Article
Chemistry, Multidisciplinary
Xiao-yang Chen, Fei Qian, Yao-yao Wang, Yan Liu, Yuan Sun, Wei-bin Zha, Kun Hao, Fang Zhou, Guang-ji Wang, Jing-wei Zhang
Summary: The study demonstrated that 20(S)-Rh2 enhances the therapeutic effect of levofloxacin against Staphylococcus aureus by increasing drug accumulation within cells, inhibiting efflux transporters, and stabilizing the drug-target complex in lysosome-like acidic conditions.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Pharmacology & Pharmacy
Hong-can Ren, Jian-guo Sun, A. Ji-ye, Sheng-hua Gu, Jian Shi, Feng Shao, Hua Ai, Jing-wei Zhang, Ying Peng, Bei Yan, Qing Huang, Lin-sheng Liu, Yang Sai, Guang-ji Wang, Cheng-guang Yang
Summary: This study aimed to investigate the pharmacokinetics of the deglycosylation metabolite PPD following Rh2 administration and develop a mechanism-based pharmacokinetic model. Results showed that a certain percentage of Rh2 was transformed into PPD and entered systemic circulation, highlighting the importance of studying deglycosylation kinetics for future pharmacokinetic studies of similar drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Donna S. Cox, Muhammad Rehman, Tahira Khan, Katherine Ginman, Joanne Salageanu, Robert R. LaBadie, Katty Wan, Bharat Damle
Summary: This study aimed to evaluate the pharmacokinetics (PK) and safety of coadministration of nirmatrelvir/ritonavir or ritonavir alone with midazolam and dabigatran, two commonly used drugs. The results showed that coadministration with nirmatrelvir /ritonavir or ritonavir alone significantly increased the exposure of midazolam and dabigatran. However, the exposure of midazolam was comparable between nirmatrelvir/ritonavir and ritonavir alone, suggesting that nirmatrelvir had no additional effect. The slightly higher dabigatran exposure when coadministered with nirmatrelvir/ritonavir compared to ritonavir alone indicated a minor incremental effect of nirmatrelvir.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lei He, Donglin Feng, Hui Guo, Yueyuan Zhou, Zhaozhao Li, Kuo Zhang, Wangqian Zhang, Shuning Wang, Zhaowei Wang, Qiang Hao, Cun Zhang, Yuan Gao, Jintao Gu, Yingqi Zhang, Weina Li, Meng Li
Summary: This study provides the first analysis of the pharmacokinetics of BPC157, showing linear pharmacokinetic characteristics in rats and beagle dogs. The main excretory pathways of BPC157 were found to be urine and bile. These findings are important for the clinical translation of BPC157.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Yue Li, Teng Wang, Hao-Hao Shi, Yu-Ming Wang, Chang-Hu Xue, Qing-Rong Huang, Tian-Tian Zhang
Summary: Sea cucumber-derived sulfated sterols showed more significant bioactivities due to the unique structure of the sulfate group, but their absorption, pharmacokinetics, and tissue distribution remain unknown. This study investigated the absorption characteristics, pharmacokinetics, and tissue distribution of sea cucumber sterols, finding that they are absorbed quickly and mainly accumulate in the liver. These results provide insights for the development of functional foods and nutraceuticals containing sea cucumber sterols.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Xinze Liu, Xin Jin, Xinmin Wu, Lin Feng, Hongmei Yang, KaiJing Sun, Xue Yang, Ruina Lv, Yuhe Ren, Mengle Xie, Jianhua Lv, Lan Yao, Daiyao Liu, Wei Wu, Shuying Liu, Changbao Chen, Xilin Wan
Summary: This study investigated the effects of different configurations of ginsenoside Rh2 on non-small cell lung cancer cells. It was found that ginsenoside Rh2 can inhibit cell proliferation and colony formation, induce cell cycle arrest, and promote apoptosis. The 20(R)-configuration of ginsenoside Rh2 exhibited a stronger effect.
