Article
Neurosciences
Detao Meng, Zhaohui Jin, Yixuan Wang, Boyan Fang
Summary: The study aimed to investigate the effect of neuropsychiatric symptoms on cognitive decline in patients with Parkinson's disease. Longitudinal data from the Parkinson's Progression Markers Initiative cohort were analyzed using linear mixed-effects models and generalized estimating equations. The results showed that depression, anxiety, apathy, and psychosis were associated with global cognitive decline, and patients with these symptoms were more likely to meet the criteria for mild cognitive impairment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Mattia Siciliano, Rosa De Micco, Andrea Gerardo Russo, Fabrizio Esposito, Valeria Sant'Elia, Lucia Ricciardi, Francesca Morgante, Antonio Russo, Jennifer G. Goldman, Carlo Chiorri, Gioacchino Tedeschi, Luigi Trojano, Alessandro Tessitore
Summary: This study identified three distinct memory-related phenotypes in patients with mild cognitive impairment related to Parkinson's disease (PD-MCI) through cluster analysis. These phenotypes were associated with motor and non-motor features as well as patients' quality of life. The findings contribute to understanding the pathophysiological mechanisms underlying PD-MCI and its subtypes and guiding appropriate treatments.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Alexandra R. Goncalves, Alexandre Mendes, Nuno Vila-Cha, Joana Darnasio, Joana Fernandes, Sara M. Cavaco
Summary: The study found that Parkinson's disease patients who underwent appendectomy earlier in life exhibited more severe motor symptoms, cognitive dysfunction, and lower functional independence after disease onset.
NEUROLOGICAL SCIENCES
(2021)
Article
Psychology, Multidisciplinary
Sonia Di Tella, Matteo De Marco, Francesca Baglio, Maria Caterina Silveri, Annalena Venneri
Summary: This study investigated the impact of cognitive reserve on functional connectivity in patients with Parkinson's disease and found that individuals with low cognitive reserve had weaker functional connectivity in the prefrontal cortex and basal ganglia. They also exhibited downregulation of attentional control networks and compensatory upregulation of medial frontal regions. These findings enhance our understanding of the mechanisms underlying cognitive impairments in Parkinson's disease.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Xiao Deng, Seyed Ehsan Saffari, Samuel Yong Ern Ng, Nicole Chia, Jayne Yi Tan, Xinyi Choi, Dede Liana Heng, Zheyu Xu, Kay-Yaw Tay, Wing-Lok Au, Nan Liu, Adeline Ng, Eng-King Tan, Louis C. S. Tan
Summary: This study found that PD patients had significantly lower levels of lipid biomarkers, while PD-MCI patients had higher levels of TC, TG, and Apo A1. TC, TG, and Apo A1 may be useful biomarkers for PD-MCI.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
H. Bejr-kasem, F. Sampedro, J. Marin-Lahoz, S. Martinez-Horta, J. Pagonabarraga, J. Kulisevsky
Summary: In this study, 35.1% of PD patients developed minor hallucinations during follow-up. These patients showed increased prevalence of subjective cognitive decline at 5 years, but not formal cognitive impairment. Additionally, they exhibited differences in gray matter volume at baseline in certain brain regions. Further longitudinal analyses may be needed to determine whether these findings indicate a higher risk of future cognitive deterioration.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Brendan P. Lucey, Julie Wisch, Anna H. Boerwinkle, Eric C. Landsness, Cristina D. Toedebusch, Jennifer S. McLeland, Omar H. Butt, Jason Hassenstab, John C. Morris, Beau M. Ances, David M. Holtzman
Summary: Sleep monitoring may provide markers for future Alzheimer's disease, but the relationship between sleep and cognitive function in preclinical and early symptomatic Alzheimer's disease is not well understood. Both short and long sleep times have been associated with future cognitive impairment, suggesting that certain levels of sleep are important for maintaining cognitive function.
