Review
Medical Laboratory Technology
Huiqing Liu, Xingqi Meng, Jinyuan Wang, Yi Wei, Jinru Tang, Xiaocan Lei, Weiguo He, Suyun Li
Summary: PCOS is an endocrinemetabolic disease affecting reproductive aged women, potentially leading to various complications. Recent studies have identified a protein called SAA that may be associated with PCOS, serving as a potential inflammatory biomarker.
CLINICA CHIMICA ACTA
(2021)
Article
Endocrinology & Metabolism
Marie-Louise Marschalek, Rodrig Marculescu, Christian Schneeberger, Julian Marschalek, Didier Dewailly, Johannes Ott
Summary: This study aimed to evaluate saliva stress markers and subjective psychological distress in women with polycystic ovary syndrome (PCOS). The results showed no significant differences in salivary biomarkers between PCOS women and healthy controls, but stress scores evaluated by questionnaires were significantly higher in PCOS women. BMI, hirsutism, and age appeared to be the main factors influencing subjective stress in PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Joanna Jurewicz, Joanna Majewska, Andrzej Berg, Katarzyna Owczarek, Radoslaw Zajdel, Dorota Kaleta, Andrzej Wasik, Dominik Rachon
Summary: This study evaluated the potential association between BPA and its analogues BPS and BPF with the diagnosis of PCOS. The results showed that serum BPS concentrations were significantly higher in women with PCOS, while no significant differences were found in serum BPA and BPF concentrations compared to control subjects. Furthermore, a negative correlation was found between serum BPA and metabolic parameters in women with PCOS.
ENVIRONMENTAL POLLUTION
(2021)
Article
Endocrinology & Metabolism
Yuanyuan Peng, Hongyue Yang, Jiahui Song, Di Feng, Zhijing Na, Hongyu Jiang, Yaxin Meng, Bei Shi, Da Li
Summary: This study analyzed the association between leptin and polycystic ovary syndrome (PCOS). The results showed that serum leptin levels were significantly higher in patients with PCOS and were associated with multiple metabolic markers. Combined detection of leptin and anti-Mullerian hormone (AMH) had high accuracy in diagnosing PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tianhe Li, Tingting Zhang, Huimin Gao, Ruixia Liu, Muqing Gu, Yuxi Yang, Tianyu Cui, Zhongbing Lu, Chenghong Yin
Summary: The study demonstrated that treatment with tempol alleviated ovarian dysfunction and glucose tolerance in PCOS rats, reduced intestinal oxidative stress, and modulated gut microbiota composition. Tempol intervention is suggested as a potential therapeutic approach for PCOS due to its ability to improve PCOS phenotype by restoring gut dysbiosis.
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Article
Obstetrics & Gynecology
Yanli Hong, Jiayun Wu, Simin Yu, Miao Hui, Sipei Lin
Summary: The interaction between obesity and insulin resistance in polycystic ovary syndrome (PCOS) may be related to miRNA regulation through exosomes. Overexpression of miR-20b-5p and miR-106a-5p in serum exosomes can inhibit adipocyte differentiation and alleviate insulin resistance in PCOS mouse models.
REPRODUCTIVE SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Natalia Wendland, Justyna Opydo-Szymaczek, Malgorzata Mizgier, Grazyna Jarzabek-Bielecka
Summary: The study found that there was no significant association between the pathogenicity of subgingival biofilms and PCOS in young patients. Certain microorganisms levels and infection rates were significantly higher in the control group compared to the PCOS group.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Biochemistry & Molecular Biology
Youngjae Ryu, Yong Jin Kim, Yoon Young Kim, Jungwoo Kim, Sung Woo Kim, Hoon Kim, Seung Yup Ku
Summary: This study successfully established a PCOS model in mice using STZ, with findings indicating that low doses of STZ can induce PCOS features without causing diabetes features. Different doses of STZ treatment had varying effects on body weight, blood glucose levels, and hormone levels in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Anna Bizon, Grzegorz Franik, Justyna Niepsuj, Marta Czwojdzinska, Marcin Lesniewski, Artur Nowak, Malwina Szynkaruk-Matusiak, Pawel Madej, Agnieszka Piwowar
Summary: This study aimed to evaluate the relationship between selected serum sex hormones and lipid profiles in women with PCOS, dividing them into different phenotypes, BMI values, and presence of hyperlipidemia. Significant associations were found between phenotype, BMI, hyperlipidemia, and androgen hormone concentrations, as well as changes in SHBG concentrations with triglyceride levels and HDL-C. However, estradiol concentration was not associated with lipid profile parameters. Overall, irregularities in sex hormone concentrations during PCOS may reflect the concentration of SHBG or the ratio of SHBG and total testosterone, rather than a direct association with lipid profile parameters.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Mala S. Sivanandy, Sierra K. Ha
Summary: Polycystic ovary syndrome (PCOS) is an endocrinological disorder with significant implications for women's reproductive, metabolic, and psychological health. The lack of a specific diagnostic test poses challenges in diagnosing PCOS, resulting in underdiagnosis and undertreatment. Anti-Mullerian hormone (AMH) appears to be a promising diagnostic marker for PCOS, with elevated levels correlating highly with PCOS features such as polycystic ovarian morphology, hyperandrogenism, and oligo/amenorrhea.
