Article
Developmental Biology
Sara L. Jones, Amir Aviram, Ludmila Porto, Tianhua Huang, Abheha Satkunaratnam, Jon F. R. Barrett, Nir Melamed, Elad Mei-Dan
Summary: The study found that in women with abnormal FTS analytes, those with elevated UtA-PI are at increased risk of FGR. However, the predictability of FGR based on UtA-PI is moderate-to-poor.
Article
Obstetrics & Gynecology
Suchada Erjongmanee, Vorapong Phupong
Summary: This study aimed to determine the predictive value of first-trimester serum SHARP1 level and second-trimester uterine artery Doppler in singleton pregnancy for the prediction of preeclampsia. The study demonstrated that combining the first-trimester serum SHARP1 level with the second-trimester uterine artery PI had good sensitivity to predict preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Luiza Meelhuysen Sousa Aguiar, Lumena Goncalves Machado Zanotto, Carlos Henrique Mascarenhas Silva, Marianna Amaral Pedroso
Summary: A retrospective study showed that using both transverse and longitudinal Doppler techniques during the first trimester morphological examination can reliably measure the pulsatility index of uterine arteries in pregnant women, without affecting the final outcome of preeclampsia screening.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Medical Laboratory Technology
Laurence Caron, Alexandre Fillion, Yves Giguere, Francois Audibert, Jean-Claude Forest, Cedric Gasse, Mario Girard, Genevieve Laforest, Paul Guerby, Emmanuel Bujold
Summary: The combination of maternal markers PAPP-A, free beta-hCG, PlGF and AFP has demonstrated a predictive value in Down syndrome screening. Adding nuchal translucency further increases the detection rate to above 95% with a false-positive rate below 5%.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Sakita K. Moungmaithong, Angel H. S. Kwan, Ada W. Tse, Natalie K. C. Wong, Michelle S. S. Lam, Jing Wang, Liona C. Poon, Daljit S. Sahota
Summary: International professional organizations recommend aspirin prophylaxis to women at high risk for preterm preeclampsia (PE) in the first trimester. However, the UK Fetal Medicine Foundation (FMF) screening test using mean arterial pressure (MAP), uterine artery pulsatility index (UTPI), and placental growth factor (PlGF) has shown lower detection rates (DRs) in Asian population studies. Additional biomarkers are needed in Asian women to improve screening for preterm and term PE.
Review
Obstetrics & Gynecology
Sarah L. Malone, Rani Haj Yahya, Stefan C. Kane
Summary: Preeclampsia is a common and important complication of pregnancy. Accurate prediction and identification of high-risk individuals can help prevent complications. However, traditional prediction models have low predictive value. Multiparametric screening tests, which combine patient characteristics, biomarkers, and ultrasound Doppler indices, have shown to be more effective in detecting high-risk individuals for preeclampsia.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2022)
Article
Peripheral Vascular Disease
Eliza C. Miller, Benjamin Carper, Natalie A. Bello, C. Noel Bairey Merz, Philip Greenland, Lisa D. Levine, David M. Haas, William A. Grobman, Rebecca B. McNeil, Judith H. Chung, Jennifer Jolley, George R. Saade, Robert M. Silver, Hyagriv N. Simhan, Ronald J. Wapner, Corette B. Parker
Summary: Higher resistance and pulsatility indices measured on second trimester uterine artery Doppler were associated with increased odds of incident hypertension 2-7 years later, and may be biomarkers of higher maternal cardiovascular risk.
