Article
Nutrition & Dietetics
Xinge Xu, Jingwei Wu, Yuxin Jin, Kunlun Huang, Yuanyuan Zhang, Zhihong Liang
Summary: This study investigated the effect of S. boulardii and its postbiotics on DSS-induced ulcerative colitis in mice. The results showed that S. boulardii and postbiotics intervention improved colonic shortening and tissue damage, increased the expression of intestinal tight junction protein, reduced the secretion of pro-inflammatory factors, increased the secretion of anti-inflammatory factors, and maintained the homeostasis of intestinal microorganisms. Postbiotics intervention was more effective than probiotics. In conclusion, S. boulardii and its postbiotics effectively alleviate DSS-induced colitis in mice by modulating host immunity and maintaining intestinal homeostasis. Postbiotics are promising next-generation biotherapeutics for ulcerative colitis treatment.
Article
Food Science & Technology
Hye-Jung Moon, Suk-Heung Oh, Ki-Bum Park, Youn-Soo Cha
Summary: This study investigated the alleviating effects of kimchi and Leuconostoc mesenteroides DRC 1506 on ulcerative colitis (UC). Mice were orally given a dose of 1 x 10(9) CFU/day of freeze-dried kimchi suspension and DRC for 3 weeks, and UC was induced with dextran sulfate sodium (DSS). The results showed that the kimchi and DRC groups reduced colitis symptoms and improved the inflammatory response and mucosal barrier function in the colon.
Article
Plant Sciences
Huibiao Li, Xiaohong Chen, Jiayao Liu, Muyuan Chen, Ming Huang, Guoxin Huang, Xinlin Chen, Qin Du, Jiyan Su, Rongfeng Lin
Summary: The study found that Centella asiatica ethanol extract significantly reduced inflammation in mice with UC, alleviating symptoms of colitis and potentially serving as an effective treatment in clinical practice.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jia-Li Wang, Xiao Han, Jun-Xiang Li, Rui Shi, Lei-Lei Liu, Kai Wang, Yu-Ting Liao, Hui Jiang, Yang Zhang, Jun-Cong Hu, Li-Ming Zhang, Lei Shi
Summary: The study reveals the differential intestinal microbiota and metabolites in the pathogenesis of ulcerative colitis (UC), suggesting that different microbiota and metabolites may cause varying degrees of colitis. Some microbiota and metabolites may have protective roles against colitis, influencing the composition and function of intestinal mucus barrier under colitis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Nutrition & Dietetics
Tao Wang, Junquan Tian, Wenxuan Su, Fan Yang, Jie Yin, Qian Jiang, Yuying Li, Kang Yao, Tiejun Li, Yulong Yin
Summary: This study evaluated the optimal dosage of ornithine a-ketoglutarate (OKG) and explored its preventive effect on DSS-induced colitis in mice. Results showed that 1% OKG supplementation increased body weight, serum growth hormone (GH), insulin (INS), alkaline phosphatase (ALP), and certain amino acids, while decreasing urea nitrogen (BUN), NH3L, and Ile. Moreover, 1% OKG supplementation prevented DSS-induced colitis in mice by altering microbial compositions and reducing the secretion of inflammatory cytokines in serum.