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Min Zhang, Chong Liu, Xiao-Qiong Yuan, Fei-Peng Cui, Yu Miao, Wen Yao, Dan-Yu Qin, Yan-Ling Deng, Pan-Pan Chen, Jia-Yue Zeng, Xiao-Ying Liu, Yang Wu, Cheng-Ru Li, Wen-Qing Lu, Yu-Feng Li, Qiang Zeng
Summary: Phthalate exposures are associated with increased prevalence of polycystic ovary (PCO) and polycystic ovary syndrome (PCOS).
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Chang Shan, Yu-chen Zhu, Jie Yu, Yi Zhang, Yu-ying Wang, Nan Lu, Jie Cai, Wei Liu, Tao Tao
Summary: This study found that Chinese women with PCOS have lower levels of vitamin D compared to controls, especially in those with hyperandrogenemia. Higher levels of 25(OH)D were independently associated with lower risks of hyperandrogenemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Yue Che, Jie Yu, Yu-Shan Li, Yu-Chen Zhu, Tao Tao
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, affecting fertility and increasing the risk of various health problems. The current understanding of its pathogenesis is still incomplete, leading to difficulties in accurate diagnosis and personalized treatment. This article summarizes the current findings on the genetic, epigenetic, gut microbiota, brain responses, and metabolomics aspects of PCOS, highlighting the challenges in phenotyping and potential treatment approaches. It also discusses the intergenerational transmission of PCOS, providing insights for better management in the future.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Matthias Zehnder, Georgios N. Belibasakis
Summary: This narrative review discusses the use of biomarkers in clinical Endodontic research, highlighting the importance of addressing clinical problems through suitable diagnostic biomarkers. The study focuses on two clinical issues, reversible versus irreversible pulpitis and persistent idiopathic dentoalveolar pain, to demonstrate the role of biomarkers in understanding complex dental pathologies and guiding appropriate treatment strategies.
INTERNATIONAL ENDODONTIC JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fabio R. M. Leite, Gustavo G. Nascimento, Holger J. Moller, Georgios N. Belibasakis, Nagihan Bostanci, Patricio C. Smith, Rodrigo Lopez
Summary: The study found that fast gingivitis development was associated with higher levels of non-organized response and lower levels of organized response, while slow responders were not associated with gingivitis. The results suggest that individual variability may play a role in susceptibility to gingivitis.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Engineering, Biomedical
Matthew Blakeley, Prashant K. Sharma, Hans J. Kaper, Nagihan Bostanci, Thomas Crouzier
Summary: Disruption of lubrication between oral surfaces due to salivary gland hypofunction can negatively impact quality of life. Research suggests that functionalizing polyethylene glycol with wheat germ agglutinin and immobilizing it on oral epithelial cells and tissue can mimic the salivary film, providing long-lasting relief from mucosal dryness.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Nilminie Rathnayake, Anders Gustafsson, Timo Sorsa, Anna Norhammar, Nagihan Bostanci
Summary: This study aimed to investigate whether salivary PGLYRP1 and associated molecules of the immune response is a cumulative outcome of both MI and periodontal inflammation. The results showed that MI patients had higher salivary PGLYRP1 levels, and the levels of PGLYRP1 in non-MI subjects were correlated with periodontal inflammation. Salivary PGLYRP1 concentrations also showed positive correlations with other inflammatory markers.
JOURNAL OF PERIODONTOLOGY
(2022)
Review
Microbiology
Preethi Balan, Georgios Belibasakis, Saso Ivanovski, Nagihan Bostanci, Chaminda Jayampath Seneviratne
Summary: The microbial etiology of periodontitis has been extensively studied, but the translation of this knowledge into therapeutic interventions is limited. This review emphasizes the need for innovative clinical interventions beyond conventional therapies and highlights the importance of understanding the structure and function of subgingival microbiota for developing microbiome-based interventions.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Georgios N. Belibasakis, Daniel Belstrom, Sigrun Eick, Ulvi K. Gursoy, Anders Johansson, Eija Koenoenen
Summary: This narrative review provides an overview of the collective knowledge on periodontal microbiology, with a focus on the European contribution in the global field. It discusses the etiological concepts of periodontal disease, particularly the ecological plaque hypothesis and its interpretation. The review also explores anaerobic microbiology, the discovery of periodontal pathogens and their virulence factors, as well as biofilms. Additionally, it highlights the evolution of molecular methods and high-throughput platforms in understanding the periodontal microbiome. Finally, the review examines the role of different microbial species in periodontal diagnosis, the use of microbial and host biomarkers, and the application of antimicrobials in treatment.
