Article
Nutrition & Dietetics
Lana Schumann, Annett Wilken-Schmitz, Sandra Trautmann, Alexandra Vogel, Yannick Schreiber, Lisa Hahnefeld, Robert Gurke, Gerd Geisslinger, Irmgard Tegeder
Summary: Progranulin deficiency in mice leads to a stronger preference for fatty taste and an increase in body weight, potentially due to reduced CD36 expression in the tongue.
Article
Agriculture, Dairy & Animal Science
Deepankumar Shanmugamprema, Karthi Muthuswamy, Vinithra Ponnusamy, Gowtham Subramanian, Thirunavukkarasu Velusamy, Vasanth Krishnan, Selvakumar Subramaniam
Summary: This study analyzed the effects of chronic high-fat diet feeding on fat taste perception in Mus booduga, and found that it altered CD36 and GPR120 mediated fat taste perception.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2022)
Article
Behavioral Sciences
Catherine Anna-Marie Graham, Leta Pilic, Ella Mcgrigor, Megan Brown, Isabelle Jane Easton, Jonathan Nyuma Kean, Verity Sarel, Yasmin Wehliye, Natalie Davis, Nisrin Hares, Deanna Barac, Alexandra King, Yiannis Mavrommatis
Summary: The study examined the relationship between genetics, fat and bitter taste sensitivity, and dietary fat intake in healthy UK adults. Results showed associations between TAS2R38 and CD36 genes with bitter and fat taste sensitivity, as well as a negative correlation between bitter taste sensitivity and saturated fat intake. Participants with specific gene variants had different perceptions of bitterness and fat taste, suggesting further exploration in a larger cohort.
Review
Physiology
Rosario B. Jaime-Lara, Brianna E. Brooks, Carlotta Vizioli, Mari Chiles, Nafisa Nawal, Rodrigo S. E. Ortiz-Figueroa, Alicia A. Livinski, Khushbu Agarwal, Claudia Colina-Prisco, Natalia Iannarino, Aliya Hilmi, Hugo A. Tejeda, Paule V. Joseph
Summary: This systematic review summarizes emerging evidence examining the biological mechanisms of fat taste and smell. The existing literature suggests that proteins such as CD36 and GPR120 play important roles in fat chemosensation. Additionally, neural circuits, key brain regions, ingestive cues, postingestive signals, and genetic polymorphism are discussed in relation to fat perception and consumption.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Endocrinology & Metabolism
Tongzhu Meng, Stan Kubow, Daiva E. Nielsen
Summary: This study investigated the associations between CD36 gene variants and fat consumption in different BMI categories. The results showed that CD36 variants were associated with fat intake and food categories, which may play a role in subsequent associations with chronic disease biomarkers. Associations differed by BMI status and dietary fat type.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Review
Endocrinology & Metabolism
Vinithra Ponnusamy, Gowtham Subramanian, Karthi Muthuswamy, Deepankumar Shanmugamprema, Vasanth Krishnan, Thirunavukkarasu Velusamy, Selvakumar Subramaniam
Summary: The present review examines the importance of taste sensation in making nutritionally important decisions and its relationship with altered taste sensitivity and genetic polymorphisms in obesity.
