Article
Oncology
Kathryn M. Muilenburg, Carly C. Isder, Prakash Radhakrishnan, Surinder K. Batra, Quan P. Ly, Mark A. Carlson, Michael Bouvet, Michael A. Hollingsworth, Aaron M. Mohs
Summary: Pancreatic cancer is difficult to resect completely. Fluorescence-guided surgery (FGS) can help achieve complete tumor resections by using contrast agents that target biomarkers expressed in malignant tissue. Mucins, a family of glycoproteins, are upregulated in pancreatic cancer and have the potential to serve as biomarkers for FGS. This review summarizes the biomarker traits of mucins and their potential use in FGS for pancreatic cancer.
Article
Pharmacology & Pharmacy
Li Qin, Dongning Huang, Jian Huang, Fuhui Qin, Haixin Huang
Summary: This bioinformatics study aimed to identify crucial anti-cancer targets, functional processes, and molecular mechanisms of Pachyman in treating hepatocellular carcinoma (HCC). The findings suggest that ALB and VEGFA may be potent pharmacological targets of Pachyman for HCC treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Sabeeta Kapoor, Elisabetta Damiani, Shan Wang, Ravirajan Dharmanand, Chakrapani Tripathi, Jorge Enrique Tovar Perez, Wan Mohaiza Dashwood, Praveen Rajendran, Roderick Hugh Dashwood
Summary: Epigenetic mechanisms, specifically the deregulation of bromodomain (BRD) functions, play a significant role in colorectal cancer (CRC) and other malignancies. This study shows that overexpression of BRD9 is associated with poor prognostic outcomes in CRC patients. Natural polyphenols such as Epigallocatechin-3-gallate (EGCG), Equol, Quercetin, and Aspalathin were identified as potential BRD9 antagonists, as they reduced colon cancer cell viability, inhibited colony formation, and increased DNA damage and apoptosis.
Review
Medicine, Research & Experimental
Roberta Mastrantonio, Hua You, Luca Tamagnone
Summary: Semaphorins play a crucial role in cancer by controlling various biological processes, especially in cell-cell communication, migration, metastasis, and immune responses. Research suggests that Semaphorins could serve as important biomarkers for predicting patient survival and treatment response in cancer. Targeting Semaphorin signaling has shown potential in interfering with tumor growth and metastasis, making it a promising avenue for novel therapeutic strategies in cancer treatment.
Review
Biochemistry & Molecular Biology
Maria Grazia Cerrito, Emanuela Grassilli
Summary: The development of high-throughput approaches has enabled the identification of novel actionable targets for colorectal cancer treatment and the development of specific inhibitors, leading to treatment innovations such as re-sensitizing drug-resistant tumors in combination with chemotherapy and inducing synthetic lethality in tumors with specific oncogenic mutations.
Review
Pharmacology & Pharmacy
Haseeb Ahsan, Salman Ul Islam, Muhammad Bilal Ahmed, Young Sup Lee
Summary: Cancer is a complex disease that can be prevented or suppressed through chemoprevention. Targeting molecules such as Nrf2, STAT3, and Src, which are involved in various pathways of cancer, can reduce oxidative stress and inflammation and stop cancer initiation and progression.
Article
Oncology
Giorgia Dinoi, Andrea Mariani, Enrica Martinelli, Alessandra Ciucci, Gian Franco Zannoni, Amy L. Weaver, Gary L. Keeney, George Vasmatzis, Panos Z. Anastasiadis, Francesco Fanfani, Giovanni Scambia, Daniela Gallo
Summary: By analyzing protein levels in 36 hysterectomy samples, it was found that CHK1, FBXW7, and PPP2R1B were associated with disease progression and death risk in uterine serous endometrial cancer patients. These findings help identify new clinically relevant biomarkers and potential drug targets.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eun-Ryeong Hahm, Su-Hyeong Kim, Krishna B. Singh, Shivendra Singh
Summary: The study revealed that Withaferin A (WA) may prevent breast cancer by downregulating genes associated with cellular senescence, upregulating p21, affecting cellular response to stress, and decreasing glycolysis-related proteins. Additionally, NRF2 knockout cells were found to be more resistant to WA-induced apoptosis, suggesting a potential mechanism for WA's chemopreventive efficacy in breast cancer.
