Article
Medicine, General & Internal
Ya-Hui Wei, Yu Cai, Bonnie N. K. Choy, Bai-Bing Li, Ruo-Shi Li, Chen Xing, Xia Wang, Tian Tian, Yuan Fang, Mei Li, Ying-Zi Pan
Summary: NTG patients showed higher DCR values compared to controls, with some DCRs being negatively correlated with CCT and IOP, while others were positively correlated with these factors. The cornea was more deformable in NTG compared to HTG or controls, indicating a potential biomechanical mechanism underlying glaucomatous optic neuropathy in NTG patients.
CHINESE MEDICAL JOURNAL
(2021)
Article
Ophthalmology
Thibaut Gaboriau, Remi Dubois, Boris Foucque, Florence Malet, Cedric Schweitzer
Summary: The purpose of this study was to compare the 24-hour intraocular pressure (IOP) related fluctuations monitoring between two groups of visual field progression rates in patients with open angle glaucoma (OAG). The results showed that patients with higher visual field progression rates had significantly higher amplitudes and absolute areas under the 24-hour monitoring curve. Therefore, this monitoring method can help adjust the treatment strategy for glaucoma earlier.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Health Care Sciences & Services
Wei-Yang Lu, Ci-Wen Luo, Shyan-Tarng Chen, Yu-Hsiang Kuan, Shun-Fa Yang, Han-Yin Sun
Summary: The study found that comorbidities such as hypotension, sleep disturbances, peptic ulcers, and allergic rhinitis are more highly associated with NTG than POAG.
Review
Medicine, General & Internal
Aditya Belamkar, Alon Harris, Francesco Oddone, Alice Verticchio Vercellin, Anna Fabczak-Kubicka, Brent Siesky
Summary: Primary open-angle glaucoma (POAG) is prevalent in aging Asian populations, with distinctive characteristics and genetic differences compared to other ethnicities. Further research is needed to improve treatment plans for this high prevalence of glaucoma in Asian populations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Electrical & Electronic
Ching Hymn Christopher Lee, I. K. Karunaratne, Yifan Wei, Zidong Chen, Iok Tong Chong, Yangfan Yang, Minbin Yu, D. C. C. Lam
Summary: The study demonstrated that continuous intraocular pressure profiles from chipless contact lens sensor can reduce noise, but may still be affected by noise from tears and eyelids in in vivo experiments. The newly designed dual-compliance, dual-element CLS effectively reduces the sensing noise of intraocular pressure.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Medicine, General & Internal
Younhea Jung, Kyoung Ohn, Heejong Shin, Si Eun Oh, Chan Kee Park, Hae-Young Lopilly Park
Summary: This study investigated the clinical factors associated with elevated TNF-alpha and its level in the aqueous humor of patients with open-angle glaucoma (OAG). It was found that a positive TNF-alpha level was associated with greater IOP fluctuation and higher systolic blood pressure in OAG patients. In NTG patients, a positive TNF-alpha level was associated with the presence of central scotoma.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Yousef Alqurashi, Mohamed Elsherif, Rosalia Moreddu, Magdalena Cieslak, Hemeth Dhaliwal, Khamis Essa, Haider Butt
Summary: Glaucoma is a leading cause of irreversible blindness, and intraocular pressure (IOP) is the most important biomarker for its diagnosis and monitoring. Current IOP monitoring techniques are invasive and inconvenient, while laser-processed contact lenses offer a potential solution for continuous and non-invasive monitoring of IOP variations.
APPLIED SCIENCES-BASEL
(2022)
Article
Biology
Jan Lestak, Martin Fus, Marain Rybar, Antonin Benda
Summary: The aim of this study was to compare the values of vessel density (VD) and perfusion parameters in the ophthalmic artery (OA) and central retinal artery (CRA) between hypertensive glaucoma (HTG) and normotensive glaucoma (NTG) patients. The results showed no differences in visual field (VF), VD, PSV-OA, and EDV-CRA between the two groups. However, statistically significant differences were observed in PSV of CRA, EDV of OA, and resistance index (RI) of both CRA and OA.