Article
Clinical Neurology
Ganqiang Liu, Chunming Ni, Jiamin Zhan, Weimin Li, Junfeng Luo, Zhixiang Liao, Joseph J. Locascio, Wenbiao Xian, Ling Chen, Zhong Pei, Jean-Christophe Corvol, Jodi Maple-Grodem, Meghan C. Campbell, Alexis Elbaz, Suzanne Lesage, Alexis Brice, Albert Y. Hung, Michael A. Schwarzschild, Michael T. Hayes, Anne-Marie Wills, Bernard Ravina, Ira Shoulson, Pille Taba, Sulev Koks, Thomas G. Beach, Florence Cormier-Dequaire, Guido Alves, Ole-Bjorn Tysnes, Joel S. Perlmutter, Peter Heutink, Jacobus J. van Hilten, Roger A. Barker, Caroline H. Williams-Gray, Clemens R. Scherzer
Summary: The study shows that specific mitochondrial haplogroups are associated with the progression of cognitive decline in patients with Parkinson's disease, but not with the progression of motor impairment. This finding suggests that mitochondrial haplotypes may be a useful tool for stratifying patients based on their risk of cognitive decline.
Article
Geriatrics & Gerontology
Juan Huang, Lin Chen, Binbin Hu, Hui Wang, Xinyue Zhang, Xingfu Tian, Shu Wang, Wei Huang
Summary: The prevalence and related factors of subjective cognitive complaints (SCCs) differ between early-stage and advanced-stage Parkinson's disease (PD) patients. Higher nonmotor symptoms questionnaire (NMSQ) scores are associated with SCCs in early-stage PD, while lower attention and visuospatial/executive abilities scores are related to SCCs in advanced-stage PD.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Yi Fang, Shaobing Dai, Chongyao Jin, Xiaoli Si, Luyan Gu, Zhe Song, Ting Gao, Ying Chen, Yaping Yan, Xinzhen Yin, Jiali Pu, Baorong Zhang
Summary: This study investigated the clinical implication of AQP4 polymorphisms in Parkinson's disease (PD) by analyzing patients and controls. The results showed that genetic variations of AQP4 might contribute to altered cognitive decline in PD, with rs162009 likely being a novel genetic prognostic marker of cognitive decline in the disease.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Xiaojuan Dan, Yang Hu, Junyan Sun, Linlin Gao, Yongtao Zhou, Jinghong Ma, Julien Doyon, Tao Wu, Piu Chan
Summary: This study found that altered cerebellar functional connectivity in early PD patients during resting state is influenced not only by motor deficits, but also by cognitive deficits, highlighting the interaction between motor and cognitive functioning and possibly reflecting compensatory mechanisms in early PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Sarah J. Ozinga, Elise Baron, Mandy Miller Koop, Andrew Bazyk, Jay L. Alberts
Summary: This study aimed to investigate the impact of cognitive errors on postural stability in PD patients and controls under dual-task conditions. Results showed an increase in postural sway in PD patients during epochs surrounding cognitive errors, while controls did not show this correlation.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Geriatrics & Gerontology
Sung Hoon Kang, Jinhee Kim, Jungyeun Lee, Seong-Beom Koh
Summary: Cognitive impairment is often accompanied by gait disturbance in patients with Parkinson's disease (PD). This study aimed to investigate the association between gait parameters and mild cognitive impairment (MCI), as well as the correlation between performance on comprehensive neuropsychological tests and gait parameters in PD patients. The results showed that gait velocity and stride length were associated with MCI in PD patients, and these gait parameters were primarily influenced by attention and frontal-executive function.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Alfonso Delgado-Alvarez, Cristina Delgado-Alonso, Miriam Goudsmit, Rocio Garcia-Ramos, Maria Jose Gil-Moreno, Maria Valles-Salgado, Maria Diez-Cirarda, Maria Dolores Zamarron-Cassinello, Jorge Matias-Guiu, Jordi A. Matias-Guiu
Summary: The Cross-Cultural Dementia (CCD) is a new screening tool that evaluates cognitive impairment from a cross-cultural perspective. It reduces the bias of education, language, and cultural differences. The CCD showed good discrimination properties and cut-off scores for dementia and extended its application to prodromal stages of Alzheimer's disease and Parkinson's disease.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
Yi Xiao, Ruwei Ou, Tianmi Yang, Kuncheng Liu, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Junyu Lin, Huifang Shang
Summary: The study revealed that subjective cognitive complaints in patients with early-onset PD are associated with older age, higher apathy levels, and lower cognitive assessment scores, while in late-onset PD patients, they are linked to higher apathy and anxiety levels.
FRONTIERS IN NEUROLOGY
(2021)