Article
Ophthalmology
Naoya Imanaga, Nobuhiro Terao, Shozo Sonoda, Shota Sawaguchi, Yukihide Yamauchi, Taiji Sakamoto, Hideki Koizumi
Summary: The purpose of this study was to investigate the relationship between scleral thickness and choroidal structure in CSC eyes. The results showed a significant positive correlation between scleral thickness and the luminal/stromal ratio in the posterior choroid. Scleral thickness had a stronger correlation with the ratio compared to subfoveal choroidal thickness.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Kazuyoshi Okawa, Tatsuya Inoue, Ryo Asaoka, Keiko Azuma, Ryo Obata, Rei Arasaki, Shouko Ikeda, Arisa Ito, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono
Summary: Cigarette smoking is associated with increased SFCT in patients with CSC. Thicker choroid in smoking CSC patients may play an important role in modulating the disease. Age, SE, and past smoking history are key factors influencing SFCT.
Article
Multidisciplinary Sciences
Yihao Xia, Xiaodong Li, Jiaqi Zhang, Xuejun Xie
Summary: This study evaluated the choroidal vascularity index (CVI) in central serous chorioretinopathy (CSC) and found that CVI is increased in acute CSC eyes and fellow eyes. There was no significant difference in CVI between acute and chronic CSC eyes. The area selected for CVI calculation may influence the outcomes of the study and requires further research.
Article
Multidisciplinary Sciences
Hooshang Faghihi, Alireza Mahmoudi, Elias Khalili Pour, Nazanin Ebrahimiadib, Kaveh Fadakar, Fariba Ghassemi, Ahmad Mirshahi, Alireza Khodabande, Hassan Khojasteh, Fatemeh Bazvand, Mohammadreza Mehrabi Bahar, Hamid Riazi-Esfahani
Summary: This study investigated differences in choroidal biomarkers between avascular (aFIPED) and vascularized (vFIPED) flat irregular pigment epithelial detachments in eyes with chronic CSC. The results showed that vFIPED patients had lower SFCT and higher CVI compared to aFIPED patients. Measurement of CVI along with SFCT may help differentiate aFIPED from vFIPED in CSC patients.
Article
Medicine, General & Internal
Filippo Tatti, Claudio Iovino, Giuseppe Demarinis, Emanuele Siotto Pintor, Marco Pellegrini, Oliver Beale, Kiran Kumar Vupparaboina, Mohammed Abdul Rasheed, Giuseppe Giannaccare, Jay Chhablani, Enrico Peiretti
Summary: The aim of this study was to evaluate choroidal vascularity in unilateral central serous chorioretinopathy (CSC) using en face optical coherence tomography (OCT) images. The study included 40 eyes of 20 CSC patients and 20 eyes of 10 healthy individuals. The results showed no significant differences in choroidal vascularity index (CVI) between different layers of the choroid in CSC-affected eyes and fellow eyes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Ryoh Funatsu, Shozo Sonoda, Hiroto Terasaki, Hideki Shiihara, Naohisa Mihara, Juun Horie, Taiji Sakamoto
Summary: This study used UWF-OCT to analyze the choroidal morphological changes in CSC patients and found that the choroid is thicker in CSC patients, even in the peripheral areas. The macular choroidal thickening is more severe in the upper-dominant type of VVDP.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Enrico Borrelli, Marco Battista, Costanza Barresi, Domenico Grosso, Maria Cristina Gabela, Alberto Quarta, Andrea Saladino, Riccardo Sacconi, Lea Querques, Francesco Bandello, Giuseppe Querques
Summary: The purpose of this study was to quantitatively evaluate the inner and outer choroidal changes in the fellow eyes of patients with unilateral central serous chorioretinopathy (CSC). The results showed that both the choriocapillaris and stromal areas were increased in the unaffected eyes of unilateral CSC patients, along with a higher choroidal vascularity index. Additionally, the percentage and number of choriocapillaris flow deficits were also increased in these patients.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Etsuyo Horiguchi, Jun Takeuchi, Ryo Tomita, Keiko Asai, Yuyako Nakano, Hikaru Ota, Yosuke Taki, Yasuki Ito, Hiroko Terasaki, Koji M. Nishiguchi, Keiko Kataoka
Summary: This retrospective study evaluated choroidal hemodynamics after half-dose photodynamic therapy (PDT) for central serous chorioretinopathy (CSC) using laser speckle flowgraphy. The study found that half-dose PDT reduced choroidal blood flow in the treated area, with current smoking status blunting this effect.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Naomi Nishigori, Yuki Muraoka, Masaharu Ishikura, Takahiro Kogo, Naoko Ueda-Arakawa, Manabu Miyata, Hiroshi Tamura, Masayuki Hata, Ayako Takahashi, Masahiro Miyake, Akitaka Tsujikawa
