Article
Biochemistry & Molecular Biology
Ulf Hedstrom, Lisa Oberg, Outi Vaarala, Goran Dellgren, Martin Silverborn, Leif Bjermer, Gunilla Westergren-Thorsson, Oskar Hallgren, Xiaohong Zhou
Summary: The study found that airway epithelial cells in patients with Chronic Obstructive Pulmonary Disease (COPD) are damaged, and COPD epithelial cells show differential gene expression on COPD airway scaffolds compared to normal epithelial cells, with increased proliferation and maintained basal cell phenotype.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Article
Medicine, Research & Experimental
Caspar Schiffers, Cheryl van de Wetering, Robert A. Bauer, Aida Habibovic, Milena Hristova, Christopher M. Dustin, Sara Lambrichts, Pamela M. Vacek, Emiel F. M. Wouters, Niki L. Reynaert, Albert van der Vliet
Summary: The downregulation of DUOX1 in the airways of patients with Chronic Obstructive Pulmonary Disease (COPD) may contribute to the pathogenesis of COPD, leading to airway remodeling and emphysema. Animal studies also demonstrate that Duox1 deficiency exacerbates lung pathology induced by smoke exposure.
Article
Medicine, Research & Experimental
Ella Katz-Kiriakos, Deborah F. Steinberg, Colin E. Kluender, Omar A. Osorio, Catie Newsom-Stewart, Arjun Baronia, Derek E. Byers, Michael J. Holtzman, Dawn Katafiasz, Kristina L. Bailey, Steven L. Brody, Mark J. Miller, Jennifer Alexander-Brett
Summary: The study revealed that IL-33 secretion relies on the nSMase2-regulated multivesicular endosome (MVE) pathway and is cosecreted with exosomes as surface-bound cargo. COPD patients showed increased secretion of IL-33 isoforms and elevated nSMase2 expression, providing potential therapeutic targets for chronic airway diseases driven by type 2 inflammation.
Article
Immunology
Miguel Angel Martinez-Garcia, David de la Rosa-Carrillo, Juan Jose Soler-Cataluna, Pablo Catalan-Serra, Marta Ballester, Yolanda Roca Vanaclocha, Marcos Agramunt, Javier Ballestin, Alberto Garcia-Ortega, Grace Oscullo, Cristina Navarro-Soriano, Alvar Agusti
Summary: This study aimed to assess the temporal evolution of bronchiectasis in patients with COPD. Results indicated that the presence of chronic purulent sputum production, number of pathogenic microorganism isolations in sputum, and number of hospitalizations due to exacerbations of COPD were independent risk factors for the progression or development of BE.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Lijing Wang, Hongjun Zhao, Indu Raman, Mei Yan, Qiong Chen, Quan-Zhen Li
Summary: The mechanisms underlying chronic obstructive pulmonary disease (COPD) remain unclear. This study identified differentially expressed genes and miRNAs in peripheral blood mononuclear cells (PBMCs) of COPD patients, compared with normal controls. The results suggest that miRNAs and mRNAs are involved in the pathogenesis of COPD.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Editorial Material
Multidisciplinary Sciences
John V. Fahy, Richard M. Locksley
Summary: Smoking leads to chronic obstructive pulmonary disease (COPD). Some COPD patients exhibit elevated levels of eosinophil cells, indicating type 2 inflammation, and blocking this inflammation can enhance their lung health.
Article
Respiratory System
Hyonsoo Joo, Seoung Ju Park, Kyung Hoon Min, Chin Kook Rhee
Summary: This study found that high plasma IL-33 level was significantly associated with the risk of exacerbation in COPD patients during prospective follow-up. The expression of IL-33 in the lung was positively correlated with smoking and negatively correlated with lung function.
