling-Zhi Xu, Bing-Qiu Li, Fang-Yu Li, Mei-Na Quan, Wei Qin, Ying Li, Wen-Wen Li, Yu Zhao, Yi-Ping Wei, Jian-Ping Jia
Summary: This study investigated the relationship between plasma Wnt2b levels and Alzheimer's disease (AD) and found that Wnt2b decline is associated with cognitive impairment in AD. Upregulation of Wnt2b can effectively prevent downregulation of canonical Wnt signaling, mitochondrial dysfunction, intracellular calcium overload, and neuronal damage in AD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Yue Zhang, Jianping Jia
Summary: In this study, betaine was found to inhibit AβO-induced neuroinflammation in microglia by suppressing the activation of the NLRP3 inflammasome and NF-κB, suggesting its potential as an effective modulator for AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Meina Quan, Qi Wang, Wei Qin, Wei Wang, Fangyu Li, Tan Zhao, Tingting Li, Qiongqiong Qiu, Shuman Cao, Shiyuan Wang, Yan Wang, Hongmei Jin, Aihong Zhou, Jiliang Fang, Longfei Jia, Jianping Jia
Summary: This study investigated the effects of APOE epsilon 4 and known pathogenic gene mutation on cognitive domains and circuit imaging markers in preclinical familial Alzheimer's disease (FAD). Neuropsychological tests and MRI scanning were conducted on 139 asymptomatic subjects, revealing changes in hippocampal volume, functional connectivity, and diffusion indices in the genetic groups compared to controls. These findings contribute to the early identification and development of preventive strategies for Alzheimer's disease.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Oncology
Yan Wang, Ying Li, Yan Li, Tingting Li, Qi Wang, Qigeng Wang, Shuman Cao, Fangyu Li, Jianping Jia
Summary: This study selected four potential biomarkers and measured their plasma levels in patients with Alzheimer's disease and amnestic mild cognitive impairment, developing a composite panel for screening and diagnosing these two conditions.
BIOMARKER RESEARCH
(2023)
Article
Medicine, General & Internal
Wenwen Li, Yana Pang, Yan Wang, Fan Mei, Mengmeng Guo, Yiping Wei, Xinyue Li, Wei Qin, Wei Wang, Longfei Jia, Jianping Jia
Summary: This study identified a novel Chinese familial Alzheimer's disease (FAD) causal gene mutation, ZDHHC21 p.T209S, which leads to aberrant protein palmitoylation and contributes to the pathogenesis of AD. These findings provide new insights for further investigation and development of therapeutic interventions.
Review
Health Care Sciences & Services
Meina Quan, Xuechu Wang, Min Gong, Qi Wang, Yan Li, Jianping Jia
Summary: PCCD is a condition in which patients with a history of SARS-CoV-2 infection develop cognitive impairment in various domains. Understanding the risk factors and management strategies of PCCD is important for disease management. This paper reviews epidemiology, diagnostic markers, risk factors, and available treatments for PCCD.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)