Review
Biochemistry & Molecular Biology
Hans-Joachim Gabius, Mare Cudic, Tammo Diercks, Herbert Kaltner, Jurgen Kopitz, Kevin H. Mayo, Paul V. Murphy, Stefan Oscarson, Rene Roy, Andreas Schedlbauer, Stefan Toegel, Antonio Romero
Summary: The text emphasizes the importance of the sugar code, highlighting the diversity of sugars and the specificity in recognition processes. The enormous potential of glycan biosynthetic enzymes and the development of sugar receptors lay the foundation for understanding the sugar code.
Article
Developmental Biology
Carolyn J. P. Jones, Sandra Wilsher, Giulio Russo, John D. Aplin
Summary: This study investigated glycosylation in feline placentae and found significant changes in glycan distribution throughout pregnancy. Tri-tetraantennary complex N-glycan and alpha-galactosyl residues decreased in mid-pregnancy but remained at the invasion front. Other unique glycans were present in invading cells. Polylactosamine was found in the basal lamina and syncytial secretory granules clustered near the apical membrane. Decidual cells expressed beta-galactosyl residues and highly branched N-glycan levels increased over time. Differentiation pathways of lamellar and invasive cytotrophoblast are suggested.
Article
Anatomy & Morphology
Sofia Passaponti, Valentina Pavone, Laura Cresti, Francesca Ietta
Summary: Research shows that during pregnancy, highly glycosylated proteins are present in both the maternal endometrium and blastocyst in a specifically controlled manner, which is crucial for the implantation and development of the blastocyst. Carbohydrates play a fundamental role in cell-cell and cell-matrix recognition, and the study highlights the importance of glycan-epitopes at the feto-maternal interface in humans.
Article
Developmental Biology
Carolyn J. P. Jones, John D. Aplin
Summary: The glycotype at the fetomaternal interface was compared among endotheliochorial cat, lion, and dog placentae using 24 lectins. There was a high similarity in glycan expression between cat and lion placentae, except for the presence of terminal a-galactose in lion trophoblast. The dog showed notable differences, especially in the trophoblast, which may be attributed to species-specific glycotypes resulting from evolutionary divergence.
Review
Biochemistry & Molecular Biology
Junya Kojima, Masanori Ono, Naoaki Kuji, Hirotaka Nishi
Summary: The placenta is crucial for establishing pregnancy and fetal well-being in humans, allowing for maternal physiological adaptation and embryonic immunological acceptance. Placental tissue varies widely among species, making it challenging to directly apply findings from animal studies to human research. Artificial induction of early villous differentiation can potentially elucidate the causes of perinatal diseases and aid in the development of novel therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Natalia Gebara, Julia Scheel, Renata Skovronova, Cristina Grange, Luca Marozio, Shailendra Gupta, Veronica Giorgione, Federico Caicci, Chiara Benedetto, Asma Khalil, Benedetta Bussolati
Summary: This study characterized extracellular vesicles (EVs) from amniotic fluid, showing that they originate from fetal and placental cells. It was found that EVs from amniotic fluid in preeclampsia, a hypertensive disorder, have antiangiogenic effects, which may impact fetal development or surrounding fetal membranes.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Chemistry, Applied
Wilailak Janjamroon, Pongsert Sriprom, Acharee Kaewlaoyoong, Nicholas Kiprotich Cheruiyot, Lasuardi Permana, Kanjana Manamoongmongkol, Lamphung Phumjan
Summary: Thailand, one of the largest sugarcane producers, has a potential issue of organochlorine pesticide residues in its plantation soil. In this study, the OCP residues in sugarcane at different processing stages were investigated and high concentrations of OCPs were found in the samples. Bagasse and raw sugar had the highest OCP concentrations, while sugarcane juice had the lowest. The study also suggests the possible persistent OCP presence in plantation soil, potentially due to illegal use.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2024)
Article
Pharmacology & Pharmacy
Zongli Ren, Ning Cui, Minglin Zhu, Raouf A. Khalil
Summary: The study suggests that placental ischemia-induced proinflammatory cytokines may be one of the causes of preeclampsia. Modulating cytokines and metalloproteinases can improve vascular and uteroplacental remodeling, alleviating symptoms of preeclampsia.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Boris Schnider, Yacine M'Rad, Jalaa el Ahmadie, Alexandre G. de Brevern, Anne Imberty, Frederique Lisacek