MOLECULAR CARCINOGENESIS
(2021)
Review
Biochemistry & Molecular Biology
Phuong Linh Nguyen, Jungsook Cho
Summary: Histamine and its receptors play important roles in cancer biology, promoting cancer development, growth, and metastasis through interactions with different HRs, and regulating immune cell infiltration with immunomodulatory function. Various HR ligands affect tumor progression in different cancer types, and HR subtype expression levels may serve as prognostic biomarkers in multiple cancers.
Review
Medicine, Research & Experimental
Akanksha Esmeeta, Subhamay Adhikary, V Dharshnaa, P. Swarnamughi, Z. Ummul Maqsummiya, Antara Banerjee, Surajit Pathak, Asim K. Duttaroy
Summary: Colon cancer, the third most common cancer, can be inhibited by plant-based compounds through various mechanisms. However, there are challenges in using these compounds, such as poor solubility, absorption, and intellectual property issues. Traditional medicines have advantages and limitations in treating cancer. This review focuses on the benefits and challenges of using bioactive compounds derived from plants for colon cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ga-Eun Lee, Cheol-Jung Lee, Hyun-Jung An, Han Chang Kang, Hye Suk Lee, Joo Young Lee, Sei-Ryang Oh, Sung-Jun Cho, Dae Joon Kim, Yong-Yeon Cho
Summary: Fargesin inhibits cancer cell growth by suppressing cell cycle transition and EGF-induced cell transformation through multiple signaling pathways, including CDK/cyclin and Rb-E2F pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Laura Necula, Lilia Matei, Denisa Dragu, Ioana Pitica, Ana Neagu, Coralia Bleotu, Carmen C. Diaconu, Mihaela Chivu-Economescu
Summary: This article provides an overview of the application of the collagen family as biomarkers in cancer therapy, and discusses their role in promoting tumor growth and creating a permissive environment for metastatic dissemination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Abedul Haque, Daniel Brazeau, Arm R. Amin
Summary: Although cancer is the second deadliest disease worldwide, recent advances in precision treatments are promising. However, challenges remain due to the heterogeneity and mutational burdens of cancer cells. Chemoprevention, especially with natural dietary compounds, is considered a rational and appealing strategy to prevent carcinogenesis, particularly in high-risk populations.
EUROPEAN JOURNAL OF CANCER
(2021)
Review
Oncology
Chia-Jung Li, Yen-Dun Tony Tzeng, Yi-Han Chiu, Hung-Yu Lin, Ming-Feng Hou, Pei-Yi Chu
Summary: Breast cancer emergencies have rapidly evolved in medicine over the past decade, with targeted therapy emerging as a new important treatment modality that offers advantages over traditional surgery, radiotherapy, and chemotherapy.
Article
Oncology
Venkateshwar Madka, Jagan M. R. Patlolla, Karthikkumar Venkatachalam, Yuting Zhang, Gopal Pathuri, Nicole Stratton, Stanley Lightfoot, Naveena B. Janakiram, Altaf Mohammed, Chinthalapally V. Rao
Summary: Colon cancer is a significant health problem that is increasing in occurrence, especially among young adults. Previous studies have shown promising preventive effects of drugs like Sulindac and DFMO, but long-term use at high doses can cause side effects. This study explores alternative strategies for preventing colon cancer using low-dose combinations of these drugs, as well as testing the efficacy of Sulindac derivatives. The results suggest that these treatment regimens can effectively inhibit tumor progression without causing toxicity, making them a promising approach for colon cancer prevention.