Review
Ophthalmology
Austin R. Fox, John H. Fingert
Summary: Glaucoma is a leading cause of irreversible blindness worldwide, characterized by optic nerve damage and visual field defects. While elevated intraocular pressure (IOP) is a significant risk factor, normal tension glaucoma (NTG) can occur within the normal range of IOP. Genetic mutations in optineurin (OPTN), TANK binding kinase 1 (TBK1), and myocilin (MYOC) have been identified as the primary causes of NTG. In this review, we examine pedigree studies and clinical features of NTG associated with these mutations.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
Article
Medicine, General & Internal
Antonio Maria Fea, Martina Menchini, Alessandro Rossi, Chiara Posarelli, Lorenza Malinverni, Michele Figus
Summary: The study investigated the efficacy and safety of the XEN63 implant in open-angle glaucoma patients, showing significant reduction in intraocular pressure and the need for hypotensive medications, with good short-term safety profile.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Jing Na He, Tsz Kin Ng, Shi Yao Lu, Pancy Oi Sin Tam, Poemen P. Chan, Clement C. Tham, Chi Pui Pang, Li Jia Chen, Wai Kit Chu
Summary: This study investigated the association between the ANGPT2 gene and primary open-angle glaucoma (POAG) in the Chinese population. The results showed that the SNP rs11775442 was associated with normal tension glaucoma (NTG) in the Hong Kong cohort, while rs13269021 was associated with NTG in males in the Shantou cohort. Further studies are needed to confirm the association between the ANGPT2 locus and NTG in Chinese males.
Article
Engineering, Electrical & Electronic
Miao Yuan, Zhiduo Liu, Xiaoting Wu, Haoyang Gou, Yugui Zhang, Xin Ning, Weijun Li, Zhaohui Yao, Yijun Wang, Weihua Pei, Hongda Chen
Summary: Intraocular pressure (IOP) is a key indicator for glaucoma, and real-time monitoring with microfluidic contact lens sensors offers flexibility, straightforward reading, and low cost. A high-sensitivity microfluidic contact lens sensor based on bilateral wall structure and dyed fish oil as the liquid indicator is developed, showing a sensitivity of 660 mu m/mmHg and a linear regression coefficient of 0.999 in the operating range of 10-30 mmHg. The sensor demonstrates stable response to IOP changes and synchronization with pressure in multiple cycles at a pressure change rate of 3 mmHg/s. With its high sensitivity, linearity, and flexibility, the sensor holds great potential for clinical application of IOP monitoring.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Ophthalmology
Ruyi Zhai, Jingyi Cheng, Huan Xu, Zhaobin Fang, Xu Chen, Siyu Qiu, Xinghuai Sun, Richard K. Lee, Ming Xiao, Xiangmei Kong
Summary: The mean amplitude of intraocular pressure excursion (MAPE) was found to be higher in primary open angle glaucoma patients compared to healthy volunteers, and it exhibited the highest score in PLS regressions evaluating visual field deficits. The area under the ROC curve for glaucoma detection using MAPE was 0.822, indicating its effectiveness in diagnosis.
Article
Genetics & Heredity
Hyun-Tae Shin, Byung Woo Yoon, Je Hyun Seo
Summary: Differences in allele frequencies associated with intraocular pressure related SNPs between Koreans and other ethnicities were observed, which may explain the high prevalence of open-angle glaucoma with normal intraocular pressure predominantly in Koreans and East Asians.
BMC MEDICAL GENOMICS
(2021)
Article
Ophthalmology
Naoki Tojo, Atsushi Hayashi
Summary: Among the intraocular pressure (IOP) indicators studied, the range of IOP fluctuation was the most important and significantly larger in normal tension glaucoma (NTG) eyes compared to non-glaucoma eyes, according to 24-hour IOP measurements with a contact lens sensor (CLS).
JOURNAL OF GLAUCOMA
(2022)
Article
Clinical Neurology
Fedele Dono, Stefano Consoli, Giacomo Evangelista, Annalisa Ricci, Mirella Russo, Claudia Carrarini, Angelo Di Iorio, Laura Bonanni, Francesca Anzellotti, Marco Onofrj, Stefano L. Sensi
Summary: This study evaluated the neuropsychiatric side effects of prophylactic use of levetiracetam (LEV), a third-generation anti-seizure medication, in patients with brain tumor-related epilepsy (BTRE). The results showed that compared to a group of BTRE patients, a group taking LEV as prophylaxis had higher severity of neuropsychiatric symptoms. The study emphasizes the importance of accurate epileptological evaluations in selecting patients who would benefit most from anti-seizure medication in brain tumor patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Health Policy & Services
Andrea Di Blasio, Teresa Morano, Federica Lancia, Gianluca Viscioni, Angelo Di Iorio, Simona Grossi, Ettore Cianchetti, Lucia Cugusi, Stefano Gobbo, Marco Bergamin, Anna D'Eugenio, Laura Masini, Massimo Rinaldi, Maria Teresa Scognamiglio, Anastasios Vamvakis, Giorgio Napolitano
Summary: The study aimed to compare the effects of personal feedback and online supervised physical exercise sessions on the sleep of breast cancer survivors, finding that a combination of both interventions could improve both the quality and quantity of sleep.