PHARMACOGNOSY MAGAZINE
(2022)
Review
Biochemistry & Molecular Biology
Olga I. Butranova, Elena A. Ushkalova, Sergey K. Zyryanov, Mikhail S. Chenkurov, Elena A. Baybulatova
Summary: Infections pose significant risks for elderly patients, with high consumption of antimicrobial agents leading to increased toxicity, organ deterioration, longer hospital stays, ICU admissions, disability, and even death. The efficacy and safety of antibiotics in the elderly are influenced by age-related changes in physiological and pathological factors, affecting drug absorption, distribution, metabolism, and excretion. Pharmacokinetic changes in elderly patients are also influenced by factors like body composition, nutritional status, and concomitant drug use. Understanding these age-related pharmacokinetic alterations is crucial for optimizing antibiotic therapy in the elderly.
Article
Food Science & Technology
Shanoo Suroowan, Hassan Hadi Abdallah, Mohamad Fawzi Mahomoodally
Summary: Herbal and conventional medicine combination can be potentially dangerous, leading to perilous herb-drug interactions and toxicity. Different plant species have different pharmacological properties, and should not be mixed with drugs having the same properties. Herbal medicines should be used at low doses for a short period of time and under the supervision of healthcare professionals to avoid potential adverse and toxic effects.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Oncology
Wenmo Liu, Siqi Wang, Qinchuan Yang, Xinyao Feng, Bin Yu, Xianghui Yu
Summary: 20(s)-ginsenoside Rh2 sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis, enhancing its anti-tumor effect.
Article
Medicine, Research & Experimental
Tianxiang Yu, Jiachen Xu, Qinyan Wang, Xue Han, Yu Tu, Yi Wang, Wu Luo, Mengyang Wang, Guang Liang
Summary: This study found that 20(S)-Rh2 alleviates cardiac damage induced by Ang-II through inhibition of the JNK/AP-1 pathway, reducing myocardial fibrosis, hypertrophy, and inflammation. These findings provide evidence for the use of 20(S)-Rh2 as an effective regimen for HHF.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Srinivas Reddy Jitta, Salwa, Navya Ajitkumar Bhaskaran, Shirleen Miriam Marques, Lalit Kumar
Summary: This article reviews the adverse effects of Ritonavir and recent approaches in the development of nanoformulations. It also discusses the patents filed on Ritonavir. While most research focuses on enhancing the solubility and oral bioavailability of the drug, researchers should also consider toxicity evaluation during formulation development.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Oncology
Shunji Takahashi, Masato Karayama, Masato Takahashi, Junichiro Watanabe, Hironobu Minami, Noboru Yamamoto, Ichiro Kinoshita, Chia-Chi Lin, Young-Hyuck Im, Issei Achiwa, Emi Kamiyama, Yasuyuki Okuda, Caleb Lee, Yung-Jue Bang
Summary: In this study, it was found that the combination of trastuzumab deruxtecan with ritonavir or itraconazole did not have a significant impact on the pharmacokinetics of the drug, with good safety profile and promising antitumor activity demonstrated.
CLINICAL CANCER RESEARCH
(2021)
Article
Plant Sciences
Haibo Zhang, Jun-Koo Yi, Hai Huang, Sijun Park, Wookbong Kwon, Eungyung Kim, Soyoung Jang, Si-Yong Kim, Seong-kyoon Choi, Duhak Yoon, Sung-Hyun Kim, Kangdong Liu, Zigang Dong, Zae Young Ryoo, Myoung Ok Kim
Summary: In this study, the researchers demonstrated the anticancer effect of G-Rh2 in colorectal cancer (CRC) cells by suppressing the Axl signaling pathway. G-Rh2 showed potential as a candidate for the prevention and treatment of CRC.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shuai Bian, Meichen Liu, Song Yang, Shuyan Lu, Siming Wang, Xueyuan Bai, Daqing Zhao, Jiawen Wang
Summary: 20(S)-GRh2 inhibits proliferation and induces apoptosis in HeLa cells by activating intrinsic apoptotic pathway and causing mitochondrial dysfunction, while enhancing autophagy by promoting AMPK phosphorylation and suppressing mTOR activity. The use of autophagy inhibitors enhances 20(S)-GRh2-induced apoptosis, while autophagy inducers promote cell survival. Additionally, the protective autophagy induced by 20(S)-GRh2 inhibits the AMPK/mTOR pathway, promoting apoptosis in cervical cancer cells.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Olga I. Butranova, Elena A. Ushkalova, Sergey K. Zyryanov, Mikhail S. Chenkurov
Summary: Neonatal infections, particularly neonatal sepsis, contribute significantly to mortality rates and require empiric antibiotic therapy. However, the rise of antibacterial resistance has led to the use of antibiotics from higher-risk groups associated with less clinical experience. Choosing the proper dosing regimen is complicated in neonates due to the high variability in the maturation of organ systems. The developmental changes of pharmacokinetic parameters in preterm and full-term infants should be considered in neonatal intensive care units.
