Article
Chemistry, Multidisciplinary
Jin-yi Liu, Wei-qi Fu, Xiang-jin Zheng, Wan Li, Li-wen Ren, Jin-hua Wang, Cui Yang, Guan-hua Du
Summary: Avasimibe demonstrated potent anticancer effects on human glioblastoma cells by inhibiting proliferation, inducing apoptosis, and regulating multiple signaling pathways. The drug showed promising potential as a chemotherapy treatment for glioblastoma.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Mohamed Y. Zaky, Rehab Mahmoud, Ahmed A. Farghali, Hany Abd El-Raheem, Ahmed Hassaballa, Mohamed Mohany, Dalal Hussien M. Alkhalifah, Wael N. Hozzein, Abdelrahman Mohamed
Summary: This study successfully synthesized and characterized a novel Cu/Fe layer double hydroxide (LDH) nanocomposite for the treatment of prostate cancer. The results demonstrated that Cu/Fe LDH had significant anticancer activities against prostate cancer cells, reducing cell viability, inhibiting cell migration, inducing cell cycle arrest, and triggering apoptosis. It also showed good safety impact on normal cells.
Article
Biochemistry & Molecular Biology
Feng-Lung Tsai, Han-Li Huang, Mei-Jung Lai, Jing-Ping Liou, Shiow-Lin Pan, Chia-Ron Yang
Summary: The study found that MPT0G236, a pan-HDAC inhibitor, specifically targets malignant tumor cells and exhibits significant anticancer activity in human colorectal cancer cells, making it a potential candidate for colorectal cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Dahye Yun, So Young Yoon, Soo Jung Park, Yoon Jung Park
Summary: Herbal plants enriched with isoquinoline alkaloids have been used in traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. These alkaloids induce cell death through cell cycle arrest, apoptosis, and autophagy. The molecular mechanisms of these effects may involve binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Tahereh Tajik, Kaveh Baghaei, Vahid Erfani Moghadam, Naser Farrokhi, Seyed Alireza Salami
Summary: Plant-derived extracellular vesicles (EVs) have gained attention in recent years due to their proven therapeutic properties. In this study, EVs were isolated from two different chemotypes of cannabis and classified as high-CBD and low-CBD EVs. These EVs exhibited different cytotoxicity and anticancer effects. The findings suggest that CDEVs could be an ideal natural vehicle for delivering bioactive phytocannabinoids and a promising strategy in cancer management.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Wei Cai, Jieyi Li, Cheng Chen, Jiajia Wu, Jiabin Li, Xiaowen Xue
Summary: The study synthesized a series of 1,2-didehydro-3-ox-andrographolide derivatives based on two Michael acceptors, with compound 10b showing the most significant inhibitory activities against HCT116 and MCF-7 cells. Mechanistic investigation indicated that compound 10b inhibited HCT116 cell proliferation by inducing apoptosis and arresting cell cycle progression in a concentration-dependent manner.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xing Huang, Chang-Hao Zhang, Hao Deng, Dan Wu, Hong-Yan Guo, Jung Joon Lee, Fen-Er Chen, Qing-Kun Shen, Li-Li Jin, Zhe-Shan Quan
Summary: A series of quillaic acid derivatives with different substituents were synthesized and evaluated for their antitumor activity against human cancer cell lines. One compound showed strong antiproliferative activity and induced apoptosis and cell cycle arrest by modulating signaling pathways.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Shade' A. Ahmed, Patricia Mendonca, Samia S. Messeha, Karam F. A. Soliman
Summary: This study demonstrates that fucoxanthin has anticancer effects in triple-negative breast cancer cells, with a stronger effect in MDA-MB-231 cells. Fucoxanthin targets VEGF-A and VEGF-C, inhibits cell proliferation and migration, and induces cell cycle arrest and apoptosis.