Article
Nutrition & Dietetics
Muthuswamy Karthi, Shanmugamprema Deepankumar, Ponnusamy Vinithra, Subramanian Gowtham, Krishnan Vasanth, Palanivelu Praveen Raj, Rajasekaran Senthilkumar, Subramaniam Selvakumar
Summary: This study identified an association between SNP in the CD36 gene and factors such as oral fat detection threshold, peptide-YY levels, food choice, and lipid profiles in obese individuals. Obese individuals had significantly lower levels of peptide YY in saliva compared to non-obese individuals.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Gema Fruhbeck, Sara Becerril, Marina Martin, Beatriz Ramirez, Victor Valenti, Rafael Moncada, Victoria Catalan, Javier Gomez-Ambrosi, Camilo Silva, Maria A. Burrell, Javier Escalada, Amaia Rodriguez
Summary: This study analyzed the role of the guanylin system in changes in food preference after sleeve gastrectomy in obesity. The results showed that circulating concentrations of GUCA2B increased after sleeve gastrectomy and were negatively associated with fat preference. Furthermore, sleeve gastrectomy upregulated the expression of GUCA2A and GUCA2B in taste bud cells and downregulated the expression of the lingual lipid sensor CD36.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Nutrition & Dietetics
Laurent Brondel, Didier Quilliot, Thomas Mouillot, Naim Akhtar Khan, Philip Bastable, Vincent Boggio, Corinne Leloup, Luc Penicaud
Summary: Obesity is the result of an alteration in the homeostatic feedback of energy balance, leading to a temporary or prolonged positive energy balance. Food plays a key role in reward-based energy intake, and an alteration in the brain reward system may contribute to the development of obesity by increasing the attractiveness and consumption of fat-rich foods. Understanding this altered reward system may have implications for the diagnosis, management, and treatment of obesity.
Article
Biochemistry & Molecular Biology
Fangjun Lin, Yan Liu, Trina Rudeski-Rohr, Naima Dahir, Ashley Calder, Timothy A. Gilbertson
Summary: Adiponectin, an important metabolic hormone, modulates gustatory function by enhancing insulin sensitivity and stimulating glucose and fatty acid metabolism. Experimental results showed that adiponectin receptors are highly expressed in the taste system and enhance taste cell responses to fatty acids by increasing cell surface expression of the fat taste receptor CD36.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Paulo Henrique Evangelista-Silva, Rodrigo Pereira Prates, Jaqueline Santos Moreira Leite, Lauane Gomes Moreno, Francemilson Goulart-Silva, Elizabethe Adriana Esteves
Summary: Piqui oil increased caloric intake, reduced fasting blood glucose, and attenuated absorption of monosaccharides and fatty acids without affecting body weight or visceral fat.
Article
Nutrition & Dietetics
Arnaud Bernard, Johanne Le Beyec-Le Bihan, Loredana Radoi, Muriel Coupaye, Ouidad Sami, Nathalie Casanova, Cedric Le May, Xavier Collet, Pascaline Delaby, Cindy Le Bourgot, Philippe Besnard, Severine Ledoux
Summary: This study aimed to explore the impact of bariatric surgery on taste perceptions, finding that only RYGB surgery led to changes in fat sensitivity. However, perceptions of fat and sweet tastes were not consistent among patients who underwent the same surgery.
Article
Gastroenterology & Hepatology
Amira Sayed Khan, Aziz Hichami, Babar Murtaza, Marie-Laure Louillat-Habermeyer, Christophe Ramseyer, Maryam Azadi, Semen Yesylevskyy, Floriane Mangin, Frederic Lirussi, Julia Leemput, Jean-Francois Merlin, Antonin Schmitt, Muhtadi Suliman, Jerome Bayardon, Saeed Semnanian, Sylvain Juge, Naim Akhtar Khan
Summary: Two high affinity agonists of tongue taste receptors (CD36/ GPR120) have been synthesized, acting as fat taste enhancers and triggering the activation of the tongue-gut satiation loop in male mice. These agents were found to reduce daily fat-rich food intake and body weight gain in diet-induced obese male mice.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yunxia Li, Xingguo Huang, Guan Yang, Kang Xu, Yulong Yin, Gabriele Brecchia, Jie Yin
Summary: CD36, located on the cell membrane, plays a critical role in regulating lipid metabolism and is associated with lipid dysmetabolism and obesity. However, the specific mechanisms by which CD36 regulates lipid metabolism and its role in metabolic diseases remain unclear. This review summarizes the latest research on the role of membrane CD36 in fat metabolism, focusing on CD36-mediated fat sensing and transport, and critically discusses the factors affecting CD36-mediated fat dysfunction. Finally, it reviews previous clinical evidence and considers future research directions.
