Article
Ophthalmology
Supriya Arora, Dmitrii S. Maltsev, Niroj Kumar Sahoo, Deepika C. Parameshwarappa, Claudio Iovino, Tarun Arora, Alexei N. Kulikov, Filippo Tatti, Ramesh Vankatesh, Nikitha Gurram Reddy, Ram Snehith Pulipaka, Sumit Randhir Singh, Enrico Peiretti, Jay Chhablani
Summary: The study evaluated the visual acuity and factors influencing it in central serous chorioretinopathy using a new multimodal imaging-based classification. Factors such as foveal involvement and outer retinal atrophy showed strong correlation with visual acuity, while age and duration of the disease also played a significant role. The study suggests that objective parameters of this new classification can help in establishing treatment guidelines for CSCR.
Review
Chemistry, Medicinal
Stefano Da Pozzo, Pierluigi Iacono, Alessandro Arrigo, Maurizio Battaglia Parodi
Summary: Central serous chorioretinopathy (CSC) is a contentious disease involving various eye structures, with multiple therapeutic options available. Imaging plays a crucial role in evaluating and guiding treatment, while biomarkers serve as diagnostic and prognostic reference points.
Article
Ophthalmology
Enrico Borrelli, Chiara Vigano, Marco Battista, Riccardo Sacconi, Carlotta Senni, Lea Querques, Domenico Grosso, Francesco Bandello, Giuseppe Querques
Summary: This study assessed the diagnostic accuracy of individual and combined imaging modalities for the detection of CNV in CSC. The results showed that OCTA had a higher diagnostic accuracy in identifying CNV than other imaging modalities. The combination of ICGA and structural OCT also achieved comparable diagnostic efficiency.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Physiology
Fabao Xu, Cheng Wan, Lanqin Zhao, Qijing You, Yifan Xiang, Lijun Zhou, Zhongwen Li, Songjian Gong, Yi Zhu, Chuan Chen, Cong Li, Li Zhang, Chong Guo, Longhui Li, Yajun Gong, Xiayin Zhang, Kunbei Lai, Chuangxin Huang, Hongkun Zhao, Daniel Ting, Chenjin Jin, Haotian Lin
Summary: The study aimed to predict the recurrence of central serous chorioretinopathy (CSC) patients using machine learning. The ensemble model performed the best among six different algorithms, demonstrating high accuracy in predicting recurrence at both 3 and 6 months. The simplified model showed comparable predictive power to the ensemble model.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Naomi Nishigori, Yuki Muraoka, Masaharu Ishikura, Takahiro Kogo, Naoko Ueda-Arakawa, Manabu Miyata, Hiroshi Tamura, Masayuki Hata, Ayako Takahashi, Masahiro Miyake, Akitaka Tsujikawa
Summary: We investigated the change in wide-field choroidal thickness in patients with central serous chorioretinopathy (CSC) after reduced fluence photodynamic therapy (rf-PDT). The study found that before treatment, all eyes showed choroidal thickening, and after rf-PDT, the choroidal thickness significantly decreased in the irradiated macular area as well as outside the arcade vessels in all quadrants. The choroidal thickness did not differ in the control group between the initial visit and follow-up.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Naoya Imanaga, Nobuhiro Terao, Shozo Sonoda, Shota Sawaguchi, Yukihide Yamauchi, Taiji Sakamoto, Hideki Koizumi
Summary: The purpose of this study was to investigate the relationship between scleral thickness and choroidal structure in CSC eyes. The results showed a significant positive correlation between scleral thickness and the luminal/stromal ratio in the posterior choroid. Scleral thickness had a stronger correlation with the ratio compared to subfoveal choroidal thickness.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Kazuyoshi Okawa, Tatsuya Inoue, Ryo Asaoka, Keiko Azuma, Ryo Obata, Rei Arasaki, Shouko Ikeda, Arisa Ito, Maiko Maruyama-Inoue, Yasuo Yanagi, Kazuaki Kadonosono
Summary: Cigarette smoking is associated with increased SFCT in patients with CSC. Thicker choroid in smoking CSC patients may play an important role in modulating the disease. Age, SE, and past smoking history are key factors influencing SFCT.
