期刊
INFECTION GENETICS AND EVOLUTION
卷 36, 期 -, 页码 55-61出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.meegid.2015.08.037
关键词
Mammalian orthoreovirus; Genome sequencing; Pathogenesis
资金
- National Natural Science Foundation of China [31402204]
- State Key Laboratory of Veterinary Biotechnology [SKLVBP201421]
- Basic Scientific Research Operation Cost of State-leveled Public Welfare Scientific Research Courtyard [0302014011]
Mammalian reoviruses (MRVs) are associated with pulmonary infections and have been isolated from humans and various animals experiencing respiratory illness. We report here the first case of an MRV detected in the masked palm civet, which showed the highest similarity to the serotype 3 MRV. Reovirus particles were identified by electron microscopic examination of both negative-stain and thin-section. Genomic pattern analysis on SDS-PAGE showed that MPC/04 had 10-segmented double-strand RNA genome. Intranasal infection of four-week-old female BALB/c mice resulted in fatal respiratory distress but not other routes. Infections caused tissue damage and inflammation. MPC/04 grew to higher titers in the lungs than in other tissues. This research strongly suggests a need for additional experimentation to understand the pathogenic mechanisms of mammalian orthoreoviruses in infected animals and humans. (C) 2015 Elsevier B.V. All rights reserved.
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