Article
Chemistry, Analytical
Qianyang Huang, Ying Liu, Yuna Cheng, Fujian Jia, Chunchao Pu, Qinghua Yan, Zhaoyu Chang, Ping Liao, Dandan Ma, Lei Xu, Hua Zhang, Yuanzhi Lu, Xin Liu, Kang Liu
Summary: Rheumatoid arthritis (RA) is an autoimmune disorder characterized by joint and tissue inflammation. Cardiovascular disease (CVD) is the main cause of morbidity and mortality in RA patients. The development of new therapeutics for joint symptoms has not adequately addressed the cardiovascular burden in RA management. Recent attention has focused on circulating dimethylarginines as potential biomarkers for CVD. The study presented a high-throughput method for simultaneous quantification of creatinine, arginine, and dimethylarginines in human serum. The results revealed that the serological ratio of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) was significantly elevated in RA patients, suggesting its potential value in detecting CVD and improving clinical outcomes in RA management.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Biochemical Research Methods
Yalong Wang, Maria D. Person, Mark T. Bedford
Summary: Arginine methylation is an important posttranslational modification, playing a crucial role in biological regulation and disease development. In this study, pan-methylarginine antibodies were generated using a novel antigen approach, enabling the observation of substrate scavenging by PRMT1 and the increased ADMA levels of splicing factor SmD1 upon PRMT5 inhibition. Additionally, blocking the catalysis of both SDMA and ADMA resulted in the loss of interaction between SmD1 and SMN. These findings contribute to a better understanding of the biological functions and regulatory mechanisms of arginine methylation.
Article
Biochemistry & Molecular Biology
Anna Drohomirecka, Joanna Was, Natalia Wiligorska, Tomasz M. Rywik, Krzysztof Komuda, Dorota Sokolowska, Anna Lutynska, Tomasz Zielinski
Summary: Methylated arginine metabolites can disrupt nitric oxide synthesis, leading to endothelium dysfunction and inadequate vasodilation. This study aimed to investigate the dynamics of arginine derivatives during physical exercise in heart failure patients and assess its impact on patient outcomes.
Article
Veterinary Sciences
Carlotta Valente, Carlo Guglielmini, Marco Baron Toaldo, Giovanni Romito, Carlo Artusi, Laura Brugnolo, Barbara Contiero, Helen Poser
Summary: Plasmatic concentrations of dimethylarginines in dogs with MMVD are influenced by the stage of heart disease, with significantly higher levels of ADMA and SDMA observed in dogs in advanced stages. Elevated dimethylarginine levels may serve as biomarkers of disease severity in dogs with MMVD.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Gamze Gultekin, Serdar Pasa, Kerem Ural, Hasan Erdogan, Gizem Gonulveren, Mehmet Gultekin
Summary: The study examined the levels of arginine, SDMA, and ADMA in dogs with CanL and their relation to renal and cardiovascular parameters. The results showed that dogs with CanL had high blood pressure, increased creatinine, cystatin-C, phosphorus, potassium, and low-density lipoprotein concentrations, as well as decreased high-density lipoprotein concentration. The concentration of arginine was low, while the levels of ADMA and SDMA were high in dogs with CanL. These findings contribute to the understanding of the pathophysiology of CanL and can guide future diagnostic and therapeutic studies.
MICROBIAL PATHOGENESIS
(2023)
Article
Transplantation
Amy Y. M. Au, Kevin Mantik, Forough Bahadory, Paul Stathakis, Hayley Guiney, Jonathan Erlich, Robert Walker, Richie Poulton, Andrea Rita Horvath, Zoltan H. Endre
Summary: Elevated plasma methylarginine concentrations are associated with chronic kidney disease (CKD) and cardiovascular disease. A cohort at high risk of poor kidney health outcomes was identified using plasma cystatin C-based estimated glomerular filtration rate trajectories. Methylarginine metabolites were measured in plasma samples from the cohort, and the concentrations were found to facilitate risk stratification for CKD progression.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pediatrics
Beata Sarecka-Hujar, Izabela Szoltysek-Boldys, Ilona Kopyta
Summary: This study compared the levels of arginine derivatives in children with epilepsy treated with multiple AEDs, finding that epileptic children receiving three or more AEDs had lower concentrations of hArg and hArg/ADMA ratios. Additionally, a positive correlation was observed between hArg and ADMA concentrations in children with epilepsy taking two AEDs.
