Article
Clinical Neurology
Jing Wei, Zhifan Zou, Jiping Li, Yuqing Zhang
Summary: Deep-brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for motor symptoms of advanced Parkinson's disease (PD). This study aimed to investigate the local field potential (LFP) distribution patterns in dorsomedial and dorsolateral subparts of STN. The results showed weaker gamma oscillations and coherence in the dorsomedial part compared to the dorsolateral part, indicating the potential of targeting the dorsomedial STN for DBS in PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Morgane Soler-Rico, Jean-Baptiste Peeters, Vincent Joris, Maxime Delavallee, Thierry Duprez, Christian Raftopoulos
Summary: This study retrospectively analyzed the implantation of DBS targeting the STN using MRI under general anesthesia. It found a high rate of postoperative MLE (90.7%) and prolonged clinical improvement, providing valuable information for the treatment of Parkinson's disease.
ACTA NEUROCHIRURGICA
(2022)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Rasha Hyder, Andreas Hojlund, Mads Jensen, Erik L. Johnsen, Karen Ostergaard, Yury Shtyrov
Summary: The study found that bilateral and right unilateral STN stimulation resulted in significant dissociations in the processing of action and abstract verbs, with greater neuromagnetic responses for action verbs. For morphosyntactic processing, only left unilateral stimulation yielded significant dissociations, with greater neuromagnetic responses to the incorrect inflections.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Martin M. Reich, Joey Hsu, Michael Ferguson, Frederic L. W. V. J. Schaper, Juho Joutsa, Jonas Roothans, Robert C. Nickl, Anneke Frankemolle-Gilbert, Jay Alberts, Jens Volkmann, Michael D. Fox
Summary: The study demonstrates that the decline in cognitive function caused by deep brain stimulation (DBS) is related to the connectivity between the stimulation site and a specific brain network associated with memory impairment. Transforming this network into a heat map can help identify DBS patients at risk of delayed-onset side-effects and guide reprogramming efforts.
Article
Geriatrics & Gerontology
Ritesh A. Ramdhani, Jeremy Watts, Myriam Kline, Toni Fitzpatrick, Martin Niethammer, Anahita Khojandi
Summary: This study investigated the effects of high-frequency and low-frequency STN-DBS on spatiotemporal gait kinematics in patients with advanced Parkinson's disease. It was found that high-frequency STN-DBS significantly improved trunk and lumbar kinematics.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Review
Clinical Neurology
Hengameh Zahed, Jose Rafael Pantoja Zuzuarregui, Ro'ee Gilron, Timothy Denison, Philip A. Starr, Simon Little
Summary: Sleep disturbances are common nonmotor complications of Parkinson's disease, potentially contributing to disease progression. Limited options currently exist to modulate sleep disturbances, prompting the need for further research into neurophysiological changes affecting sleep in PD.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Kathryn M. Miller, Joseph R. Patterson, Joseph Kochmanski, Christopher J. Kemp, Anna C. Stoll, Christopher U. Onyekpe, Allyson Cole-Strauss, Kathy Steece-Collier, Jacob W. Howe, Kelvin C. Luk, Caryl E. Sortwell
Summary: Preclinical studies suggest a potential link between STN DBS and neuroprotection of nigrostriatal dopamine neurons through BDNF signaling, but the impact on alpha-synuclein aggregation and neuroinflammation remains unclear. The study in male rats using the PFF model showed that STN DBS did not affect PFF-induced accumulation of pSyn inclusions in the SNpc, but it did lead to increased BDNF protein in the striatum. These results indicate the potential of STN DBS in modifying the long-term consequences of synucleinopathy.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Lais M. Oliveira, Marta Ruiz-Lopez, Alexandre Boutet, Gavin J. B. Elias, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Renato P. Munhoz, Alfonso Fasano
Summary: The study found that using the advanced functions of the patient programmer delays programming optimization and is associated with a higher number of side effects. Therefore, there is a need for other faster and safer stimulation programming methods.
