Article
Clinical Neurology
Vincenzo Rizzo, Carmen Terranova, Giovanni Raffa, Salvatore Massimiliano Cardali, Filippo Flavio Angileri, Giuseppina Marzano, Maria Catena Quattropani, Antonino Germano, Paolo Girlanda, Angelo Quartarone
Summary: Brain tumors can lead to abnormal cortical excitability in affected hemispheres, with decreased SICI, ICF, and SAI. Further research is needed to investigate the relationship between cortical excitability and motor impairment in these patients.
FRONTIERS IN NEUROLOGY
(2021)
Review
Neurosciences
Mengjie Zhang, Ting He, Quan Wang
Summary: NIBS has been shown to improve motor and cognitive function in patients with MSA-P and MSA-C, but further research is needed to explore its long-term effects and underlying mechanisms.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Medicine, General & Internal
Michal Starosta, Natalia Cichon, Joanna Saluk-Bijak, Elzbieta Miller
Summary: This review examines the current evidence of the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in post-stroke rehabilitation and discusses the effects of different stimulation types on motor function, cognitive function, depression, and aphasia. The findings suggest that rTMS is safe and can modulate cortical excitability to improve overall performance. However, the methodological problem of conducting double-blinding studies in stroke rehabilitation research is highlighted.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Ole Numssen, Anna-Leah Zier, Axel Thielscher, Gesa Hartwigsen, Thomas R. Knosche, Konstantin Weise
Summary: Transcranial magnetic stimulation (TMS) is a useful tool for studying causal structure-function relationships in the human brain, but the complex distribution of induced electric fields makes it challenging to precisely identify the stimulated neuronal populations. This study proposes a method to rapidly and feasibly localize cortical regions at the individual subject level by combining experimental data and numerically modeled fields. By establishing a functional link between the induced electric field and the modulated effect, the research demonstrates a fundamental step towards fully exploiting the potential of TMS for practical and clinical applications.
Review
Medicine, General & Internal
Andres Pino-Esteban, Alvaro Megia-Garcia, David Martin-Caro Alvarez, Hector Beltran-Alacreu, Juan Avendano-Coy, Julio Gomez-Soriano, Diego Serrano-Munoz
Summary: Transcranial direct current stimulation (tDCS) is a non-invasive, well-tolerated, and safe technique that can affect brain excitability, particularly in individuals over the age of 60. Studies have shown that anodal tDCS applied over the motor cortex may be effective in improving balance and posture control in healthy older adults, but further high-quality randomized controlled trials are needed to determine the most effective protocols and potential benefits for this population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Jin Zhang, Wen-Hao Huang, Ya-Dan Zheng, Xin Li, Hao-Xiang Jiang, Min-Zhi Su, Xiao-Yan Huang, Zu-Lin Dou, Zhi-Ming Tang
Summary: The study found that auricular acupuncture can modulate the excitability of the motor cortex area controlling the upper limbs. MEP amplitude, tapping score, and tapping speed significantly increased under the real stimulation condition, while decreased under the sham stimulation condition.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Engineering, Biomedical
Jian-Min Chen, Xiao-Lu Li, Qin-He Pan, Ye Yang, Sen-Ming Xu, Jian-Wen Xu
Summary: Non-invasive brain stimulation (NIBS) has been used for motor function recovery, but its effects in spinal cord injury (SCI) populations are unclear. This meta-analysis aims to analyze the existing evidence on the effects and safety of NIBS for motor dysfunction after SCI, providing a reference for clinical decision-making.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Clinical Neurology
Gaia Bonassi, Elisa Pelosin, Giovanna Lagravinese, Ambra Bisio, Giorgio Grasselli, Marco Bove, Laura Avanzino
Summary: The study showed that when peripheral electrical stimulation was delivered 25 and 35 ms earlier to the ipsilateral cerebellum in healthy subjects, there was a significantly weaker cerebellar brain inhibition (CBI). This suggests that somatosensory inputs may modulate the inhibitory effect of the cerebellum on the primary motor cortex.
CLINICAL NEUROPHYSIOLOGY
(2021)
Review
Neurosciences
Jose Antonio Camacho-Conde, Maria del Rosario Gonzalez-Bermudez, Marta Carretero-Rey, Zafar U. Khan
Summary: Brain stimulation has become a widely accepted therapeutic approach in recent years, with non-invasive techniques like rTMS and tDCS, as well as invasive techniques like DBS, being commonly used to treat various neurological disorders. Technological advancements have led to the development of precise devices capable of producing well-controlled and effective brain stimulation.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Neurosciences
Milan Pantovic, Lidio Lima de Albuquerque, Sierra Mastrantonio, Austin S. Pomerantz, Erik W. Wilkins, Zachary A. Riley, Mark A. Guadagnoli, Brach Poston
Summary: Transcranial direct current stimulation (tDCS) applied to the primary motor cortex (M1) improves motor learning in relatively simple motor tasks performed with the hand and arm, but its effect on complex motor tasks involving whole-body coordination is unclear. This study found that tDCS applied over multiple days can improve motor learning in a complex overhand throwing task.
