Article
Cell Biology
Chathurika Henpita, Rajesh Vyas, Chastity L. Healy, Tra L. Kieu, Aditi U. Gurkar, Matthew J. Yousefzadeh, Yuxiang Cui, Aiping Lu, Luise A. Angelini, Ryan D. O'Kelly, Sara J. McGowan, Sanjay Chandrasekhar, Rebecca R. Vanderpool, Danielle Hennessy-Wack, Mark A. Ross, Timothy N. Bachman, Charles McTiernan, Smitha P. S. Pillai, Warren Ladiges, Mitra Lavasani, Johnny Huard, Donna Beer-Stolz, Claudette M. St. Croix, Simon C. Watkins, Paul D. Robbins, Ana L. Mora, Eric E. Kelley, Yinsheng Wang, Timothy D. O'Connell, Laura J. Niedernhofer
Summary: Cardiomyopathy is a progressive disease of the myocardium leading to impaired contractility. This study shows that endogenous genotoxic stress contributes to the development of cardiomyopathy by activating the p53 pathway and increasing oxidative stress, leading to cardiac myocyte apoptosis, dilated cardiomyopathy, and sudden death.
Review
Biochemistry & Molecular Biology
Hamza El Hadi, Anne Freund, Steffen Desch, Holger Thiele, Nicolas Majunke
Summary: Cardiomyopathies are a diverse group of heart muscle disorders with potentially fatal consequences such as arrhythmias and heart failure. They are a leading cause of heart transplantation worldwide. Recent advancements in understanding the molecular basis and diagnostic evaluation have paved the way for targeted therapies. However, further research is needed to improve risk assessment and prevention strategies for sudden cardiac death.
Article
Cardiac & Cardiovascular Systems
Fabrizio Ricci, Behzad Banihashemi, Mirnabi Pirouzifard, Jan Sundquist, Kristina Sundquist, Richard Sutton, Artur Fedorowski, Bengt Zoller
Summary: This study found a high familial incidence of dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), which is associated with genetic resemblance. The strongest aggregation was observed in relatives of affected females with HCM, while the association was attenuated for DCM.
Review
Cardiac & Cardiovascular Systems
Upasana Tayal, James S. Ware, Neal K. Lakdawala, Stephane Heymans, Sanjay K. Prasad
Summary: This review provides a practical primer for clinicians on the genetic basis of dilated cardiomyopathy, including the clinical relevance, key genetic concepts, which patients may benefit from genetic testing, common genetic tests performed, how to interpret genetic results, and the clinical applications. Areas for future research in this dynamic field are also discussed.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Upasana Tayal, James S. Ware, Neal K. Lakdawala, Stephane Heymans, Sanjay K. Prasad
Summary: This review provides a practical primer for clinicians on the genetic basis of dilated cardiomyopathy, introducing key concepts, explaining genetic testing, interpretation of results, and clinical applications, as well as highlighting areas for future research in this field.
EUROPEAN HEART JOURNAL
(2021)
Article
Cell Biology
Yuanxiu Song, Hongxia Li, Shuhong Ma, Min Zhu, Wen-Jing Lu, Feng Lan, Ming Cui
Summary: Alcoholic cardiomyopathy (ACM) is a myocardial injury caused by long-term heavy drinking. This study used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to establish an in vitro model of ACM and found that AngII and AT1R play a role in alcohol-induced myocardial damage through oxidative stress. The mechanism may involve the regulation of NOX.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Jan Haas, Karen S. Frese, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Rewati Tappu, Rouven Nietsch, Oguz Firat Tugrul, Michael Wisdom, Carsten Dietrich, Ali Amr, Tanja Weis, Torsten Niederdraenk, Michael P. Murphy, Thomas Krieg, Marcus Doerr, Uwe Voelker, Jens Fielitz, Norbert Frey, Stephan B. Felix, Andreas Keller, Hugo A. Katus, Benjamin Meder
Summary: This study identified a new set of metabolomic biomarkers for heart failure (HF) through a multi-OMICS approach, revealing underlying biological cascades that potentially represent suitable intervention targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Youxu Jiang, Xiaowei Li, Tianwei Guo, Wen-Jing Lu, Shuhong Ma, Yun Chang, Yuanxiu Song, Siyao Zhang, Rui Bai, Hongyue Wang, Man Qi, Hongfeng Jiang, Hongjia Zhang, Feng Lan
Summary: This study successfully generated a PLN knockout human induced pluripotent stem cell line using CRISPR-Cas9 technology. The study found that PLN deficiency leads to the development of a cardiac failure phenotype primarily through abnormal calcium ion transport and cellular energy metabolism imbalance.
