Review
Endocrinology & Metabolism
Juergen Honegger, Isabella Nasi-Kordhishti
Summary: Transsphenoidal surgery (TSS) is the preferred initial treatment for Cushing's disease (CD), with microscopic TSS and endoscopic TSS being the two available surgical techniques. Repeat TSS can achieve remission rates of over 70% for microadenomas. Early postoperative assessment of remission status and a steroid-sparing protocol are recommended for postoperative management. Prophylactic antithrombotic measures can significantly reduce the risk of postoperative thromboembolic events. Prevention or successful treatment of cortisol withdrawal syndrome remains a challenge. The development of functional imaging holds promise for improved preoperative detection of microadenomas. Intraoperative identification of microadenomas using specific fluorescent targeting is a promising future avenue.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Sema Ciftci, Ozlem Soyluk, Alev Selek, Selvinaz Erol, Zeliha Hekimsoy, Ayse Esen, Huseyin Dursun, Serdar Sahin, Gonca Oruk, Meral Mert, Huseyin Soylu, Banu Sarer Yurekli, Melek Eda Ertorer, Tulay Omma, Mehtap Evran, Mine Adas, Seher Tanrikulu, Kadriye Aydin, Zafer Pekkolay, Bulent Can, Ersen Karakilic, Zuleyha Karaca, Habib Bilen, Zeynep Canturk, Berrin Cetinarslan, Pinar Kadioglu, Sema Yarman
Summary: The purpose of this study was to determine the cut-off levels of basal DHEA-S percentile rank in the differential diagnosis of Cushing's syndrome. The results showed that the DHEA-S percentile rank was significantly different between different groups, and a cut-off level of less than 20% was identified for the differential diagnosis of CD and adrenal CS.
HORMONE AND METABOLIC RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Lyda Z. Rojas, Sergio Alejandro Gomez-Ochao, Luis E. Echeverria, Paula Katherine Bautista-Nino, Lukas Hunziker, Michele F. Eisenga, Taulant Muka
Summary: This study aimed to analyze the association of circulating dehydroepiandrosterone sulfate (DHEA-S) levels with cardiovascular outcomes in patients with chronic Chagas cardiomyopathy (CCM). The results showed that higher DHEA-S levels were associated with lower mortality, heart transplantation, and LVAD implantation. Further larger studies are needed to confirm the results and assess causality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Rinkoo Dalan, Stefan R. Bornstein, Bernhard O. Boehm
Summary: This article discusses the significant advancements in medicine and healthcare in the 21st century Digital Age, primarily driven by the application of data technologies and artificial intelligence. A short story is shared to depict the future state for Cushing's Disease patients and the proposed diagnostic and management approaches. The article postulates a complete reinvention of endocrinology care in the Digital Age.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Behavioral Sciences
Anna-Karin Lennartsson, Elin Arvidson, Mats Borjesson, Ingibjorg H. Jonsdottir
Summary: This study found that individuals reporting prolonged stress have lower levels of the anabolic hormone dehydroepiandrosterone sulfate (DHEA-S), and the production capacity of DHEA-S is attenuated during acute stress. These findings suggest that reduced DHEA-S production may be one of the links between stress and poor health.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2022)
Article
Geriatrics & Gerontology
C. . Tamer Erel, Ipek Betul Ozcivit Erkan, Neslihan Gokmen Inan, Kubra Hamzaoglu Canbolat, Sena Alkan, Dildar Konukoglu, Yalim Dikmen
Summary: This study aimed to compare the clinical course and outcomes of Covid-19 between premenopausal and postmenopausal women, and investigate the factors that influence disease severity. The results showed that premenopausal women had a more favorable prognosis, and age, postmenopausal status, and serum levels of dehydroepiandrosterone sulfate were important predictors of the severity of Covid-19 in women.