BMC PULMONARY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ming Zhang, Lei Fang, Liang Zhou, Antonio Molino, Maria Rosaria Valentino, Shuanying Yang, Jie Zhang, Yali Li, Michael Roth
Summary: In COPD patients, airway epithelial cells show increased phosphorylation of MAPK15 and ULK1, as well as enhanced expression of Beclin1 and the ratio of LC3II to LC3I. Cigarette smoke extract activates the MAPK15-ULK1 signaling pathway, leading to mitophagy and mitochondrial oxidative stress in airway epithelial cells. Targeting this pathway may be a potential therapeutic strategy for COPD.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Rubing Mo, Jun Zhang, Yongxing Chen, Yipeng Ding
Summary: The present study aimed to evaluate the role of nicotine in the progression of COPD. The findings showed that nicotine treatment induced pyroptosis in 16HBE cells, leading to increased cell death and suppressed cell proliferation.
MOLECULAR MEDICINE REPORTS
(2022)
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Matt D. Johansen, Rashad M. Mahbub, Sobia Idrees, Duc H. Nguyen, Stefan Miemczyk, Prabuddha Pathinayake, Kristy Nichol, Nicole G. Hansbro, Linden J. Gearing, Paul J. Hertzog, David Gallego-Ortega, Warwick J. Britton, Bernadette M. Saunders, Peter A. Wark, Alen Faiz, Philip M. Hansbro
Summary: Patients with COPD are more susceptible to SARS-CoV-2 infection and develop severe viral infection and inflammation. COPD pBECs are more susceptible to viral infection possibly due to increased co-receptor expression and protease imbalances. A prominent cluster of IFN-responsive club/goblet cells emerges during infection, which may contribute to immune responses. Therapeutic interventions can suppress viral replication and inflammation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Respiratory System
Jonathan C. Weissler, Traci N. Adams
Summary: Recent studies have highlighted the potential differences in eosinophilic diseases in asthma and COPD, with the detection of peripheral blood eosinophils potentially aiding in the management of COPD patients.
Article
Multidisciplinary Sciences
Xiao-Xiao Han, Yan-Ge Tian, Xue-Fang Liu, Di Zhao, Xue-Hang Du, Hao-Ran Dong, Su-Xiang Feng, Jian-Sheng Li
Summary: This study used network pharmacology and pharmacodynamics to explore the molecular mechanism and effects of Tanreqing capsule (TRQ) in the treatment of acute-exacerbation chronic obstructive pulmonary disease (AECOPD). The results showed that TRQ had a favorable anti-inflammatory effect and achieved its efficacy by regulating the expression of relevant targets.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Wenjia Qiu, Ning Kang, Yanxu Wu, Yongjun Cai, Li Xiao, Haiyan Ge, Huili Zhu
Summary: MAIT cells in COPD patients exhibit distinct biological functions, producing more IL-17 and less IFN-γ compared to healthy individuals, and are correlated with inflammation levels and lung function. These cells are highly expressed in inflammatory tissues, suggesting a potential role in COPD immunopathology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pathology
Liting Chen, Gaoxiang Wang, Xiaolu Long, Hongyan Hou, Jia Wei, Yang Cao, Jiaqi Tan, Weiyong Liu, Liang Huang, Fankai Meng, Lifang Huang, Na Wang, Jianping Zhao, Gang Huang, Ziyong Sun, Wei Wang, Jianfeng Zhou
Summary: In this study using RT-ddPCR, it was found that 92.3% of COVID-19 patients had viremia in their blood. The blood viral load was significantly higher in critical patients compared to general and severe patients, indicating a potential correlation with disease severity.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2021)
Letter
Biology
Qiuyu Li, Cheng Cui, Fei Xu, Jianping Zhao, Nan Li, Haichao Li, Tianbing Wang, Hua Zhang, Na Liu, Yudong Wei, Xiaoye Niu, Yan Xu, Jianping Dong, Xueting Yao, Xiaohong Wang, Yahong Chen, Haiyan Li, Chunli Song, Jie Qiao, Dongyang Liu, Ning Shen
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Microbiology
Yanjiao Lu, Zhenli Huang, Meijia Wang, Kun Tang, Shanshan Wang, Pengfei Gao, Jungang Xie, Tao Wang, Jianping Zhao
Summary: Lymphopenia, elevated level of d-dimer, hs-CTnI and hs-CRP were independent predictors of mortality in young adults with severe COVID-19, and young adults with two or more abnormalities above were more prone to death. Similar predictive effects of these factors were also observed in all-age patients with severe COVID-19.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Article
Multidisciplinary Sciences
Yi Wang, Lei Zhang, Guo-Rao Wu, Qing Zhou, Huihui Yue, Li-Zong Rao, Ting Yuan, Biwen Mo, Fa-Xi Wang, Long-Min Chen, Fei Sun, Jia Song, Fei Xiong, Shu Zhang, Qilin Yu, Ping Yang, Yongjian Xu, Jianping Zhao, Huilan Zhang, Weining Xiong, Cong-Yi Wang
Summary: Despite extensive studies, the mechanisms underlying PF remain poorly understood. This study found altered MBD2 expression in macrophages in lungs from different types of PF patients and mice with PF, and Mbd2 deficiency protected against BLM-induced PF. Mbd2 selectively influenced TGF-β1 production and M2 macrophage program through Ship promoter binding in macrophages.
