Article
Geriatrics & Gerontology
Woori Moon, Ji Won Han, Jong Bin Bae, Seung Wan Suh, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim
Summary: This study investigated the disease burden of various dementias and mild cognitive impairment in a representative South Korean population, predicting a significant increase in disability-adjusted life-years and years lived with disability due to these conditions by 2065.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Yanxia Lu, Tamas Fulop, Xinyi Gwee, Tih Shih Lee, Wee Shiong Lim, Mei Sian Chong, Philip Lin Kiat Yap, Keng Bee Yap, Fang Pan, Tze-Pin Ng
Summary: This study found that cardiovascular risk factors and vascular pathology contribute to cognitive impairment and dementia, especially in older adults with diabetes who are more likely to develop MCI and dementia.
Review
Clinical Neurology
Petros Stamatelos, Alexandra Economou, Leonidas Stefanis, George Yannis, Sokratis G. Papageorgiou
Summary: Driving is a complex task that requires the integrity and cooperation of cognition, motor, and somatosensory skills, all impacted by neurological diseases. Neurologists play a critical role in assessing the fitness to drive of cognitively impaired individuals. Research indicates that, despite numerous guidelines and recommendations, there is still no widely accepted approach for evaluating the driving ability of cognitively impaired individuals.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Andrea Horta-Barba, Saul Martinez-Horta, Jesus Perez-Perez, Arnau Puig-Davi, Natascia de Lucia, Giuseppe de Michele, Elena Salvatore, Stefanie Kehrer, Josef Priller, Simone Migliore, Ferdinando Squitieri, Anna Castaldo, Caterina Mariotti, Veronica Mananes, Jose Luis Lopez-Sendon, Noelia Rodriguez, Asuncion Martinez-Descals, Filipa Julio, Cristina Januario, Marianna Delussi, Marina de Tommaso, Sandra Noguera, Jesus J. Ruiz-Idiago, Emilia Sitek, Renata Wallner, Angela Nuzzi, Javier Pagonabarraga, Jaime Kulisevsky
Summary: This study developed a specific assessment tool, the Parkinson's Disease-Cognitive Rating Scale (PD-CRS), to evaluate the cognitive status of Huntington's disease patients and monitor the progression of cognitive impairment. Through evaluating 180 gene-positive patients, criteria for classifying normal cognition, mild cognitive impairment, and dementia were established, and the PD-CRS demonstrated good sensitivity and specificity. Additionally, the PD-CRS captured cognitive progression in different cognitive groups and showed sensitivity to change in mild cognitive impairment and dementia.
JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Calum A. Hamilton, Fiona E. Matthews, Paul C. Donaghy, John-Paul Taylor, John T. O'Brien, Nicola Barnett, Kirsty Olsen, Jim Lloyd, George Petrides, Ian G. McKeith, Alan J. Thomas
Summary: The study found differences in cognitive profiles and progression between probable MCI-LB and MCI-AD, with MCI-LB patients showing less impaired recognition memory, greater initial impairments in verbal fluency and perception of line orientation, and an expedited decline in visuo-constructional functions. However, no clear diagnostic group differences were found in deterioration speeds for global cognition, language, overall memory, attention or other executive functions.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Neurosciences
Israel Martinez-Nicolas, Thide E. Llorente, Francisco Martinez-Sanchez, Juan J. G. Meilan
Summary: Through speech analysis, this study found that some speech parameters vary due to vascular pathologies, and can accurately predict the diagnosis probability of diabetes and hypertension over 95%, and hypercholesterolemia and heart disease over 80%. These findings may contribute to exploring the causes and developments of cognitive impairment diseases.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Tran Thanh Duy Linh, Yi-Chen Hsieh, Li-Kai Huang, Chaur-Jong Hu
Summary: Population aging poses challenges to the treatment of cognitive impairment or dementia, with vascular dementia being the second leading cause after Alzheimer's disease. There have been fewer drug trials targeting vascular dementia compared to Alzheimer's dementia in the past decade, and investment from international pharmaceutical companies in this area remains insufficient.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Geriatrics & Gerontology
Rwei-Ling Yu, Ruey-Meei Wu
Summary: Mild cognitive impairment (MCI) is a common non-motor symptom in patients with Parkinson's disease (PD), but lacks consistent diagnostic criteria. Different types of cognitive impairments have different progression rates. This review provides an overview of the diagnostic criteria for PD-MCI and the heterogeneity of patients' cognitive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Jasmin E. Guevara, Natalie E. Kurniadi, Kevin Duff
Summary: This study quantifies cognitive change in patients with mild cognitive impairment (MCI) using standardized regression-based (SRB) z-scores. The findings show a significant decline in cognitive function over time, especially in learning and memory. Patients who progressed to dementia (MCI-Decline) showed more decline compared to those who remained stable (MCI-Stable). The study highlights the value of SRB in quantifying cognitive decline and identifying individuals at higher risk for MCI progression.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Paul C. C. Donaghy, Calum Hamilton, Rory Durcan, Sarah Lawley, Sally Barker, Joanna Ciafone, Nicola Barnett, Kirsty Olsen, Michael Firbank, Gemma Roberts, Jim Lloyd, Louise M. M. Allan, Ranjan Saha, Ian G. G. McKeith, John T. T. O'Brien, John-Paul Taylor, Alan J. J. Thomas
Summary: Through the investigation of patients with mild cognitive impairment with Lewy bodies (MCI-LB), it was found that MCI-LB patients have more symptoms, and a 10-point symptom scale can effectively differentiate MCI-LB and MCI-AD. These findings are important for clinicians to diagnose and treat MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Alfonso Delgado-Alvarez, Thomas Rune Nielsen, Cristina Delgado-Alonso, Maria Valles-Salgado, Juan I. Lopez-Carbonero, Rocio Garcia-Ramos, Maria Jose Gil-Moreno, Maria Diez-Cirarda, Jorge Matias-Guiu, Jordi A. Matias-Guiu
Summary: This study aimed to validate the Cross-Cultural Neuropsychological Test Battery (CNTB) in Spanish patients with Alzheimer's disease (AD) and Parkinson's disease with mild cognitive impairment (PD-MCI). The results showed that the CNTB exhibited appropriate diagnostic properties in AD and PD, including those stages with mild cognitive impairment. This supports the utility of the CNTB for the early detection of cognitive impairment in AD and PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)