HOME HEALTH CARE SERVICES QUARTERLY
(2022)
Article
Clinical Neurology
Mirella Russo, Claudia Carrarini, Angelo Di Iorio, Raffaello Pellegrino, Amalia Cecilia Bruni, Salvatore Caratozzolo, Annalisa Chiari, Stefano Pretta, Camillo Marra, Maria Sofia Cotelli, Andrea Arighi, Giorgio G. Fumagalli, Tatiana Cataruzza, Francesca Caso, Cristina Paci, Mara Rosso, Serena Amici, David Giannandrea, Andrea Pilotto, Simona Luzzi, Annalisa Castellano, Fabrizia D'antonio, Antonina Luca, Giorgio Gelosa, Tommaso Piccoli, Marco Mauri, Federica Agosta, Claudio Babiloni, Barbara Borroni, Marco Bozzali, Massimo Filippi, Daniela Galimberti, Roberto Monastero, Cristina Muscio, Lucilla Parnetti, Daniela Perani, Laura Serra, Vincenzo Silani, Pietro Tiraboschi, Annachiara Cagnin, Alessandro Padovani, Laura Bonanni
Summary: The LBCRS and AT-DLB questionnaires have good accuracy in the diagnosis of DLB and enhance the interpretation of international consensus diagnostic criteria.
NEUROLOGICAL SCIENCES
(2022)
Article
Environmental Sciences
Raffaello Pellegrino, Angelo Di Iorio, Cristina Maria Del Prete, Giovanni Barassi, Teresa Paolucci, Lucrezia Tognolo, Pietro Fiore, Andrea Santamato
Summary: This study aimed to compare the effect of US-guided needling (UGN) to UGN plus Biocompatible Electrical Neurostimulation (BEN) in the treatment of calcific tendinopathy of the shoulder (CTS). The results showed significant improvement in self-perceived functional performance and reduction of shoulder pain in both groups, with a multiplicative effect observed.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Food Science & Technology
Cristina Maria Del Prete, Mattia Giuseppe Viva, Stefania De Trane, Fabrizio Brindisino, Giovanni Barassi, Alessandro Specchia, Angelo Di Iorio, Raffaello Pellegrino
Summary: This study conducted a cross-sectional analysis on patients with UMNS spasticity and found that women may require more attention to the treatment of spasticity in adductor muscles, especially the adductor group. According to the pattern of disability, patients with hemiparesis more frequently needed treatment in the upper limb, while patients with diplegia/double-hemiparesis more frequently required treatment in the adductor and crux muscles.
Article
Clinical Neurology
Fedele Dono, Giacomo Evangelista, Stefano Consoli, Davide Rodorigo, Mirella Russo, Claudia Carrarini, Martina Di Pietro, Maria Vittoria De Angelis, Massimiliano Faustino, Francesca Anzellotti, Marco Onofrj, Angelo Di Iorio, Stefano L. Sensi, Valerio Frazzini, Catello Vollono
Summary: The temporal lobe plays a central role in regulating the Central Autonomic Network and cardiovascular functions. This study suggests that Perampanel (PER) may increase vagal tone and have a cardioprotective effect by reducing the risk of cardiac arrhythmias.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Letter
Clinical Neurology
Claudia Carrarini, Dario Calisi, Matteo Alessandro De Rosa, Angelo Di Iorio, Damiano D'Ardes, Raffaello Pellegrino, Stefano Gazzina, Andrea Pilotto, Andrea Arighi, Tiziana Carandini, Annachiara Cagnin, Stefano Mozzetta, Maurizio Gallucci, Domenico Marco Bonifati, Cinzia Costa, Fabrizia D'Antonio, Giuseppe Bruno, Francesco Cipollone, Claudio Babiloni, Alessandro Padovani, Marco Onofrj, Laura Bonanni
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Roberto Paganelli, Alessia Paganelli, Graham Pawelec, Angelo Di Iorio
Summary: Natural antibodies against aggregation-prone proteins have been discovered in healthy individuals, and these proteins may play a pathogenic role in neurodegenerative diseases of ageing. The study examines the levels of natural antibodies to amyloid beta in Italian patients with Alzheimer's dementia, vascular dementia, non-demented Parkinson's disease patients, and healthy elderly controls. The results show that the levels of amyloid beta antibodies are similar in Alzheimer's patients compared to controls, but surprisingly reduced in Parkinson's disease patients, which may identify individuals more prone to amyloid aggregation.
