Article
Clinical Neurology
Niels Okkels, Jacob Horsager, Miguel Labrador-Espinosa, Pernille L. Kjeldsen, Malene F. Damholdt, Janne Mortensen, Karsten Vestergard, Karoline Knudsen, Katrine B. Andersen, Tatyana D. Fedorova, Casper Skjaerbaek, Hanne Gottrup, Allan K. Hansen, Michel J. Grothe, Per Borghammer
Summary: Cholinergic changes are highly relevant in the progression of dementia with Lewy bodies. This study found significant loss of cholinergic terminals in newly diagnosed patients with dementia with Lewy bodies, which correlated with atrophy of cholinergic cell clusters in the basal forebrain. The study also suggests that cholinergic system degeneration is linked with brain metabolism and degeneration of other neurotransmitter systems.
Article
Psychology, Clinical
Alan J. Thomas, Calum A. Hamilton, Sally Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Michael Firbank, Gemma Roberts, Louise M. Allan, John O'Brien, John-Paul Taylor, Paul C. Donaghy
Summary: Impaired olfaction may serve as a potential biomarker for early Lewy body disease, particularly in cases of mild cognitive impairment with Lewy bodies (MCI-LB). Olfactory function was significantly worse in individuals with probable MCI-LB compared to those with MCI-AD and healthy controls. A lower cutoff score of ≤ 7 on the SS-16 is recommended for identifying early LB disease in memory services.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Review
Cell Biology
Augoustos Tsamourgelis, Peter Swann, Leonidas Chouliaras, John T. O'Brien
Summary: Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia. Proteomics has revealed protein dysregulation in the brain and peripheral tissues in DLB, which shares common features with other dementias but also has unique protein signatures. Identifying novel protein targets and diagnostic biomarkers could lead to new therapeutics and improved clinical trials for DLB.
AGEING RESEARCH REVIEWS
(2023)
Review
Clinical Neurology
Melissa J. Armstrong
Summary: Dementia with Lewy bodies (DLB) is a specific presentation of a pathological alpha-synucleinopathy, with recent advances including updated diagnostic criteria and recognition of prodromal states. Research shows common co-occurrence of Alzheimer's disease pathology in individuals with DLB, impacting biomarker use and progression. Identifying biomarkers and effective therapies remain key areas of focus for future research in DLB.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Article
Clinical Neurology
Kurt A. Jellinger
Summary: PDD and DLB are two major neurocognitive disorders in the spectrum of Lewy body diseases with overlapping clinical and neuropathological features. DLB has higher Braak LB scores and neuritic Braak stages, as well as more severe neuropathological features like Thal A beta phases and neuritic Braak stages. Worse prognosis in DLB is linked to increased Braak neuritic stages and more severe cerebral amyloid angiopathy.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Clinical Neurology
Rotem Iris Orad, Tamara Shiner
Summary: Dementia with Lewy bodies presents a diagnostic challenge due to clinical overlap with other neurodegenerative conditions, such as Parkinson's disease dementia and Alzheimer's disease. Neuroimaging plays a central role in improving diagnostic accuracy and management of this disorder.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Monica Gagliardi, Radha Procopio, Giuseppe Nicoletti, Maurizio Morelli, Marco D'Amelio, Aldo Quattrone, Grazia Annesi
Summary: The study aimed to evaluate LRP10 gene mutations in PD and DLB patients from Southern Italy, finding only 2 missense and 3 synonymous variants in patients and control subjects, and a rare variant p.L622F in a PD case. These results indicate that LRP10 mutations are not a common cause of PD and DLB in Southern Italy.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Martyna M. Grochowska, Ana Carreras Mascaro, Valerie Boumeester, Domenico Natale, Guido J. Breedveld, Hanneke Geut, Wiggert A. van Cappellen, Agnita J. W. Boon, Anneke J. A. Kievit, Esther Sammler, Piero Parchi, Pietro Cortelli, Dario R. Alessi, Wilma D. J. van de Berg, Vincenzo Bonifati, Wim Mandemakers
Summary: Loss-of-function variants in the LRP10 gene are linked to Parkinson's disease, dementia, and other neurodegenerative disorders. LRP10 is highly expressed in astrocytes and interacts with SORL1, potentially playing a crucial role in vesicle trafficking pathways. The specific pattern of LRP10 incorporation into Lewy bodies suggests its involvement in neurodegenerative diseases.