PROGRESS IN LIPID RESEARCH
(2022)
Article
Food Science & Technology
Vinithra Ponnusamy, Gowtham Subramanian, Karthi Muthuswamy, Deepankumar Shanmugamprema, Keerthana Vasanthakumar, Vasanth Krishnan, Selvakumar Subramaniam
Summary: This study aimed to investigate the relationship between tongue papillae density, taste sensitivity, and BMI in the Indian population. The results showed a negative correlation between papillae density and BMI, with higher BMIs associated with lower papillae density and reduced sensitivity to fat taste. Furthermore, there were regional differences in papillae density on the tongue, with the front-right section having higher density than the front-left section. Overall, this study demonstrates a strong relationship between taste sensitivity, BMI, and tongue papillae density in various regions of the tongue in the Indian population.
FOOD RESEARCH INTERNATIONAL
(2023)
Correction
Oncology
Malgorzata Wachowska, Magdalena Gabrysiak, Angelika Muchowicz, Weronika Bednarek, Joanna Barankiewicz, Tomasz Rygiel, Louis Boon, Pawel Mroz, Michael R. Hamblin, Jakub Golab
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Allergy
Inge Van de Walle, Karen Silence, Kevin Budding, Liesbeth Van de Ven, Kim Dijkxhoorn, Elisabeth de Zeeuw, Cafer Yildiz, Sofie Gabriels, Jean-Michel Percier, Johanna Wildemann, Jan Meeldijk, Peter J. Simons, Louis Boon, Linda Cox, Rob Holgate, Rolf Urbanus, Henny G. Otten, Jeanette H. W. Leusen, Christophe Blanchetot, Hans de Haard, C. Erik Hack, Peter Boross
Summary: ARGX-117 is a promising new complement inhibitor that uniquely targets both the classical and lectin pathways by binding to the Sushi-2 domain of C2. It prevents complement-mediated cytotoxicity in in vitro models for autoimmune hemolytic anemia and antibody-mediated rejection of organ transplants.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Xiaofei Xu, Errol Prens, Edwin Florencia, Pieter Leenen, Luis Boon, Patrick Asmawidjaja, Anne-Marie Mus, Erik Lubberts
Summary: The up-regulation of IL-19 and IL-24 induced by IL-17A in skin stromal cells contributes to keratinocyte proliferation. Depletion of IL-10 leads to increased expression of IL-23/IL-17 pathway related cytokines followed by significant up-regulation of IL-19 and IL-24.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mary Frances Wedekind, Katherine E. Miller, Chun-Yu Chen, Pin-Yi Wang, Brian J. Hutzen, Mark A. Currier, Brooke Nartker, Ryan D. Roberts, Louis Boon, Joe Conner, Stephanie LaHaye, Benjamin J. Kelly, David Gordon, Peter White, Elaine R. Mardis, Timothy P. Cripe
Summary: In murine osteosarcoma models, there were divergent responses to immunotherapy, with mice bearing K7M2 showing better survival outcomes with combination therapy. K7M2 exhibited higher expression of immune-related genes and immune cell infiltrates compared to F420.
Article
Cardiac & Cardiovascular Systems
Jesus Gil-Pulido, Nuria Amezaga, Ivana Jorgacevic, Helga D. Manthey, Melanie Roesch, Theresa Brand, Peter Cidlinsky, Sarah Schafer, Andreas Beilhack, Antoine-Emmanuel Saliba, Kristina Lorenz, Louis Boon, Immo Prinz, Ari Waisman, Thomas Korn, Clement Cochain, Alma Zernecke
Summary: IL-23R(+) gamma delta T cells predominantly found in the aortic root promote early atherosclerotic lesion formation, plaque necrosis, and inflammation at this site. Targeting IL-23R may be explored as a therapeutic approach to mitigate atherosclerotic lesion development.