Article
Ophthalmology
Zhiqiao Liang, Jinfeng Qu, Lvzhen Huang, Dandan Linghu, Jie Hu, Enzhong Jin, Hui Xu, Hongyan Li, Ye Tao, Xiulan Xu, Guodong Liu, Yan Li, Mingwei Zhao
Summary: The study included 173 cases of CSCR patients and compared the outcomes of cases with or without subfoveal fibrin. The results showed that half-dose verteporfin photodynamic therapy was an effective and safe treatment option, with no significant differences in treatment outcomes and resolution rates of subfoveal fibrin.
Article
Multidisciplinary Sciences
Yihao Xia, Xiaodong Li, Jiaqi Zhang, Xuejun Xie
Summary: This study evaluated the choroidal vascularity index (CVI) in central serous chorioretinopathy (CSC) and found that CVI is increased in acute CSC eyes and fellow eyes. There was no significant difference in CVI between acute and chronic CSC eyes. The area selected for CVI calculation may influence the outcomes of the study and requires further research.
Article
Multidisciplinary Sciences
Junseo Ko, Jinyoung Han, Jeewoo Yoon, Ji In Park, Joon Seo Hwang, Jeong Mo Han, Kyu Hyung Park, Daniel Duck-Jin Hwang
Summary: This study developed a deep learning-based classification model using multiple spectral domain optical coherence tomography (SD-OCT) images to diagnose central serous chorioretinopathy (CSC). The proposed model achieved high accuracy in cross-validation testing and outperformed other models in distinguishing between acute, chronic, and normal cases. The results suggest that the automated deep learning-based model can serve as a supplementary tool for ophthalmologists in the diagnosis and management of CSC.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Melvin Gerardy, Nilufer Yesilirmak, Richard Legras, Francine Behar-Cohen, Elodie Bousquet
Summary: This study investigated cone density in the asymptomatic fellow eye of patients with unilateral central serous chorioretinopathy (CSCR). The results showed a significant decrease in cone density in the asymptomatic fellow eyes compared to healthy controls, suggesting cone cells could be damaged independently of visual acuity and retinal disruptions.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Liang Han, Jose Ronaldo Lima de Carvalho, Rait Parmann, Tongalp H. Tezel, Stanley Chang, Tarun Sharma, Janet R. Sparrow
Summary: qAF was correlated with SD-OCT detectable features in CSC patients, while NIR-AF images were helpful in detecting lesions. Elevated qAF levels were associated with specific CSC-related abnormalities, indicating a potential role in disease progression.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Jose Ignacio Fernandez-Vigo, Francisco Javier Moreno-Morillo, Emilio Lopez-Varela, Jorge Novo-Bujan, Marcos Ortega-Hortas, Barbara Burgos-Blasco, Lorenzo Lopez-Guajardo, Juan Donate-Lopez
Summary: This study assessed the repeatability of flow signal voids (FSV) measurements of the choriocapillaris (CC) and choroid (CH) in central serous chorioretinopathy (CSCR) using Swept-Source optical coherence tomography angiography (SS-OCTA). The results showed that SS-OCTA offers good repeatability for quantifying macular FSV in both CSCR eyes and fellow eyes.
Article
Multidisciplinary Sciences
Geun Woo Lee, Yun Young Kim, Kyung Jun Choi, Se Woong Kang
Summary: This retrospective cross-sectional study aimed to investigate biomarkers associated with visual symptoms and best corrected visual acuity (BCVA) improvement after photodynamic therapy (PDT) for central serous chorioretinopathy. Forty-two consecutive eyes from 42 patients who underwent successful PDT were divided into complete (20 eyes) and incomplete recovery groups (22 eyes) based on improvement in subjective visual complaints. Clinical characteristics, such as central foveal thickness (CFT), foveal avascular zone (FAZ) area, and changes in signal voiding of the choriocapillaris, were compared between the two groups. The study found that CFT and FAZ areas at baseline were significantly different between the groups. Logistic regression analysis showed that greater CFT predicted complete recovery from visual complaints. Reduction or disappearance of signal voiding in the choriocapillaris was more frequent in the complete recovery group. The study also revealed correlations between FAZ area before PDT and BCVA before and after treatment, as well as BCVA improvement during the study period.
