NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses

(2015) Bipasha Mukherjee et al.   NEOPLASIA

The Brain Microenvironment Preferentially Enhances the Radioresistance of CD133+ Glioblastoma Stem-like Cells

(2015) Muhammad Jamal et al.   NEOPLASIA

Autophagy in tumorigenesis and cancer therapy: Dr. Jekyll or Mr. Hyde?

(2012) Shengtao Zhou et al.   CANCER LETTERS

Cordyceps militarisGrown on Germinated Soybean Induces G2/M Cell Cycle Arrest through Downregulation of Cyclin B1 and Cdc25c in Human Colon Cancer HT-29 Cells

(2012) Mohammad Lalmoddin Mollah et al.   Evidence-based Complementary and Alternative Medicine

NVP-BEZ235 alone and in combination in mantle cell lymphoma: an effective therapeutic strategy

(2012) Monica Civallero et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

mTOR Signaling Pathway and mTOR Inhibitors in Cancer Therapy

(2012) Alejandro Gomez-Pinillos et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Can irradiation of potential cancer stem-cell niche in the subventricular zone influence survival in patients with newly diagnosed glioblastoma?

(2012) Tejpal Gupta et al.   JOURNAL OF NEURO-ONCOLOGY

The mTOR Pathway in Lung Cancer and Implications for Therapy and Biomarker Analysis

(2012) Simon Ekman et al.   Journal of Thoracic Oncology

Curcumin induces permanent growth arrest of human colon cancer cells: Link between senescence and autophagy

(2012) Grazyna Mosieniak et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Combination of Rad001 (Everolimus) and Propachlor Synergistically Induces Apoptosis through Enhanced Autophagy in Prostate Cancer Cells

(2012) Sheng Tai et al.   MOLECULAR CANCER THERAPEUTICS

The potential value of the neutral comet assay and the expression of genes associated with DNA damage in assessing the radiosensitivity of tumor cells

(2012) Sundarraj Jayakumar et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Autophagy and Apoptosis Act as Partners to Induce Germ Cell Death after Heat Stress in Mice

(2012) Mianqiu Zhang et al.   PLoS One

Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function

(2012) N. Jaber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity

(2012) Emmanouil Fokas et al.   Radiation Oncology

Knockdown of Checkpoint Kinase 1 Is Associated with the Increased Radiosensitivity of Glioblastoma Stem-Like Cells

(2012) Jun Wu et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature

(2011) E. Fokas et al.   CANCER RESEARCH

NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor

(2011) Tsutomu Mori et al.   CELL CYCLE

Induction of autophagy promotes differentiation of glioma-initiating cells and their radiosensitivity

(2011) Wenzhuo Zhuang et al.   INTERNATIONAL JOURNAL OF CANCER

Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer

(2011) Aymen A Elfiky et al.   Journal of Translational Medicine

GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway

(2011) J. J. Wallin et al.   MOLECULAR CANCER THERAPEUTICS

Induction of autophagy in temozolomide treated malignant gliomas

(2011) Manabu Natsumeda et al.   NEUROPATHOLOGY

Berberine Radiosensitizes Human Esophageal Cancer Cells by Downregulating Homologous Recombination Repair Protein RAD51

(2011) Qiao Liu et al.   PLoS One

The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Induces Tumor Regression in a Genetically Engineered Mouse Model of PIK3CA Wild-Type Colorectal Cancer

(2011) Jatin Roper et al.   PLoS One

A Mechanism for Synergy with Combined mTOR and PI3 Kinase Inhibitors

(2011) Shujie Yang et al.   PLoS One

Epstein-Barr Virus Nuclear Antigen 3C Facilitates G1-S Transition by Stabilizing and Enhancing the Function of Cyclin D1

(2011) Abhik Saha et al.   PLoS Pathogens

Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy

(2010) Wenzhuo Zhuang et al.   BRAIN RESEARCH

Activity of the Novel Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 against T-Cell Acute Lymphoblastic Leukemia

(2010) F. Chiarini et al.   CANCER RESEARCH

Dual Inhibition of PI3K and mTORC1/2 Signaling by NVP-BEZ235 as a New Therapeutic Strategy for Acute Myeloid Leukemia

(2010) N. Chapuis et al.   CLINICAL CANCER RESEARCH

Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells

(2010) Jun Sunayama et al.   NEURO-ONCOLOGY

Crosstalk Between the PI3K/mTOR and MEK/ERK Pathways Involved in the Maintenance of Self-Renewal and Tumorigenicity of Glioblastoma Stem-Like Cells

(2010) Jun Sunayama et al.   STEM CELLS

The role of autophagy in sensitizing malignant glioma cells to radiation therapy

(2009) W. Zhuang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Blockade Is an Effective Radiosensitizing Strategy for the Treatment of Non-Small Cell Lung Cancer Harboring K-RAS Mutations

(2009) G. Konstantinidou et al.   CANCER RESEARCH

Combined Bcl-2/Mammalian Target of Rapamycin Inhibition Leads to Enhanced Radiosensitization via Induction of Apoptosis and Autophagy in Non-Small Cell Lung Tumor Xenograft Model

(2009) K. W. Kim et al.   CLINICAL CANCER RESEARCH

MDM2 Controls the Timely Expression of Cyclin A to Regulate the Cell Cycle

(2009) R. Frum et al.   MOLECULAR CANCER RESEARCH

NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

(2009) T.-J. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor, and both can be maintained long-term in vitro

(2008) Qiang Huang et al.   BMC CANCER

Class I PI3 Kinase Inhibition by the Pyridinylfuranopyrimidine Inhibitor PI-103 Enhances Tumor Radiosensitivity

(2008) R. Prevo et al.   CANCER RESEARCH

NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations

(2008) V. Serra et al.   CANCER RESEARCH