Article
Endocrinology & Metabolism
Mario Detomas, Barbara Altieri, Wiebke Schlotelburg, Silke Appenzeller, Sven Schlaffer, Roland Coras, Andreas Schirbel, Vanessa Wild, Matthias Kroiss, Silviu Sbiera, Martin Fassnacht, Timo Deutschbein
Summary: The case presented a rare occurrence where a patient first had ACTH-independent CS and then developed CD. The successful treatment of CD after surgery and pathological examination indicated that different subtypes of Cushing's syndrome can develop in a single individual.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Ariana Diaz, Luciano D'Attilio, Federico Penas, Bettina Bongiovanni, Estefania Massa, Agata Cevey, Natalia Santucci, Oscar Bottasso, Nora Goren, Maria Luisa Bay
Summary: Tuberculosis (TB) is a health problem characterized by an immuno-endocrine imbalance. Glucocorticoids (GC) and peroxisome proliferator-activated receptors (PPARs) play important roles in counteracting inflammation. This study investigates the contribution of PPAR gamma in immunoendocrine-metabolic interactions in TB patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hong Jiang, Zhenghao Li, Yuhao Sun, Jie Ren, Fuhua Yan, Qingfang Sun, Hongjiang Wei, Liuguan Bian
Summary: This study used quantitative susceptibility mapping (QSM) to assess longitudinal susceptibility changes in Cushing's disease (CD) patients before and after resolution of hypercortisolism. The results showed irreversibly altered susceptibility values in certain brain regions after resolution of hypercortisolism, which were significantly correlated with changes in gray matter/white matter volumes and clinical features. Additionally, decreased susceptibility was found in several regions in CD patients. This research suggests that chronic exposure to hypercortisolism may lead to susceptibility alterations and be closely correlated with altered brain volumes and clinical features.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Materials Science, Multidisciplinary
Masayasu Taki, Keiji Kajiwara, Eriko Yamaguchi, Yoshikatsu Sato, Shigehiro Yamaguchi
Summary: Researchers have developed a dye, LAQ1, based on the BTBT scaffold that meets the requirements of LD staining, high photostability, and biocompatibility. With LAQ1, they were able to capture ultrasmall LDs using STED microscopy with super-resolution imaging, and perform long-term trajectory analysis.
ACS MATERIALS LETTERS
(2021)
Article
Medicine, General & Internal
Bernhard Michels, Andreas Holzamer, Bernhard M. Graf, Andre Bredthauer, Walter Petermichl, Anika Muller, York Alexander Zausig, Diane Inge Bitzinger
Summary: This study found that lower preoperative BChE levels were associated with higher risk of postoperative complications after TAVI. The sustained reduction in BChE activity in the complication group suggests a potential role of BChE as a biomarker for identifying at-risk patients. Predicting the length of hospital stay may be important for efficient management of resources and staff for these patients.
Review
Endocrinology & Metabolism
Kyla Wright, Elisabeth F. C. van Rossum, Elcin Zan, Nicole Werner, Alan Harris, Richard A. Feelders, Nidhi Agrawal
Summary: Endogenous Cushing's syndrome (CS) requires timely diagnosis due to the risks it poses. Traditional diagnostic modalities have limitations, leading to the need for repeated testing. Additionally, the identification of adrenocorticotropic hormone (ACTH)-secreting adenomas can be challenging. Newer methods, such as hair analysis and advanced imaging techniques, offer more accurate and non-invasive diagnostic options for CS patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Masaaki Yamamoto, Takahiro Nakao, Wataru Ogawa, Hidenori Fukuoka
Summary: Cushing's disease is caused by ACTH-secreting pituitary tumors and may have severe clinical manifestations, with 20% of tumors showing aggressive behavior. Understanding the pathophysiology of aggressive ACTHomas is limited, making treatment challenging.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Physiology
Corina Bello, Paul Philipp Heinisch, Maks Mihalj, Thierry Carrel, Markus M. Luedi