INTERNATIONAL JOURNAL OF CARDIOLOGY CARDIOVASCULAR RISK AND PREVENTION
(2021)
Article
Obstetrics & Gynecology
Manel Mendoza, Erika Bonacina, Berta Serrano, Marta Ricart, Lourdes Martin, Eva Lopez-Quesada, Angels Vives, Anna Maroto, Pablo Garcia-Manau, Clementina De Antonio, Cristina Tusquets, Gabriela Moreano, Mireia Armengol-Alsina, Elena Carreras
Summary: Implementing routine first-trimester screening for preeclampsia in six Catalan maternities significantly reduces the incidence of preterm preeclampsia and maternal ICU admission.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Droima Stevens, Veronique Schiffer, Carmen Severens-Rijvers, Johnny de Nobrega Teixeira, Ashlee van Haren, Marc Spaanderman, Salwan Al-Nasiry
Summary: The study revealed that histologic decidual vasculopathy is associated with abnormal uterine artery Doppler, independent of clinical phenotype during pregnancy.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Pharmacology & Pharmacy
Z. Avul, C. M. Guven, B. S. Feyzioglu, S. O. Sancar
Summary: This study aimed at evaluating the hypothesis that 6-14 months pregnant women diagnosed with COVID-19 may have abnormal placental function detectable by increased uterine artery Doppler indices in the second trimester and whether these women could benefit from treatment; it was observed that uterine artery Doppler indices were significantly increased in second trimester women with COVID-19 infection compared to those without COVID-19, suggesting that Doppler Ultrasound measurement may be a potential method for the management of high-risk pregnancies after asymptomatic/mild COVID-19 infection.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Z. Avul, C. M. Guven, B. S. Feyzioglu, S. O. Sancar
Summary: This study aimed to evaluate whether 6-14 months pregnant women diagnosed with COVID-19 may have abnormal placental function detectable by increased uterine artery Doppler indices in the second trimester and whether these women could benefit from treatment. A total of 63 women diagnosed with COVID-19 during the first trimester of their pregnancy and 68 healthy women were involved in the study. The results showed that uterine artery Doppler indices were significantly increased in second trimester women with COVID-19 compared to those without COVID-19, indicating potential high-risk pregnancies.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Obstetrics & Gynecology
Anna Meroni, Margaret Mascherpa, Monica Minopoli, Benjamin Lambton, Rawan Elkalaawy, Alexander Frick, Basky Thilaganathan
Summary: Routine mid-gestational uterine artery Doppler can modify the risk for preterm pre-eclampsia after first-trimester combined pre-eclampsia screening. Women at low risk in the first trimester but with high mid-gestational uterine artery Doppler resistance had a higher prevalence of preterm pre-eclampsia. This suggests that pregnancy care should not be de-escalated for women at high risk in the first trimester with low mid-gestational uterine artery Doppler resistance, and escalation of care may be justified for women at low risk but with high mid-gestational uterine artery Doppler resistance.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medicine, General & Internal
Stella Capriglione, Ferdinando Antonio Gulino, Silvia Latella, Giovanna De Felice, Maurizio Filippini, Miriam Farinelli, Francesco Giuseppe Martire, Elsa Viora
Summary: This study aimed to evaluate the efficacy of a screening test conducted in the first trimester in identifying the risk of developing preeclampsia. The results showed that the test performed well in identifying women at high risk and emphasized the importance of medical history evaluation in screening.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Stephanie Springer, Katharina Worda, Marie Franz, Eva Karner, Elisabeth Krampl-Bettelheim, Christof Worda
Summary: Early prediction of fetal growth restriction is important for treatment options and neonatal outcomes. This study assessed the association of parameters used in first-trimester screening and the development of fetal growth restriction. The findings showed that PAPP-A levels and uterine artery Doppler pulsatility index weresignificantly associated with fetal growth restriction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
G. P. Guy, K. Leslie, D. Diaz Gomez, K. Forenc, E. Buck, A. Khalil, B. Thilaganathan