ACTA NEUROPATHOLOGICA
(2021)
Article
Clinical Neurology
Stephen Joza, Michele T. Hu, Ki-Young Jung, Dieter Kunz, Ambra Stefani, Petr Dusek, Michele Terzaghi, Dario Arnaldi, Aleksandar Videnovic, Mya C. Schiess, Wiebke Hermann, Jee-Young Lee, Luigi Ferini-Strambi, Simon J. G. Lewis, Laurene Leclair-Visonneau, Wolfgang H. Oertel, Elena Antelmi, Friederike Sixel-Doering, Valerie Cochen De Cock, Claudio Liguori, Jun Liu, Federica Provini, Monica Puligheddu, Alessandra Nicoletti, Claudio L. A. Bassetti, Jitka Buskova, Yves Dauvilliers, Raffaele Ferri, Jacques Y. Montplaisir, Michael Lawton, Han-Joon Kim, Frederik Bes, Birgit Hoegl, Karel Sonka, Giuseppe Fiamingo, Pietro Mattioli, Maria Lorena Lavadia, Jessika Suescun, Kyung Ah Woo, Sara Marelli, Kaylena Ehgoetz Martens, Annette Janzen, Giuseppe Plazzi, Brit Mollenhauer, Mariana Fernandes, Yuanyuan Li, Pietro Cortelli, Michela Figorilli, Calogero Edoardo Cicero, Carolin Schaefer, Lily Guiraud, Giuseppe Lanza, Jean-Francois Gagnon, Jun-Sang Sunwoo, Abubaker Ibrahim, Nicola Girtler, Claudia Trenkwalder, Luca Baldelli, Amelie Pelletier, Ronald B. Postuma
Summary: The synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, have a long prodromal period with progressive subclinical symptoms. Idiopathic REM sleep behavior disorder is an early predictor of these diseases and provides an opportunity for intervention with neuroprotective therapy.
Article
Clinical Neurology
Cecilia Tremblay, Geidy E. Serrano, Anthony J. Intorcia, Lucia Sue, Jeffrey R. Wilson, Charles H. Adler, Holly A. Shill, Erika Driver-Dunckley, Shyamal H. Mehta, Thomas G. Beach
Summary: The decline of olfactory function is frequently observed in aging. This study found that tau pathology is commonly observed in the olfactory bulb of normally aging individuals, but it does not independently contribute to age-related olfactory decline. Further involvement of the brain seems to be necessary for age-related olfactory impairment.
Article
Clinical Neurology
Jing Xu, Jia Li, Ya-juan Sun, Wei Quan, Li Liu, Qing-hui Zhang, Yi-dan Qin, Xiao-chen Pei, Hang Su, Jia-jun Chen
Summary: In this study, mRNA expression profiles were analyzed to identify potential biomarkers and mechanisms distinguishing between Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB). Seven hub genes were found to be significantly associated with PDD, suggesting their involvement in the heterogeneous pathogenesis of PDD and DLB. Additionally, several signaling pathways related to different diseases were identified.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Noah J. Graves, Yann Gambin, Emma Sierecki
Summary: Like many neurodegenerative diseases, Parkinson's disease (PD) is characterized by the formation of proteinaceous aggregates in brain cells. Additionally, these aggregates are also found in other disorders, collectively referred to as synucleinopathies. Despite the diversity in pathologies and symptoms, aSyn aggregates are a common marker and potential driver of these diseases. This review compares PD, DLB, and MSA, highlighting the role of aSyn aggregates in each disorder and discussing the relationship between aSyn strains and the cellular environment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Stefania Pezzoli, Raquel Sanchez-Valle, Aleix Solanes, Matthew J. Kempton, Oliver Bandmann, Jae Il Shin, Annachiara Cagnin, Jennifer G. Goldman, Doug Merkitch, Michael J. Firbank, John-Paul Taylor, Javier Pagonabarraga, Jaime Kulisevsky, Frederic Blanc, Norma Verdolini, Annalena Venneri, Joaquim Radua
Summary: The study found that visual hallucinations in patients with Parkinson's disease and dementia with Lewy bodies are associated with reductions in grey matter volume in certain brain regions, as well as lower verbal immediate memory performance in Parkinson's disease patients.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Marina Friesen, Stephanie Ziegler-Waldkirch, Milena Egenolf, Paolo D'Errico, Christina Helm, Charlotte Mezo, Nikolaos Dokalis, Daniel Erny, Natalie Katzmarski, Romina Coelho, Desiree Loreth, Marco Prinz, Melanie Meyer-Luehmann
Summary: The study shows an age-dependent increase in Aβ load in the olfactory bulb of APP-transgenic mice, which correlates with worsening olfactory performance. The presence of α-syn significantly reduces Aβ deposits and improves olfactory function in the mice.