Summary: IDO is a rate-limiting enzyme in the tryptophan catabolism pathway, playing a crucial role in immune modulation and the pathogenesis of various diseases. Its involvement has been extensively studied in autoimmune processes and highly malignant cancers, with potential as a predictive biomarker and therapeutic target in immune-mediated diseases. Additionally, IDO shows promise as a biomarker in the pre-operative setting for decision-making and treatment of surgical patients experiencing trauma-induced stress.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Anna Mehlich, Marek Bolanowski, Dawid Mehlich, Przemyslaw Witek
Summary: Cushing's disease is a severe endocrine disorder caused by the overproduction of adrenocorticotropic hormone by a pituitary adenoma, resulting in chronic hypercortisolism. This hormone excess affects glucose homeostasis, leading to various degrees of glucose intolerance, including impaired fasting glucose, impaired glucose tolerance, and Diabetes Mellitus. While surgery is the most effective treatment for controlling cortisol levels and glucose metabolism, a significant number of patients require additional therapies due to persistent or recurrent disease. Medical therapies have shown clinical efficacy in managing Cushing's disease, with potential effects on glucose metabolism. Further studies are needed to determine optimal management strategies for patients with glucose intolerance or diabetes. In this article, we discuss the pathophysiology of impaired glucose metabolism and review the clinical efficacy of medical therapies for Cushing's disease, particularly their effects on glucose homeostasis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Judith Anthofer, Sylvia Bele, Christina Wendl, Martin Kieninger, Florian Zeman, Elisabeth Bruendl, Nils-Ole Schmidt, Karl-Michael Schebesch
Summary: This study analyzed the effectiveness of intra-arterial nimodipine infusion in the treatment of severe cerebral vasospasm after SAH. The results showed that continuous infusion significantly reduced the incidence of cerebral infarction, but was associated with a higher rate of decompressive craniectomy, VP shunting, and tracheotomy.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Oncology
Anna-Katharina Meissner, Robin Gutsche, Norbert Galldiks, Martin Kocher, Stephanie T. Juenger, Marie-Lisa Eich, Manuel Montesinos-Rongen, Anna Brunn, Martina Deckert, Christina Wendl, Wolfgang Dietmaier, Roland Goldbrunner, Maximilian Ruge, Cornelia Mauch, Nils-Ole Schmidt, Martin Proescholdt, Stefan Grau, Philipp Lohmann
Summary: MRI radiomics can predict the intracranial BRAF V600E mutation status in patients with melanoma brain metastases noninvasively, and the method shows high diagnostic performance.
Article
Clinical Neurology
Johannes Falter, Karl-Michael Schebesch, Nils Ole Schmidt
Summary: The study reveals a significant decrease in neurosurgical emergency admissions during the lockdown period, especially for nontraumatic spinal cases and patients with intracranial hemorrhage. However, there was no difference in the severity of diseases between baseline years and the lockdown period for admitted patients.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2022)
Article
Endocrinology & Metabolism
Ralf Oheim, Elena Tsourdi, Lothar Seefried, Gisela Beller, Max Schubach, Eik Vettorazzi, Julian Sturznickel, Tim Rolvien, Nadja Ehmke, Alena Delsmann, Franca Genest, Ulrike Krueger, Tomasz Zemojtel, Florian Barvencik, Thorsten Schinke, Franz Jakob, Lorenz C. Hofbauer, Stefan Mundlos, Uwe Kornak
Summary: The impact of genetic testing on the differential diagnosis of adult LBMD was investigated in this study. Clinical criteria for predicting monogenic forms were also defined. The results showed that genetic testing can easily distinguish overlapping spectra of monogenic adult LBMD, and the proposed clinical criteria can help maximize the diagnostic yield.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Eileen Guelke, Mohammad Alsalem, Maja Kirsten, Eik Vettorazzi, Chi-un Choe, Ute Hidding, Simone Zittel-Dirks, Carsten Buhmann, Miriam Schaper, Alessandro Gulberti, Christian K. E. Moll, Wolfgang Hamel, Johannes Koeppen, Christian Gerloff, Monika Poetter-Nerger
Summary: This study identifies the MoCA as an alternative test for the preoperative evaluation of PD patients, which can be used to detect neuropsychological deficits and predict postoperative improvement in quality of life.
