Article
Cell Biology
Andrea Schmitt, Laura Tatsch, Alisa Vollhardt, Thomas Schneider-Axmann, Florian J. Raabe, Lukas Roell, Helmut Heinsen, Patrick R. Hof, Peter Falkai, Christoph Schmitz
Summary: This study utilized stereology to investigate the numbers and densities of different cell types in the brains of individuals with schizophrenia. The results indicated a reduction in oligodendrocytes in the CA4 region in schizophrenia patients, which was absent in the control group.
Article
Biochemistry & Molecular Biology
Amira Bryll, Wirginia Krzysciak, Paulina Karcz, Maciej Pilecki, Natalia Smierciak, Marta Szwajca, Anna Skalniak, Tadeusz J. Popiela
Summary: Our study identified an objective molecular biomarker of schizophrenia outcome, based on biochemical indices in peripheral and cerebral tissues. Distinguishing two endophenotypes of schizophrenia, our research highlighted differences in life quality, symptoms, and neurotransmitter metabolites. The study suggests further investigation on the balance of microcircuits and redox systems for predicting potential biomarkers of neuropsychiatric diseases.
Article
Clinical Neurology
J-W Thielen, B. W. Mueller, D- Chang, A. Krug, S. Mehl, A. Rapp, H. Walter, G. Winterer, K. Vogeley, S. Klingberg, M. Wagner, T. Kircher
Summary: In this study, the cortical thickness of different subregions of the cingulate gyrus was assessed in patients with schizophrenia-spectrum disorder. The findings suggest that the cortical thickness in the posterior part of the cingulate gyrus is increased and related to illness duration, while cortical thickness in the anterior parts is decreased and unrelated to illness duration. Memory performance is only related to cortical thickness in the anterior parts of the cingulate gyrus.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Richard Gaus, Melanie Popal, Helmut Heinsen, Andrea Schmitt, Peter Falkai, Patrick R. Hof, Christoph Schmitz, Alisa Vollhardt
Summary: This study investigates the structural and functional abnormalities of the anterior cingulate cortex (ACC) and von Economo neurons (VENs) in schizophrenia, revealing lower total neuron number and VENs in patients compared to controls. These findings provide evidence for the involvement of ACC and VENs in the pathophysiology of schizophrenia.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Psychiatry
Qiong Huang, Lulu Hou, Wenpei Zhang, Renlai Zhou
Summary: This study examined the neural functional dysregulation in individuals with high test anxiety (HTA) using functional connectivity (FC) analysis. The results showed that individuals with HTA have deficits in prefrontal control and tend to recruit more resources to deal with emotional interference during tests. The dysregulated functional connectivity between the ACC and frontal-parietal regions may underlie the pathophysiology of test anxiety.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Juan Angel Aibar-Duran, Iluminada Corripio Collado, Alexandra Roldan Bejarano, Raquel Sanchez Nevado, Ignacio Aracil Bolanos, Julia Garcia-Cornet, Anna Alonso-Solis, Eva M. Grasa Bello, Cristian de Quintana Schmidt, Fernando Munoz Hernandez, Joan Molet Teixido, Rodrigo Rodriguez Rodriguez
Summary: This study summarizes the outcomes after three years of follow-up of patients with treatment-resistant schizophrenia (TRS) treated with deep brain stimulation (DBS) and discusses surgical, clinical, and imaging analysis. The results showed a trend toward improvement in positive and general symptoms in TRS patients treated with DBS. Connectomic analysis will help in understanding the interaction of this treatment with the disease and in designing future trials.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Zixiao Yang, Jianping Song, Wei Zhu, Ying Mao
Summary: This report presents a case of cingulate gyrus glioma treated with a gravity-assisted, fully endoscopic resection technique, which successfully removed the tumor, improved motor dysfunction in the patient, and preserved important brain functional areas. This case demonstrates the value of gravity-assisted endoscopic resection in dominant cingulate gyrus tumors surrounded by eloquent parenchyma.
ACTA NEUROCHIRURGICA
(2021)
Article
Biochemistry & Molecular Biology
Yachao He, Xiaoqun Zhang, Ivana Flais, Per Svenningsson
Summary: The levels of Prosaposin and Progranulin are reduced in schizophrenia patients. Knockdown of Prosaposin in the cingulate cortex leads to behavioral abnormalities and increased protein levels associated with circuitry dysfunction in schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Saida Haider, Sidrah Shahzad, Zehra Batool, Sadia Sadir, Laraib Liaquat, Saiqa Tabassum, Tahira Perveen
Summary: Spirulina has neuroprotective effects and ameliorates psychosis-like symptoms in an animal model of SZ. It regulates neurotransmission and other biomarkers, improving behavioral deficits and restoring immune response dysfunction.
Article
Clinical Neurology
Jose Vina, Joaquin Escudero, Miquel Baquero, Monica Cebrian, Juan Antonio Carbonell-Asins, Jose Enrique Munoz, Encarnacion Satorres, Juan Carlos Melendez, Jose Ferrer-Rebolleda, Ma del Puig Cozar-Santiago, Jose Manuel Santabarbara-Gomez, Mariona Jove, Reinald Pamplona, Francisco Jose Tarazona-Santabalbina, Consuelo Borras
Summary: This study suggests that genistein may have a therapeutic role in delaying the onset of dementia in patients with prodromal Alzheimer's disease.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Psychiatry
Michael MacKinley, Sabrina D. Ford, Peter Jeon, Jean Theberge, Lena Palaniyappan
Summary: Patients with higher central antioxidant tone at first presentation of psychosis have better functional outcomes in early stages of illness, indicating a key role for central antioxidant tone in early psychosis.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Clinical Neurology
Bernd Lenz, Sarah Gerhardt, Rafat Boroumand-Jazi, Anna Eichler, Verena Nadine Buchholz, Peter A. Fasching, Johannes Kornhuber, Tobias Banaschewski, Herta Flor, Stella Guldner, Maren Prignitz, Frauke Nees
Summary: Prenatal androgenization is associated with behavior and mental health in adolescence and adulthood. This study found that prenatal androgen load is related to frontal cortex volumes in a sex-dependent manner, with different effects in males and females. These findings contribute to our understanding of sex differences in behavior and mental health.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Martina Ardizzi, Francesca Ferroni, Maria Alessandra Umilta, Chiara Pinardi, Antonino Errante, Francesca Ferri, Elisabetta Fadda, Vittorio Gallese
Summary: Empathy for pain brain regions are commonly activated by both artistic and non-artistic painful facial expressions, suggesting the importance of empathy in the aesthetic experience of artworks. Additionally, a distinct activation was found in the posterior cingulate cortex/precuneus for non-artistic stimuli.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2021)
Article
Neurosciences
Massimo Lumaca, Peter Vuust, Giosue Baggio
Summary: Compositionality, a hallmark of human language and symbolic systems, shows variation in individuals. This study reveals that individual biases in compositional behavior are related to the anatomy and functional topology of semantic networks.
Article
Psychiatry
Zhaoyuan Tu, Feng Wu, Xiaowei Jiang, Lingtao Kong, Yanqing Tang
Summary: This research aimed to explore gender differences in brain function images in MDD, finding specific patterns and diagnostic differences in male and female patients with MDD. The occipital lobe, calcarine, DLPFC, and DCG were identified as main different brain regions between male and female patients, potentially serving as biomarkers for diagnosing and treating MDD.
FRONTIERS IN PSYCHIATRY
(2022)