Article
Pharmacology & Pharmacy
Yicong Bian, Jian Meng, Sheng Ma, Guangze Li, Yuya Wang, Shaorong Li, Linsheng Liu, Chenrong Huang, Hua Zhang, Dafang Zhong, Liyan Miao
Summary: This trial investigated the metabolite profiles, mass balance and pharmacokinetics of fuzuloparib, a novel poly (ADP-ribose) polymerase inhibitor, in subjects with advanced solid cancers. The results showed that fuzuloparib was widely metabolized and excreted completely through urine and faeces in patients.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jian Shi, Jingcheng Xiao, Xinwen Wang, Sun Min Jung, Barry E. Bleske, John S. Markowitz, Kennerly S. Patrick, Hao-Jie Zhu
Summary: This study quantified the relationship between plasma CES1 protein concentrations and d-methylphenidate pharmacokinetics, revealing a significant negative correlation and suggesting that CES1 protein could explain approximately 50% of the variability in AUCs. Physiologically-based pharmacokinetic modeling simulations indicated that an individualized dosing strategy based on CES1 may reduce d-methylphenidate exposure variability in pediatric patients. This proof-of-concept study demonstrates that a hepatic DME's plasma protein could serve as a biomarker for predicting its metabolic function and the pharmacokinetics of its substrate drugs.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Joseph M. Collins, Rong Lu, Xinwen Wang, Hao-Jie Zhu, Danxin Wang
Summary: This study identified NR1H3 as a key factor regulating the expression of CES1 and demonstrated that its effect is splice isoform-specific and ligand independent.
DRUG METABOLISM AND DISPOSITION
(2022)
Article
Biochemical Research Methods
Wenhao Qu, Xianglian Li, Guidi Tian, Linsheng Liu, Liyan Miao
Summary: In this study, a sensitive rapid assay for the simultaneous detection of warfarin enantiomers in mouse dried blood spot samples was developed and validated. The method showed high precision and reliability, and the samples remained stable at room temperature.
ANALYTICAL BIOCHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Ting Ma, Anqi Li, Yueyang Guo, Shaotong Li, Meng Li, Siqi Feng, Hongmin Liu
Summary: Epigenetics plays a critical role in autophagy, and LSD1, as an important epigenetic enzyme, directly regulates the expression of autophagy-related genes and activates autophagy through regulating the activities of other proteins. Dysregulation of autophagy is closely related to the occurrence of various diseases, and development of LSD1 inhibitors provides a new direction for their treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Analytical
Shenjia Huang, Linsheng Liu, Xiaoxue Liu, Lin Song, Chenrong Huang, Liyan Miao
Summary: In this study, a sensitive and rapid UHPLC-MS/MS method was developed for the simultaneous analysis of several compounds in the cytosol and nucleus. The method showed reliable linearity and accuracy and was applied in HL-60 cells.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Review
Medicine, Research & Experimental
Jiapeng Li, Yanling Xue, Xinwen Wang, Logan S. Smith, Bing He, Shuhan Liu, Hao-Jie Zhu
Summary: This study investigates the roles of human host proteins in the lifecycle of SARS-CoV-2 and their potential as therapeutic targets for COVID-19 treatment. The researchers summarize the tissue-specific expressions of selected host proteins and their impact on viral infection and drug therapy based on proteomics data. The findings provide valuable insights for the development of safe and effective therapeutics for COVID-19.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Gui-Min Xue, Chen-Guang Zhao, Jin-Feng Xue, Kun Du, Jiang-Jing Duan, Hao Pan, Meng Li, Hui Chen, Yan-Jun Sun, Wei-Sheng Feng, Ting Ma, Wen -Da Zhang
Summary: Chemical investigation of Achillea alpina L. led to the isolation of twenty sesquiterpenoids. Among them, achigermalide D not only significantly enhanced glucose consumption but also regulated insulin resistance by suppressing the NLRP3 inflammasome pathway.
