Review
Pharmacology & Pharmacy
Lalita Subedi, Bhakta Prasad Gaire
Summary: The search for novel therapeutic agents for cerebral ischemia/stroke has led to a focus on neuroprotective phytochemicals with anti-inflammatory properties as potential drug candidates. Studies have shown that these compounds reduce brain inflammation by decreasing proinflammatory microglia and macrophages while promoting anti-inflammatory responses, leading to improved outcomes in animal stroke models.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Immunology
Marta Vicente-Rodriguez, Nisha Singh, Federico Turkheimer, Alba Peris-Yague, Karen Randall, Mattia Veronese, Camilla Simmons, Abdul Karim Haji-Dheere, Jayanta Bordoloi, Kerstin Sander, Ramla O. Awais, Erik Arstad, Nima Consortium, Diana Cash, Christine A. Parker
Summary: By utilizing TSPO PET imaging, we can detect peripherally-induced neuroinflammation in the central nervous system, primarily arising from a combination of microglia, astrocytes, and monocyte-derived macrophages.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Pharmacology & Pharmacy
Sana Rubab, Komal Naeem, Isra Rana, Namrah Khan, Maryam Afridi, Izhar Ullah, Fawad Ali Shah, Sadia Sarwar, Fakhar Ud Din, Ho-Ik Choi, Cheol-Ho Lee, Chang-Wan Lim, Abir Abdullah Alamro, Jin-Ki Kim, Alam Zeb
Summary: The study developed curcumin-loaded nanostructured lipid carriers (CUR-NLCs) and demonstrated their neuroprotective effects in depression and anxiety models induced by lipopolysaccharide. The optimized CUR-NLCs showed promising results in terms of drug release, behavior tests, and brain tissue analysis, indicating their potential therapeutic use for depression and anxiety.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Food Science & Technology
Imrana Jazuli, Goh Bey Hing, Lakshmi Selvaratnam, Deepa Alex, Lee Learn Han, Yatinesh Kumari
Summary: Alzheimer's disease is a significant challenge to healthcare systems and economies worldwide, characterized by progressive memory dysfunction. Neuroinflammation plays a critical role in its progression. Available drugs primarily focus on symptomatic treatment, highlighting the need for safe adjunctive agents with specific targets and mechanisms of action. Swietenia macrophylla has shown potential neuroprotective properties, including anti-inflammatory, antioxidant, anti-acetylcholinesterase, and anti-mitochondrial dysfunction effects.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Immunology
Timon Fiedler, Richard Fairless, Kira Pichi, Roman Fischer, Fabian Richter, Roland E. Kontermann, Klaus Pfizenmaier, Ricarda Diem, Sarah K. Williams
Summary: This study investigates the therapeutic potential of blocking TNFR1 and stimulating TNFR2 in a mouse model of multiple sclerosis (MS). The results show that this combinatorial approach can ameliorate symptoms of MS, reduce demyelination, inflammatory infiltration, and axonal degeneration. Additionally, it promotes the survival of retinal ganglion cells (RGC) and activates neuroprotective signaling pathways. Therefore, regulating the balance of TNFR signaling may be a novel therapeutic approach for inflammatory demyelinating diseases.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Nanoscience & Nanotechnology
Mi Zhou, Tianxu Zhang, Xiaolin Zhang, Mei Zhang, Shaojingya Gao, Tao Zhang, Songhang Li, Xiaoxiao Cai, Jun Li, Yunfeng Lin
Summary: Researchers have found that tetrahedral framework nucleic acid (tFNA) nanomaterials can protect and regulate astrocytes in stroke, reducing brain damage and promoting neurological function recovery.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Mi Zhou, Tianxu Zhang, Xiaolin Zhang, Mei Zhang, Shaojingya Gao, Tao Zhang, Songhang Li, Xiaoxiao Cai, Jun Li, Yunfeng Lin
Summary: Astrocytes play a crucial biphasic role in ischemic stroke, and protecting and regulating these cells is essential for stroke treatment. Using tFNA nanomaterials can effectively inhibit astrocytic apoptosis, activation, and polarization, thereby reducing brain injury and facilitating neurological function recovery.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Immunology
Yuko Morita, Takahide Itokazu, Toru Nakanishi, Shin-ichiro Hiraga, Toshihide Yamashita
Summary: This study successfully established an ON rat model induced by AQP4-IgG, replicating the histological characteristics of NMO patients, which is significant for exploring the pathogenesis and potential therapeutic drugs for ON.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Tu-Wen Chen, Po-Ying Wu, Yao-Tseng Wen, Tushar Dnyaneshwar Desai, Chin-Te Huang, Pei-Kang Liu, Rong-Kung Tsai
Summary: Supplementing with vitamin B3 has been found to protect retinal ganglion cells from damage and has multiple neuroprotective properties.
