Letter
Biochemistry & Molecular Biology
Shouhong Wang, Yun-Bo Shi
Summary: Tissue regeneration is crucial for biomedical developments, but many human organs cannot regenerate. Research shows that there is a significant difference in tail regeneration between Xenopus laevis and the closely related species Xenopus tropicalis, with Xenopus laevis experiencing a refractory period while Xenopus tropicalis does not. Further studies in Xenopus tropicalis may provide insights into the genetic basis of this evolutionary divergence and how tissue regenerative capacity is controlled, with implications for human regenerative medicine.
CELL AND BIOSCIENCE
(2021)
Article
Developmental Biology
Momoko Deguchi, Taro Fukazawa, Takeo Kubo
Summary: Xenopus laevis tadpoles can regenerate whole tails after amputation. The previously uncharacterized genes rfem.L and rfem.S were identified as essential for tail regeneration under Il11 signaling in a subset of leukocytes with a macrophage-like gene expression profile.
Article
Biochemistry & Molecular Biology
Shouhong Wang, Yuki Shibata, Liezhen Fu, Yuta Tanizaki, Nga Luu, Lingyu Bao, Zhaoyi Peng, Yun-Bo Shi
Summary: Animal regeneration is a natural process that relies on the level of thyroid hormone (T3), which is responsible for the loss of regenerative ability in many organs during development. The metamorphic stages in amphibians, similar to postembryonic development in humans, provide a good model to study the gradual loss of regenerative ability and the role of T3 in this process.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Makoto Nakamura, Hitoshi Yoshida, Yuka Moriyama, Itsuki Kawakita, Marcin Wlizla, Kimiko Takebayashi-Suzuki, Marko E. Horb, Atsushi Suzuki
Summary: Inhibition of TGF-beta 1 prevents tail regeneration in Xenopus tropicalis tadpoles, and TGF-beta 1 regulates cell proliferation through the activation of Smad2/3.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Fisheries
Nathalia Pentagna, Thayse Pinheiro da Costa, Fellipe Soares dos Santos Cardoso, Fernanda Martins de Almeida, Ana Maria Blanco Martinez, Jose Garcia Abreu, Michael Levin, Katia Carneiro
Summary: The research focused on the control of myeloid cells behavior during Xenopus tail regeneration by Histone Deacetylase (HDAC). The study showed the importance of myeloid differentiation in modulating the regenerative ability of Xenopus tadpoles in an HDAC activity-dependent manner, as well as the essential role of 15-LOX activity during tail regeneration. The spatial and temporal dynamics of lipid droplets were found to be functionally linked to the synthesis of lipid mediators in myeloid cells during the inflammatory response.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sung-Wook Nam, Jeong-Pil Chae, Yong Hwan Kwon, Mi-Young Son, Jae-sung Bae, Mae-Ja Park
Summary: Xenopus laevis is a suitable animal model for toxicology research due to its advantages in embryogenesis. A convenient embryo housing device is essential for handling a large number of embryos simultaneously in toxicological studies. The 3D fabrication of single-egg trapping devices can be used to culture Xenopus embryos for efficient assessment of malformation caused by toxicants.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Valentina Saccomanno, Heather Love, Amy Sylvester, Wen-Chang Li
Summary: The study showed that the lateral line system plays a crucial role in Xenopus tadpole motor responses to suction stimulation, initiating swimming reliably. Additionally, the afferent and efferent activities of the tadpole anterior lateral line nerve were analyzed, with sensory interneurons located using calcium imaging techniques.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Cell Biology
Li Yang, Youwei Chen, Huahua Liu, Yu Liu, Feng Yuan, Qianyan Li, Gufa Lin
Summary: This study uncovered the role of Evi5 in appendage regeneration in amphibians. Evi5 expression is upregulated in response to limb and tail amputation in both axolotls and Xenopus tadpoles. Knockdown of Evi5 impairs limb development and blastema formation in Xenopus, affecting proliferation and causing apoptosis in limb blastema cells. RNA-sequencing analysis identified the involvement of Evi5 in key signaling pathways and lysine demethylases in the process of limb regeneration. Evi5 knockdown also hampers tail regeneration in Xenopus tadpoles and axolotl larvae.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nanoka Suzuki, Akinori Kanai, Yutaka Suzuki, Hajime Ogino, Haruki Ochi
Summary: The Klf15-dependent adrenergic receptor signaling through regeneration enhancers plays a central role in the genetic network for kidney regeneration in Xenopus laevis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Jessica E. Hawley, Aleksandar Z. Obradovic, Matthew C. Dallos, Emerson A. Lim, Karie Runcie, Casey R. Ager, James Mckierman, Christopher B. Anderson, Guarionex J. Decastro, Joshua Weintraub, Renu Virk, Israel Lowy, Jianhua Hu, Matthew G. Chaimowitz, Xinzheng Guo, Ya Zhang, Michael C. Haffner, Jeremy Worley, Mark N. Stein, Andrea Califano, Charles G. Drake
Summary: Compared to other malignancies, the tumor microenvironment of prostate cancer is lacking in immune infiltrates. This study conducted single-cell RNA sequencing analysis of metastatic sites and identified consistent immune subpopulations across multiple sites. It also observed dynamic changes in these subpopulations in response to treatment and correlated them with clinical outcomes.