Summary: The study evaluates the clinical effectiveness of implementing a first-trimester combined pre-eclampsia screening program in a public healthcare setting. The results show a significant reduction in screen-positive rate, increased aspirin use, and effective identification of preterm pre-eclampsia.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
V. Velle-Forbord, R. B. Skrastad, O. Salvesen, M. S. Kramer, N. H. Morken, E. Vanky
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2019)
Article
Public, Environmental & Occupational Health
Imre Janszky, Johan Hakon Bjorngaard, Pal Romundstad, Lars Vatten, Nicola Orsini
CLINICAL EPIDEMIOLOGY
(2019)
Review
Multidisciplinary Sciences
Edward Antwi, Mary Amoakoh-Coleman, Dorice L. Vieira, Shreya Madhavaram, Kwadwo A. Koram, Diederick E. Grobbee, Irene A. Agyepong, Kerstin Klipstein-Grobusch
Article
Chemistry, Analytical
Ragnhild Bergene Skrastad, Olav Spigset, Trond Oskar Aamo, Trine Naalsund Andreassen
Summary: Phosphatidylethanol (PEth) 16:0/18:1 has gained popularity as a marker for high alcohol consumption, with studies showing it remains stable in whole blood samples for up to 28 days, regardless of storage temperature. For long-term storage, samples should be stored at -80 degrees C to maintain stability.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2021)
Article
Health Care Sciences & Services
John Allotey, Kym I. E. Snell, Melanie Smuk, Richard Hooper, Claire L. Chan, Asif Ahmed, Lucy C. Chappell, Peter von Dadelszen, Julie Dodds, Marcus Green, Louise Kenny, Asma Khalil, Khalid S. Khan, Ben W. Mol, Jenny Myers, Lucilla Poston, Basky Thilaganathan, Anne C. Staff, Gordon C. S. Smith, Wessel Ganzevoort, Hannele Laivuori, Anthony O. Odibo, Javier A. Ramirez, John Kingdom, George Daskalakis, Diane Farrar, Ahmet A. Baschat, Paul T. Seed, Federico Prefumo, Fabricio da Silva Costa, Henk Groen, Francois Audibert, Jacques Masse, Ragnhild B. Skrastad, Kjell A. Salvesen, Camilla Haavaldsen, Chie Nagata, Alice R. Rumbold, Seppo Heinonen, Lisa M. Askie, Luc J. M. Smits, Christina A. Vinter, Per M. Magnus, Kajantie Eero, Pia M. Villa, Anne K. Jenum, Louise B. Andersen, Jane E. Norman, Akihide Ohkuchi, Anne Eskild, Sohinee Bhattacharya, Fionnuala M. McAuliffe, Alberto Galindo, Ignacio Herraiz, Lionel Carbillon, Kerstin Klipstein-Grobusch, SeonAe Yeo, Helena J. Teede, Joyce L. Browne, Karel G. M. Moons, Richard D. Riley, Shakila Thangaratinam
HEALTH TECHNOLOGY ASSESSMENT
(2020)
Article
Substance Abuse
Trine Finanger, Olav Spigset, Rolf W. Grawe, Trine N. Andreassen, Trine N. Lokken, Trond O. Aamo, Guro E. Bratt, Kristin Tommervik, Vibeke S. Langaas, Kristin Finseras, Kjell A. B. Salvesen, Ragnhild B. Skrastad
Summary: This study investigated the prevalence of early prenatal alcohol exposure in a general population of pregnant women in Norway, using positive PEth values as an indicator. The results showed that approximately 1.4% of women had a positive PEth sample around gestational week 12, while 0.4% had a positive sample around week 24. Further research on using PEth as a diagnostic tool for alcohol exposure in the antenatal setting is warranted.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Genetics & Heredity
B. Liv Gansmo, A. Benedicte Lie, Marthe T. Maehlen, Lars Vatten, Pal Romundstad, Kristian Hveem, Per E. Lonning, Stian Knappskog
Summary: The study found a potential association between the MDM2 del1518 variant and the risk of rheumatoid arthritis, as well as indications that combinational genotypes and haplotypes in the MDM2 locus may be related to rheumatoid arthritis.
Article
Clinical Neurology
Petter C. Borchgrevink, Mari Glette, Astrid Woodhouse, Stephen Butler, Tormod Landmark, Pal Romundstad, Ola Dale, Tore C. Stiles, Kaare H. Bonaa, Dagfinn Thorsvik, Sabina Thunte, Stein Kaasa
Summary: The purpose of this study was to provide a comprehensive overview, distribution, and ranking of chronic pain conditions in the general population. The findings showed that a higher proportion of participants had chronic pain based on clinical examination compared to self-report in a survey. Among those with examination-verified chronic pain, the majority had chronic primary pain, musculoskeletal pain, and multiple chronic pain conditions. The study also revealed that two-thirds of chronic pain conditions could not be explained by underlying diseases. The most prevalent chronic pain conditions were nonspecific low back pain and neck pain. There was no significant difference in psychopathology between participants with chronic primary pain and chronic secondary pain. Therefore, this study highlights the importance of addressing chronic pain as a public health issue and focusing on prevention and rehabilitation.