Article
Clinical Neurology
Meghan E. Hill, Luke A. Johnson, Jing Wang, David Escobar Sanabria, Remi Patriat, Scott E. Cooper, Michael C. Park, Noam Harel, Jerrold L. Vitek, Joshua E. Aman
Summary: Excessive STN beta-band synchronized oscillations are biomarkers for PD. This case study reveals abnormal responses to beta power in different treatment conditions, indicating the need for further research.
MOVEMENT DISORDERS
(2023)
Review
Psychology, Multidisciplinary
Joshua A. Wilt, Amanda R. Merner, Jaclyn Zeigler, Michelle Montpetite, Cynthia S. Kubu
Summary: Deep Brain Stimulation (DBS) is a safe and effective treatment for Parkinson's Disease (PD) in improving motor symptoms, but concerns about its effects on patients' personality remain. Research shows that while there is little evidence of changes in dispositional traits following DBS, there is some positive progress in characteristic adaptations. Further research is needed in exploring the impact on narrative identity after DBS treatment for PD.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Katharine A. Henry, Rohin Singh, Nan Zhang, Mark K. Lyons, Karen McNett, Matthew T. Neal, Shyamal H. Mehta
Summary: This study aimed to objectively assess changes in swallowing in Parkinson's disease (PD) patients following Deep Brain Stimulation (DBS) surgery using gold standard video fluoroscopy (VFS). The results showed that there was no clinically meaningful improvement or reduction in swallow function with DBS, regardless of the site of bilateral lead implantation.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Taylor R. Greif, Asra Askari, Amanda Cook Maher, Parag G. Patil, Carol Persad
Summary: This study suggests that more anterior stimulation of the left subthalamic nucleus may uniquely contribute to verbal fluency decline in patients with Parkinson's disease post-DBS, possibly due to connections to frontal regions. Future research should investigate the effect of DBS lead trajectory on verbal fluency outcomes.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Clinical Neurology
Gian D. Pal, Daniel M. Corcos, Leo Verhagen Metman, Zvi Israel, Hagai Bergman, David Arkadir
Summary: Genetic subtyping of patients with Parkinson's disease may help predict the cognitive and motor outcomes of subthalamic deep brain stimulation. However, there are still controversies and gaps in understanding the effects of STN-DBS on PD patients with pathogenic variants in the GBA1 gene. Further research is needed to determine the clinical significance, risk-to-benefit ratio, and strategies to minimize the negative effects of STN-DBS. Genetic testing for GBA1 may be considered in PD patients considering DBS to properly assess the potential risks and benefits.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Diogo Cordeiro, Zhiyuan Xu, Chelsea E. Li, Christian Iorio-Morin, David Mathieu, Nathaniel D. Sisterson, Hideyuki Kano, Luca Attuati, Piero Picozzi, Kimball A. Sheehan, Cheng-Chia Lee, Roman Liscak, Jana Jezkova, L. Dade Lunsford, Jason Sheehan
JOURNAL OF NEUROSURGERY
(2020)
Review
Clinical Neurology
Ismail Zaed, Luca Attuati, Concezione Tommasino, Enrico Massimo Arosio, Pierina Navarria, Antonella Stravato, Giovanni Colombo, Piero Picozzi
WORLD NEUROSURGERY
(2020)
Letter
Clinical Neurology
Andrea Franzini, Luca Attuati, Maurizio Fornari, Franco Servadei, Pierina Navarria, Piero Picozzi
ACTA NEUROCHIRURGICA
(2020)
Letter
Clinical Neurology
Andrea Cardia, Irene Zerbetto, Delia Cannizzaro, Piero Picozzi, Maurizio Fornari, Paolo Levi Setti, Franco Servadei
JOURNAL OF NEUROSURGICAL SCIENCES
(2020)
Article
Clinical Neurology
Andrea Franzini, Luca Attuati, Ismail Zaed, Shayan Moosa, Antonella Stravato, Pierina Navarria, Piero Picozzi
JOURNAL OF NEUROSURGERY
(2020)
Article
Clinical Neurology
Adomas Bunevicius, Rithika Kormath Anand, Mohanad Suleiman, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Marco Perez Caceres, David Mathieu, Cheng-chia Lee, Huai-che Yang, Piero Picozzi, Andrea Franzini, Luca Attuati, Herwin Speckter, Jeremy Olivo, Samir Patel, Christopher P. Cifarelli, Daniel T. Cifarelli, Joshua D. Hack, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Kareem R. Fakhoury, Chad G. Rusthoven, Ronald E. Warnick, Jason Sheehan
Summary: SRS provides durable tumor control and acceptable rates of vision preservation in perioptic meningiomas. A prescription dose of >= 12 Gy is associated with improved tumor control, while a dose to the optic apparatus of >= 10 Gy and tumor progression are associated with post-SRS visual decline.
