期刊
ACTA OTO-LARYNGOLOGICA
卷 129, 期 3, 页码 297-301出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/00016480802225884
关键词
Allergic rhinitis; thymic stromal lymphopoietin; T cell; cytokine; interleukin-4
资金
- National Natural Science Fund of China [30672302, 30700935]
- Natural Science Fund of Hainan Province [30632]
Conclusion. Thymic stromal lymphopoietin (TSLP) played an important role in the pathogenesis of allergic rhinitis (AR) and can be regarded a potential therapeutic target for the management of AR. Objective. To evaluate the possible role of TSLP in the pathogenesis of AR. Patients and methods. We enrolled 16 patients of AR to investigate the expression of TSLP in nasal mucosa and evaluate the link of TSLP and interleukin-4 (IL-4). Expression of TSLP was detected by immunohistochemical analysis and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), and concentrations of TSLP and IL-4 were measured by enzyme-linked immunosorbent assay (ELISA). Results. TSLP was detected in all samples and the mRNA and protein expression of TSLP is increased significantly in AR nasal mucosa compared with normal control (P0.05). TSLP production is tightly correlated with IL-4 and severity of AR (P0.05).
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