Article
Ophthalmology
Yasuo Yamana, Satoshi Yamana, Eiichi Uchio
Summary: The study found a positive correlation between t-tIgE, s-sIgE, and t-sIgE levels in patients with pollen-induced AC. Pollen-induced AC is caused by sensitization of the conjunctiva to pollen, while food-induced AC may be induced by different pathological mechanisms.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Hongmei Wang, Xiaodan Jiang, Pei Zhang, Yingyu Li, Yiren Wang, Xuemin Li
Summary: In this study, the positive rates of allergen-specific IgE in the tear fluid of Chinese patients with common allergic conjunctivitis in autumn and winter were determined. The most common allergen was found to be house dust mites. Measuring specific IgE in tears may be a non-invasive method to diagnose and evaluate the severity of conjunctivitis, which is more suitable to reflect the local conditions of ocular surface inflammation.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tatsuma Kishimoto, Waka Ishida, Isana Nakajima, Ken Fukuda, Kenji Yamashiro
Summary: Dry eye disease (DED) and allergic conjunctivitis have interactions and can exacerbate each other in mice, leading to ocular surface epithelial damage and aggravated allergic signs and symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jose Carlos Zarzuela, Roberto Reinoso, Alicia Armentia, Amalia Enriquez-de-Salamanca, Alfredo Corell
Summary: Conjunctival intraepithelial lymphocytes, tear soluble molecules, and commensal microbiota play important roles in ocular mucosal immune response. This study analyzed the cellular and microbial populations of the conjunctiva and tear fluid to identify biomarkers for allergic conjunctivitis. The results showed distinct differences between perennial and seasonal allergic conjunctivitis, including changes in lymphocyte populations and cytokine levels.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Jiayu Bao, Lei Tian, Yifan Meng, Binge Wu, Jingyi Wang, Jing He, Qiyan Shao, Chengshuo Wang, Ying Jie, Luo Zhang
Summary: Measuring the total IgE level in tears can accurately assess the severity and predict the prognosis of seasonal allergic conjunctivitis (SAC).
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Article
Medicine, General & Internal
Yuqing Wu, Hao Jiang, Xujiao Zhou, Zimeng Zhai, Pei Yang, Shuyun Zhou, Hao Gu, Jianjiang Xu, Jiaxu Hong
Summary: This study investigated the morphological and functional changes of meibomian glands in pediatric and adult patients with allergic conjunctivitis. The results showed that meibomian glands in pediatric patients improved after treatment, while there was no improvement in adult patients. Age and baseline meibomian gland area ratio were predictors of improvement in meibomian glands.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
I-Hui Lin, Ming-Chin Tsai, Jun-Peng Chen, Lin-Shien Fu
Summary: The study found that for two thirds of atopic children, a specific allergen could be identified during follow-up tests. Specific allergens could be identified through MAST tests and further assist in treatment options.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Immunology
Zhan Zhao, Yuqin Deng, Lei Xiang, Jin Chen, Jing Wan, Jinli Sun, Yonggang Kong, Qingquan Hua
Summary: This study aimed to evaluate the clinical efficacy of omalizumab in patients with allergic rhinitis by analyzing the ratio of total IgE level at week 16 to baseline. Retrospective analysis of 62 patients showed that 48 patients demonstrated significant improvement after 16 weeks of treatment, while 14 patients did not show significant improvements. The ratio of total IgE levels at week 16 to baseline was higher in responders compared to non-responders. In conclusion, the ratio of total IgE level at week 16 to baseline correlated with the clinical response to omalizumab in moderate to severe allergic rhinitis patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Allergy
Paul Engeroff, Kevin Plattner, Federico Storni, Franziska Thoms, Kayluz Frias Boligan, Lukas Muerner, Alexander Eggel, Stephan von Gunten, Martin F. Bachmann, Monique Vogel
Summary: The study demonstrates that glycan-specific IgG anti-IgE autoantibodies can downregulate serum IgE levels and anaphylactic activity, providing potential therapeutic implications for allergic diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yasuhiro Gon, Shuichiro Maruoka, Kenji Mizumura
Summary: Omalizumab is a therapeutic agent for severe bronchial asthma. It improves symptoms, reduces exacerbation risk, and enhances quality of life. However, it is associated with high treatment costs and lacks clear methods to identify responders.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Allergy
Mohamed H. Shamji, Rudolf Valenta, Theodore Jardetzky, Valerie Verhasselt, Stephen R. Durham, Peter A. Wurtzen, R. J. Joost van Neerven
Summary: IgE-mediated allergy is a common hypersensitivity disease impacting over 30% of the population. Allergen-specific IgE triggers release of inflammatory mediators, while inducing IgG and IgA antibodies can compete with IgE for allergen binding to prevent allergic responses. Anti-IgE treatment can also prevent IgE from binding to receptors on mast cells and basophils to inhibit allergic reactions.
Article
Veterinary Sciences
Hannah M. Terhaar, Rachel A. Allbaugh, Jonathan P. Mochel, Lionel Sebbag
Summary: The study determined that the protein profile in equine tears varies between health and disease, with an increase in serum albumin in tears of horses with ocular disease. This suggests that serum albumin may serve as a biomarker for ocular insult in horses, similar to other species. Further research could investigate the protein levels in horses with specific ocular conditions to determine the biological importance of albumin on the equine ocular surface.
VETERINARY OPHTHALMOLOGY
(2021)
Review
Allergy
Paul Engeroff, Monique Vogel
Summary: IgE can bind to two receptors, playing different roles on different cells, inducing allergic reactions on one hand and participating in IgE regulation and antigen presentation on the other. In inflammation and immune homeostasis, CD23 plays an important modulatory role.
Article
Cell Biology
Jing Wu, Yuee Liu, Min Xie, Yanzhi Cui, Yaona Wei, Yan Cheng, Jing Yang, Hongxia Zhang, Lei Wang
Summary: The aim of this study was to analyze the distribution characteristics of specific allergens based on IgE tests conducted on patients with allergic diseases in Shanxi, China. The study found that mugwort, dust mite mix, and common ragweed were the most common inhaled allergens, while crab, egg white, and sea fish mix were the most common ingested allergens. The distribution of these allergens varied according to disease profile, season, and age group, and multiple allergens could cosensitize patients.
CELLULAR MICROBIOLOGY
(2023)
Article
Environmental Sciences
Jin Zhou, Lijun Fan, Hualiang Lin, Dehui Zheng, Lihong Yang, Dan Zhuo, Jiayang Zhuoma, Huan Li, Shiyu Zhang, Zengliang Ruan
Summary: This time-stratified case-crossover study quantified the risk of allergic conjunctivitis (AC) in children in Guangzhou, China due to short-term exposure to PMs. The study collected data on children's daily AC outpatient visits and air pollution and meteorological data from February 20, 2016 to December 31, 2018. The results showed that short-term exposure to PMs increased the risk of AC in children, with girls and children aged 1 to 6 years being more sensitive to PM exposure.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
