Targeting ryanodine receptors for anti-arrhythmic therapy

Effects of Dantrolene on Ischemia-Reperfusion Injury in Animal Models: TABLE 1.

(2016) Joshua A. Boys et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction

(2010) Xiaojuan Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure

(2010) Makoto Ono et al.   CARDIOVASCULAR RESEARCH

Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation

(2010) Simon Sedej et al.   CARDIOVASCULAR RESEARCH

Ryanodine Receptor Phosphorylation by Calcium/Calmodulin-Dependent Protein Kinase II Promotes Life-Threatening Ventricular Arrhythmias in Mice With Heart Failure

(2010) Ralph J. van Oort et al.   CIRCULATION

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2R2474S/+ Knock-In Mouse Model

(2010) Shigeki Kobayashi et al.   CIRCULATION JOURNAL

Purkinje Cells From RyR2 Mutant Mice Are Highly Arrhythmogenic But Responsive to Targeted Therapy

(2010) Guoxin Kang et al.   CIRCULATION RESEARCH

ImpairedS-Nitrosylation of the Ryanodine Receptor Caused by Xanthine Oxidase Activity Contributes to Calcium Leak in Heart Failure

(2010) Daniel R. Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice

(2010) Jian Shan et al.   JOURNAL OF CLINICAL INVESTIGATION

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

(2010) J. Fauconnier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calmodulin Kinase II, Sarcoplasmic Reticulum Ca2+ Leak, and Atrial Fibrillation

(2010) Dobromir Dobrev et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Hypersensitivity of excitation-contraction coupling in dystrophic cardiomyocytes

(2009) Nina D. Ullrich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death

(2009) Andriy E. Belevych et al.   CARDIOVASCULAR RESEARCH

Sudden Infant Death Syndrome in Mice With an Inherited Mutation in RyR2

(2009) Nitin Mathur et al.   Circulation-Arrhythmia and Electrophysiology

Calcium/Calmodulin-Dependent Protein Kinase II Contributes to Cardiac Arrhythmogenesis in Heart Failure

(2009) Can M. Sag et al.   Circulation-Heart Failure

Animal models of arrhythmogenic cardiomyopathy

(2009) M. D. McCauley et al.   Disease Models & Mechanisms

Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass

(2009) Fredrick A. Hilliard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor

(2009) Shigeki Kobayashi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

(2009) Hiroshi Watanabe et al.   NATURE MEDICINE

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

(2009) Andrew M Bellinger et al.   NATURE MEDICINE

RyR1 S-Nitrosylation Underlies Environmental Heat Stroke and Sudden Death in Y522S RyR1 Knockin Mice

(2008) William J. Durham et al.   CELL

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL

Identification of Target Domains of the Cardiac Ryanodine Receptor to Correct Channel Disorder in Failing Hearts

(2008) Takeshi Yamamoto et al.   CIRCULATION

CaMKII and Its Role in Cardiac Arrhythmia

(2008) JEFFREY R. ERICKSON et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Remodeling of ryanodine receptor complex causes "leaky" channels: A molecular mechanism for decreased exercise capacity

(2008) A. M. Bellinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA