Article
Biochemistry & Molecular Biology
Evelin Patko, Edina Szabo, Alexandra Vaczy, Dorottya Molitor, Eniko Tari, Lina Li, Adrienne Csutak, Gabor Toth, Dora Reglodi, Tamas Atlasz
Summary: Despite the high probability of glaucoma-related blindness, the cause of glaucoma and effective therapeutic strategies for neuroprotection remain unclear. However, vascular factors are believed to play a significant role in glaucoma development. This study investigated the protective effects of PACAP1-38 on the retinal vasculature and molecular changes in hypoxia in a microbeads model of ocular hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Mohammad Shamsul Ola, Ahmed Z. Alanazi, Ajmaluddin Malik, Abdul Malik, Mohammed Ahmed, Salim S. Al-Rejaie, Abdullah S. Alhomida
Summary: Diabetic retinopathy is a major cause of blindness and its prevalence is increasing with the diabetes pandemic. Early neurodegeneration caused by oxidative stress has been identified as a key factor in microvascular damage in the diabetic retina. Phytochemicals with high antioxidant properties have shown promise in preventing and treating diabetes-induced retinal damage.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Maria Consiglia Trotta, Sami Gharbia, Hildegard Herman, Bianca Mladin, Andrei Hermenean, Cornel Balta, Coralia Cotoraci, Victor Eduard Peteu, Carlo Gesualdo, Francesco Petrillo, Marilena Galdiero, Roberto Alfano, Mihaela Gherghiceanu, Michele D'Amico, Settimio Rossi, Anca Hermenean
Summary: The study found that aged mice had decreased endogenous levels of RvD1 in the retina, as well as sex-related differences in neuroinflammation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Junkai Tan, Guo Liu, Chunlin Lan, Iok-Hou Pang, Xiaolin Luo, Shen Wu, Ning Fan, Jingxue Zhang, Ningli Wang, Xuyang Liu
Summary: The study demonstrates that LV-mediated C3 transgene expression has neuroprotective effects on retinal ischemia/reperfusion injury in rats, potentially serving as a novel neuroprotective approach for certain retinopathies.
Article
Biochemistry & Molecular Biology
Edward Xie, Urooba Nadeem, Bingqing Xie, Mark D'Souza, Dinanath Sulakhe, Dimitra Skondra
Summary: Using a computational bioinformatics approach, we identified drug/chemical classes associated with retinal neuroprotection and found potential treatments such as anti-diabetics, lipid-lowering medicines, and antioxidants that could be repurposed for retinal neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Siqi Li, Qiuyi Song, Bin Wu, Guanghan Kan, Fei Wang, Jiawei Yang, Siquan Zhu
Summary: This study used prolonged tail suspension to simulate microgravity in space and observed the potential eye health impacts on rats. The results showed significant choroidal thickening, optic nerve demyelination, reduced survival of retinal ganglion cells, and fluctuations in intraocular pressure. The severity of these changes increased with longer suspension time.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Waleed M. Renno, Mohammad Afzal, Bincy Paul, Divya Nair, Jijin Kumar, Jassim M. Al-Hassan
Summary: Preparations from the epidermal gel secretion of Arabian Gulf catfish showed potent anti-inflammatory and healing properties in clinical trials for diabetic foot ulcers and other disorders. A unique protein and lipid preparation from the catfish secretion accelerated the healing of nerve injuries in rats, enhancing neurobehavioral performance and histomorphological regeneration. SPF-FB treatment decreased neurobehavioral deficits, promoted axonal regeneration, and protected spinal neurons by modulating astrocytic activity and GAP-43 expression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pediatrics
Jaylyn Waddell, Nicholas C. Rickman, Min He, Ningfeng Tang, Cynthia F. Bearer
Summary: This study investigates the impact of neonatal exposure to hypoxic-ischemic encephalopathy (HIE) on membrane protein distribution in the cerebellum. The results showed that HIE significantly affects the percentage of L1 cell adhesion molecule in lipid rafts, with no effect from hypothermia treatment. This article explores potential new treatments and addresses the limitations of current treatments for HIE.
PEDIATRIC RESEARCH
(2022)
Article
Food Science & Technology
Pinghui Wei, Meiqin He, Ying Wang, Guoge Han
Summary: High-fat diet accelerates choroidal neovascularization in age-related macular degeneration. This study investigates the effects of high-fat diet on retinal and retinal pigment epithelium/choroidal acylcarnitine metabolism. The results show that high-fat diet promotes weight gain, dyslipidemia, and neovascular formation, accompanied by different changes in isomerism of metabolites.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Behavioral Sciences
Roxana Noriega-Navarro, Ricardo Jesus Martinez-Tapia, Ruben Gonzalez-Rivera, Alicia Ochoa-Sanchez, Julio Cesar Abarca-Magana, Lucia Landa-Navarro, Veronica Rodriguez-Mata, Perla Ugalde-Muniz, Armando Perez-Torres, Abraham Landa, Luz Navarro
Summary: This study examined the effects of recombinant human thioredoxin 1 (rhTrx1) on rats with traumatic brain injury (TBI) using the controlled cortical impact (CCI) model. The results showed that rats subjected to TBI in the light phase exhibited more severe body weight loss, reduced food intake, spontaneous pain, motor impairment, and neuronal damage in specific hippocampus and striatum regions. However, rats treated with rhTrx1 and those subjected to TBI in the dark phase showed better recovery in body weight, food intake, motor impairment, and pain after three days.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Di Li, Yan Zhang, Lina Lu, Ling Zhang, Jialing Ma, Jiaxuan Ji, Haiying Li, Gang Chen
Summary: Sec22b may play a neuroprotective role after TBI by upregulating autophagy levels, reducing cell apoptosis, neurological deficits, and blood-brain barrier permeability.
BRAIN RESEARCH BULLETIN
(2021)
Review
Immunology
Sean K. Wang, Constance L. Cepko
Summary: This review discusses the roles of microglia in various eye disorders and explores the potential of targeting microglia for disease treatment. Different approaches include depleting microglia, reprogramming microglia, and inhibiting their downstream effects. Future research is needed to fully utilize the therapeutic value of microglia in eye diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Serhat Imamoglu, Ebru Yalin Imamoglu, Serkan Erdenoz, Alev Cumbul, Unal Uslu, Samil AktaS, Fahri Ovali
Summary: The study showed that magnesium sulfate could reduce apoptosis, preserve RGCs, and decrease retinal VEGFR-2 and GFAP expressions in a preterm hypoxic-ischemic rat model.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Surgery
Juan San Cristobal Epalza, Teodoro Palomares, Ignacio Garcia-Alonso, Borja Herrero de la Parte
Summary: This study introduced a new retinal IR model in rats based on CRAO, achieved by increasing IOP. Histological examination of retinal samples revealed visible damage and dendritic swelling, with an increase in the number of cells showing cytoplasmic swelling after inducing IOP to 150 mm Hg. The proposed model is considered reliable for studying drugs to prevent retinal IR injury.
EUROPEAN SURGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Susanne Buerger, Jie Meng, Annette Zwanzig, Mike Beck, Maik Pankonin, Peter Wiedemann, Wolfram Eichler, Jan Darius Unterlauft
Summary: The study demonstrates that both PEDF receptors, PEDF-R and LR, are co-expressed in RGC and R28 retinal precursor cells, and their expression is upregulated by VEGF and under hypoxic conditions. These receptors mediate the pro-survival effects of PEDF on RGC by enhancing the expression of anti-apoptotic and neuroprotective factors. This highlights the importance of both PEDF receptors for the viability of retinal neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)