Article
Pharmacology & Pharmacy
Shane M. Fresnoza, Giorgi Batsikadze, Lynn Elena Mueller, Constanze Rost, Michael Chamoun, Walter Paulus, Min-Fang Kuo, Michael A. Nitsche
Summary: Dopamine plays a crucial role in neuroplasticity and has dosage-dependent effects on motor cortex plasticity. Different dosages of dopamine precursor such as L-DOPA can either impair, abolish, preserve, or reverse plasticity in healthy individuals. Similarly, selective D1-like and D2-like receptor activation has excitatory and inhibitory effects on plasticity. However, the effects of nonselective dopamine agonists like apomorphine on plasticity have not been extensively explored in humans.
Article
Public, Environmental & Occupational Health
A. N. M. Ehtesham Kabir, Sharmin Afroze, Zubair Amin, Agnihotri Biswas, Sabina Ashrafee Lipi, Mahbuba Khan, Khaleda Islam, Shamsul Haque, M. A. K. Azad Choudhury, Mohammod Shahidullah
Summary: The national kangaroo mother care programme in Bangladesh has shown positive outcomes from 2016 to 2020, with an increase in facilities and decent coverage. Mortality of babies receiving kangaroo mother care has been decreasing, but post-discharge follow-up remains low.
BULLETIN OF THE WORLD HEALTH ORGANIZATION
(2022)
Article
Clinical Neurology
Akhil Mohan, Jayme S. Knutson, David A. Cunningham, Morgan Widina, Kyle O'Laughlin, Tarun Arora, Xin Li, Ken Sakaie, Xiaofeng Wang, Ken Uchino, Ela B. Plow
Summary: This study aims to investigate the potential benefits of combining Contralaterally Controlled Functional Electrical Stimulation (CCFES) with a new rTMS approach that stimulates intact, contralesional higher motor cortices (cHMC) on severely impaired stroke survivors. By targeting spared neural substrates and engaging the unimpaired limb in movement of the impaired limb, a more favorable effect on paretic upper limb function is anticipated.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Jean-Marc Therrien-Blanchet, Marie Chantal Ferland, Meriem Badri, Marie-Andree Rousseau, Amira Merabtine, Emelie Boucher, Lydia Helena Hofmann, Jean-Francois Lepage, Hugo Theoret
Summary: This study investigated three non-invasive brain stimulation techniques, namely Paired Associative Stimulation (PAS), Transcranial Direct Current Stimulation (tDCS), and Transcranial Alternating Current Stimulation (tACS), for modulating cortical excitability. The results showed that these stimulation protocols had heterogeneous and variable effects on cortical excitability, and did not significantly modulate corticospinal excitability. Approximately 41% of participants showed increased corticospinal excitability in response to the interventions.
Article
Materials Science, Biomaterials
Hamzah Magsood, R. L. Hadimani
Summary: Transcranial magnetic stimulation (TMS) is a non-invasive technique used for diagnosis and treatment of neurological conditions, but the lack of realistic physical models has hindered the development of new protocols. A research team has developed an accurate brain and head phantom for testing TMS effects, created through segmentation of MRI images and filling with conductive polymer, with SEM images and voltage measurements confirming its anatomical accuracy.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Orthopedics
Robert Alfaro, Kevin Kinter, Alexander Mihas, Grettel Castro, Pura Rodriguez, Juan Zevallos, Adel Elkbuli, Noel Barengo, Juan Ruiz-Pelaez
Summary: The study found that Hispanic ethnicity was associated with a higher likelihood of postoperative complications in obese patients undergoing total knee arthroplasty compared to non-Hispanics. Hispanic patients were more likely to receive transfusion and have prolonged length of stay, but less likely to experience wound disruption.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2021)
Editorial Material
Pediatrics
Adriana Montealegre-Pomar, Nathalie Charpak
Article
Pediatrics
Nathalie Charpak, Rejean Tessier, Juan Gabriel Ruiz, Felipe Uriza, Jose Tiberio Hernandez, Darwin Cortes, Adriana Montealegre-Pomar
Summary: This study aimed to determine whether providing Kangaroo mother care (KMC) in infancy affected brain volumes in young adulthood. The results showed that the volumes of the main brain structures associated with intelligence, attention, memory, and coordination were larger in the group that had received KMC. Multivariate linear regression analysis demonstrated the direct relationship between brain volumes and duration of KMC.