Article
Health Care Sciences & Services
Heinz Voeller, Dominik Bindl, Klaus Nagels, Reiner Hofmann, Eik Vettorazzi, Karl Wegscheider, Eckart Fleck, Stefan Stoerk, Eckhard Nagel
Summary: The CardioBBEAT trial compared the cost and effectiveness of a bidirectional remote monitoring system with standard care for HF patients, finding a neutral impact on nonhospitalized days but increased total costs, with no effect on mortality risk. However, the remote monitoring system significantly improved disease-specific quality of life for patients.
TELEMEDICINE AND E-HEALTH
(2022)
Article
Clinical Neurology
Renaud Tamisier, Jean-Louis Pepin, Martin R. Cowie, Karl Wegscheider, Eik Vettorazzi, Anna Suling, Christiane Angermann, Marie-Pia D'Ortho, Erland Erdmann, Anita K. Simonds, Virend K. Somers, Helmut Teschler, Patrick Levy, Holger Woehrle
Summary: This sub study analyzed the effectiveness of adaptive servo ventilation (ASV) in treating central sleep apnea (CSA) in heart failure patients. The results showed that after 12 months, the ASV group had better respiratory measures compared to the control group. However, the differences in sleep measures were unlikely to be clinically significant. ASV therapy also led to an increase in periodic leg movements during sleep (PLMS), which may be associated with increased cardiovascular risk.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Medicine, Research & Experimental
Susanne G. R. Klotz, Gesche Ketels, Christian A. Behrendt, Hans-Helmut Koenig, Sebastian Kohlmann, Bernd Loewe, Johannes Petersen, Sina Stock, Eik Vettorazzi, Antonia Zapf, Inke Zastrow, Christian Zoellner, Hermann Reichenspurner, Evaldas Girdauskas
Summary: This study aims to evaluate the effectiveness of an Enhanced Recovery After Surgery (ERAS) program after minimally invasive heart valve surgery through a randomized controlled trial. The interprofessional approach, including surgical, anesthesiological, physiotherapeutic, advanced nursing, and psychosocial components, is the key factor of the ERAS process. A clinical implication guideline will be developed to facilitate the adoption of the ERAS model in other heart teams.
Article
Medicine, General & Internal
Bernd Loewe, Yvonne Nestoriuc, Viola Andresen, Eik Vettorazzi, Antonia Zapf, Sina Huebener, Kerstin Maehder, Luisa Peters, Ansgar W. Lohse
Summary: This study aims to compare the common and disease-specific factors in the persistence and modification of gastrointestinal symptoms in UC and IBS patients, and evaluate the effectiveness of improving symptoms by modifying dysfunctional symptom expectations and illness-related anxiety.
Article
Respiratory System
Till J. Demal, Franziska W. Sitzmann, Lennart Bax, Yskert von Kodolitsch, Jens Brickwedel, Johanna Konertz, Daniel M. Gaekel, Ahmed J. Sadeq, Tilo Koelbel, Eik Vettorazzi, Hermann Reichenspurner, Christian Detter
Summary: The independent risk factors for postoperative strokes after thoracic aortic surgery include advanced age, acute type A dissection, aortic arch surgery, concomitant coronary artery bypass grafting, and high extracorporeal circulation time. Hemodynamic and embolic strokes have distinct risk profiles.
