期刊
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
卷 29, 期 2, 页码 295-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.idc.2015.02.005
关键词
Lyme disease; Borrelia burgdorferi; Laboratory diagnosis; Serology
资金
- Intramural Research Program National Institute of Allergy and Infectious Diseases, NIH
The majority of laboratory tests performed for the diagnosis of Lyme disease are based on detection of the antibody responses against B burgdorferi in serum. The sensitivity of antibody-based tests increases with the duration of the infection. Patients early in their illness are more likely to have a negative result. There is a need to simplify the testing algorithm for Lyme disease, improving sensitivity in early disease while still maintaining high specificity and providing information about the stage of infection. The development of a point of care assay and biomarkers for active infection would be major advances for the field.
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