Review
Clinical Neurology
Andrea Franzini, Maria Pia Tropeano, Simone Olei, Mario De Robertis, Zefferino Rossini, Luca Attuati, Davide Milani, Federico Pessina, Elena Clerici, Pierina Navarria, Piero Picozzi
Summary: Trigeminal neuralgia in patients with multiple sclerosis is challenging to manage, often treated with Gamma Knife radiosurgery. This study evaluated the safety, efficacy, and durability of GKRS for TN in MS patients, finding short-term pain control was effective but long-term control was limited. Repeat GKRS was found to be safe and effective in prolonging pain relief.
WORLD NEUROSURGERY
(2021)
Review
Clinical Neurology
Andrea Franzini, Zefferino Rossini, Shayan Moosa, Maria Pia Tropeano, Davide Milani, Luca Attuati, Elena Clerici, Pierina Navarria, Federico Pessina, Piero Picozzi
Summary: Medial thalamotomy using stereotactic radiosurgery (SRS) is effective for select patients with treatment-resistant pain and remarkably safe when modern radiation delivery platforms are used. More studies are warranted to shed light on differences in patient responses.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Adomas Bunevicius, Stylianos Pikis, Rithika Kormath Anand, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Tomas Chytka, Roman Liscak, Marco Perez Caceres, David Mathieu, Cheng-Chia Lee, Huai-Che Yang, Piero Picozzi, Andrea Franzini, Luca Attuati, Herwin Speckter, Jeremy Olivo, Samir Patel, Christopher P. Cifarelli, Daniel T. Cifarelli, Joshua D. Hack, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Kareem R. Fakhoury, Chad G. Rusthoven, Ronald E. Warnick, Jason Sheehan
Summary: The study found that SRS treatment for clinoid meningiomas can achieve good tumor control and visual preservation in the majority of patients. A higher radiosurgical prescription dose is associated with better tumor control, while radiation dose to the optic apparatus of >= 10 Gy and pre-existing visual impairment increase the risk of visual deterioration.
ACTA NEUROCHIRURGICA
(2021)
Letter
Clinical Neurology
Andrea Franzini, Elena Clerici, Pierina Navarria, Federico Pessina, Piero Picozzi
CHILDS NERVOUS SYSTEM
(2021)
Article
Clinical Neurology
Adomas Bunevicius, Jungeun Ahn, Sarah Fribance, Selcuk Peker, Batu Hergunsel, Darrah Sheehan, Kimball Sheehan, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdelkarim, Amr M. N. El-Shehaby, Reem M. Emad, Tomas Chytka, Roman Liscak, Roberto Martinez Alvarez, Nuria Martinez Moreno, Anne-Marie Langlois, David Mathieu, Cheng-Chia Lee, Huai-Che Yang, Manjul Tripathi, Ronald E. Warnick, Herwin Speckter, Camilo Albert, Piero Picozzi, Andrea Franzini, Luca Attuati, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Caleb E. Feliciano Valls, Carlos H. Carbini, Samir Patel, Jason Sheehan
Summary: The study shows that SRS treatment provides durable local control for patients with olfactory groove meningiomas, with an acceptable safety profile, and allows preservation or improvement of olfactory function in the majority of patients.