Article
Cardiac & Cardiovascular Systems
Nobuyuki Enzan, Shouji Matsushima, Tomomi Ide, Takeshi Tohyama, Kouta Funakoshi, Taiki Higo, Hiroyuki Tsutsui
Summary: This study compared the effectiveness of ACE inhibitors and ARBs in the recovery of left ventricular ejection fraction (LVEF) in patients with dilated cardiomyopathy (DCM). The study found that the use of ARBs was associated with a higher frequency of LVEF recovery compared to ACE inhibitors.
Review
Chemistry, Medicinal
Yuejin Li, Md Rezaul Karim, Buheng Wang, Jiangnan Peng
Summary: Heart disease is the leading cause of death worldwide, and green tea consumption has been associated with lower morbidity and mortality from cardiovascular diseases. Tea catechins play a significant role in cardiovascular health, with antioxidative, anti-inflammatory, and anti-apoptosis effects. The most abundant catechin, EGCG, also has the capability to regulate cardiac muscle contraction and protect against oxidative stress and inflammation.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Yukinobu Ito, Makoto Yoshida, Hirotake Masuda, Daichi Maeda, Yukitsugu Kudo-Asabe, Michinobu Umakoshi, Hiroshi Nanjo, Akiteru Goto
Summary: This study investigated morphological differences in intercalated discs (ICDs) in patients with DCM, and found that reduced N-cadherin immunostaining intensity and ICD scattering were specific to DCM. The results suggest that disorganized ICDs contribute to the development of DCM and that N-cadherin immunostaining is useful for pathological diagnosis.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Denise Zaffalon, Efstathios Papatheodorou, Ahmed Merghani, Harshil Dhutia, Eleonora Moccia, Aneil Malhotra, Christopher J. Miles, Virginia Attard, Tessa Homfray, Rajan Sharma, Marta Gigli, Matteo Dal Ferro, Marco Merlo, Michael Papadakis, Gianfranco Sinagra, Sanjay Sharma, Gherardo Finocchiaro
Summary: This study investigated the role of electrocardiogram (ECG) in differentiating between physiological and pathological cardiac remodeling. The ECG was abnormal in a high percentage of patients with dilated cardiomyopathy (DCM), while it was usually normal in athletes with significant cardiac remodeling.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Hiromitsu Kanamori, Akihiro Yoshida, Genki Naruse, Susumu Endo, Shingo Minatoguchi, Takatomo Watanabe, Tomonori Kawaguchi, Toshiki Tanaka, Yoshihisa Yamada, Nobuhiro Takasugi, Takuma Ishihara, Atsushi Mikami, Nagisa Miyazaki, Kazuhiko Nishigaki, Shinya Minatoguchi, Tatsuhiko Miyazaki, Hiroyuki Okura
Summary: The study revealed that autophagy serves as a predictive marker for LVRR in DCM patients, with prognostic value. LVRR-positive patients had a higher number of autophagic vacuoles and higher expression levels. Autophagy may offer novel pathologic insights into strategies for treating the failing DCM heart.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Biology
Giuseppina Mastrototaro, Pierluigi Carullo, Jianlin Zhang, Beatrice Scellini, Nicoletta Piroddi, Simona Nemska, Maria Carmela Filomena, Simone Serio, Carol A. Otey, Chiara Tesi, Fabian Emrich, Wolfgang A. Linke, Corrado Poggesi, Simona Boncompagni, Marie-Louise Bang, Nuno Guimaraes-Camboa
Summary: Palladin (PALLD) is a protein associated with actin and immunoglobulin in the heart. Its role in the heart has been unclear due to embryonic lethality in knockout mice. However, a study found that PALLD is necessary for normal cardiac function, as its deletion in adult mice led to cardiac abnormalities and dysfunction. Additionally, PALLD interacts with other proteins such as CARP/Ankrd1 and FHOD1. This research sheds light on the importance of PALLD in the heart.
Article
Biochemistry & Molecular Biology
Brahim El Mathari, Pascale Briand, Alain Corbier, Bruno Poirier, Veronique Briand, Alice Raffenne-Devillers, Marie-Pierre Harnist, Etienne Guillot, Frederique Guilbert, Philip Janiak
Summary: Apelin has been shown to improve cardiac function in dilated cardiomyopathy mainly by reducing peripheral vascular resistance, without significant effects on load-independent indices of myocardial contractility.