Article
Geriatrics & Gerontology
Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Antimo Moretti, Giovanni Iolascon, Eleonora Sparvieri, Domiziano Tarantino, Toshiko Tanaka, Luigi Ferrucci
Summary: Aging is characterized by chronic low-level inflammation and is associated with geriatric syndromes such as sarcopenia and frailty. Leukocyte-derived ratios, specifically neutrophil-to-lymphocyte ratio (NL-ratio) and monocyte-to-lymphocyte ratio (ML-ratio), may be implicated in age-related mechanisms that affect body composition and muscle strength. Further studies are needed to determine their usefulness for early detection of sarcopenia, myosteatosis, and frailty in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Michele Abate, Raffaello Pellegrino, Angelo Di Iorio, Vincenzo Salini
Summary: The aim of this study was to evaluate the changes in vitamins, hormones, free radicals, and antioxidant substances during the season and their association with performance improvement after training. The results showed that athletes had better performance after training, but no significant relationships were found between vitamin and hormone levels and the performance improvement. However, there was an indirect relationship between oxidative stress and performance improvement.
Article
Health Care Sciences & Services
Giovanni Barassi, Maurizio Panunzio, Antonella Di Iulio, Angelo Di Iorio, Raffaello Pellegrino, Antonio Colombo, Giuseppe Di Stefano, Piero Galasso, Stefania Spina, Umberto Vincenzi, Andrea Santamato, Giorgio Scivoletto
Summary: The aim of this study was to evaluate the effects of integrated thermal rehabilitation care (ITRC) on postural balance and health-related quality of life in subjects with basic autonomy. The results showed that ITRC was able to improve postural balance and quality of life. Therefore, ITRC can be considered an effective treatment for a variety of musculoskeletal disorders.
Article
Geriatrics & Gerontology
Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Antimo Moretti, Giovanni Iolascon, Eleonora Sparvieri, Domiziano Tarantino, Luigi Ferrucci
Summary: The study finds that the collagen turnover marker P3NP is associated with changes in muscle density and physical performance. Participants with lower P3NP levels perform better in terms of muscle density and physical performance and have a lower risk of developing chronic degenerative age-related diseases. The interaction between P3NP and factors such as leptin, muscle density, and fat mass affects muscle density and physical performance.
Article
Endocrinology & Metabolism
Giovanni Barassi, Raffaello Pellegrino, Celeste Di Matteo, Loris Prosperi, Edoardo Di Simone, Celeste Marinucci, Noemi Pepe, Federico Papa, Marta Odorisio, Valentina Zincani, Ilaria Gabriella Micolucci, Ali Younes, Angelo Di Iorio
Summary: This study considered data from 10 patients with non-specific chronic low back pain. The patients underwent six sessions of electrical neuromodulation applied to the areas of the skin with the most perturbed electrical conduction. The study observed improvements in the balance of electrical activity, temperature, disability caused by chronic low back pain, and pressure-pain threshold.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Meeting Abstract
Clinical Neurology
S. Consoli, F. Dono, G. Evangelista, F. Anzellotti, M. Onofrj, A. Di Iorio, L. Bonanni, S. L. Sensi
Article
Medicine, General & Internal
Rossella D'Aloisio, Luca Di Antonio, Lisa Toto, Marco Rispoli, Angelo Di Iorio, Giancarlo Delvecchio, Rodolfo Mastropasqua
Summary: This study investigated the impact of oral administration of a combination of astaxanthin, lutein, folic acid, vitamin D3, and bromelain with antioxidants on choroidal blood flow in patients with age-related intermediate macular degeneration. Results showed significant differences in choroidal thickness and choriocapillary vessel density between the case group and control group after six months of supplementation.
MEDICINA-LITHUANIA
(2022)