Article
Ophthalmology
Afiqq Aiman Abd Ghapor, Igor Iezhitsa, Renu Agarwal, Nurul Alimah Abdul Nasir
Summary: Trans-resveratrol (TR) protects against retinal and optic nerve damage caused by NMDA-induced changes by preventing retinal cell apoptosis.
CURRENT EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Chun-Yuan Cheng, Lassina Barro, Shang-Ting Tsai, Tai-Wei Feng, Xiao-Yu Wu, Che-Wei Chao, Ruei-Siang Yu, Ting-Yu Chin, Ming Fa Hsieh
Summary: The use of EGCG-loaded liposomes can effectively inhibit neuroinflammation induced by LPS, protect neurons, and improve motor impairment. This treatment approach has the potential to be a valuable candidate for disease-modifying therapy for Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Rebekka Rust, Claudia Chien, Michael Scheel, Alexander U. Brandt, Jan Dorr, Jens Wuerfel, Katharina Klumbies, Hanna Zimmermann, Mario Lorenz, Klaus-Dieter Wernecke, Judith Bellmann-Strobl, Friedemann Paul
Summary: In a randomized trial involving 61 patients with progressive multiple sclerosis, treatment with epigallocatechin gallate did not slow the progression of brain atrophy or improve clinical and radiologic disease activity markers, but demonstrated a good safety profile.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Review
Neurosciences
Shuang Chen, Da Xu, Liu Fan, Zhi Fang, Xiufeng Wang, Man Li
Summary: This article reviews the regulation of NMDAR and its possible mechanisms in epilepsy, discussing the role of NMDAR in onset, development, and treatment, and providing more evidence for future studies.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Maria S. Hadjiagapiou, George Krashias, Christina Christodoulou, Marios Pantzaris, Anastasia Lambrianides
Summary: Synaptic dysfunction and disrupted communication between neuronal and glial cells are essential in the mechanisms of multiple sclerosis. Antibodies to the NR2 subunit of NMDAR were detected in MS patients and were correlated with clinical outcome. Furthermore, there may be a link between NR2 reactivity and anti-coagulant antibody levels in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Victor Valverde-Salazar, Daniel Ruiz-Gabarre, Vega Garcia-Escudero
Summary: Alzheimer's disease (AD) is a common form of dementia characterized by memory decline, cognitive impairment, and several pathological changes in the brain. Oxidative stress and inflammation play important roles in the development of AD. Green tea and its active compound EGCG have shown potential therapeutic effects in modulating AD through their antioxidative and anti-inflammatory properties. EGCG can regulate inflammatory processes, reduce protein aggregation, and promote neuronal survival pathways, making it a suitable candidate for the treatment of neurodegenerative disorders involving oxidative stress and inflammation.
Article
Biotechnology & Applied Microbiology
Yiming Wang, Wenqi Luo, Feng Lin, Wanguo Liu, Rui Gu
Summary: EGCG-Se NP shows superior neuroprotective effect in spinal cord injury (SCI) through scavenging reactive oxygen species (ROS) and attenuating inflammation, making it a promising and effective treatment option.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Rafael Rivas-Santisteban, Alejandro Lillo, Jaume Lillo, Joan-Biel Rebassa, Joan S. Contesti, Carlos A. Saura, Rafael Franco, Gemma Navarro
Summary: The study revealed the formation of complexes between cannabinoid CB2 receptors and NMDA receptors, and demonstrated that cannabinoids can modulate NMDA receptor function. Activation of CB2 receptors inhibited NMDA receptor-mediated signaling in activated primary microglia and hippocampal neurons from APP(Sw/Ind) mice. Overexpression of macromolecular CB2-NMDA receptor complexes in brain slices and primary cells from APP(Sw/Ind) mice indicates a potential tool for modulating excessive glutamate input by cannabinoids.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Casey J. Keuthan, Julie A. Schaub, Meihan Wei, Weixiang Fang, Sarah Quillen, Elizabeth Kimball, Thomas V. Johnson, Hongkai Ji, Donald J. Zack, Harry A. Quigley
Summary: The level of intraocular pressure (IOP) is a major risk factor for glaucomatous optic neuropathy. This study found that the unmyelinated optic nerve region is differentially susceptible to IOP-induced damage compared to the myelinated region. Gene expression patterns in the unmyelinated optic nerve showed significant differences compared to the myelinated optic nerve and retina. Changes in gene expression induced by optic nerve injury were more extensive in the myelinated region than the unmyelinated region.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Judith Bellmann-Strobl, Friedemann Paul, Jens Wuerfel, Jan Doerr, Carmen Infante-Duarte, Elmira Heidrich, Benedict Koertgen, Alexander Brandt, Caspar Pfuller, Helena Radbruch, Rebekka Rust, Volker Siffrin, Orhan Aktas, Christoph Heesen, Juergen Faiss, Frank Hoffmann, Mario Lorenz, Benno Zimmermann, Sergiu Groppa, Klaus-Dieter Wernecke, Frauke Zipp
Summary: In patients with RRMS, adding oral EGCG to GA did not show superiority over placebo in affecting MRI and clinical disease activity. Despite indications of EGCG bioavailability, it did not influence immune parameters. However, treatment with up to 800 mg of EGCG daily was safe and well tolerated.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Ophthalmology
Mona Safizadeh, Amirreza Shaabani, Alireza Kamalipour, Masoud Aghsaei Fard, Kaileen Yeh, Mehdi Yaseri, Nikoo Hamzeh, Nassim Khatibi, Harsha Laxmana Rao, Robert Weinreb, Sasan Moghimi
Summary: OCTA can be used to detect reduced capillary density in fellow eyes of PXG patients, enabling earlier detection of glaucomatous loss in pseudoexfoliation disease and enhancing disease management.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dong-Ju Park, Ju-Bin Kang, Murad-Ali Shah, Phil-Ok Koh
Summary: The study demonstrated that EGCG exerts neuroprotective effects in ischemic brain damage by regulating thioredoxin expression and modulating the interaction between ASK1 and thioredoxin.
NEUROCHEMICAL RESEARCH
(2021)
Article
Ophthalmology
Thanadet Chuangsuwanich, Tin A. Tun, Fabian A. Braeu, Xiaofei Wang, Zhi Yun Chin, Satish K. Panda, Martin Buist, Dan Milea, Nicholas Strouthidis, Shamira Perera, Monisha Esther Nongpiur, Tin Aung, Michael J. A. Girard
Summary: This study aimed to assess the strains in optic nerve head (ONH) induced by intraocular pressure (IOP) and gaze in subjects with high-tension glaucoma (HTG) and normal-tension glaucoma (NTG). The results showed that NTG subjects experienced higher strains due to gaze, while HTG subjects experienced higher strain due to IOP elevation, and these differences were most pronounced in the lamina cribrosa (LC) tissue.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Jing Zhao, Graydon Gonsalvez, Manuela Bartoli, Barbara A. Mysona, Sylvia B. Smith, Kathryn E. Bollinger
Summary: The study evaluated the ability of S1R to modulate reactivity responses of optic nerve head astrocytes (ONHAs) and found that S1R activation enhanced ONHA reactivity characteristics, which may have important implications for the survival of retinal ganglion cells.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Yue Zhang, Kai Cao, Ruiqi Pang, Ning Wang, Xin Qu, Jun Kang, Ningli Wang, Hanruo Liu
Summary: The area of the ONSAS obtained by transorbital ultrasonography can accurately evaluate the intracranial pressure (ICP), and a mathematical formula considering BMI and MABP as contributing parameters is the best predictive model.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)