Article
Acoustics
J. Allotey, R. Whittle, K. I. E. Snell, M. Smuk, R. Townsend, P. von Dadelszen, A. E. P. Heazell, L. Magee, G. C. S. Smith, J. Sandall, B. Thilaganathan, J. Zamora, R. D. Riley, A. Khalil, S. Thangaratinam
Summary: This study externally validated published prediction models for stillbirth using individual participant data (IPD) meta-analysis. The results showed that these models had generally poor and uncertain predictive performance, with limited evidence to support their clinical application. The study highlighted methodological shortcomings in the development of these models and called for further research to validate and improve them.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Clinical Neurology
Ilari Rautalin, Jaakko Kaprio, Tor Ingebrigtsen, Pekka Jousilahti, Maja-Lisa Lochen, Pal Richard Romundstad, Veikko Salomaa, Anne Vik, Tom Wilsgaard, Ellisiv B. Mathiesen, Marie Sandvei, Miikka Korja
Summary: The study suggests that a lower body mass index (BMI) is associated with an increased risk of subarachnoid hemorrhage (SAH), while a higher BMI is not significantly associated with SAH risk. However, the increased risk of low BMI is only present in smokers and hypertensive men, but not in nonsmokers or men with normal blood pressure. Therefore, smoking and hypertension may have a modifying effect on the previously reported inverse association between BMI and SAH risk.
Article
Cardiac & Cardiovascular Systems
Abigail Fraser, Amanda R. Markovitz, Eirin B. Haug, Julie Horn, Pal Richard Romundstad, Havard Dalen, Janet Rich-Edwards, Bjorn Olav Asvold
Summary: Women with a history of obstetric complications have an increased risk of cardiovascular disease, but there is currently no recommendation to specifically target them for CVD screening. However, pregnancy complications can identify women who would benefit from primordial and primary prevention efforts in later life.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paulina Majewska, Marie Softeland Sandvei, Sasha Gulati, Tomm B. Mueller, Karen Walseth Hara, Pal Richard Romundstad, Ole Solheim
Summary: This study aimed to assess the return to work after the treatment of unruptured intracranial aneurysms (UIAs). A nationwide registry-based study was conducted in Norway from 2008 to 2018, including adult patients of working age with a record of sickness leave on the day of treatment. The results showed that patients who underwent endovascular treatment returned to work earlier compared to those treated with surgical clipping.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Substance Abuse
Ragnhild Bergene Skrastad, Trond Oskar Aamo, Trine Naalsund Andreassen, Hilde Havnen, Kristian Hveem, Steinar Krokstad, Oyvind Salvesen, Olav Spigset
Summary: This study examined the association between PEth in blood and alcohol consumption in 24,574 subjects in the HUNT4 study. The study found that a cut-off of 0.03-0.06 mu mol/l (or 20-40 ng/ml) can detect alcohol consumption above 1-2 units/day, and a cut-off of 0.1 mu mol/l (70 ng/ml) is appropriate for a threshold of three units per day. The results provide optimal cut-off PEth concentrations for defined levels of alcohol consumption.
ALCOHOL AND ALCOHOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Marie Klevjer, Humaira Rasheed, Pal R. Romundstad, Erik Madssen, Ben M. Brumpton, Anja Bye
Summary: This study used Mendelian randomization to explore the causal association between resting heart rate (RHR) and atrial fibrillation (AF), and found an inverse causal relationship between them, especially when RHR was below 90 beats per minute. The results challenge the current observational knowledge on RHR and AF.
Article
Medicine, General & Internal
Kym I. E. Snell, John Allotey, Melanie Smuk, Richard Hooper, Claire Chan, Asif Ahmed, Lucy C. Chappell, Peter Von Dadelszen, Marcus Green, Louise Kenny, Asma Khalil, Khalid S. Khan, Ben W. Mol, Jenny Myers, Lucilla Poston, Basky Thilaganathan, Anne C. Staff, Gordon C. S. Smith, Wessel Ganzevoort, Hannele Laivuori, Anthony O. Odibo, Javier Arenas Ramirez, John Kingdom, George Daskalakis, Diane Farrar, Ahmet A. Baschat, Paul T. Seed, Federico Prefumo, Fabricio da Silva Costa, Henk Groen, Francois Audibert, Jacques Masse, Ragnhild B. Skrastad, Kjell A. Salvesen, Camilla Haavaldsen, Chie Nagata, Alice R. Rumbold, Seppo Heinonen, Lisa M. Askie, Luc J. M. Smits, Christina A. Vinter, Per Magnus, Kajantie Eero, Pia M. Villa, Anne K. Jenum, Louise B. Andersen, Jane E. Norman, Akihide Ohkuchi, Anne Eskild, Sohinee Bhattacharya, Fionnuala M. McAuliffe, Alberto Galindo, Ignacio Herraiz, Lionel Carbillon, Kerstin Klipstein-Grobusch, Seon Ae Yeo, Joyce L. Browne, Karel G. M. Moons, Richard D. Riley, Shakila Thangaratinam