Article
Immunology
Marija Rakic, Tanja Lunic, Marina Bekic, Sergej Tomic, Katarina Mitic, Stefan Graovac, Bojan Bozic, Biljana Bozic Nedeljkovic
Summary: This study examined the effects of vitamin B complex (VBC - B1, B2, B3, B5, B6, and B12) on LPS-stimulated microglial cells and neurons. The results showed that VBC treatment reduced inflammation and neurotoxicity in microglia, and induced changes in phenotype towards M2 microglia type.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Hongxiang Hong, Xu Lu, Chunshuai Wu, Jiajia Chen, Chu Chen, Jinlong Zhang, Chao Huang, Zhiming Cui
Summary: Paeoniflorin, a compound extracted from Paeonia lactiflora Pall, has shown preventive and therapeutic effects in various types of nervous system disorders. However, comprehensive knowledge about the pharmacological effects of paeoniflorin on the nervous system is currently not available online. This review summarizes the pharmacological aspects of paeoniflorin and its possible mechanisms, highlighting its potential in the prevention and treatment of disorders like cerebral ischemia, subarachnoid hemorrhage, vascular dementia, Alzheimer's disease, Parkinson's disease, depression, post-traumatic syndrome disorder, and epilepsy.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Wanxu Guo, Xiaoxiao Yao, Ranji Cui, Wei Yang, Lei Wang
Summary: This review outlines the antidepressant effect and mechanism of action of Paeoniflorin (PF), including increasing monoamine neurotransmitter levels, inhibiting the HPA axis, promoting neuroprotection, enhancing neurogenesis in the hippocampus, and elevating brain-derived neurotrophic factor (BDNF) levels. The potential application of PF in the treatment of depression is discussed.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Angel Cores, Noelia Carmona-Zafra, Olmo Martin-Camara, Juan Domingo Sanchez, Pablo Duarte, Mercedes Villacampa, Paloma Bermejo-Bescos, Sagrario Martin-Aragon, Rafael Leon, J. Carlos Menendez
Summary: Curcumin analogues with the fragment of piperlongumine showed broad-spectrum activity in the treatment of Alzheimer's disease, with good absorption, antioxidant properties, and the ability to inhibit inflammation.
Article
Pharmacology & Pharmacy
Chunting Zhang, Hongyong Wang, Weiwei Liang, Yueqing Yang, Chaohua Cong, Ying Wang, Shuyu Wang, Xudong Wang, Di Wang, Di Huo, Honglin Feng
Summary: The study demonstrates that DPDS provides neuroprotection by inhibiting microglia-mediated neuroinflammatory injury. DPDS attenuates neuroinflammation by inhibiting the I kappa B/NF-kappa B pathway and NLRP3 inflammasome activation. This finding was further validated in both in vitro and in vivo experiments.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Neurosciences
Fankai Gao, Rui Chen, Shuo Li, An Li, Bo Bai, Rulin Mi, Guofang Xue
Summary: Neuroinflammation is important in epilepsy development and can be delayed by suppressing it. Recent studies have shown that (+)-borneol has neuroprotective effects by reducing neuroinflammation. In this research, the effects of different doses of (+)-borneol on neuroinflammation in an epileptogenesis model were examined. The results suggest that (+)-borneol reduces neuroinflammation by inhibiting the NF-KB pathway activation, exerts neuroprotective effects, and may have an inhibitory effect in epileptogenesis.
Article
Veterinary Sciences
Ryo Muko, Hiroshi Matsuda, Masa-aki Oikawa, Taekyun Shin, Kenshiro Matsuda, Hiroaki Sato, Tomoya Sunouchi, Akane Tanaka
Summary: This study demonstrated that eHRG acts as a dual regulator of neutrophils in horses, affecting adhesion, migration, phagocytosis, reactive oxygen species production, and lysosome maturation.