Summary: The UniLectin portal is a website that centralizes curated and predicted data on lectins and provides support for the study of lectomes. The latest update includes new modules and details our knowledge of the human lectome, featuring 215 unevenly characterized lectins, with a focus on structural information.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Obstetrics & Gynecology
Panchan Zheng, Dan Chen, Baoying Ye, Xingyu Yang, Weiwei Cheng
Summary: This study found that complete PP is associated with a lower risk of PE, while PA is associated with a higher risk of GH-PE.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Review
Cell Biology
Bum-Kyu Lee, Jonghwan Kim
Summary: Understanding the molecular mechanisms of early human placenta development is crucial for maternal and fetal health. Recent advancements in human trophoblast models offer new opportunities, but the application of high-throughput omics tools in this field remains limited. Integration of omics approaches with human in vitro model systems has the potential to enhance our understanding of placental development and associated complications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ruta Navakauskiene, Deimante Zukauskaite, Veronika Viktorija Borutinskaite, Tetiana Bukreieva, Giedre Skliute, Elvina Valatkaite, Aiste Zentelyte, Lina Piesiniene, Volodymyr Shablii
Summary: Cryopreservation of placenta tissue allows for the isolation of mesenchymal stromal cells (MSCs) for future cell therapy and regenerative medicine. However, concerns about the impact on molecular characteristics, such as epigenetic regulation, still exist. In this study, we compared the characteristics of human placental MSCs isolated from fresh and cryopreserved placenta tissue. We found that cryopreservation did not significantly affect the immunophenotype, differentiation capacity, or epigenetic profile of the MSCs. Additionally, we demonstrated that both fresh and cryopreserved MSCs from placenta tissue have a positive effect on improving pregnancy outcomes in a mouse model, with fresh MSCs showing a higher capacity to restore fertility in mice with premature ovarian failure compared to cryopreserved MSCs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Rinaldo Rodrigues dos Passos Junior, Raiany Alves de Freitas, Vanessa Dela Justina, Sebastian San Martin, Victor Vitorino Lima, Fernanda Regina Giachini
Summary: This study found that insufficient protein O-GlcNAcylation caused by decreased placental nutritional apport contributes to placental dysfunction during hypertensive pregnancy, impairing fetal growth.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rona Karahoda, Sampada Kallol, Michael Groessl, Edgar Ontsouka, Pascale Anderle, Christa Fluck, Frantisek Staud, Christiane Albrecht
Summary: This study investigates the gestational age-dependent changes in the gene expression of key steroidogenic enzymes in human placentas, as well as explores the role of trophoblast cells in steroid biosynthesis and metabolism. The research provides insights into the cellular origin of steroidogenesis in the human placenta and highlights the functional activity of steroidogenic enzymes in primary human trophoblasts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Louise Fliedel, Khair Alhareth, Nathalie Mignet, Thierry Fournier, Karine Andrieux
Summary: This review explores the use of nanocarriers for pregnancy-associated therapies, focusing on placental-based models for evaluation. Through categorizing and studying different types of placental models, it offers guidance on research and treatment in this field.
Article
Cell Biology
Abril Alondra Barrientos-Bonilla, Paola Belem Pensado-Guevara, Abraham Puga-Olguin, Rasajna Nadella, Aurora del Carmen Sanchez-Garcia, Laura Mireya Zavala-Flores, Arnulfo Villanueva-Olivo, Iliana Tamara Cibrian-Llanderal, Maria de Jesus Rovirosa-Hernandez, Daniel Hernandez-Baltazar
Summary: This study evaluated the impact of BrdU on liver function and found that multiple injections of BrdU did not induce hepatocellular damage.
Article
Cell Biology
Pan Zhang, Qun Feng, Wenxiao Chen, Xizhuang Bai
Summary: It was found that catalpol antagonizes LPS-mediated inflammation and suppressive osteoblast differentiation by inhibiting inflammation and promoting osteoblast differentiation. This finding contributes to a better understanding of the pathogenesis of osteoporosis.