Article
Nutrition & Dietetics
Yue Sun, Chenjie Ling, Linsheng Liu, Jianwei Zhang, Jian Wang, Xing Tong, Khemayanto Hidayat, Mengting Chen, Xiaofang Chen, Hui Zhou, Jiaying Xu, Liqiang Qin, Wanzhan Zhu, Jing Yang
Summary: Research shows that combining WP or WPH with an energy-restricted diet can help older women with weight loss, with WPH being more effective in reducing body weight, BMI, and body fat percentage, possibly due to its impact on the tricarboxylic acid cycle pathway.
Article
Acoustics
Thomas P. Brutnell, Xinwen Wang, Jianxin Bao
Summary: This study summarizes previous animal studies and proposes subtyping of noise-induced hearing loss (NIHL) as a promising strategy to improve the accuracy of audiological assessments. By combining this enhanced phenotyping capability with genetic association studies, drug efficacy can be better predicted, increasing the likelihood of success in clinical trials.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Article
Biochemical Research Methods
Lucy Her, Jian Shi, Xinwen Wang, Bing He, Logan S. S. Smith, Hui Jiang, Hao-Jie Zhu
Summary: This study utilized a recently developed allele-specific protein expression (ASPE) assay to identify cis-acting regulatory variants of the CES1 gene. It found two significant associations between regulatory variants and CES1 protein expression and activity. ASPE demonstrated improved statistical power compared to conventional gene expression-based approaches.
Article
Gastroenterology & Hepatology
Jessica M. Ferrell, Matthew Dilts, Zachary Stahl, Shannon Boehme, Sabita Pokhrel, Xinwen Wang, John Y. L. Chiang
Summary: This study investigated the role of bile acid signaling through Tgr5 in regulating metabolism during the progression from fatty liver to nonalcoholic steatohepatitis and fibrosis using a high fat, high fructose, and high sucrose (HFS) diet in mice. The results showed that Tgr5 knockout mice exhibited increased glucose intolerance on the HFS diet, despite gaining the same amount of weight as wild type mice. These mice also accumulated more hepatic cholesterol and triglycerides and showed upregulation of lipogenic genes. The expression of genes involved in fatty acid and cholesterol metabolism pathways was altered in Tgr5 knockout mice, with elevated expression of cholesterol 7alpha-hydroxylase (Cyp7a1) gene. Surprisingly, hepatic inflammation and fibrosis were reduced in Tgr5 knockout mice fed the HFS diet, possibly due to altered serotonin signaling in the liver.
Article
Chemistry, Multidisciplinary
Logan S. Smith, Xinwen Wang, Jian Shi, Bing He, Hao-Jie Zhu
Summary: This study conducted a genome-wide association study (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with altered TPMT protein expression in human livers. The study found 31 SNPs that were associated with differential expression of TPMT protein. Additionally, the study showed that European ancestry was associated with significantly higher hepatic TPMT protein expression than African ancestry.
PHARMACEUTICAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Varsha Bhatt-Mehta, Xinyue Jing, Xinwen Wang, Hao-Jie Zhu
Summary: The study aims to evaluate whether maternal and umbilical cord plasma concentrations of methadone and its metabolite, EDDP, could predict the need for NOWS treatment. The results suggest that the maternal-to-cord methadone plasma concentration ratio could be a potential biomarker for predicting the need for NOWS treatment.
Article
Gastroenterology & Hepatology
Bandar D. Alrehaili, Mikang Lee, Shogo Takahashi, Robert Novak, Bipin Rimal, Shannon Boehme, Samuel A. J. Trammell, Trisha J. Grevengoed, Devendra Kumar, Yazen Alnouti, Katya Chiti, Xinwen Wang, Andrew D. Patterson, John Y. L. Chiang, Frank J. Gonzalez, Yoon-Kwang Lee
Summary: This study investigated the physiological function of BAAT in bile acid and lipid metabolism using Baat(-/-) mice. The results showed that BAAT deletion affected bile acid synthesis and metabolism, altered energy metabolism and microbiome structure in mice. Furthermore, when fed a westernized diet, Baat(-/-) mice showed compromised weight gain and impaired insulin secretion.
HEPATOLOGY COMMUNICATIONS
(2022)