Article
Pharmacology & Pharmacy
Sachin Nashik Sanap, Amol Chhatrapati Bisen, Anjali Mishra, Arpon Biswas, Sristi Agrawal, Karan Singh Yadav, Atul Krishna, Sidharth Chopra, Madhav Nilakanth Mugale, Rabi Sankar Bhatta
Summary: A QbD approach was used to formulate nanoliposomes (NLs) for controlled drug release of antifungal drug fluconazole (FCZ). The optimized FCZ-NLs showed higher drug permeation flux and availability compared to the marketed formulation, indicating their potential as an ocular drug delivery system.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rapee Jarungsirawat, Wanassnant Kajthunyakarn, Chaipat Siriwachirachai, Thaned Pongjanyakul
Summary: The study formulates and evaluates fluconazole tablets for preparing a disinfectant mixture with anticandidal activity, providing a solution for preventing denture stomatitis caused by Candida species.
Article
Biochemistry & Molecular Biology
Amy R. Biermann, Elora G. Demers, Deborah A. Hogan
Summary: Transcription factor Mrr1 regulates various genes including putative methylglyoxal reductases, which are important in metabolizing toxic metabolite methylglyoxal. Studies in Clavispora lusitaniae showed that Mrr1 regulates expression of MG reductases and also plays a role in fluconazole resistance. Endogenous and host-derived MG can induce MDR1 and other Mrr1-regulated genes causing increased drug resistance in Candida species, potentially contributing to fungal treatment failure.
MOLECULAR MICROBIOLOGY
(2021)
Article
Microbiology
Amir Arastehfar, Melika Laal Kargar, Shahla Roudbar Mohammadi, Maryam Roudbary, Nayereh Ghods, Ladan Haghighi, Farnaz Daneshnia, Mahin Tavakoli, Jalal Jafarzadeh, Mohammad Taghi Hedayati, Huiwei Wang, Wenjie Fang, Agostinho Carvalho, Macit Ilkit, David S. Perlin, Cornelia Lass-Floerl
Summary: RVVC is a common fungal infection that may be caused by dysbiosis and other factors. FLZR and FLZT phenotypes were found to contribute to fluconazole therapeutic failure, with Iran having a heavy burden of RVVC. Research on RVVC remains limited.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Patrick B. Mazi, Margaret A. Olsen, Dustin Stwalley, Adriana M. Rauseo, Chapelle Ayres, William G. Powderly, Andrej Spec
Summary: This study quantified the mortality attributable to Candida bloodstream infections in the modern era of echinocandins, finding that the mortality was more pronounced in patients at lowest risk of developing the infection. Patients at the lowest risk who went untreated had higher mortality rates compared to treated patients.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Microbiology
J. D. Sobel
Summary: A review of vaginal isolates of Candida albicans obtained from a university vaginitis referral clinic over a 10-year period revealed an increase in fluconazole resistance, which has been associated with treatment choice. Factors contributing to azole resistance in Candida albicans vaginal infection are discussed.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Laura A. Doorley, Jeffrey M. Rybak, Elizabeth L. Berkow, Qing Zhang, Joachim Morschhauser, P. David Rogers
Summary: Candida parapsilosis is a common cause of invasive candidiasis worldwide, particularly in pediatric and neonatal populations. A study found that nonsynonymous mutations in the CpMRR1 gene are important genetic determinants of fluconazole resistance in clinical isolates of C. parapsilosis, primarily driven by upregulation of MFS and ABC transporters.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Hui Lu, Wanqian Li, Malcolm Whiteway, Hongkang Wang, Shuo Zhu, Zhe Ji, Yanru Feng, Lan Yan, Ting Fang, Liping Li, Tingjunhong Ni, Xiaolong Zhang, Quanzhen Lv, Zichao Ding, Lijuan Qiu, Dazhi Zhang, Yuanying Jiang
Summary: The study found that 14α-methylsterols replace ergosterol to allow Candida albicans to survive Fluconazole (FLC), but Erg251 inactivated by CZ66 results in the loss of 14α-methylsterol synthesis and cell death of Candida albicans treated with FLC. Establishing Erg251 as a synergistic lethal target protein of FLC should direct research to identify specific small molecule inhibitors of 14α-methylsterol synthesis and open the way to abolishing fungal FLC tolerance.
Article
Infectious Diseases
Dawid Zyrek, Joanna Nowicka, Magdalena Pajaczkowska, Ewa Morgiel
Summary: Research confirms that Candida strains resistant to fluconazole may occur slightly more frequently in patients on systemic methotrexate therapy, but there is no solid evidence to support the hypothesis that methotrexate induces resistance to azoles among endogenous Candida strains in patients with rheumatological diseases.
Article
Pharmacology & Pharmacy
Sheridan M. Hoy
Summary: Oteseconazole is an orally administered azole antifungal agent that inhibits fungal cell membrane formation and integrity. It is the first drug approved for reducing the incidence of recurrent vulvovaginal candidiasis (RVVC) in the USA. Clinical development for the treatment of onychomycosis, invasive, and opportunistic infections is ongoing.
Article
Microbiology
Petr Jaros, Maria Vrublevskaya, Kristyna Lokocova, Jana Michailidu, Irena Kolouchova, Katerina Demnerova
Summary: The use of antibiotics and antifungals to control infections caused by pathogenic microorganisms is currently ineffective due to emerging resistance. Boswellia serrata extract containing boswellic acids has shown promising antifungal activity against Candida species.
Article
Microbiology
Luana Mendonca Dias, Marlise Inez Klein, Tulio Morandin Ferrisse, Karine Sousa Medeiros, Claudia Carolina Jordao, Amanda Bellini, Ana Claudia Pavarina
Summary: This study evaluated the potential of successive applications of sub-lethal doses of antimicrobial photodynamic therapy (aPDT) mediated by Photodithazine (PDZ) and curcumin (CUR) associated with LED in the viability, reactive oxygen species (ROS) production, and gene expression of Candida albicans. Results showed that CUR-mediated aPDT could induce C. albicans resistance in biofilms, while PDZ-mediated aPDT had a susceptible effect on C. albicans cells in biofilms. The production of ROS was higher in the biofilms than in the planktonic cultures, and SOD1 expression was the highest in PDZ-mediated aPDT.
Article
Biochemistry & Molecular Biology
Jakub Suchodolski, Jakub Muraszko, Przemyslaw Bernat, Anna Krasowska
Summary: Studies have shown that lactate can reduce Candida albicans' resistance to fluconazole by affecting the expression of the ERG11 gene and ergosterol content, leading to the delocalization of the Cdr1 protein and inhibition of efflux.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Microbiology
Hui Lu, Manjari Shrivastava, Malcolm Whiteway, Yuanying Jiang
Summary: Fluconazole is widely used in the clinical treatment of C. albicans infections, but long-term use may lead to resistance. To enhance its efficacy, identifying potential drug targets that synergize with fluconazole and exploring combinatorial strategies show promise.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Xueqi Chen, Jiyong Wu, Lei Sun, Jing Nie, Shan Su, Shujuan Sun
Summary: The study revealed that BEH alone or in combination with FLC exhibited potent antifungal activity against C. albicans, possibly through increasing intracellular calcium concentration, activating metacaspase activity to reduce virulence, and anti-biofilms, but not related to drug efflux.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