Article
Physiology
Nicoletta Piroddi, E. Rosalie Witjas-Paalberends, Claudia Ferrara, Cecilia Ferrantini, Giulia Vitale, Beatrice Scellini, Paul J. M. Wijnker, Vasco Sequiera, Dennis Dooijes, Cristobal dos Remedios, Saskia Schlossarek, Man Ching Leung, Andrew Messer, Douglas G. Ward, Annibale Biggeri, Chiara Tesi, Lucie Carrier, Charles S. Redwood, Steven B. Marston, Jolanda van der Velden, Corrado Poggesi
JOURNAL OF GENERAL PHYSIOLOGY
(2019)
Article
Cell Biology
Steven Marston, Juan Eiros Zamora
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
(2020)
Article
Cell Biology
Steven Marston
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
(2019)
Editorial Material
Cell Biology
Elisabeth Ehler, Steven B. Marston
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
(2019)
Article
Physiology
O'neal Copeland, Andrew Messer, Andrew Jabbour, Corrado Poggesi, Sanjay Prasad, Steven Marston
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Physiology
Peter T. Wright, Sharmane F. Tsui, Alice J. Francis, Kenneth T. MacLeod, Steven B. Marston
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Multidisciplinary Sciences
Trisha Tucholski, Wenxua Cai, Zachery R. Gregorich, Elizabeth F. Bayne, Stanford D. Mitchell, Sean J. McIlwain, Willem J. de Lange, Max Wrobbel, Hannah Karp, Zachary Hite, Petr G. Vikhorev, Steven B. Marston, Sean Lal, Amy Li, Cristobal dos Remedios, Takushi Kohmoto, Joshua Hermsen, J. Carter Ralphe, Timothy J. Kamp, Richard L. Moss, Ying Ge
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Review
Biochemistry & Molecular Biology
Khulud Alsulami, Steven Marston
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Biographical-Item
Cell Biology
Steven Baxter Marston
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
(2021)
Review
Physiology
Steven Marston
Summary: Contractility, the generation of force and movement by molecular motors, is a key characteristic of muscles. Studying contractility at the subcellular level offers unique advantages, allowing direct investigation of contractile protein properties and easy manipulation of experimental conditions. This mini review provides an overview of current methods for measuring force production at the subcellular level.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elumalai Pavadai, Michael J. Rynkiewicz, Zeyu Yang, Ian R. Gould, Steven B. Marston, William Lehman
Summary: This study reveals the phosphorylation regulation mechanism of cardiac-specific tropomyosin by utilizing protein modeling and molecular dynamics simulation. The results suggest that phosphorylated residues may interact closely with tropomyosin and the N-lobe of TnC, thereby affecting cardiac muscle contraction and relaxation.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Cell Biology
Steven Marston
Summary: Ca2+ acts on troponin and tropomyosin to regulate the thin filament, but in cardiac muscle, adrenaline can enhance contractility and relaxation rate by phosphorylating troponin I, leading to an increased release of Ca2+. Recent studies have used molecular dynamics simulations and other techniques to investigate the precise mechanism of how phosphorylation of troponin I modulates troponin dynamics to produce the desired effects.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
(2023)
Review
Cardiac & Cardiovascular Systems
Steven Marston, Jose Renato Pinto
Summary: In cardiac muscle, the action of adrenaline on beta 1 receptors is essential for enhancing contractility, heart rate, and relaxation through PKA activation. Lusitropy plays a crucial role in shortening the heartbeat during increased heart rate. PKA phosphorylates TnI and PLB, leading to faster relaxation and Ca2+ removal. This review examines the relationship between decreased lusitropy and cardiac dysfunction, discusses the impact of mutations in PLB and thin filament proteins, and evaluates the therapeutic potential of restoring suppressed lusitropy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Chemistry, Physical
Zeyu Yang, Steven B. Marston, Ian R. Gould
Summary: Adrenaline acts on beta 1 receptors in the heart muscle to enhance contractility, increase heart rate, and relaxation rate. Phosphorylation of cardiac troponin I affects the modulation system. Mutations suppress the phosphorylation-dependent change, causing key parts of the system to be disordered and difficult to resolve through conventional structural approaches.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Cardiac & Cardiovascular Systems
Petr G. Vikhorev, Natalia N. Vikhoreva, WaiChun Yeung, Amy Li, Sean Lal, Cristobal G. dos Remedios, Cheavar A. Blair, Maya Guglin, Kenneth S. Campbell, Magdi H. Yacoub, Pieter de Tombe, Steven B. Marston
Summary: This study investigates the effects of truncating mutations in the titin gene (TTN) on the function and characteristics of myofibrils. The researchers found that these mutations lead to decreased length-dependent activation and increased elasticity of myofibrils. They also observed decreased phosphorylation levels of TnI and MyBP-C in DCM patients with TTN-truncating variants.
CARDIOVASCULAR RESEARCH
(2022)