Article
Veterinary Sciences
Yitong Zhang, Lanmei Yin, Xianglin Zeng, Jun Li, Yuebang Yin, Qiye Wang, Jianzhong Li, Huansheng Yang
Summary: The study investigated the effects of high-dose iron on intestinal damage and regeneration in mice with colitis. The results showed that high-dose iron exacerbated intestinal injury but promoted intestinal repair by regulating intestinal epithelial cell renewal and intestinal stem cell activity.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Agriculture, Multidisciplinary
Ping-Yun Fan-Jiang, Pei-Sheng Lee, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
Summary: The study showed that PTS significantly reduced the accumulation of plasma interleukin6 induced by HFD and DSS, inhibited the formation of aberrant crypt foci, and decreased the colon weight-to-length ratio in HFD/DSS-induced colitis mice. PTS also suppressed the expressions of IL-1 beta, CHOP, COX-2, and TGF-beta 1/Smad2, while maintaining Muc2 and E-cadherin expressions. Post-treatment with PTS further reduced the colon weight-to-length ratio and loss of Muc2 in HFD/DSS-induced colitis mice, indicating its potential in preventing colitis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Xuan-qing Chen, Xiang-yu Lv, Shi-jia Liu
Summary: BTW significantly improved the inflammatory symptoms of mice with acute colitis, and the latent mechanism of BTW may be related to various signaling pathways, including the modulation of intestinal microflora and inflammatory signaling pathways, such as IL-6/STAT3.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Kaitlyn M. Sommer, Youngsoo Lee, Sharon M. Donovan, Ryan N. Dilger
Summary: This study aims to determine if different mRNA purification methods can reduce interference caused by DSS. The results show that spin column purification is more effective than LiCl purification, but no method can completely eliminate interference. Therefore, caution should be exercised when interpreting gene expression results in animal studies using DSS-induced colitis.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Pathology
Li-Yin Hung, Christopher F. Pastore, Bonnie Douglas, De'Broski R. Herbert
Summary: The study demonstrates that myeloid-derived IL-33 plays a key role in restraining colitic disease, while intestinal epithelial cell-derived IL-33 is dispensable for disease severity or tissue recovery.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meishan Yue, Jialu Huang, Xiaolan Ma, Peng Huang, Yisong Liu, Jianguo Zeng
Summary: This study found that PRO, an anti-inflammatory ingredient in Macleaya cordata, can alleviate inflammation symptoms and restore the intestinal barrier in DSS-induced colitis mice. PRO also regulates the composition of gut microbiota.
Article
Medicine, Research & Experimental
Li Liang, Qingqing Xiong, Jingxia Kong, Chenying Tian, Linfeng Miao, Xiaofeng Zhang, Huahua Du
Summary: The study demonstrated that intraperitoneal iron supplementation could alleviate colonic and systemic inflammation, restore intestinal barrier function, regulate intestinal immune homeostasis, and increase mucous secretion of goblet cells in the colon.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Dadi Xie, Fengfeng Li, Deshui Pang, Shiyuan Zhao, Meihua Zhang, Zhongfa Ren, Chunmei Geng, Changshui Wang, Ning Wei, Pei Jiang
Summary: This study aimed to evaluate the utility metabolomic analysis of target tissues in exploring new biomarkers for early diagnosis and treatment of IBD. The results showed significant changes in amino acid, organic acid, glucide, and purine profiles, impacting pathways ranging from amino acid metabolism to purine metabolism. Using GC-MS-based profiling of metabolite changes may provide a more comprehensive view for understanding IBD pathogenesis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Agriculture, Multidisciplinary
Qun Wang, Chujing Wang, Abdullah, Wenni Tian, Zhenyuan Qiu, Mingyue Song, Yong Cao, Jie Xiao
Summary: This study demonstrates that hydroxytyrosol can effectively prevent colitis by alleviating inflammation, promoting intestinal barrier regeneration, and modulating the gut microbiota.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Tian-Yuan Yu, Yi-Ming Feng, Wei-Song Kong, Shan-Ni Li, Xue-Jiao Sun, Gui Zhou, Rui-Fang Xie, Xin Zhou
Summary: This study aimed to evaluate the effect of the natural polyphenol gallic acid (GA) on the NLRP3 inflammasome in DSS-induced colitis in mice. The results showed that GA could attenuate weight loss, relieve symptoms, and improve colonic morphological injury in mice with colitis. GA also reduced the levels of pro-inflammatory cytokines and downregulated the protein and mRNA expressions of the NLRP3 pathway. Furthermore, GA inhibited the expression of inflammatory markers and suppressed NO release in macrophage cells.
FRONTIERS IN PHARMACOLOGY
(2023)