Article
Cardiac & Cardiovascular Systems
Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Juan Carlos Zevallos, Juan Gabriel Ruiz Pelaez, Sandra Chaparro, Javier Jimenez Carcamo
Summary: This study examined the management, outcomes, and resource use of frail patients hospitalized for ST-segment elevation myocardial infarction (STEMI). The findings showed that frail patients had lower odds of overall revascularization and coronary angiography, but higher odds of receiving coronary artery bypass grafting and hemodynamic support. Frail patients also had higher in-hospital mortality, longer length of stay, and higher costs. The study suggests that collaborative efforts can improve management strategies, resource use, and patient outcomes.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Juan Carlos Zevallos, Juan Gabriel Ruiz-Pelaez, Md Ashfaq Ahmed, Zhenwei Zhang, Peter McGranaghan, Emir Veledar, Javier Jimenez, Sandra Chaparro
Summary: Myocarditis is significantly associated with higher in-hospital mortality and adverse hospital outcomes among patients with COVID-19. The rate of in-hospital mortality is higher in COVID-19 hospitalizations with myocarditis, and the survival rate is lower. Myocarditis is also significantly associated with increased odds of cardiac arrest, cardiogenic shock, mechanical ventilation, and acute respiratory distress syndrome. Early suspicion of myocarditis is important for prompt diagnosis and management.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Juan Gabriel Ruiz Pelaez, Sandra Chaparro, Javier Jimenez
Summary: This study assessed the impact of COVID-19 on percutaneous coronary artery intervention (PCI) and coronary artery bypass grafting (CABG) hospitalizations. It found that there was a decrease in PCI and CABG hospitalizations from 2019 to 2020, while viral pneumonia hospitalizations increased. The study emphasizes the importance of implementing initiatives to encourage patients to receive treatments and control the spread of COVID-19 to improve PCI and CABG hospitalizations.
CORONARY ARTERY DISEASE
(2023)
Article
Economics
Darwin Cortes, Dario Maldonado, Juan Gallego, Nathalie Charpak, Rejean Tessier, Juan Gabriel Ruiz, Jose Tiberio Hernandez, Felipe Uriza, Julieth Pico
Summary: This study compares the educational effects of Traditional Care (TC) and Kangaroo Mother Care (KMC) on the long-term consequences of prematurity or low birth weight. The results show that KMC has a greater impact on preschool attendance and school absenteeism compared to TC, but has a weaker effect on math test scores.
JOURNAL OF HEALTH ECONOMICS
(2022)
Article
Gerontology
Muni Rubens, Venkataraghavan Ramamoorthy, Anshul Saxena, Juan G. Ruiz-Pelaez, Md Ashfaq Ahmed, Zhenwei Zhang, Peter McGranaghan, Sandra Chaparro, Javier Jimenez
Summary: This study found that including frailty as a risk factor in comorbidity-based models can significantly improve the predictability of unplanned 30-day readmission and in-hospital mortality among heart failure patients.
JOURNAL OF AGING AND HEALTH
(2023)
Article
Computer Science, Information Systems
Duvan A. Gomez, Nathalie Charpak, Adriana Montealegre, Jose Tiberio Hernandez
Summary: Visual data analysis helps experts explore relationships, patterns, outliers, and unexpected changes in different phenomena. In longitudinal studies, this becomes more important due to complex processes and a large number of variables. VALS, a framework for visually exploring longitudinal clinical data, includes a data model, task categorization, feature engineering techniques, and interactive visualizations. Developed in collaboration with healthcare experts, a VALS-based tool prototype was shown to be useful in a real-world case study.
Article
Medicine, General & Internal
Alexandra Galbo, Nicole Izhakoff, Connor Courington, Grettel Castro, Juan Lozano, Juan Ruiz-Pelaz
Summary: This study investigates the association between the use of e-cigarettes during pregnancy and unfavorable birth outcomes, using data from the Pregnancy Risk Assessment Monitoring System. The findings suggest that women who reported e-cigarette use during pregnancy had a 62% increased odds of experiencing unfavorable birth outcomes.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Muni Rubens, Sandra Chaparro, Anshul Saxena, Juan Gabriel Ruiz-Pelaez, Juan Zevallos, Javier Jimenez
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Muni Rubens, Sandra Chaparro, Anshul Saxena, Juan Gabriel Ruiz-Pelaez, Juan Carlos Zevallos, Javier Jimenez
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Justin J. Cheng, Bu Jung Kim, Catherine Kim, Pura Rodriguez de la Vega, Marcia Varella, Carolyn D. Runowicz, Juan Ruiz-Pelaez
Summary: This study found that insurance status did not significantly impact the effect of race on ovarian cancer survival, but the extent of disease did. Ovarian cancer mortality was similar between non-Hispanic black and non-Hispanic white women with distant disease, but higher in non-Hispanic black women with regional disease. Further research is recommended to investigate the reasons behind this disparity.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
