Article
Engineering, Electrical & Electronic
Behnam Faraji, Korosh Rouhollahi, Akram Nezhadi, Zahra Jamalpoor
Summary: Deep brain stimulation (DBS) is an effective treatment for movement problems caused by various neurodegenerative diseases, such as Parkinson's disease. Recent studies have developed closed-loop DBS techniques to reduce hand tremors, particularly in Parkinson's patients. This study contributes by demonstrating the correlation between hand tremor and rigidity symptoms and proposing a non-integer proportional integral derivative (PID) control technique based on proximal policy optimization (PPO) to simultaneously reduce hand tremor and stiffness.
IEEE SENSORS JOURNAL
(2023)
Article
Clinical Neurology
Alexander Calvano, Lars Timmermann, Philipp Alexander Loehrer, Carina Renate Oehrn, Immo Weber
Summary: Acoustic stimulation has the potential to improve motor symptoms in Parkinson's disease (PD). Specifically, binaural beat stimulation (BBS) in the gamma frequency range is associated with synchronized cortical oscillations at 40 Hz, which is believed to have a prokinetic function in PD. However, more studies are needed to fully understand the clinical relevance of BBS and optimize its therapeutic effects.
FRONTIERS IN NEUROLOGY
(2023)
Review
Psychology, Multidisciplinary
Joshua A. Wilt, Amanda R. Merner, Jaclyn Zeigler, Michelle Montpetite, Cynthia S. Kubu
Summary: Deep Brain Stimulation (DBS) is a safe and effective treatment for Parkinson's Disease (PD) in improving motor symptoms, but concerns about its effects on patients' personality remain. Research shows that while there is little evidence of changes in dispositional traits following DBS, there is some positive progress in characteristic adaptations. Further research is needed in exploring the impact on narrative identity after DBS treatment for PD.
FRONTIERS IN PSYCHOLOGY
(2021)
Correction
Neurosciences
Yijie Lai, Yunhai Song, Daoqing Su, Linbin Wang, Chencheng Zhang, Bomin Sun, Jorik Nonnekes, Bastiaan R. Bloem, Dianyou Li
Summary: A correction to this paper has been published.
NPJ PARKINSONS DISEASE
(2021)
Review
Anesthesiology
R. L. H. Yim, K. M. M. Leung, C. C. M. Poon, M. G. Irwin
Summary: Parkinson's disease patients have a higher risk of peri-operative complications, necessitating multidisciplinary management and specialized care. Continuous dopaminergic treatment, peri-operative disease pathway development, and telemedicine are improving peri-operative care. Management for advanced Parkinson's disease is evolving with potential for integrated care and changes in anaesthetic management.
Article
Clinical Neurology
Ahro Kim, Han-Joon Kim, Aryun Kim, Yoon Kim, Ahwon Kim, Jed Noel A. Ong, Hye Ran Park, Sun Ha Paek, Beomseok Jeon
Summary: This study aimed to investigate mortality and factors associated with mortality and causes of death after deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease. The results showed that 18.7% of patients died, with pneumonia being the most common cause of death. Older age, earlier disease onset, higher preoperative falling score while on medication, and higher preoperative total levodopa equivalent daily dose were associated with a higher risk of mortality.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Jana Peeters, Alexandra Boogers, Tine Van Bogaert, Till Anselm Dembek, Robin Gransier, Jan Wouters, Wim Vandenberghe, Philippe De Vloo, Bart Nuttin, Myles Mc Laughlin
Summary: The study investigates the use of evoked potentials (EPs) to predict clinical outcomes in Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS). It finds that EPs can accurately predict clinical DBS responses, and combining EPs with imaging data further improves this prediction.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Tianqi Hu, Hutao Xie, Yu Diao, Houyou Fan, Delong Wu, Yifei Gan, Fangang Meng, Yutong Bai, Jianguo Zhang
Summary: This study aimed to investigate the effects of STN-DBS on PD patients with different levels of depression and identify predictors of these effects. The results showed that patients with moderate depression had better improvement, and gender (female) and preoperative HAMA scores were predictors of the effects of STN-DBS on PD depression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Computer Science, Information Systems
Shawki Saleh, Bouchaib Cherradi, Oussama El Gannour, Soufiane Hamida, Omar Bouattane
Summary: In this study, machine learning algorithms and acoustic datasets were used to predict Parkinson's disease. The cross-validation technique was employed to enhance the model's performance, and optimal hyperparameters tuning was applied to improve the prediction results. The best classifiers were selected and two independent ensemble voting classifiers were built, achieving accuracy rates of 96.41% and 97.35%, respectively.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Neurosciences
Michael S. Okun, Patrick T. Hickey, Andre G. Machado, Alexis M. Kuncel, Warren M. Grill
Summary: The study shows that Temporally Optimized Patterned Stimulation (TOPS) is as effective as standard DBS in reducing motor symptoms of Parkinson's disease (PD), and in some cases, even more effective. TOPS stimulation is well-tolerated and reduces estimated energy use.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Neurosciences
Fateme Pol, Mohammad Ali Salehinejad, Hamzeh Baharlouei, Michael A. Nitsche
Summary: Studies have shown that tDCS targeting the motor cortex and supplementary motor area bilaterally appears promising for gait rehabilitation in PD, while targeting the dorosolateral prefrontal cortex or cerebellum has shown more heterogeneous results. Further research is needed to compare the efficacy of different tDCS protocols and optimize the intervention approach.
TRANSLATIONAL NEURODEGENERATION
(2021)
Review
Health Care Sciences & Services
Daniel van Poppelen, Annelie N. M. Tromp, Rob M. A. de Bie, Joke M. Dijk
Summary: Based on a retrospective case series and literature review, it was found that patients with Parkinson's disease who have persisting medication related motor response fluctuations despite DBS or CLI treatment may benefit from an additional or alternative treatment with either CLI or DBS.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Clinical Neurology
Yu Ma, Suhua Miao, Rongsong Zhou, Qi Zhang, Hao Chen, Yanhua Liang
Summary: Remote programming offers a feasible and acceptable approach to timely and economic management for patients with Parkinson's disease after deep brain stimulation implantation.
WORLD NEUROSURGERY
(2021)
Review
Neurosciences
Tino Zaehle
Summary: Fatigue is a common non-motor symptom in Parkinson's disease (PD) that significantly impacts quality of life, yet progress in understanding its causes and developing effective treatments is slow. Transcranial direct current stimulation (tDCS) is considered a potential therapeutic option for treating fatigue in patients with neuropsychiatric disorders.