Article
Biochemistry & Molecular Biology
Jeonghyeon Seo, Da Eun Lee, Seong Mi Kim, Eunjung Kim, Jin-Kyung Kim
Summary: The study found that LicA, a major active component of licorice, has anticancer activity against ovarian cancer cells. LicA inhibited cell viability and induced G2/M phase arrest in SKOV3 cells. LicA also induced apoptosis by increasing reactive oxygen species levels, reducing mitochondrial membrane potential, and promoting caspase activation and cytochrome c release. Furthermore, LicA reduced STAT3 protein levels and downstream signaling, suggesting its potential as an anti-cancer agent.
Review
Biochemistry & Molecular Biology
Sandra Lucia Teniente, Adriana Carolina Flores-Gallegos, Sandra Cecilia Esparza-Gonzalez, Lizeth Guadalupe Campos-Muzquiz, Sendar Daniel Nery-Flores, Raul Rodriguez-Herrera
Summary: Polyphenols are bioactive phytochemicals with various beneficial activities, including antioxidant, anti-inflammatory, immunomodulatory, and antiviral effects. Extracts from natural sources, such as pomegranate peel extract (PPE), containing polyphenols have shown potential in cancer prevention and treatment. The review summarizes recent scientific reports on the anticancer activity of polyphenols found in PPE, including their mechanisms of action in cervical cancer models.
Review
Medicine, Research & Experimental
Nasreddine El Omari, Saad Bakrim, Asaad Khalid, Mohammed Albratty, Ashraf N. Abdalla, Learn-Han Lee, Khang Wen Goh, Long Chiau Ming, Abdelhakim Bouyahya
Summary: Cancer progression is influenced by epigenetic events, with histone modification playing a key role in gene expression. Belinostat, a pan-HDAC inhibitor, has shown effectiveness in the treatment of T-cell lymphoma and solid malignancies. By indirectly promoting acetylated histone accumulation and restoring normal gene expressions, belinostat exhibits potential anti-cancer therapeutic effects through various pathways. Additionally, it has been found to increase p21WAF1, a cyclin-dependent kinase inhibitor involved in cell cycle arrest and apoptosis. Investigative trials have supported belinostat's potential as a valuable anti-cancer drug.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Bin He, Wenkan Zhang, Jiaming He
Summary: The study demonstrated that fraxinellone (FRA) isolated from the D. dasycarpus plant inhibited the proliferation and migration of osteosarcoma cells, induced cell apoptosis, and increased autophagy flux. The pro-apoptotic effect of FRA was achieved through excessive autophagy flux, providing new ideas for future osteosarcoma treatment and offering theoretical support for the anti-cancer mechanism of FRA.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Xuehua Zhang, Leilei Zhao, Jinlong Xiao, Yudi Wang, Yunmeng Li, Chaoqun Zhu, He Zhang, Yurui Zhang, Xiao Zhu, Yucui Dong
Summary: 5-Demethylnobiletin, an active ingredient in citrus polymethoxyflavones, was found to inhibit the proliferation of various tumor cells. This study explored its anti-tumor effect on glioblastoma and its molecular mechanisms. The results showed that 5-Demethylnobiletin significantly inhibited the viability, migration, and invasion of glioblastoma cells. It induced cell cycle arrest at the G0/G1 phase and apoptosis by regulating various proteins and inhibiting specific signaling pathways. The in vivo model also confirmed its inhibitory effect on U87-MG cell growth. Therefore, 5-Demethylnobiletin holds promise as a potential glioblastoma treatment drug.
FRONTIERS IN ONCOLOGY
(2023)
Review
Plant Sciences
Qiao Liu, Jin-Jian Lu, Hui-Jie Hong, Qi Yang, Yitao Wang, Xiao-Jia Chen
Summary: This review systematically summarizes the anticancer effects and underlying mechanisms of O. japonicus extracts and its active compounds. It is found that they exert potential anti-cancer effects, including cell cycle arrest, apoptosis and autophagy activation, and inhibition of metastasis and angiogenesis. The review also discusses the pharmacokinetics, toxicity, and clinical utility of O. japonicus extracts and active compounds, as well as their prospects in immunotherapy and combination chemotherapy.