PERIODONTOLOGY 2000
(2023)
Article
Chemistry, Multidisciplinary
Felix J. Geissel, Varvara Platania, Niccolo DeBerardinis, Charlotte Skjoldebrand, Georgios N. Belibasakis, Cecilia Persson, Gry Hulsart-Billstrom, Maria Chatzinikolaidou, Georgios A. Sotiriou
Summary: Bone implants often fail due to bacterial colonization and loose biofilm infections. A novel nanoparticle coating composed of silver and bioglass has been developed to address these issues. The coating is produced using a scalable and reproducible process and exhibits both antibacterial and osteogenic properties. The silver-ion release inhibits biofilm formation, while the coating maintains high biocompatibility.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Microbiology
Ana Parga, Daniel Manoil, Malin Brundin, Ana Otero, Georgios N. Belibasakis
Summary: This study assessed the effect of AHLs on biofilm formation and transcriptional regulations in Enterococcus faecalis and found that AHLs promote biofilm formation and up-regulate a transcriptional network involved in virulence and stress tolerance.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Microbiology
Rolf Claesson, Anders Johansson, Georgios N. Belibasakis
Summary: The aim of this study was to compare the prevalence and proportions of three bacterial species in periodontitis pocket samples from young and old patients. The results showed that the prevalence of Aggregatibacter actinomycetemcomitans was higher in young patients, while Porphyromonas gingivalis was similarly distributed in both age groups. Parvimonas micra was more prevalent in old patients. Furthermore, the proportion of samples containing A. actinomycetemcomitans and P. micra together was higher than when P. gingivalis was present.
Article
Dentistry, Oral Surgery & Medicine
Nil Yakar, Nagihan Bostanci, Gueven Ozdemir, Harika Atmaca, Asena Turedi, Cagdas Sahin, Timur Kose, Gulnur Emingil
Summary: This study compared the levels of cytokines in saliva between postmenopausal and regularly menstruating women, and found that there was no significant difference after adjusting for other factors. Age may be a stronger confounding factor.
JOURNAL OF PERIODONTOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Nagihan Bostanci, Georgios N. N. Belibasakis
Summary: The interface of molecular science and technology is guiding the transformation of personalized to precision healthcare. The application of proteomics, genomics, transcriptomics, and metabolomics is shaping the suitability of biomarkers for disease. Incorporation of molecular discoveries into routine clinical practice relies on the development of customized assays and devices that enable the rapid delivery of analytical data to the clinician, while the patient is still in session.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Rolf Claesson, Anders Johansson, Georgios N. Belibasakis
Summary: Diagnosis and treatment in dentistry rely on clinical examination, but microbiological analysis can provide supportive evidence to aid decision-making. Clinical microbiology can improve treatment outcomes for conditions such as periodontitis, endodontic infections, and odontogenic abscesses.
FRONTIERS IN ORAL HEALTH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Hazel Ozuna, Ian Snider, Georgios N. Belibasakis, Jan Oscarsson, Anders Johansson, Silvia M. Uriarte
Summary: Periodontitis is an imbalanced disease caused by the interaction between the microbial ecosystem and the host immune response. The disease-associated microbial community consists of known oral pathogens and newly emerging species, which grow within the periodontal pocket and evade the host immune response. This review focuses on the virulence factors and potential pathogenicity of these oral pathogens in periodontitis, highlighting the recent discovery of virulence factors in Filifactor alocis and comparing them with those associated with Aggregatibacter actinomycetemcomitans. Synergistic and/or mutualistic interactions between these oral pathogens might contribute to disease progression.
FRONTIERS IN ORAL HEALTH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Timo Sorsa, Solomon Olusegun Nwhator, Dimitra Sakellari, Andreas Grigoriadis, Kehinde Adesola Umeizudike, Ella Brandt, Mutlu Keskin, Taina Tervahartiala, Pirjo Parnanen, Shipra Gupta, Ritin Mohindra, Nagihan Bostanci, Nurcan Buduneli, Ismo Tapani Raisanen
Summary: The manuscript highlights the benefits of active-matrix metalloproteinase-8 (aMMP-8) chairside/point-of-care diagnostic tools in oral and systemic diseases. Previous studies support aMMP-8 as a more precise biomarker compared to other markers. The lateral flow aMMP-8 point-of-care testing shows comparable results to protease activity assays and can be applied in various medical fields.
FRONTIERS IN ORAL HEALTH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Georgios N. N. Belibasakis, George Hajishengallis
Summary: The 2nd International Conference on Oral Mucosal Immunity and the Microbiome (OMIM) was held successfully with the participation of 29 international speakers. This conference, being the first conference travel in the post-pandemic era, holds significant importance for academic exchange in the field of oral health.
FRONTIERS IN ORAL HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Binbin Chang, Zhang Wang, Hui Cheng, Tingyuan Xu, Jieyu Chen, Wan Wu, Yizhi Li, Yong Zhang
Summary: Acacetin can attenuate sepsis-induced ALI by inhibiting the inflammatory response and promoting macrophage polarization. This study is of great significance for the development of new treatments for sepsis-induced ALI.
Review
Biochemistry & Molecular Biology
Nikoleta Bizymi, Andreas M. Matthaiou, Irene Mavroudi, Aristea Batsali, Helen A. Papadaki
Summary: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that have immunomodulatory properties. They interact extensively with other innate or adaptive immune cells and can either enhance or attenuate immune responses depending on the triggering conditions. However, their positive role in host defense mechanisms is rarely discussed in the literature.