期刊
INFECTION GENETICS AND EVOLUTION
卷 32, 期 -, 页码 354-360出版社
ELSEVIER
DOI: 10.1016/j.meegid.2015.03.035
关键词
Intragenic recombination; 3SEQ; Evolutionary constraint; Genome evolution; Viral evolution
资金
- James S. McDonnell Foundation
- NSF from Advancing Theory in Biology [F020952]
Rotavirus is a genetically diverse pathogen with an eleven-segmented, double-stranded RNA genome. Intrasegmental recombination has been proposed as a potential mechanism to generate antigenic diversity and a possible route of escape from vaccine-imposed selective pressure. Here intrasegmental recombination was studied by performing a genome-wide scan across the eleven genome segments of 797 publically available rotavirus strains. Sixty-two sequences, or 0.7% of sequences analyzed, have evidence of intrasegmental homologous recombination. None of the specific recombination events is seen in more than one sequence. This uniqueness is consistent with either a spurious finding of recombination or the possibility that recombinant sequences arise naturally but are rapidly purged from the rotavirus population through selection. Arguments for the former explanation are presented. This analysis finds no evidence that intrasegmental recombination leads to ongoing transmission or plays a constructive role in rotavirus evolution. These results have practical implications for phylogenetic analyses and suggest a fundamental constraint that may have shaped rotavirus genome structure and evolution. (C) 2015 Elsevier B.V. All rights reserved.
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