Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets

Gpr126 is essential for peripheral nerve development and myelination in mammals

(2011) K. R. Monk et al.   DEVELOPMENT

G Protein-coupled Receptor Signaling via Src Kinase Induces Endogenous Human Transient Receptor Potential Vanilloid Type 6 (TRPV6) Channel Activation

(2011) Jennifer Spehr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trends in the exploitation of novel drug targets

(2011) Mathias Rask-Andersen et al.   NATURE REVIEWS DRUG DISCOVERY

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor

(2011) K. D. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Three-Gene panel on urine increases PSA specificity in the detection of prostate cancer

(2011) Marina Rigau et al.   PROSTATE

Deorphanization of Novel Peptides and Their Receptors

(2010) Akihiko Ozawa et al.   AAPS Journal

GPR56 Plays varying roles in endogenous cancer progression

(2010) Lei Xu et al.   CLINICAL & EXPERIMENTAL METASTASIS

Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis

(2010) Shu Feng et al.   ENDOCRINE-RELATED CANCER

Membrane receptors: Structure and function of the relaxin family peptide receptors

(2010) Roy C.K. Kong et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

G protein-coupled receptors: novel targets for drug discovery in cancer

(2010) Rosamaria Lappano et al.   NATURE REVIEWS DRUG DISCOVERY

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

(2010) H. J. Snippert et al.   SCIENCE

Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124

(2010) F. Kuhnert et al.   SCIENCE

Regulation of bone formation and remodeling by G-protein-coupled receptor 48

(2009) J. Luo et al.   DEVELOPMENT

Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice

(2009) Ryo Yamashita et al.   DEVELOPMENTAL DYNAMICS

Activation of an Olfactory Receptor Inhibits Proliferation of Prostate Cancer Cells

(2009) Eva M. Neuhaus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse

(2009) Aurélia Ravni et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Olfactory receptors: G protein-coupled receptors and beyond

(2009) Marc Spehr et al.   JOURNAL OF NEUROCHEMISTRY

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

A G Protein-Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination

(2009) K. R. Monk et al.   SCIENCE

G-Protein-Coupled Receptor GPR49 is Up-regulated in Basal Cell Carcinoma and Promotes Cell Proliferation and Tumor Formation

(2008) Keiji Tanese et al.   AMERICAN JOURNAL OF PATHOLOGY

New Strategies in Drug Discovery for GPCRs: High Throughput Detection of Cellular ERK Phosphorylation

(2008) Michael Crouch et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation

(2008) F. Carreira-Barbosa et al.   DEVELOPMENT

The atypical cadherin Flamingo is required for sensory axon advance beyond intermediate target cells

(2008) Martin C. Steinel et al.   DEVELOPMENTAL BIOLOGY

Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4

(2008) Yasuaki Mohri et al.   DEVELOPMENTAL DYNAMICS

Orphan G Protein-coupled Receptor GPR56 Regulates Neural Progenitor Cell Migration via a Gα12/13 and Rho Pathway

(2008) Tokuichi Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lgr5 marks cycling, yet long-lived, hair follicle stem cells

(2008) Viljar Jaks et al.   NATURE GENETICS

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

The Cadherin Flamingo Mediates Level-Dependent Interactions that Guide Photoreceptor Target Choice in Drosophila

(2008) Pei-Ling Chen et al.   NEURON

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2

(2008) J. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orphan GPCR research

(2007) S Chung et al.   BRITISH JOURNAL OF PHARMACOLOGY