Article
Oncology
Venkateshwar Madka, Gaurav Kumar, Gopal Pathuri, Yuting Zhang, Stanley Lightfoot, Adam S. Asch, Altaf Mohammed, Vernon E. Steele, Chinthalapally Rao
CANCER PREVENTION RESEARCH
(2020)
Review
Cell Biology
Chinthalapally V. Rao, Adam S. Asch, Daniel J. J. Carr, Hiroshi Y. Yamada
Meeting Abstract
Biochemistry & Molecular Biology
Nagendra Yarla, Gopal Pathuri, Hariprasad Gali, Janani Panneerselvam, Parthasarathy Chandrakesan, Venkateshwar Madka, Chinthalapally Rao
Article
Oncology
Parthasarathy Chandrakesan, Janani Panneerselvam, Randal May, Nathaniel Weygant, Dongfeng Qu, William R. Berry, Kamille Pitts, Ben Z. Stanger, Chinthalapally Rao, Michael S. Bronze, Courtney W. Houchen
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Oncology
Janani Panneerselvam, Priyanga Mohandoss, Ravi Patel, Hamza Gillan, Michael Li, Kirtana Kumar, DangHuy Nguyen, Nathaniel Weygant, Dongfeng Qu, Kamille Pitts, Stanley Lightfoot, Chinthalapally Rao, Courtney Houchen, Michael Bronze, Parthasarathy Chandrakesan
MOLECULAR THERAPY-ONCOLYTICS
(2020)
Article
Biochemistry & Molecular Biology
Xunhao Xiong, Geeta Rao, Ram Vinod Roy, Yushan Zhang, Nicolas Means, Anindya Dey, Martha Tsaliki, Sounik Saha, Sanjib Bhattacharyya, Shailendra Kumar Dhar Dwivedi, Chinthalapally Rao, Daniel J. McCormick, Danny Dhanasekaran, Kai Ding, Elizabeth Gillies, Min Zhang, Da Yang, Resham Bhattacharya, Priyabrata Mukherjee
Article
Cell Biology
Chinthalapally Rao, Mudassir Farooqui, Avanish Madhavaram, Yuting Zhang, Adam S. Asch, Hiroshi Y. Yamada
Article
Oncology
Chinthalapally V. Rao, Chao Xu, Mudassir Farooqui, Yuting Zhang, Adam S. Asch, Hiroshi Y. Yamada
Summary: Genomic instability plays a crucial role in the evolution and treatment of lung adenocarcinoma, with genes associated with survival potentially serving as future therapeutic targets. The immune system has been identified as a key player in suppressing genomic instability and cancer development in the lungs, suggesting potential avenues for chemotherapy, chemoprevention, and immunomodulation approaches.
Article
Oncology
Janani Panneerselvam, Venkateshwar Madka, Rajani Rai, Katherine T. Morris, Courtney W. Houchen, Parthasarathy Chandrakesan, Chinthalapally V. Rao
Summary: The Western-style diet high in fat is a major cause of obesity and increased risk of colon cancer, with inflammatory molecules playing a key role in the connection between obesity and colon tumorigenesis. IL-23 is significant in the impact of a Western-style diet on obesity, gut microbiome, and colon tumorigenesis, suggesting it as a potential target for prevention and treatment. Pro-inflammatory eicosanoids and gut bacterial toxins facilitate IL-23 production, which is crucial in the progression of obesity-associated colon tumors.
Article
Oncology
Venkateshwar Madka, Jagan M. R. Patlolla, Karthikkumar Venkatachalam, Yuting Zhang, Gopal Pathuri, Nicole Stratton, Stanley Lightfoot, Naveena B. Janakiram, Altaf Mohammed, Chinthalapally V. Rao
Summary: Colon cancer is a significant health problem that is increasing in occurrence, especially among young adults. Previous studies have shown promising preventive effects of drugs like Sulindac and DFMO, but long-term use at high doses can cause side effects. This study explores alternative strategies for preventing colon cancer using low-dose combinations of these drugs, as well as testing the efficacy of Sulindac derivatives. The results suggest that these treatment regimens can effectively inhibit tumor progression without causing toxicity, making them a promising approach for colon cancer prevention.
Meeting Abstract
Oncology
Nagendra Sastri Yarla, Gopal Pathuri, Hariprasad Gali, Venkateshwar Madka, Janani Panneerselvam, Parthasarathy Chandrakesan, Courtney W. Houchen, Elizabeth R. Glaze, Jennifer Fox, David McCormick, Chinthalapally Rao
Meeting Abstract
Oncology
Altaf Mohammed, Venkateshwar Madka, Gaurav Kumar, Anil Singh, Nicole Stratton, Stanley Lightfoot, Mark S. Miller, Chinthalapally Rao
Meeting Abstract
Oncology
Chinthalapally Rao, Venkateshwar Madka, Yuting Zhang, Gopal Pathuri, Janani Panneerselvam, Nicole Stratton, Niklas K. Finnberg, Howard P. Safran, Jennifer Fox, Shizuko Sei, Elizabeth R. Glaze, Robert Shoemaker, Wafik S. El-Deiry
Meeting Abstract
Oncology
Venkateshwar Madka, Yuting Zhang, Gopal Pathuri, Janani Panneerselvam, Nicole Stratton, Anil Singh, Shizuko Sei, Jennifer Fox, Chinthalapally Rao
Meeting Abstract
Oncology
Venkateshwar Madka, Gopal Pathuri, Hariprasad Gali, Nandini Kumar, Nagendra Sastri Yarla, Anh Bao, Adam S. Asch, Chinthalapally Rao