Article
Endocrinology & Metabolism
Y. Qin, S. Zhang, S. Cui, X. Shen, J. Wang, X. Cui, M. Zuo, Z. Gao, J. Zhang, J. Yang, H. Zhu, B. Chang
Summary: The study found a positive correlation between high urinary excretion rate of glucose (UEGL) and uric acid metabolism, leading to lower serum uric acid (SUA) levels. Additionally, high UEGL was associated with increased urinary excretion rate of uric acid (UEUA) and renal clearance of uric acid (CLUA). Furthermore, high UEGL reduced the risk of hyperuricaemia in patients with type 2 diabetes.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Rheumatology
P. Towiwat, A. Tangsumranjit, K. Ingkaninan, K. Jampachaisri, N. Chaichamnong, B. Buttham, W. Louthrenoo
Summary: Decaffeinated coffee (DC) significantly decreased SUA during the intervention period. However, in non-hyperuricaemic participants, SUA significantly increased with caffeinated coffee (CC).
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Giuseppe Ambrosio, Marisa G. Crespo Leiro, Lars H. Lund, Stefano Coiro, Andrea Cardona, Gerasimos Filippatos, Roberto Ferrari, Massimo F. Piepoli, Andrew J. S. Coats, Stefan D. Anker, Cecile Laroche, Luis Almenar-Bonet, Pentti Poder, David Bierge Valero, Anna Frisinghelli, Aldo P. Maggioni
Summary: The study suggests that elevated serum uric acid (sUA) is associated with poor outcomes in heart failure (HF) patients, with varying effects across different left ventricular ejection fraction (LVEF) phenotypes.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Vlad-Sabin Ivan, Roxana Buzas, Adina-Flavia Cutina Morgovan, Paul Ciubotaru, Melania Ardelean, Daniel Goje, Ilie Rosca Ciprian, Romulus Timar, Daniel Lighezan
Summary: The study examined the direct relationship between serum uric acid and ejection fraction in 303 heart failure patients, concluding that higher uric acid levels are associated with a lower ejection fraction of the left ventricle.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Corrado Pelaia, Daniele Pastori, Giuseppe Armentaro, Sofia Miceli, Velia Cassano, Keti Barbara, Giulia Pelaia, Maria Perticone, Raffaele Maio, Pasquale Pignatelli, Francesco Violi, Francesco Perticone, Giorgio Sesti, Angela Sciacqua
Summary: This study demonstrates a significant decline in renal function over time in COPD patients, with uric acid (UA) and diabetes identified as the two strongest predictors.
Article
Cardiac & Cardiovascular Systems
Takahide Fujihashi, Yasuhiko Sakata, Kotaro Nochioka, Masanobu Miura, Ruri Abe, Shintaro Kasahara, Masayuki Sato, Hajime Aoyanagi, Shinsuke Yamanaka, Hideka Hayashi, Takashi Shiroto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Hiroaki Shimokawa
Summary: This study found a U-shaped prognostic effect of serum uric acid levels, with abnormal transitions to either higher or lower levels associated with poor prognosis in elderly patients.
Article
Biochemistry & Molecular Biology
Jin-Woo Park, Ji-Hyeon Noh, Jong-Min Kim, Hwa-Young Lee, Kyoung-Ah Kim, Ji-Young Park
Summary: This study found that the polymorphisms of ABCG2 rs2231142 and SLC2A9 rs3733591 may elevate blood uric acid levels.
Article
Endocrinology & Metabolism
Ying He, Jincheng Feng, Bo Zhang, Qiong Wu, Yongjie Zhou, Diao He, Daofeng Zheng, Jiayin Yang
Summary: This study utilized Mendelian randomization (MR) analysis to explore the causality between serum uric acid (SUA) levels and the risk of cardiovascular disease (CVD) in individuals with type 2 diabetes (T2D). The results did not find supporting evidence for a causal association between SUA levels and the risk of heart failure.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Mainak Banerjee, Rimesh Pal, Indira Maisnam, Subhankar Chowdhury, Satinath Mukhopadhyay
Summary: The use of SGLT2 inhibitors was found to significantly reduce the risk of gout in individuals with type 2 diabetes mellitus (T2DM) or heart failure (HF), and this effect was not dependent on baseline serum uric acid levels or the ability to lower serum uric acid. The metabolic and anti-inflammatory effects of SGLT2 inhibitors may primarily mediate their anti-gout benefits.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Hongxuan Xu, Quan Wang, Yunqing Liu, Lingbing Meng, Huanyu Long, Li Wang, Deping Liu
Summary: The study found that both high and low uric acid levels are predictive of hypertensive heart failure, while high-density lipoprotein cholesterol and fasting blood sugar are also associated with this condition, but low-density lipoprotein cholesterol is not correlated.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Jie Zhang, Wenyan Sun, Fei Gao, Jie Lu, Kelei Li, Yijun Xu, Yushuang Li, Changgui Li, Ying Chen
Summary: This study aimed to explore the relationship between the changes in SUA level and free glucocorticoids and inflammatory factors in acute and remission stages of gouty arthritis. A total of 50 acute gout patients were included in a prospective study. Results showed that SUA levels were significantly reduced during the acute flare, while 24-hour fractional excretion of uric acid and 24-hour urinary uric acid excretion increased significantly. The percent change in SUA was associated with changes in 24-hour fractional excretion of uric acid and C-reactive protein, while the percent change in 24-hour urinary uric acid excretion was associated with changes in 24-hour urinary free cortisol, interleukin 1 beta, and interleukin 6.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jia Liu, Mei-Li Zheng, Mulei Chen, Kuibao Li, Xiaoming Zhu, Yuanfeng Gao
Summary: This retrospective observational study analyzed the relationship between serum uric acid level and left ventricular hypertrophy (LVH) in patients with coronary heart disease (CHD), focusing on the influence of ApoE gene polymorphism. The results showed that high serum UA levels decreased the risk of LVH in ApoE epsilon 4 carriers, while increased the risk in non-epsilon 4 carriers.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jinfen Chen, Lieqiang Xu, Linyun Jiang, Yulin Wu, Long Wei, Xiaoli Wu, Shihong Xiao, Yuhong Liu, Changjun Gao, Jian Cai, Ziren Su
Summary: Sonneratia apetala seeds have been found to have potential nutraceutical benefits in lowering uric acid levels and protecting against renal injury through modulation of anti-oxidant status and inflammatory responses. These seeds also show promise in reversing hyperuricemia-induced kidney damage by activating the Nrf2 pathway and suppressing the TXNIP/NLRP3 inflammasome.
Article
Chemistry, Analytical
Yaoyu Tan, Mengyao Qi, Huan Jiang, Baihui Wang, Xia Zhang
Summary: The VO-MnCo2O4/Ag nanozyme, prepared by hydrothermal, calcination, and self-reduction methods, showed high uricase-like activity and peroxidase-like activity due to its composition and structure. The catalytic reaction of VO-MnCo2O4/Ag nanozyme significantly enhanced the SERS signal of the detected molecule. A label-free, sensitive, and reliable SERS uric acid detection system was developed based on the enzyme-like activities of VO-MnCo2O4/Ag.
ANALYTICA CHIMICA ACTA
(2023)
Article
Multidisciplinary Sciences
Naowanit Nata, Nanthawut Ninwisut, Pitchamon Inkong, Ouppatham Supasyndh, Bancha Satirapoj
Summary: Febuxostat treatment effectively reduces serum uric acid levels in CKD patients and preserves renal function, but does not improve endothelial dysfunction.
SCIENTIFIC REPORTS
(2023)
