期刊
ACTA HISTOCHEMICA
卷 115, 期 1, 页码 3-7出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.acthis.2011.05.002
关键词
Galectin-3; hCG; Endometrium
类别
资金
- Natural Science Foundation of China (NSFC) [30271354]
- Shanghai Leading Academic Discipline Project [B117]
Previous investigations on galectin-3 (gal-3) have focused mainly on its role in some malignant tumors. It was believed that gal-3 plays important roles in cell proliferation, apoptosis and adhesion in many cell types. Recently, gal-3 has been recognized as a factor related to endometrial receptivity in the human endometrium and trophoblast during embryo implantation. Human chorionic gonadotropin (hCG) is a specific embryonic hormone providing a signal from the embryo involved in preparing the receptive endometrium for embryo implantation. The current study aimed to determine whether hCG regulates gal-3 expression in endometrial cells. Our results showed that expression of gal-3 in both endometrial epithelial cells (EECs) and endometrial stromal cells (ESCs) could be regulated by hCG in an intricate manner. These results indicate that gal-3 might be regulated by hCG in preparing the endometrium for embryonic implantation. (C) 2011 Elsevier GmbH. All rights reserved.
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