Article
Oncology
Eric J. Lehrer, Jason Gurewitz, Kenneth Bernstein, Dev Patel, Douglas Kondziolka, Ajay Niranjan, Zhishuo Wei, L. Dade Lunsford, Timothy D. Malouff, Henry Ruiz-Garcia, Samir Patel, Phillip A. Bonney, Lindsay Hwang, Cheng Yu, Gabriel Zada, David Mathieu, Claire Trudel, Rahul N. Prasad, Joshua D. Palmer, Brianna M. Jones, Sonam Sharma, Kareem R. Fakhoury, Chad G. Rusthoven, Christopher P. Deibert, Piero Picozzi, Andrea Franzini, Luca Attuati, Cheng-Chia Lee, Huai-Che Yang, Manmeet S. Ahluwalia, Jason P. Sheehan, Daniel M. Trifiletti
Summary: The occurrence of symptomatic radiation necrosis (RN) in patients with renal cell carcinoma (RCC) brain metastases treated with immune checkpoint inhibitors (ICIs) and stereotactic radiosurgery (SRS) is relatively low, with most events being grade 1 to 3 and managed by medical means. Concurrent therapy with ICI/SRS does not appear to increase the risk of RN. Efforts to improve dose conformality may be the most successful strategy for mitigating RN in single-fraction SRS.
Review
Clinical Neurology
Andrea Franzini, Elena Clerici, Pierina Navarria, Piero Picozzi
Summary: Gamma Knife radiosurgery (GKRS) can be used to treat drug-resistant cluster headache (CH). The outcomes of studies on GKRS for CH are inconsistent, and the ideal target and treatment parameters are unclear. This systematic review evaluates the safety and efficacy of GKRS for drug-resistant CH, showing high short-term pain reduction rates but controversial long-term results.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
David T. Asuzu, Adomas Bunevicius, Rithika Kormath Anand, Mohanad Suleiman, Ahmed M. Nabeel, Wael A. Reda, Sameh R. Tawadros, Khaled Abdel Karim, Amr M. N. El-Shehaby, Reem M. Emad Eldin, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Marco Perez Caceres, David Mathieu, Cheng-Chia Lee, Huai-Che Yang, Piero Picozzi, Andrea Franzini, Luca Attuati, Herwin Speckter, Jeremy Olivo, Samir Patel, Christopher P. Cifarelli, Daniel T. Cifarelli, Joshua D. Hack, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Kareem R. Fakhoury, Chad G. Rusthoven, Ronald E. Warnick, Jason P. Sheehan
Summary: This international multicenter study found that the majority of patients with meningiomas in direct contact with the anterior optic pathways achieved tumor control and preservation of visual function when treated with SRS.
JOURNAL OF NEUROSURGERY
(2022)
Article
Clinical Neurology
I. Jonathan Pomeraniec, Zhiyuan Xu, Cheng-Chia Lee, Huai-Che Yang, Tomas Chytka, Roman Liscak, Roberto Martinez-Alvarez, Nuria Martinez-Moreno, Luca Attuati, Piero Picozzi, Douglas Kondziolka, Monica Mureb, Kenneth Bernstein, David Mathieu, Michel Maillet, Akiyoshi Ogino, Hao Long, Hideyuki Kano, L. Dade Lunsford, Brad E. Zacharia, Christine Mau, Leonard C. Tuanquin, Christopher Cifarelli, David Arsanious, Joshua Hack, Ronald E. Warnick, Ben A. Strickland, Gabriel Zada, Eric L. Chang, Herwin Speckter, Samir Patel, Dale Ding, Darrah Sheehan, Kimball Sheehan, Svetlana Kvint, Love Y. Buch, Alexander R. Haber, Jacob Shteinhart, Mary Lee Vance, Jason P. Sheehan
Summary: Stereotactic radiosurgery (SRS) is an effective treatment for pituitary adenomas, but the mechanism of delayed endocrine deficits is not well understood. This multicenter study aimed to evaluate radiation tolerance and identify predictors of delayed hypopituitarism after SRS for these tumors. The study found that tumor control was achieved in a high percentage of patients, but a significant number developed new loss of pituitary function, with certain factors such as tumor type, age, and radiation dose playing a role.
JOURNAL OF NEUROSURGERY
(2022)