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Behavioral Sciences
Inaki-Carril Mundinano, Juan Chen, Mitchell de Souza, Marc G. Sarossy, Marc F. Joanisse, Melvyn A. Goodale, James A. Bourne
Article
Neurosciences
William C. Kwan, Inaki-Carril Mundinano, Mitchell J. de Souza, Sammy C. S. Lee, Paul R. Martin, Ulrike Grunert, James A. Bourne
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Neurosciences
Dylan M. Fox, Inaki-Carril Mundinano, James A. Bourne
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Clinical Neurology
Mar Carmona-Abellan, Ivan Martinez-Valbuena, Carla DiCaudo, Irene Marcilla, Maria Rosario Luquin
CLINICAL AUTONOMIC RESEARCH
(2019)
Article
Neurosciences
Jihane Homman-Ludiye, Inaki Carril Mundinano, William C. Kwan, James A. Bourne
Article
Multidisciplinary Sciences
Inaki-Carril Mundinano, William C. Kwan, James A. Bourne
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Neurosciences
Carla di Caudo, Ivan Martinez-Valbuena, Inaki-Carril Mundinano, Aurelie Gennetier, Maria Hernandez, Mar Carmona-Abellan, Irene Marcilla Garcia, Eric J. Kremer, Rosario Luquin
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Article
Clinical Neurology
Mar Carmona-Abellan, Ivan Martinez-Valbuena, Irene Marcilla, Carla DiCaudo, Isabel Gil, Jorge Nunez, Maria-Rosario Luquin
Summary: The olfactory bulb (OB) in patients with neurodegenerative diseases shows increased numbers of activated microglia and reactive astrocytes. The presence of activated microglia cells is associated with phosphorylated Tau deposits, suggesting an independent contribution to the degenerative process.
NEUROLOGICAL SCIENCES
(2021)
Article
Anatomy & Morphology
Quentin Montardy, William C. Kwan, Inaki C. Mundinano, Dylan M. Fox, Liping Wang, Cornelius T. Gross, James A. Bourne
Summary: The study found that the ventromedial hypothalamus is involved in fear responses in primates, as demonstrated by flight reactions in marmoset monkeys when exposed to predators in laboratory conditions. Additionally, the anatomical connectivity of the medial hypothalamic defensive system in rodents and primates is highly conserved.
BRAIN STRUCTURE & FUNCTION
(2021)
Review
Biochemistry & Molecular Biology
Paula Fernandez-Palanca, Carolina Mendez-Blanco, Flavia Fondevila, Maria J. Tunon, Russel J. Reiter, Jose L. Mauriz, Javier Gonzalez-Gallego
Summary: Melatonin, with antioxidant, chronobiotic, and anti-inflammatory properties, shows potential as a promising treatment option for liver cancers by modulating various processes such as inhibiting oxidative stress, promoting immune response, and inducing cell cycle arrest and apoptosis.
Article
Neurosciences
Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, Maria-Teresa Tunon, Paul E. Fraser, Maria-Rosario Luquin
Summary: Protein misfolding diseases encompass a variety of disorders, with type two diabetes potentially contributing to the sporadic forms of neurodegenerative diseases. Multiple misfolded proteins in the pancreas, including alpha-synuclein and tau, may play crucial roles in the complex pathophysiology of diabetes and the development of insulin resistance in Alzheimer's and Parkinson's disease. This study reveals the co-occurrence of amylin, pancreatic alpha-synuclein, A beta, PrP, and tau in the pancreas, shedding light on common pathological pathways between neurodegenerative diseases and diabetes.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Anatomy & Morphology
Ulrike Gruenert, Sammy C. S. Lee, William C. Kwan, Inaki-Carril Mundinano, James A. Bourne, Paul R. Martin
Summary: The study identified the retinal ganglion cell types projecting to the medial subdivision of inferior pulvinar and superior colliculus in marmoset monkeys. Results showed that both PIm and SC receive input from various ganglion cell types, with different dominant cell types in each area.
BRAIN STRUCTURE & FUNCTION
(2021)
Review
Neurosciences
Leon Teo, Anthony G. Boghdadi, Jihane Homman-Ludiye, Inaki-Carril Mundinano, William C. Kwan, James A. Bourne
Summary: Infants and adults exhibit different responses to brain injuries, with Eph/ephrin signaling playing a key role in age-dependent reactive astrocyte behavior. Ephrin-A1 signaling can shift astrocytes towards neuroprotection, reducing glial scarring and preserving circuitry in adults after CNS injuries. Understanding these mechanisms could lead to improved outcomes for adults after brain injuries.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Oncology
Paula Fernandez-Palanca, Tania Payo-Serafin, Flavia Fondevila, Carolina Mendez-Blanco, Beatriz San-Miguel, Marta R. Romero, Maria J. Tunon, Jose J. G. Marin, Javier Gonzalez-Gallego, Jose L. Mauriz
Summary: This study evaluated the prognostic, diagnostic and clinicopathological value of NRP1 in liver cancer and CRC patients, showing that NRP1 overexpression is significantly correlated with lower survival and tumor development, suggesting NRP1 may be a potential and useful biomarker in both types of cancer.
Article
Architecture
Maria Alvarez
RA-REVISTA DE ARQUITECTURA
(2019)