Article
Medicine, General & Internal
Juliane Hannemann, Elin H. Thorarinnsdottir, Andre F. S. Amaral, Edzard Schwedhelm, Lena Schmidt-Hutten, Heike Stang, Bryndis Benediktsdottir, Ingibjoerg Gunnarsdottir, Thorarinn Gislason, Rainer Boeger
Summary: This study found that plasma concentrations of ADMA and SDMA were elevated in patients with the overlap of COPD and OSA, which may lead to reduced production of nitric oxide, increased pulmonary vasoconstriction, and disease progression.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Joanna Polomska, Barbara Sozanska
Summary: In our study, serum and EBC concentrations of L-ARG and its metabolites were not an indicator of pediatric bronchial asthma.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Fengyuan Mandy Yang, Liya Shen, Dengxia Denise Fan, Kuan-Hung Chen, Jongdae Lee
Summary: Activated effector T cells (Teff) and compromised regulatory T cells (Treg) are the underlying factors of many chronic inflammatory diseases. A novel pathway involving DMGV has been discovered to regulate Teff survival and expansion without compromising Treg survival, offering a potential therapeutic approach for these diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Melody D. Fulton, Tran Dang, Tyler Brown, Y. George Zheng
Summary: This study explores how local changes on adjacent residues in histone substrate regulate the activities of PRMT1 and PRMT5 enzymes. Phosphorylation at H4S1 inhibits the activity of both enzymes, while the presence of a positively charged H4K5 is important for PRMT1 catalysis. Acetylation of H4K5 or loss of the H4K5 epsilon-amine affects the methylation of H4R3.
Article
Medicine, General & Internal
Jacek Siewiera, Michal Smolenski, Natalia Jermakow, Jacek Kot, Klaudia Brodaczewska, Jacek Turyn, Magdalena A. Zabielska-Kaczorowska, Nils Ludwig, Miroslaw J. Szczepanski
Summary: While differences were observed in ADMA, arginine derivatives, and cytokine concentrations among patient groups, HBOT did not have any significant effect on these parameters, suggesting its neutral impact on inflammation and endothelial injury.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Jan Mieszkowski, Paulina Brzezinska, Blazej Stankiewicz, Andrzej Kochanowicz, Katarzyna Zolodkiewicz, Bartlomiej Niespodzinski, Joanna Reczkowicz, Tomasz Kowalik, Tomasz Waldzinski, Jedrzej Antosiewicz
Summary: This study investigates the effect of single high-dose vitamin D supplementation on serum amino acid levels in ultramarathon runners. The results show that vitamin D can impact exercise-induced changes in serum amino acids and methylated arginine metabolites, potentially affecting the body's ability to synthesize NO.
Article
Sport Sciences
Christoffer Nyborg, Martin Bonnevie-Svendsen, Helene Stole Melsom, Jorgen Melau, Ingebjorg Seljeflot, Jonny Hisdal
Summary: This study investigated the changes in plasma levels of L-arginine, ADMA, and SDMA in athletes after the Norseman Xtreme triathlon, revealing a significant decrease in NO synthesis capability post-race, potentially increasing the risk of atherosclerosis.
Article
Biochemistry & Molecular Biology
Yuan-Sheng Zhai, Jie Li, Longyun Peng, Guihua Lu, Xiuren Gao
Summary: This study aimed to investigate the regulation and role of AVP in aldosterone synthesis in the heart. The results demonstrated that AVP induced the secretion of cardiac aldosterone, possibly through CaMK and CREB phosphorylation and CYP11B2 upregulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Christopher I. White, Maurits A. Jansen, Kieran McGregor, Katie J. Mylonas, Rachel V. Richardson, Adrian Thomson, Carmel M. Moran, Jonathan R. Seckl, Brian R. Walker, Karen E. Chapman, Gillian A. Gray
Article
Cardiac & Cardiovascular Systems
Andrea Protti, Heloise Mongue-Din, Katie J. Mylonas, Alexander Sirker, Can Martin Sag, Megan M. Swim, Lars Maier, Greta Sawyer, Xuebin Dong, Rene Botnar, Jon Salisbury, Gillian A. Gray, Ajay M. Shah
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2016)
Review
Endocrinology & Metabolism
Gillian A. Gray, Christopher I. White, Raphael F. P. Castellan, Sara J. McSweeney, Karen E. Chapman