JOURNAL OF THORACIC DISEASE
(2022)
Article
Immunology
Kevin Paul, Freya Sibbertsen, Daniela Weiskopf, Marc Luetgehetmann, Madalena Barroso, Marta K. Danecka, Laura Glau, Laura Hecher, Katharina Hermann, Aloisa Kohl, Jun Oh, Julian Schulze zur Wiesch, Alessandro Sette, Eva Tolosa, Eik Vettorazzi, Mathias Woidy, Antonia Zapf, Dimitra E. Zazara, Thomas S. Mir, Ania C. Muntau, Soren W. Gersting, Gabor A. Dunay
Summary: SARS-CoV-2 remains a significant global health burden despite the availability of effective vaccines. Infection rates are increasing in children as social distancing measures are reduced, but there is still limited understanding of the pediatric immune response to SARS-CoV-2. This study found that children who had recovered from infection had an antiviral CD4+ T cell response, although this response was reduced in preschool children. Additionally, cross-reactive CD4+ T cell responses to the more recently evolved beta variant of the virus were detected. These findings have important epidemiological implications for children in relation to novel viral variants and vaccination efforts.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Respiratory System
Renaud Tamisier, Jean-Louis Pepin, Holger Woehrle, Muriel Salvat, Gilles Barone-Rochette, Cecile Rocca, Eik Vettorazzi, Helmut Teschler, Martin Cowie, Patrick Levy
Summary: This study investigated the effect of ASV on sympathetic tone in patients with HFrEF and CSA. The results showed that ASV did not effectively suppress sympathetic activation in heart failure patients and was associated with increased cardiovascular mortality.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Immunology
Gabor A. Dunay, Madalena Barroso, Mathias Woidy, Marta K. Danecka, Geraldine Engels, Katharina Hermann, Friederike S. Neumann, Kevin Paul, Jan Beime, Gabriele Escherich, Kristin Fehse, Lev Grinstein, Franziska Haniel, Luka J. Haupt, Laura Hecher, Torben Kehl, Christoph Kemen, Markus J. Kemper, Robin Kobbe, Aloisa Kohl, Thomas Klokow, Dominik Noerz, Jakob Olfe, Friderike Schlenker, Jessica Schmiesing, Johanna Schrum, Freya Sibbertsen, Philippe Stock, Stephan Tiede, Eik Vettorazzi, Dimitra E. Zazara, Antonia Zapf, Marc Luetgehetmann, Jun Oh, Thomas S. Mir, Ania C. Muntau, Soren W. Gersting
Summary: This study investigates the long-term immune response of children to SARS-CoV-2. They found that children have higher antibody levels and lower seroprevalence in families with pediatric index cases in a low-incidence setting. Children show sustained antibody responses to SARS-CoV-2.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Oncology
Elena Bady, Katharina Moller, Tim Mandelkow, Jonas B. Raedler, Cheng Yang, Julia Ebner, Magalie C. J. Lurati, Ronald Simon, Eik Vettorazzi, Franziska Buscheck, Andreas M. Luebke, David Dum, Anne Menz, Guido Sauter, Doris Hoflmayer, Soren Weidemann, Christoph Fraune, Ria Uhlig, Christian Bernreuther, Frank Jacobsen, Till S. Clauditz, Waldemar Wilczak, Eike Burandt, Stefan Steurer, Sarah Minner, Maximilian Lennartz, Niclas C. Blessin
Summary: Researchers have developed a BLEACH&STAIN mfIHC method that allows simultaneous analysis of 15 biomarkers in tumor samples. They have also found that PD-L1 expression is associated with immune cell infiltration and PD-1 expression on T cells. In breast cancer, the fluorescence intensity of PD-L1 on tumor cells has better predictive performance for overall survival compared to the percentage of PD-L1+ tumor cells.
MOLECULAR CANCER RESEARCH
(2023)
Article
Neurosciences
Odette Fruendt, Tina Mainka, Eik Vettorazzi, Ela Baspinar, Cindy Schwarz, Martin Suedmeyer, Christian Gerloff, Wolfgang H. Zangemeister, Monika Poetter-Nerger, Ute Hidding, Wolfgang Hamel, Christian K. E. Moll, Carsten Buhmann
Summary: This prospective study aimed to investigate the influence of bilateral subthalamic deep brain stimulation (STN-DBS) on car driving ability in patients with Parkinson's disease (PD). The results showed that PD-DBS patients drove unsafer than PD-nDBS patients at follow-up, which was mainly driven by two PD-DBS participants with poor baseline driving performance. However, after excluding these outliers, comparable driving performance between PD-DBS and PD-nDBS patients was demonstrated.
NPJ PARKINSONS DISEASE
(2023)