Article
Multidisciplinary Sciences
Haidong Li, Xiuchao Zhao, Yujin Wang, Xin Lou, Shizhen Chen, He Deng, Lei Shi, Junshuai Xie, Dazhong Tang, Jianping Zhao, Louis-S Bouchard, Liming Xia, Xin Zhou
Summary: The recovery process of COVID-19 patients remains unclear, with some experiencing ongoing respiratory issues. Xe-129 MRI analysis reveals higher ventilation defects and longer gas-blood exchange time in COVID-19 patients, indicating lung function impairment during recovery.
Article
Medical Laboratory Technology
Shanshan Wang, Kun Tang, Yanjiao Lu, Zhen Tian, Zhenli Huang, Meijia Wang, Jianping Zhao, Jungang Xie
Summary: The study identified differential metabolites in asthma patients and healthy subjects, including phosphatidic acid, phosphatidylglyceml, and phosphatidylethanolamine. These metabolites showed significant relevance to diagnostic and prognostic indicators of asthma, providing potential for developing new biomarkers.
CLINICA CHIMICA ACTA
(2021)
Editorial Material
Biotechnology & Applied Microbiology
Yi Wang, Jianping Zhao, Huilan Zhang, Cong-Yi Wang
Article
Surgery
Jianping Zhao, Yao Chen, Jingjing Wang, Jian Wang, Ying Wang, Songshan Chai, Yuxin Zhang, Xiaoping Chen, Wanguang Zhang
Summary: The preoperative risk grade (PRG) integrating non-tumor-specific SIR markers like PLR and ALB was significantly associated with the overall survival of intrahepatic cholangiocarcinoma (ICC) patients, showing higher predictive accuracy compared to other systems. Incorporating PRG into a nomogram improved the predictive ability of ICC prognosis.
Article
Medicine, General & Internal
Wei Zhu, Huaqiu Zhang, Yong Li, Zeyang Ding, Zhuo Liu, Yajun Ruan, Huan Feng, Ganxun Li, Bo Liu, Fan He, Ning Zhou, Jiangang Jiang, Zhixiang Wen, Gang Xu, Jianping Zhao, Bixiang Zhang, Daowen Wang, Zhouping Tang, Hui Wang, Jihong Liu
Summary: Limited data is available on the treatment for COVID-19, with the main treatment strategies including ventilatory support, multiple organ function preservation, glucocorticoid use, renal replacement therapy, anticoagulation, and restrictive fluid management. Early recognition and intervention, multidisciplinary collaboration, multi-organ function support, and personalized treatment might be the key for reducing mortality.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Yao Chen, Jianping Zhao, Zhanguo Zhang, Zeyang Ding, Yifa Chen, Xiaoping Chen, Wanguang Zhang
Summary: This study developed a DVT risk prediction model (TRN) based on data from a large number of hepatocellular carcinoma patients who underwent laparoscopic hepatectomy, demonstrating good predictive value in both internal and external validation.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Environmental Sciences
Ting Yang, Renjie Chen, Xiaoying Gu, Jianying Xu, Lan Yang, Jianping Zhao, Xiangyan Zhang, Chunxue Bai, Jian Kang, Pixin Ran, Huahao Shen, Fuqiang Wen, Kewu Huang, Yahong Chen, Tieying Sun, Guangliang Shan, Yingxiang Lin, Sinan Wu, Jianguo Zhu, Ruiying Wang, Zhihong Shi, Yongjian Xu, Xianwei Ye, Yuanlin Song, Qiuyue Wang, Yumin Zhou, Liren Ding, Ting Yang, Wanzhen Yao, Yanfei Guo, Fei Xiao, Yong Lu, Xiaoxia Peng, Biao Zhang, Dan Xiao, Zuomin Wang, Hong Zhang, Xiaoning Bu, Xiaolei Zhang, Li An, Shu Zhang, Zhixin Cao, Qingyuan Zhan, Yuanhua Yang, Lirong Liang, Bin Cao, Huaping Dai, Aaron van Donkelaar, Randall V. Martin, Tangchun Wu, Jiang He, Haidong Kan, Chen Wang