Article
Multidisciplinary Sciences
Young Ho Kim, Edward Kang, Jaeryung Oh
Summary: This study used en-face optical coherence tomography to investigate the location of pigment epithelial detachment (PED) in relation to various anatomical landmarks in the eye. The results suggest that the development of complicated PED with choroidal neovascularisation (CNV) can be attributed to both choroidal vascular abnormalities and retinal pigment epithelial insufficiency.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Ursula Schmidt-Erfurth, Zufar Mulyukov, Bianca S. Gerendas, Gregor S. Reiter, Daniel Lorand, Georges Weissgerber, Hrvoje Bogunovic
Summary: Deep learning methods allow accurate assessment of the therapeutic response to brolucizumab and aflibercept in neovascular age-related macular degeneration. Residual volumes of intraretinal fluid, subretinal fluid, and pigment epithelial detachment are associated with visual loss.
Article
Ophthalmology
Markus Schranz, Reinhard Told, Valentin Hacker, Gregor S. Reiter, Adrian Reumueller, Wolf-Dieter Vogl, Hrvoje Bogunovic, Stefan Sacu, Ursula Schmidt-Erfurth, Philipp K. Roberts
Summary: The study found that macular neovascularization parameters play a minor role in the exudation process in nAMD, and none of the MNV parameters were correlated with the treatment response.
ACTA OPHTHALMOLOGICA
(2023)
Article
Ophthalmology
Martin Michl, Martina Neschi, Alexandra Kaider, Katja Hatz, Gabor Deak, Bianca S. S. Gerendas, Ursula Schmidt-Erfurth
Summary: The objective of this study was to assess agreement in evaluating OCT variables in leading macular diseases among OCT-certified graders. Even in optimized conditions, there is disease-dependent variability in biomarker evaluation, particularly for IRF in nAMD and DMO. Our findings highlight the variability in human expert OCT grading performance and the need for AI-based automated feature analyses.
Article
Computer Science, Information Systems
Botond Fazekas, Dmitrii Lachinov, Guilherme Aresta, Julia Mai, Ursula Schmidt-Erfurth, Hrvoje Bogunovic
Summary: Segmentation of Bruch's membrane (BM) on optical coherence tomography (OCT) is crucial for the diagnosis and follow-up of age-related macular degeneration (AMD), a leading cause of blindness. Existing automated methods lack anatomical coherence and confidence feedback, limiting their real-world applicability. To address this, we propose an end-to-end deep learning method that uses an Attention U-Net to output a probability density function and considers the natural curvature of the surface. Additionally, our method estimates uncertainty and interpolates A-scans with high uncertainty. Evaluation on internal and external datasets demonstrates superior performance and strong generalization ability.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Ophthalmology
Wolf-Dieter Vogl, Sophie Riedl, Julia Mai, Gregor S. Reiter, Dmitrii Lachinov, Hrvoje Bogunovic, Ursula Schmidt-Erfurth
Summary: This study aimed to assess disease activity and the effects of intravitreal pegcetacoplan treatment on the topographic progression of geographic atrophy (GA) secondary to age-related macular degeneration. The study used automated deep learning algorithms to analyze SD-OCT scans and found that pegcetacoplan-treated eyes showed significantly slower GA lesion progression compared with sham.
OPHTHALMOLOGY RETINA
(2023)
Article
Surgery
Reinhard Told, Eva Placheta-Gyoeri, Birgit Lackner, Andreas Kuchar, Jonas Brugger, Ursula Schmidt-Erfurth, Roman Dunavoelgyi
Summary: This study compared two suturing techniques in upper eyelid blepharoplasty and assessed patient-reported outcomes using the FACE-Q(TM) Eye Module questionnaire and blinded Likert-scale gradings of two surgeons. The results showed no significant difference in patient satisfaction and appraisal of the upper eyelids between the two suturing techniques at both 7 days and 3 months after surgery. Dry eye symptoms increased postoperatively, regardless of the suturing technique, patient age, or sex.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Ophthalmology
Reinhard Told, Adrian Reumueller, Markus Schranz, Jonas Brugger, Guenther Weigert, Gregor Sebastian Reiter, Stefan Sacu, Ursula Schmidt-Erfurth
Summary: This study aimed to evaluate the individual influence of retinal thickness, intra- and sub-retinal fluid on the treatment response in patients with neovascular AMD. The results showed that retinal thickness and the presence of intra- and sub-retinal fluid had an impact on the treatment response, while junction density and vessel density did not.