CARDIOVASCULAR RESEARCH
(2022)
Article
Immunology
Cajsa H. Classon, Muzhen Li, Ada Lerma Clavero, Junjie Ma, Xiaogang Feng, Christopher A. Tibbitt, Julian M. Stark, Rebeca Cardoso, Emma Ringqvist, Louis Boon, Eduardo J. Villablanca, Antonio Gigliotti Rothfuchs, Liv Eidsmo, Jonathan M. Coquet, Susanne Nylen
Summary: Infection by strictly intestinal helminths can increase the numbers of CD4(+) T cells in the skin of mice, leading to a skewed T(H)2 cell composition and long-term effects on skin immune responses. This indicates a novel gut-to-skin cell trafficking process and worm-mediated immunosuppression.
MUCOSAL IMMUNOLOGY
(2022)
Article
Biology
Riem Gawish, Philipp Starkl, Lisabeth Pimenov, Anastasiya Hladik, Karin Lakovits, Felicitas Oberndorfer, Shane J. F. Cronin, Anna Ohradanova-Repic, Gerald Wirnsberger, Benedikt Agerer, Lukas Endler, Tumay Capraz, Jan W. Perthold, Domagoj Cikes, Rubina Koglgruber, Astrid Hagelkruys, Nuria Montserrat, Ali Mirazimi, Louis Boon, Hannes Stockinger, Andreas Bergthaler, Chris Oostenbrink, Josef M. Penninger, Sylvia Knapp
Summary: Despite progress in understanding COVID-19, limited mechanistic insight into immunological factors and disease severity remains. Scientists generated a mouse-adapted SARS-CoV-2 strain, maVie16, and found that cytokine-driven immunopathology and ACE2 dependence determine disease severity. This study provides a new tool for discovering therapies.
Article
Immunology
Saskia V. Vijver, Akashdip Singh, Eline T. A. M. Mommers-Elshof, Jan Meeldijk, Ronald Copeland, Louis Boon, Sol Langermann, Dallas Flies, Linde Meyaard, M. Ines Pascoal Ramos
Summary: The tumor microenvironment contains collagen fragments that can mediate T cell suppression through LAIR-1, leading to poor outcomes in cancer patients with high expression levels of MMPs and LAIR-1. Therapeutic strategies targeting the interaction of LAIR-1 with collagen fragments may help to reverse T cell dysfunction and improve immunity in cancer patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Jenny Sprooten, Ann Vankerckhoven, Isaure Vanmeerbeek, Daniel M. Borras, Yani Berckmans, Roxanne Wouters, Raquel S. Laureano, Thais Baert, Louis Boon, Chiara Landolfo, Antonia Carla Testa, Daniela Fischerova, Caroline Van Holsbeke, Tom Bourne, Valentina Chiappa, Wouter Froyman, Dominique Schols, Patrizia Agostinis, Dirk Timmerman, Sabine Tejpar, Ignace Vergote, An Coosemans, Abhishek D. Garg
Summary: The study established a novel biomarker resource for serum screening in patients with ovarian cancer to evaluate peripheral immunodynamics, patient survival trends, malignancy risk, and preclinical chemo-immunotherapy strategies. The in silico data-driven framework predicted that analysis of myeloid NF kappa B signaling and interferon-stimulated genes' responses could capture patients' peripheral immunodynamics effectively. Multiparametric serum profiling of patients with ovarian cancer showed that the sFIS assay can decode peripheral immunology, estimate survival trends, and co-estimate malignancy risk.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell Biology
Gaurang Jhala, Balasubramanian Krishnamurthy, Thomas C. Brodnicki, Tingting Ge, Satoru Akazawa, Claudia Selck, Prerak M. Trivedi, Evan G. Pappas, Leanne Mackin, Nicola Principe, Erwan Bremaud, David J. De George, Louis Boon, Ian Smyth, Jonathan Chee, Thomas W. H. Kay, Helen E. Thomas
Summary: IFN gamma regulates the expansion of antigen-specific CD8(+) T cells by controlling the expression of SOCS-1. Despite reduced inflammation in Ifngr-mutant mice, the expanded CD8(+) T cells may contribute to normal diabetes progression.