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2017)
Article
Endocrinology & Metabolism
Rachel V. Richardson, Emma J. Batchen, Adrian J. W. Thomson, Rowan Darroch, Xinlu Pan, Eva A. Rog-Zielinska, Wiktoria Wyrzykowska, Kathleen Scullion, Emad A. S. Al-Dujaili, Mary E. Diaz, Carmel M. Moran, Christopher J. Kenyon, Gillian A. Gray, Karen E. Chapman
JOURNAL OF ENDOCRINOLOGY
(2017)
Article
Endocrinology & Metabolism
Katie J. Mylonas, Neil A. Turner, Sumia A. Bageghni, Christopher J. Kenyon, Christopher I. White, Kieran McGregor, Robert A. Kimmitt, Richard Sulston, Valerie Kelly, Brian R. Walker, Karen E. Porter, Karen E. Chapman, Gillian A. Gray
JOURNAL OF ENDOCRINOLOGY
(2017)
Article
Multidisciplinary Sciences
I. R. Murray, Z. N. Gonzalez, J. Baily, R. Dobie, R. J. Wallace, A. C. Mackinnon, J. R. Smith, S. N. Greenhalgh, A. I. Thompson, K. P. Conroy, D. W. Griggs, P. G. Ruminski, G. A. Gray, M. Singh, M. A. Campbell, T. J. Kendall, J. Dai, Y. Li, J. P. Iredale, H. Simpson, J. Huard, B. Peault, N. C. Henderson
NATURE COMMUNICATIONS
(2017)
Editorial Material
Biology
Gillian A. Gray, Nicola K. Gray
Review
Cardiac & Cardiovascular Systems
Merry L. Lindsey, Gillian A. Gray, Susan K. Wood, Douglas Curran-Everett
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Vladislav Miscianinov, Andrea Martello, Lorraine Rose, Elisa Parish, Ben Cathcart, Tijana Mitic, Gillian A. Gray, Marco Meloni, Ayman Al Haj Zen, Andrea Caporali
Article
Radiology, Nuclear Medicine & Medical Imaging
N. B. Spath, D. M. L. Lilburn, G. A. Gray, L. M. Le Page, G. Papanastasiou, R. J. Lennen, R. L. Janiczek, M. R. Dweck, D. E. Newby, P. C. Yang, M. A. Jansen, S. Semple
CONTRAST MEDIA & MOLECULAR IMAGING
(2018)
Article
Immunology
I. S. Toor, D. Ruckerl, I. Mair, A. Thomson, A. G. Rossi, D. E. Newby, J. E. Allen, G. A. Gray
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Ana-Mishel Spiroski, Rachel Sanders, Marco Meloni, Ian R. McCracken, Adrian Thomson, Mairi Brittan, Gillian A. Gray, Andrew H. Baker
Summary: The study examined the impact of the LINC00961/SPAAR locus on cardiac endothelial cell and fibroblast function, hypoxic response, post-natal growth, development, basal cardiac function, and response to myocardial infarction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Olivia Matthews, Emma E. Morrison, John D. Tranter, Philip Starkey Lewis, Iqbal S. Toor, Abhishek Srivastava, Rebecca Sargeant, Helen Rollison, Kylie P. Matchett, Timothy J. Kendall, Gillian A. Gray, Chris Goldring, Kevin Park, Laura Denby, Neeraj Dhaun, Matthew A. Bailey, Neil C. Henderson, Dominic Williams, James W. Dear
Review
Pharmacology & Pharmacy
Tamara P. Martin, Eilidh A. MacDonald, Ali Ali Mohamed Elbassioni, Dylan O'Toole, Ali Abdullah I. Zaeri, Stuart A. Nicklin, Gillian A. Gray, Christopher M. Loughrey
Summary: Approximately 7 million people are affected by acute myocardial infarction each year, and preclinical animal models have significantly advanced our understanding of the disease. While these models have limitations, careful selection is crucial for maximizing translational potential.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Physiology
G. A. Gray, I. S. Toor, R. F. P. Castellan, M. Crisan, M. Meloni
CURRENT OPINION IN PHYSIOLOGY
(2018)
Article
Cell Biology
Abril Alondra Barrientos-Bonilla, Paola Belem Pensado-Guevara, Abraham Puga-Olguin, Rasajna Nadella, Aurora del Carmen Sanchez-Garcia, Laura Mireya Zavala-Flores, Arnulfo Villanueva-Olivo, Iliana Tamara Cibrian-Llanderal, Maria de Jesus Rovirosa-Hernandez, Daniel Hernandez-Baltazar
Summary: This study evaluated the impact of BrdU on liver function and found that multiple injections of BrdU did not induce hepatocellular damage.
Article
Cell Biology
Pan Zhang, Qun Feng, Wenxiao Chen, Xizhuang Bai
Summary: It was found that catalpol antagonizes LPS-mediated inflammation and suppressive osteoblast differentiation by inhibiting inflammation and promoting osteoblast differentiation. This finding contributes to a better understanding of the pathogenesis of osteoporosis.