Summary: The China Pulmonary Health study found that long-term exposure to ambient PM2.5 and some constituents, especially organic matter and nitrate, were associated with lower large- and small-airway function.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Yanjiao Lu, Jinkun Chen, Shanshan Wang, Zhen Tian, Yan Fan, Meijia Wang, Jianping Zhao, Kun Tang, Jungang Xie
Summary: This study highlighted the significant impact of aging on idiopathic pulmonary fibrosis (IPF) and bleomycin-induced pulmonary fibrosis (BIPF) through comprehensive gene expression profile analysis. Aging was found to be closely associated with changes in differentially expressed genes (DEGs) and the severity of pulmonary fibrosis development. Four aging-associated core genes (Slc2a3, Fga, Hp, and Thbs1) were identified as key players in the pathogenesis of pulmonary fibrosis.
FRONTIERS IN MEDICINE
(2021)
Article
Allergy
Zhenli Huang, Bohua Fu, Xuefei Qi, Yuzhu Xu, Yong Mou, Min Zhou, Yong Cao, Guorao Wu, Jungang Xie, Jianping Zhao, Yi Wang, Weining Xiong
Summary: The study found that hsa_circ_0002594 is upregulated in CD4(+) T cells and may have potential value in the diagnosis and treatment of Th2-mediated allergic asthma. The expression of hsa_circ_0002594 was higher in subgroups with a family history, positive skin pricking test (SPT), or Th2-high. After treatment with inhaled corticosteroids, hsa_circ_0002594 expression decreased.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li-Zong Rao, Yi Wang, Lei Zhang, Guorao Wu, Lu Zhang, Fa-Xi Wang, Long-Min Chen, Fei Sun, Song Jia, Shu Zhang, Qilin Yu, Jiang-Hong Wei, Hui-Ren Lei, Ting Yuan, Jinxiu Li, Xingxu Huang, Bin Cheng, Jianping Zhao, Yongjian Xu, Bi-Wen Mo, Cong-Yi Wang, Huilan Zhang
Summary: IL-24 is elevated in the serum of IPF patients and BALF of mice, and its deficiency can protect mice from lung injury and fibrosis. IL-24 synergizes with IL-4 to promote the development of M2 macrophages, playing a crucial role in the progression of pulmonary fibrosis.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Biochemistry & Molecular Biology
Yang Xia, Weixiang Chen, Hongyi Ren, Jianping Zhao, Lihua Wang, Rui Jin, Jiesen Zhou, Qiyuan Wang, Fugui Yan, Bin Zhang, Jian Lou, Shaobin Wang, Xiaomeng Li, Jie Zhou, Liming Xia, Cheng Jin, Jianjiang Feng, Wen Li, Huahao Shen
Summary: This study demonstrated the efficiency of a classifier combining chest X-ray and clinical features in distinguishing COVID-19 from influenza A/B pneumonia. The combined classifier showed significantly improved diagnostic efficacy compared to using clinical features or CXR alone, with high sensitivity and specificity. Additionally, the AI system exhibited superiority in turn-around time and diagnostic accuracy compared to experienced pulmonary physicians in the reader study.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)