Summary: We investigated the change in wide-field choroidal thickness in patients with central serous chorioretinopathy (CSC) after reduced fluence photodynamic therapy (rf-PDT). The study found that before treatment, all eyes showed choroidal thickening, and after rf-PDT, the choroidal thickness significantly decreased in the irradiated macular area as well as outside the arcade vessels in all quadrants. The choroidal thickness did not differ in the control group between the initial visit and follow-up.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Young Ho Kim, Boram Lee, Edward Kang, Jaeryung Oh
Summary: Subfoveal choroidal thickness was greater in acute CSC group compared to other groups while peripapillary choroidal thickness was significantly higher in acute and chronic CSC groups than in controls. Choroidal vascularity index outside the macula was increased in all eyes with both current and past history of CSC, suggesting potential implications for choroidal characteristics.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Review
Ophthalmology
Adrian T. T. Fung, Yi Yang, Andrew W. W. Kam
Summary: Central serous chorioretinopathy (CSC) is a common non-surgical retinopathy associated with fluid leakage. The exact cause is not fully understood, but changes in the choroid, sclera, and RPE have been observed. CSC can be divided into acute, chronic, and recurrent subtypes, and recent classifications include simple and complex based on RPE changes. Multimodal imaging is useful in the diagnosis and management of CSC and its complications. Treatment options include laser, medications, intravitreal therapy, and surgery, with argon laser and photodynamic therapy having the strongest evidence.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Beatriz Torrellas, Alejandro Filloy, Lihteh Wu, Jay Chhablani, Pedro Romero-Aroca
Summary: The aim of this study was to evaluate the effectiveness and safety of a yellow subthreshold laser for the treatment of chronic central serous chorioretinopathy. The best-corrected visual acuity improved in 93% of the patients and the subretinal fluid was completely reabsorbed in a majority of the patients after the treatment. Reductions were observed in choroidal thickness and layers, which might be responsible for the laser's effect on the inner choroidal vasculature. No laser-related complications were found.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Physiology
Yang Meng, Yishuang Xu, Lu Li, Yu Su, Lu Zhang, Changzheng Chen, Zuohuizi Yi
Summary: This study used wide-field swept-source OCT-Angiography to evaluate the choroidal thickness and choriocapillaris vascular density in eyes with central serous chorioretinopathy (CSC) compared to fellow eyes and healthy eyes. The results showed wide-field changes in choroidal thickness and choriocapillaris vascular density in eyes with CSC, suggesting the bilateral nature of the disease and the role of local factors in its development.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Aya Kamimura, Akiko Miki, Maya Kishi, Mina Okuda, Mayuka Hayashida-Hirano, Mari Sakamoto, Wataru Matsumiya, Hisanori Imai, Sentaro Kusuhara, Makoto Nakamura
Summary: The purpose of this study was to compare the two-year outcome of half-time photodynamic therapy in chronic central serous chorioretinopathy patients with and without choroidal neovascularization. The study found that htPDT was less effective in eyes with CNV regarding the recurrence and persistence of subretinal fluid.
Article
Ophthalmology
N. A. O. Y. A. Imanaga, N. O. B. U. H. I. R. O. Terao, S. H. O. T. A. Sawaguchi, T. A. M. A. K. Tamashiro, S. O. R. A. K. O. Wakugawa, Y. U. K. I. H. I. D. E. Yamauchi, H. I. D. E. K. I. Koizumi
Summary: This retrospective, cross-sectional study aimed to investigate the clinical factors related to the presence of loculation of fluid (LOF) in central serous chorioretinopathy (CSC). The study found that a thicker choroid and thicker sclera were associated with the presence of LOF in CSC. Age, sex, subfoveal choroidal thickness (SCT), and scleral thickness were also found to be related to LOF.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)