Article
Cell Biology
Tzi-Yang Lin, Tobias Gerber, Yuka Taniguchi-Sugiura, Prayag Murawala, Sarah Hermann, Lidia Grosser, Eri Shibata, Barbara Treutlein, Elly M. Tanaka
Summary: The difference in limb regeneration between salamanders and Xenopus laevis frogs lies in the dedifferentiation ability and integration of connective tissue cells, which restricts regeneration in frogs. Connective tissue cells in frog blastemas fail to fully re-express progenitor programs when transplanted into limb buds, affecting cartilage development. Additionally, there are molecular distinctions in cartilage differentiation programs between embryonic and adult frogs.
DEVELOPMENTAL CELL
(2021)
Article
Biochemical Research Methods
Rachel Ronan, Aniket Kshirsagar, Ana Lucia Rebelo, Abbah Sunny, Michelle Kilcoyne, Roisin O' Flaherty, Pauline M. Rudd, Gerhard Schlosser, Radka Saldova, Abhay Pandit, Siobhan S. McMahon
Summary: Traumatic spinal cord injury disrupts tissue integrity and function. This study investigates the role of glycosylation in regeneration and suggests that targeting glycosylation could be a promising strategy for future therapies.
JOURNAL OF PROTEOME RESEARCH
(2022)
Review
Cell Biology
Can Aztekin, Mekayla A. Storer
Summary: The ability of certain species to regenerate their appendages while others cannot remains a mystery. By studying model organisms with varying regenerative abilities, we can uncover the factors contributing to regeneration-incompetency and test perturbations that could restore appendage regrowth.
WOUND REPAIR AND REGENERATION
(2022)
Article
Cell Biology
Anastasiya S. Ivanova, Maria B. Tereshina, Karina R. Araslanova, Natalia Y. Martynova, Andrey G. Zaraisky
Summary: Warm-blooded vertebrates regenerate lost limbs and their parts much worse than fishes and amphibians. Experimental findings on tadpoles demonstrate the critical roles of ag1 and agr2 genes in the regeneration process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Lei Li, Ying Xu, Jihong Zheng, Zhe Kuang, Cong Zhang, Na Li, Gufa Lin, Chao Zhang
Summary: The study revealed a specific regulatory pattern of the melanocortin system in Xenopus laevis, where MRAP2 proteins directly interact with MC4R proteins on the cell surface in a functional antiparallel dimeric topology.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Antonella Franchini, Evelina Bertolotti
Editorial Material
Geriatrics & Gerontology
E. Ottaviani, N. Ventura, M. Mandrioli, M. Candela, A. Franchini, C. Franceschi
Article
Cell Biology
Antonella Franchini, Evelina Bertolotti
CELL AND TISSUE RESEARCH
(2011)
Article
Environmental Sciences
Antonella Franchini, Livio Casarini, Enzo Ottaviani
Article
Environmental Sciences
Antonella Franchini, Livio Casarini, Davide Malagoli, Enzo Ottaviani
Review
Pharmacology & Pharmacy
E. Ottaviani, A. Franchini, D. Malagoli
CURRENT PHARMACEUTICAL DESIGN
(2010)
Article
Marine & Freshwater Biology
Antonella Franchini
INVERTEBRATE BIOLOGY
(2008)
Article
Cell Biology
Antonella Franchini, Mauro Mandrioli, Claudio Franceschi, Enzo Ottaviani
JOURNAL OF MOLECULAR HISTOLOGY
(2012)
Article
Anatomy & Morphology
Evelina Bertolotti, Davide Malagoli, Antonella Franchini
JOURNAL OF MORPHOLOGY
(2013)
Review
Chemistry, Medicinal
Antonella Franchini, Davide Malagoli, Enzo Ottaviani
Article
Biology
Haria Negri, Antonella Franchini, Elena Gonella, Daniele Daffonchio, Peter John Mazzoglio, Mauro Mandrioli, Alberto Alma
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2009)
Article
Pharmacology & Pharmacy
A. Franchini, E. Ottaviani
Proceedings Paper
Engineering, Mechanical
Wang Qingmin, Yang Yaoen, Su Mubiao, Liu Yuhong
2012 INTERNATIONAL WORKSHOP ON INFORMATION AND ELECTRONICS ENGINEERING
(2012)
Article
Entomology
Ilaria Negri, Antonella Franchini, Mauro Mandrioli, Peter John Mazzoglio, Alberto Almai
BULLETIN OF INSECTOLOGY
(2008)
Article
Cell Biology
Abril Alondra Barrientos-Bonilla, Paola Belem Pensado-Guevara, Abraham Puga-Olguin, Rasajna Nadella, Aurora del Carmen Sanchez-Garcia, Laura Mireya Zavala-Flores, Arnulfo Villanueva-Olivo, Iliana Tamara Cibrian-Llanderal, Maria de Jesus Rovirosa-Hernandez, Daniel Hernandez-Baltazar
Summary: This study evaluated the impact of BrdU on liver function and found that multiple injections of BrdU did not induce hepatocellular damage.
Article
Cell Biology
Pan Zhang, Qun Feng, Wenxiao Chen, Xizhuang Bai
Summary: It was found that catalpol antagonizes LPS-mediated inflammation and suppressive osteoblast differentiation by inhibiting inflammation and promoting osteoblast differentiation. This finding contributes to a better understanding of the pathogenesis of osteoporosis.