Review
Plant Sciences
Syeda Nurunnesa Begum, Anindya Sundar Ray, Chowdhury Habibur Rahaman
Summary: Eugenol, as a simple phenolic compound, exhibits significant anticancer effects in various cancers through anti-metastatic, anti-proliferative, anti-angiogenic, and anti-inflammatory mechanisms.
Article
Biochemistry & Molecular Biology
Martin S. Taylor, Daniel R. Dempsey, Yousang Hwang, Zan Chen, Nam Chu, Jef D. Boeke, Philip A. Cole
BIOORGANIC CHEMISTRY
(2015)
Review
Biochemistry & Molecular Biology
Zan Chen, Philip A. Cole
CURRENT OPINION IN CHEMICAL BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Zan Chen, Stefani N. Thomas, David M. Bolduc, Xuejun Jiang, Xiangbin Zhang, Cynthia Wolberger, Philip A. Cole
Article
Biochemistry & Molecular Biology
Zan Chen, Daniel R. Dempsey, Stefani N. Thomas, Dawn Hayward, David M. Bolduc, Philip A. Cole
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Biochemical Research Methods
Samuel H. Henager, Nam Chu, Zan Chen, David Bolduc, Daniel R. Dempsey, Yousang Hwang, James Wells, Philip A. Cole
Article
Biochemistry & Molecular Biology
Zan Chen, Hanjie Jiang, Wei Xu, Xiaoguang Li, Daniel R. Dempsey, Xiangbin Zhang, Peter Devreotes, Cynthia Wolberger, L. Mario Amzel, Sandra B. Gabelli, Philip A. Cole
Article
Biochemical Research Methods
Gary C. H. Mo, Brian Ross, Fabian Hertel, Premashis Manna, Xinxing Yang, Eric Greenwald, Chris Booth, Ashlee M. Plummer, Brian Tenner, Zan Chen, Yuxiao Wang, Eileen J. Kennedy, Philip A. Cole, Karen G. Fleming, Amy Palmer, Ralph Jimenez, Jie Xiao, Peter Dedecker, Jin Zhang
Article
Chemistry, Multidisciplinary
Daniel R. Dempsey, Hanjie Jiang, Jay H. Kalin, Zan Chen, Philip A. Cole
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Article
Biochemistry & Molecular Biology
Nam Chu, Antonieta L. Salguero, Albert Z. Liu, Zan Chen, Daniel R. Dempsey, Scott B. Ficarro, William M. Alexander, Jarrod A. Marto, Yana Li, L. Mario Amzel, Sandra B. Gabelli, Philip A. Cole
Article
Oncology
Zhen-hao Fang, Yan-jing Li, Zan Chen, Jun-jie Wang, Li-hong Zhu
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2013)
Article
Biochemistry & Molecular Biology
Yun Wang, Jennifer M. Kavran, Zan Chen, Kannan R. Karukurichi, Daniel J. Leahy, Philip A. Cole
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Meeting Abstract
Biochemistry & Molecular Biology
Zan Chen, Daniel Dempsey, Wei Xu, Xiaoguang Li, Peter Devreotes, Cynthia Wolberger, Sandra Gabelli, Philip Cole
Meeting Abstract
Biochemistry & Molecular Biology
Daniel Robert Dempsey, Zan Chen, Stefani Thomas, Dawn Hayward, David Bolduc, Philip Cole
Meeting Abstract
Biochemistry & Molecular Biology
Samuel Henager, Nam Chu, Zan Chen, David Bolduc, James Wells, Philip Cole
Meeting Abstract
Biochemistry & Molecular Biology
Zan Chen, David Bolduc, Ming Yan, Xuejun Jiang, Cynthia Wolberger, Philip Cole