CURRENT EYE RESEARCH
(2023)
Article
Ophthalmology
Gregor S. Reiter, Hrvoje Bogunovic, Ferdinand Schlanitz, Wolf-Dieter Vogl, Philipp Seeboeck, Dariga Ramazanova, Ursula Schmidt-Erfurth
Summary: This study evaluated the quantitative impact of drusen and hyperreflective foci (HRF) volumes on mesopic retinal sensitivity in age-related macular degeneration (AMD) patients. The results showed a negative correlation between the volume of drusen and HRF and retinal sensitivity. The study highlights the use of AI-based methods to assess the impact of cellular changes on the development of AMD.
Article
Ophthalmology
Maximilian Pawloff, Bianca S. S. Gerendas, Gabor Deak, Hrvoje Bogunovic, Anastasiia Gruber, Ursula Schmidt-Erfurth
Summary: The purpose of this study was to evaluate the reliability of automated fluid detection in identifying retinal fluid activity in OCT scans of patients treated with anti-VEGF therapy for neovascular age-related macular degeneration. The results showed that the concordance between human expert grading and automated algorithm performance was high, indicating that deep learning-based segmentation of retinal fluid performs reliably on OCT images.
Article
Computer Science, Interdisciplinary Applications
M. Niederleithner, L. de Sisternes, H. Stino, A. Sedova, T. Schlegl, H. Bagherinia, A. Britten, P. Matten, U. Schmidt-Erfurth, A. Pollreisz, W. Drexler, R. A. Leitgeb, T. Schmoll
Summary: Optical Coherence Tomography Angiography (OCTA) has the potential to replace invasive fluorescein angiography (FA) in ophthalmology, but it still lacks the field of view compared to fluorescence fundus photography techniques. To address this issue, a custom developed high-speed swept-source OCT (SS-OCT) system is presented, which can capture ultra-wide fields of view up to 90 degrees with high resolution. Additionally, a three-dimensional deep learning based algorithm is developed for denoising volumetric OCTA data sets, enhancing the visual appearance of angiograms.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Ophthalmology
Leonard M. Coulibaly, Gregor S. Reiter, Philipp Fuchs, Dmitrii Lachinov, Oliver Leingang, Wolf-Dieter Vogl, Hrvoje Bogunovic, Ursula Schmidt-Erfurth
Summary: This study investigated the progression of geographic atrophy secondary to nonneovascular age-related macular degeneration using artificial intelligence-based precision tools. The findings revealed that early lesions have slower growth rates and there are differences in growth dynamics compared to atrophic lesions in advanced stages.
OPHTHALMOLOGY RETINA
(2023)
Article
Ophthalmology
Marlene Hollaus, Michael Georgopoulos, Johannes Iby, Jonas Brugger, Oliver Leingang, Hrvoje Bogunovic, Ursula Schmidt-Erfurth, Stefan Sacu
Summary: This study aimed to analyze the short-term changes of mean photoreceptor thickness (PRT) on the ETDRS-grid after vitrectomy and membrane peeling in patients with epiretinal membrane (ERM). The results showed significant changes in PRT after surgery, but no correlation with BCVA was found.
Article
Multidisciplinary Sciences
Teresa Araujo, Guilherme Aresta, Ursula Schmidt-Erfurth, Hrvoje Bogunovic
Summary: This study performs a comparative analysis of uncertainty estimation methods for out-of-distribution (OOD) detection in automated screening and staging of age-related macular degeneration (AMD) using retinal OCT imaging. The combination of cosine distance in the feature space and a few-shot outlier exposure (OE) approach improves the near-OOD detection performance, providing robust and reliable diagnostic systems.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Reinhard Told, Judith Kreminger, Ursula Schmidt-Erfurth, Roman Dunavoelgyi, Adrian Reumueller
Summary: This study investigated the relationship between choroidal melanoma characteristics and progression-free survival (PFS) in patients who underwent linear accelerator-based hypofractionated stereotactic photon radiotherapy. The results showed that thickness and largest basal diameter (LBD) were significantly associated with PFS. For monitoring treated choroidal melanoma, LBD assessments could be used instead of ultrasonography-based thickness measurements.
OPHTHALMOLOGY AND THERAPY
(2023)
Letter
Ophthalmology
Ursula Schmidt-Erfurth, Wolf-Dieter Vogl, Sophie Riedl, Julia Mai, Gregor S. Reiter, Dmitrii Lachinov, Hrvoje Bogunovic
OPHTHALMOLOGY RETINA
(2023)