JOURNAL OF EQUINE VETERINARY SCIENCE
(2021)
Article
Medicine, Research & Experimental
Yuna Choi, Kyungsook Jung, Hyo Jin Kim, Jiyoon Chun, Meejung Ahn, Youngheun Jee, Hyun Ju Ko, Changjong Moon, Hiroshi Matsuda, Akane Tanaka, Jeongtae Kim, Taekyun Shin
Summary: The study demonstrated that betaine has anti-inflammatory effects in experimental autoimmune uveitis (EAU) rats by increasing serum superoxide dismutase levels, downregulating pro-inflammation molecules, and suppressing inflammation in the retina and ciliary bodies. This suggests that betaine plays a role in mitigating EAU through its anti-oxidation and anti-inflammatory activities.
EXPERIMENTAL NEUROBIOLOGY
(2021)
Article
Neurosciences
Woo-Ju Song, Jang-Hyuk Yun, Myeong-Seon Jeong, Kil-Nam Kim, Taekyun Shin, Hyoung-Chun Kim, Myung-Bok Wie
Summary: Trimethyltin (TMT) is an environmental neurotoxin that affects human dopaminergic neuronal survival through various mechanisms. Several antioxidants and drugs can alleviate TMT toxicity, including by altering apoptosis-related proteins and affecting necrotic features in cells.
Article
Neurosciences
Poornima D. E. Weerasinghe-Mudiyanselage, Mary Jasmin Ang, Mai Wada, Sung-Ho Kim, Taekyun Shin, Miyoung Yang, Changjong Moon
Summary: The study revealed that acute MPTP treatment significantly decreased motor function and spine density in the hippocampus of mice, while not affecting dendritic complexity. These findings provide anatomical evidence for the ability of the acute MPTP-lesioned mouse model to replicate the non-nigrostriatal lesions of clinical PD.
Article
Chemistry, Multidisciplinary
Nayeon Yang, Myungsoon Ko, Meejung Ahn, Taekyun Shin
Summary: This study found that Norgalanthamine has anti-inflammatory and anti-oxidative properties, which can mitigate the liver injury induced by carbon tetrachloride in mice. It restores antioxidant enzyme activities, reduces lipid accumulation and inflammation, and decreases fibrosis in the liver.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Cell Biology
Jeongtae Kim, Meejung Ahn, Yuna Choi, Jiyoon Chun, Kyungsook Jung, Akane Tanaka, Hiroshi Matsuda, Taekyun Shin
Summary: This study investigated the involvement of osteopontin (OPN) in an experimental autoimmune uveoretinitis (EAU) model. The results showed that OPN was significantly upregulated in the eyes of EAU rats, suggesting its potential as an early biomarker for ocular autoimmune diseases.
NEURAL REGENERATION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Yuna Choi, Taekyun Shin
Summary: Alendronate can inhibit the inflammatory response in spinal cord injury, reduce inflammatory cell infiltration and gliosis, and improve motor and sensory function.
EXPERIMENTAL NEUROBIOLOGY
(2022)
Article
Environmental Sciences
Woo-Ju Song, Jeongtae Kim, Taekyun Shin, Myeong-Seon Jeong, Kil-Nam Kim, Jang-Hyuk Yun, Myung-Bok Wie
Summary: The study showed that esculetin and fucoidan can attenuate the neurotoxic effects of ZnO NPs in rats, possibly through modulating reactive astrocytes and proinflammatory cytokines in the brain.
Review
Anatomy & Morphology
Jeongtae Kim, Jiyoon Chun, Meejung Ahn, Kyungsook Jung, Changjong Moon, Taekyun Shin
Summary: This review discusses recent studies on experimental autoimmune uveitis (EAU) and describes a therapeutic strategy that aims to interrupt uveitogenic factors during the course of EAU, which could be beneficial for controlling human uveitis.