Article
Immunology
Nicola Principe, Wayne J. Aston, Danika E. Hope, Caitlin M. Tilsed, Scott A. Fisher, Louis Boon, Ian M. Dick, Wee Loong Chin, Alison M. McDonnell, Anna K. Nowak, Richard A. Lake, Jonathan Chee, Willem Joost Lesterhuis
Summary: This study investigated the combination effects of various chemotherapies with immune checkpoint blockade (ICB) and identified chemotherapy/ICB combinations that showed additive or non-additive effects. The combination of 5-fluorouracil (5-FU) or cisplatin with ICB had additive effects, while vinorelbine and etoposide did not provide additional benefit when combined with ICB. Furthermore, the study found that the combination of 5-FU with ICB increased inflammation in the tumor microenvironment, which may contribute to its effective combination therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Peter Rose, Natasja K. van den Engel, Julia R. Kovacs, Rudolf A. Hatz, Louis Boon, Hauke Winter
Summary: Depleting antibodies targeting myeloid-derived suppressor cells (MDSC) enhance the induction of tumor-specific T cells and delay the growth of melanoma.
Article
Immunology
Marco Gargaro, Giulia Scalisi, Giorgia Manni, Carlos G. Briseno, Prachi Bagadia, Vivek Durai, Derek J. Theisen, Sunkyung Kim, Marilena Castelli, Chenling A. Xu, Gerd Meyer zu Horste, Giuseppe Servillo, Maria A. Della Fazia, Giulia Mencarelli, Doriana Ricciuti, Eleonora Padiglioni, Nicola Giacche, Carolina Colliva, Roberto Pellicciari, Mario Calvitti, Teresa Zelante, Dietmar Fuchs, Ciriana Orabona, Louis Boon, Alban Bessede, Marco Colonna, Paolo Puccetti, Theresa L. Murphy, Kenneth M. Murphy, Francesca Fallarino
Summary: This study identifies a previously unrecognized metabolic communication pathway, in which cDC1 cells extend their immunoregulatory capacity to cDC2 through the production of L-kynurenine. This finding has potential therapeutic implications in treating autoimmune demyelinating diseases.
Article
Multidisciplinary Sciences
Ashleigh R. Poh, Christopher G. Love, David Chisanga, James H. Steer, David Baloyan, Michael Chopin, Stephen Nutt, Jai Rautela, Nicholas D. Huntington, Nima Etemadi, Megan O'Brien, Ryan O'Keefe, Lesley G. Ellies, Christophe Macri, Justine D. Mintern, Lachlan Whitehead, Gangadhara Gangadhara, Louis Boon, Ashwini L. Chand, Clifford A. Lowell, Wei Shi, Fiona J. Pixley, Matthias Ernst
Summary: Genetic ablation or therapeutic inhibition of the myeloid-specific hematopoietic cell kinase (HCK) enhances the response to immunotherapy by modifying the tumor microenvironment and promoting immune cell activation.
Article
Immunology
Anne -Charlotte Jonckheere, Brecht Steelant, Sven F. Seys, Jonathan Cremer, Ellen Dilissen, Louis Boon, Adrian Liston, Rik Schrijvers, Christine Breynaert, Jeroen A. J. Vanoirbeek, Jan L. Ceuppens, Dominique M. A. Bullens
Summary: This study investigates the role of regulatory T cells (Tregs) in maintaining the epithelial barrier and controlling tight junction expression. The results show that Treg deficiency leads to airway inflammation and decreased tight junction expression. Treatment with CTLA4-Ig effectively prevents barrier dysfunction and suppresses inflammation and cytokine secretion. Neutralization of IL-4 partially reverses the effects of Treg depletion, while neutralization of IL-6 and IFN-g has limited effects.
JOURNAL OF IMMUNOLOGY
(2022)
