Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD

Axonopathy in an α-Synuclein Transgenic Model of Lewy Body Disease Is Associated with Extensive Accumulation of C-Terminal–Truncated α-Synuclein

(2013) Dora Games et al.   AMERICAN JOURNAL OF PATHOLOGY

A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats

(2013) Silke Nuber et al.   BRAIN

Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice

(2013) Nicolas Casadei et al.   HUMAN MOLECULAR GENETICS

Developing dopaminergic cell therapy for Parkinson's disease-give up or move forward?

(2013) Olle Lindvall   MOVEMENT DISORDERS

Trophic Factor Gene Therapy for Parkinson's Disease

(2013) Jeffrey H. Kordower et al.   MOVEMENT DISORDERS

Deregulation of calcium homeostasis mediates secreted α–synuclein-induced neurotoxicity

(2013) Katerina Melachroinou et al.   NEUROBIOLOGY OF AGING

p62/SQSTM1-Dependent Autophagy of Lewy Body-Like α-Synuclein Inclusions

(2013) Yoshihisa Watanabe et al.   PLoS One

Large  -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

(2013) B.-K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan

(2012) Sören Mai et al.   Autophagy

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased olfactory bulb volume in idiopathic Parkinson's disease detected by 3.0-Tesla magnetic resonance imaging

(2012) Stefan Brodoehl et al.   MOVEMENT DISORDERS

Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein

(2012) V.E.L. May et al.   NEUROSCIENCE

α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion

(2012) Hodaka Yamakado et al.   NEUROSCIENCE RESEARCH

Paraquat, but Not Maneb, Induces Synucleinopathy and Tauopathy in Striata of Mice through Inhibition of Proteasomal and Autophagic Pathways

(2012) Jonathan Wills et al.   PLoS One

Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders

(2011) Iñaki-Carril Mundiñano et al.   ACTA NEUROPATHOLOGICA

Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease

(2011) Tito Calì et al.   BIOFACTORS

Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein

(2011) Hoa A. Lam et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Olfactory neuron-specific expression of A30P alpha-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages

(2011) Silke Nuber et al.   NEUROBIOLOGY OF DISEASE

Olfaction in Parkinson's disease and related disorders

(2011) Richard L. Doty   NEUROBIOLOGY OF DISEASE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

α-synuclein phosphorylation and truncation are normal events in the adult human brain

(2011) G. Muntané et al.   NEUROSCIENCE

Intranasal Administration of Neurotoxicants in Animals: Support for the Olfactory Vector Hypothesis of Parkinson’s Disease

(2011) Rui D. S. Prediger et al.   NEUROTOXICITY RESEARCH

Dopamine and Paraquat Enhance α-Synuclein-Induced Alterations in Membrane Conductance

(2011) Li Rebekah Feng et al.   NEUROTOXICITY RESEARCH

Progressive Neurodegeneration or Endogenous Compensation in an Animal Model of Parkinson's Disease Produced by Decreasing Doses of Alpha-Synuclein

(2011) James B. Koprich et al.   PLoS One

Errata

(2010) Kay Seidel et al.   ANNALS OF NEUROLOGY

Control of basal autophagy by calpain1 mediated cleavage of ATG5

(2010) Hong-Guang Xia et al.   Autophagy

Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology

(2010) Ayse Ulusoy et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neurodegeneration in a Transgenic Mouse Model of Multiple System Atrophy Is Associated with Altered Expression of Oligodendroglial-Derived Neurotrophic Factors

(2010) K. Ubhi et al.   JOURNAL OF NEUROSCIENCE

Clinical course of the first Asian family with Parkinsonism related to SNCA triplication

(2010) Takeshi Sekine et al.   MOVEMENT DISORDERS

Impaired sense of smell and color discrimination in monogenic and idiopathic Parkinson's disease

(2010) Lena Kertelge et al.   MOVEMENT DISORDERS

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice

(2010) Alexander Kurz et al.   PLoS One

Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein

(2009) Franz Marxreiter et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Molecular pathogenesis of Parkinson disease: insights from genetic studies

(2009) Thomas Gasser   EXPERT REVIEWS IN MOLECULAR MEDICINE

Adaptive Modifications in the Calpain/Calpastatin System in Brain Cells after Persistent Alteration in Ca2+Homeostasis

(2009) Roberto Stifanese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conditional transgenic mice expressing C-terminally truncated human α-synuclein (αSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

(2009) João Daher et al.   Molecular Neurodegeneration

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Modulation of α-synuclein expression in transgenic animals for modelling synucleinopathies — is the juice worth the squeeze?

(2009) Vladimir L. Buchman et al.   NEUROTOXICITY RESEARCH

Dopamine-Induced Conformational Changes in Alpha-Synuclein

(2009) Tiago F. Outeiro et al.   PLoS One

The olfactory vector hypothesis of neurodegenerative disease: Is it viable?

(2008) Richard L. Doty   ANNALS OF NEUROLOGY

Involvement of exon 6-mediated calpastatin intracellular movements in the modulation of calpain activation

(2008) Roberta De Tullio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Incidence and Extent of Lewy Body-Related α-Synucleinopathy in Aging Human Olfactory Bulb

(2008) Renpei Sengoku et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Paraquat-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells: Involvement of p53 and Mitochondria

(2008) Wonsuk Yang et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration

(2008) P. S. Vosler et al.   MOLECULAR NEUROBIOLOGY

Gender-related changes in increase of dopaminergic neurons in the olfactory bulb of Parkinson's disease patients

(2008) Evelien Huisman et al.   MOVEMENT DISORDERS

Cell systems and the toxic mechanism(s) of α-synuclein

(2007) Mark R. Cookson et al.   EXPERIMENTAL NEUROLOGY

Generation of a α-synuclein-based rat model of Parkinson's disease

(2007) Alessandra Recchia et al.   NEUROBIOLOGY OF DISEASE