ANATOMY & CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Poornima D. E. Weerasinghe-Mudiyanselage, Sohi Kang, Joong-Sun Kim, Jong-Choon Kim, Sung-Ho Kim, Hongbing Wang, Taekyun Shin, Changjong Moon
Summary: This study identified differentially expressed genes (DEGs) in the hippocampus of mice with EAE, a model of MS, using RNA-sequencing and RT-qPCR. The DEGs were associated with immune system processes, learning or memory, and synaptic plasticity. Gene set enrichment analysis revealed signaling pathways related to inflammatory responses and synaptic plasticity. However, further investigation is needed to determine the applicability of these findings in patients with MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ryo Muko, Tomoya Sunouchi, Shuntaro Urayama, Yuko Toishi, Kanichi Kusano, Hiroaki Sato, Masanori Muranaka, Taekyun Shin, Masa-aki Oikawa, Yoshinobu Ojima, Mohammad Ali, Yoshihiro Nomura, Hiroshi Matsuda, Akane Tanaka
Summary: In this study, DNA samples were extracted from 1700 Thoroughbred horses and analyzed for gene polymorphisms in the HRG gene. Two types of insertion/deletion polymorphisms (D1 and D2) were identified in the histidine-rich region of the HRG gene, with deletion lengths of 45 bp and 90 bp. These genetic polymorphisms in the HRG gene may be associated with athletic ability, productivity, and susceptibility to infectious diseases in Thoroughbred horses.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Sungmoo Hong, Poornima D. E. Weerasinghe-Mudiyanselage, Sohi Kang, Changjong Moon, Taekyun Shin
Summary: This study used RNA-sequencing to analyze the transcriptomes of retinas in mice with EAE and identified differentially expressed genes (DEGs) related to EAE-induced visual impairment. Gene expression analysis showed that the upregulated genes in the retinas of mice with EAE were primarily associated with immune responses and immune-mediated inflammation. In addition, gene set enrichment analysis revealed a negative enrichment of gene sets related to the neuronal system and phototransduction cascade in EAE-affected retinas. This study provides novel molecular evidence for visual impairments in EAE and indicates directions for further research to elucidate the mechanisms of these visual impairments in MS.
ANIMAL CELLS AND SYSTEMS
(2023)
Article
Urology & Nephrology
Bohye Kim, Poornima D. E. Weerasinghe-Mudiyanselage, Mary Jasmin Ang, Jeongmin Lee, Sohi Kang, Jong-Choon Kim, Sung-Ho Kim, Joong-Sun Kim, Chaeyong Jung, Taekyun Shin, Changjong Moon
Summary: This study found that structural plasticity in the hippocampus is altered in the late phase following striatal 6-OHDA infusion in rats, possibly due to prolonged suppression of the DAergic system, independent of neuroinflammation.
INTERNATIONAL NEUROUROLOGY JOURNAL
(2022)
Article
Veterinary Sciences
Sungwoong Jang, Bohye Kim, Jeongmin Lee, Sohi Kang, Joong-Sun Kim, Jong-Choon Kim, Sung-Ho Kim, Taekyun Shin, Changjong Moon
Summary: This study examined the histological characteristics and glycoconjugate composition of the olfactory mucosa (OM) in Korean native cattle. The findings suggest that glycoconjugates may play a role in olfactory chemoreception, and their labeling properties may be closely related to OM development and maturity.
JOURNAL OF VETERINARY SCIENCE
(2022)
Article
Neurosciences
Mai Wada, Mary Jasmin Ang, Poornima D. E. Weerasinghe-Mudiyanselage, Sung-Ho Kim, Jong-Choon Kim, Taekyun Shin, Changjong Moon
Summary: The study evaluated the feasibility of using C57BL/6N mice as a model for Parkinson's disease. Mice established via the acute MPTP/probenecid protocol showed dopaminergic degeneration and motor impairments, but also exhibited anxiolytic and antidepressive behaviors upon recovery. The non-motor findings may suggest limitations in using these mice to model emotional aberrations in Parkinson's disease.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2021)
Article
Cell Biology
Abril Alondra Barrientos-Bonilla, Paola Belem Pensado-Guevara, Abraham Puga-Olguin, Rasajna Nadella, Aurora del Carmen Sanchez-Garcia, Laura Mireya Zavala-Flores, Arnulfo Villanueva-Olivo, Iliana Tamara Cibrian-Llanderal, Maria de Jesus Rovirosa-Hernandez, Daniel Hernandez-Baltazar
Summary: This study evaluated the impact of BrdU on liver function and found that multiple injections of BrdU did not induce hepatocellular damage.
Article
Cell Biology
Pan Zhang, Qun Feng, Wenxiao Chen, Xizhuang Bai
Summary: It was found that catalpol antagonizes LPS-mediated inflammation and suppressive osteoblast differentiation by inhibiting inflammation and promoting osteoblast differentiation. This finding contributes to a better understanding of the pathogenesis of osteoporosis.
